Rasa3 (RAS p21 protein activator 3)

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Gene: Rasa3 (RAS p21 protein activator 3) Rattus norvegicus

Analyze

Symbol:

Rasa3

Name:

RAS p21 protein activator 3

RGD ID:

69365

Description:

Predicted to have calcium-release channel activity. Involved in cellular response to heat. Predicted to localize to intrinsic component of the cytoplasmic side of the plasma membrane. Orthologous to human RASA3 (RAS p21 protein activator 3); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-Tetrachlorodibenzofuran.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Also known as:

GAP1(IP4BP); Ins P4-binding protein; R-ras gap; R-Ras GTP activating protein; R-ras GTPase activating protein; ras GTPase-activating protein 3

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	RASA3 (RAS p21 protein activator 3)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OrthoDB, Panther
Mus musculus (house mouse):	Rasa3 (RAS p21 protein activator 3)	HGNC	EggNOG, NCBI, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):	Rasa3 (RAS p21 protein activator 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	RASA3 (RAS p21 protein activator 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	RASA3 (RAS p21 protein activator 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Rasa3 (RAS p21 protein activator 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	RASA3 (RAS p21 protein activator 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):	RASA3 (RAS p21 protein activator 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Rasa3 (RAS p21 protein activator 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	RASA2 (RAS p21 protein activator 2)	HGNC	OrthoDB
Alliance orthologs ³
Mus musculus (house mouse):	Rasa3 (RAS p21 protein activator 3)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Homo sapiens (human):	RASA3 (RAS p21 protein activator 3)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Danio rerio (zebrafish):	rasa3 (RAS p21 protein activator 3)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Saccharomyces cerevisiae (baker's yeast):	BUD2	Alliance	DIOPT (OrthoInspector\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	RasGAP1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	gap-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)

Latest Assembly:

Rnor_6.0 - RGSC Genome Assembly v6.0

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	16	75,855,360 - 75,969,349 (+)	NCBI
Rnor_6.0 Ensembl	16	81,318,633 - 81,434,363 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	16	81,320,090 - 81,434,239 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	16	80,808,492 - 80,922,641 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	16	80,710,463 - 80,824,220 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	16	80,815,596 - 80,825,940 (+)	NCBI
Celera	16	73,663,562 - 73,777,478 (+)	NCBI		Celera
Cytogenetic Map	16	q12.5	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

aplastic anemia (ISS)

Dwarfism (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(S)-nicotine (ISO)

1,1-dichloroethene (ISO)

1,2-dimethylhydrazine (ISO)

1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (ISO)

17beta-estradiol (EXP,ISO)

17beta-estradiol 3-benzoate (EXP)

17beta-hydroxy-5alpha-androstan-3-one (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

2,4,6-trinitrobenzenesulfonic acid (EXP)

3,4-methylenedioxymethamphetamine (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4-hydroxyphenyl retinamide (ISO)

5-azacytidine (ISO)

acetamide (EXP)

aflatoxin B1 (ISO)

aflatoxin B2 (ISO)

ammonium chloride (EXP)

arsane (ISO)

arsenic atom (ISO)

atrazine (EXP)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

benzo[e]pyrene (ISO)

bisphenol A (EXP,ISO)

C60 fullerene (EXP)

cadmium atom (ISO)

cadmium dichloride (EXP)

caffeine (ISO)

carbon nanotube (ISO)

cisplatin (ISO)

crocidolite asbestos (ISO)

cyclosporin A (ISO)

dexamethasone (ISO)

dibutyl phthalate (EXP)

dorsomorphin (ISO)

endosulfan (EXP)

ethanol (ISO)

ethyl methanesulfonate (ISO)

folic acid (ISO)

formaldehyde (ISO)

genistein (ISO)

gentamycin (EXP)

glyphosate (ISO)

hydrogen peroxide (ISO)

methapyrilene (ISO)

methyl methanesulfonate (ISO)

methylmercury chloride (ISO)

N-ethyl-N-nitrosourea (ISO)

nicotine (ISO)

paracetamol (ISO)

pirinixic acid (ISO)

SB 431542 (ISO)

serpentine asbestos (ISO)

sodium arsenite (ISO)

Soman (EXP)

sunitinib (ISO)

Tesaglitazar (EXP)

testosterone (EXP)

tetrachloromethane (EXP,ISO)

trichostatin A (ISO)

tris(2-butoxyethyl) phosphate (ISO)

tungsten (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to heat (IDA)

intracellular signal transduction (IEA)

negative regulation of Ras protein signal transduction (IEA)

positive regulation of GTPase activity (IEA)

release of sequestered calcium ion into cytosol (IEA)

Cellular Component

intrinsic component of the cytoplasmic side of the plasma membrane (IEA,ISO)

Molecular Function

calcium-release channel activity (IEA,ISO)

GTPase activator activity (IEA)

metal ion binding (IEA)

References

References - curated


1.	Baba H, etal., J Neurosci Res. 1995 Aug 15;41(6):846-58.
2.	GOA data from the GO Consortium
3.	NCBI rat LocusLink and RefSeq merged data July 26, 2002
4.	RGD automated data pipeline
5.	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6.	RGD automated import pipeline for gene-chemical interactions
7.	RGD, Sept. 2003
8.	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data

Additional References at PubMed

PMID:10828023	PMID:18952607

Genomics

Comparative Map Data

Rasa3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	16	75,855,360 - 75,969,349 (+)	NCBI
Rnor_6.0 Ensembl	16	81,318,633 - 81,434,363 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	16	81,320,090 - 81,434,239 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	16	80,808,492 - 80,922,641 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	16	80,710,463 - 80,824,220 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	16	80,815,596 - 80,825,940 (+)	NCBI
Celera	16	73,663,562 - 73,777,478 (+)	NCBI		Celera
Cytogenetic Map	16	q12.5	NCBI

RASA3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	13	113,977,783 - 114,132,623 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	13	113,977,783 - 114,132,623 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	13	114,747,194 - 114,898,098 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	13	113,765,296 - 113,916,197 (-)	NCBI	NCBI36		hg18	NCBI36
Build 34	13	113,765,296 - 113,916,197	NCBI
Celera	13	95,423,074 - 95,573,004 (-)	NCBI
Cytogenetic Map	13	q34	NCBI
HuRef	13	95,016,746 - 95,162,033 (-)	NCBI		HuRef
CHM1_1	13	114,715,940 - 114,865,738 (-)	NCBI		CHM1_1

Rasa3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	13,617,218 - 13,727,590 (-)	NCBI	GRCm39		mm39
GRCm39 Ensembl	8	13,616,948 - 13,727,603 (-)	Ensembl
GRCm38	8	13,567,218 - 13,677,587 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	13,566,948 - 13,677,603 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	13,567,218 - 13,677,587 (-)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	8	13,567,195 - 13,677,549 (-)	NCBI			mm8
Celera	8	13,734,036 - 13,844,447 (-)	NCBI		Celera
Cytogenetic Map	8	A1.1	NCBI
cM Map	8	6.29	NCBI

Rasa3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955404	141,060 - 225,572 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955404	140,906 - 225,278 (+)	NCBI	ChiLan1.0	ChiLan1.0

RASA3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	13	114,123,816 - 114,271,066 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	13	114,123,816 - 114,271,066 (-)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	13	95,036,382 - 95,195,480 (-)	NCBI	Mhudiblu_PPA_v0		panPan3

RASA3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	22	61,093,762 - 61,202,209 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	22	61,095,044 - 61,202,152 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	22	60,805,357 - 60,913,843 (-)	NCBI
ROS_Cfam_1.0	22	61,780,849 - 61,889,450 (-)	NCBI
UMICH_Zoey_3.1	22	61,218,315 - 61,326,769 (-)	NCBI
UNSW_CanFamBas_1.0	22	61,225,625 - 61,334,098 (-)	NCBI
UU_Cfam_GSD_1.0	22	61,252,037 - 61,360,858 (-)	NCBI

Rasa3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	195,992,373 - 196,074,750 (-)	NCBI
SpeTri2.0	NW_004937030	40,123 - 122,478 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

RASA3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	11	78,950,878 - 79,027,930 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	11	78,951,017 - 79,027,991 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	11	86,685,993 - 86,763,496 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

RASA3
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	3	91,848,158 - 91,974,675 (-)	NCBI
ChlSab1.1 Ensembl	3	91,848,160 - 91,974,555 (-)	Ensembl

Rasa3
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624793	209,616 - 336,304 (+)	NCBI

Position Markers

D16Got83

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	16	81,433,593 - 81,433,807	NCBI	Rnor6.0
Rnor_5.0	16	80,921,995 - 80,922,209	UniSTS	Rnor5.0
RGSC_v3.4	16	80,710,894 - 80,711,109	RGD	RGSC3.4
RGSC_v3.4	16	80,710,895 - 80,711,109	UniSTS	RGSC3.4
RGSC_v3.1	16	80,711,160 - 80,711,374	RGD
Celera	16	73,663,994 - 73,664,208	UniSTS
RH 3.4 Map	16	761.6	RGD
RH 3.4 Map	16	761.6	UniSTS
RH 2.0 Map	16	846.8	RGD
Cytogenetic Map	16	q12.5	UniSTS

D16Got98

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	16	81,428,943 - 81,429,154	NCBI	Rnor6.0
Rnor_5.0	16	80,917,345 - 80,917,556	UniSTS	Rnor5.0
RGSC_v3.4	16	80,715,548 - 80,715,759	UniSTS	RGSC3.4
Celera	16	73,668,647 - 73,668,858	UniSTS
Cytogenetic Map	16	q12.5	UniSTS

D16Wox25

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	16	81,435,556 - 81,435,700	NCBI	Rnor6.0
Rnor_5.0	16	80,923,958 - 80,924,102	UniSTS	Rnor5.0
RGSC_v3.4	16	80,709,002 - 80,709,146	UniSTS	RGSC3.4
Celera	16	73,662,101 - 73,662,245	UniSTS
Cytogenetic Map	16	q12.5	UniSTS

BF386157

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	16	81,407,290 - 81,407,455	NCBI	Rnor6.0
Rnor_5.0	16	80,895,692 - 80,895,857	UniSTS	Rnor5.0
RGSC_v3.4	16	80,737,247 - 80,737,412	UniSTS	RGSC3.4
Celera	16	73,690,346 - 73,690,511	UniSTS
RH 3.4 Map	16	744.6	UniSTS
Cytogenetic Map	16	q12.5	UniSTS

RH139547

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	16	81,318,767 - 81,318,970	NCBI	Rnor6.0
Rnor_5.0	16	80,807,169 - 80,807,372	UniSTS	Rnor5.0
RGSC_v3.4	16	80,825,340 - 80,825,543	UniSTS	RGSC3.4
Celera	16	73,778,581 - 73,778,784	UniSTS
RH 3.4 Map	16	743.1	UniSTS
Cytogenetic Map	16	q12.5	UniSTS

QTLs in Region (Rnor_6.0)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1600378	Arunc4	Aerobic running capacity QTL 4		0.03	exercise endurance trait (VT:0002332)	maximum distance run on treadmill (CMO:0001406)	16	1090054	86162972	Rat
1578768	Stresp22	Stress response QTL 22	2.8		thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	16	39000021	84000021	Rat
2300163	Bmd64	Bone mineral density QTL 64	5.3	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	16	41512710	86512710	Rat
2293690	Bss45	Bone structure and strength QTL 45	5.13	0.0001	lumbar vertebra morphology trait (VT:0010494)	lumbar vertebra cortical cross-sectional area (CMO:0001690)	16	41512710	86512710	Rat
7205510	Activ5	Activity QTL 5	3.78	0.00028	locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	16	46558188	90668790	Rat
7411648	Foco22	Food consumption QTL 22	15	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	16	57816357	90668790	Rat
8694429	Bw164	Body weight QTL 164	5	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	16	57816357	90668790	Rat
8694364	Abfw7	Abdominal fat weight QTL 7	12.22	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	16	57816357	90668790	Rat
631525	Pia14	Pristane induced arthritis QTL 14	4.4		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	16	59285775	89248943	Rat

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	97
Count of miRNA genes:	83
Interacting mature miRNAs:	88
Transcripts:	ENSRNOT00000067508
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	2	28	28	20	19	20	2	3	74	33	34	11	2
Low	1	15	29	21		21	6	8		2	7		6
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_031574	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB020479	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AB021982	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AB028626	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AB029088	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473970	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	D86045	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000283	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000067508 ⟹ ENSRNOP00000061587

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	16	81,349,400 - 81,434,038 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000080963 ⟹ ENSRNOP00000069783

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	16	81,318,633 - 81,434,363 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000092335

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	16	81,330,539 - 81,331,874 (-)	Ensembl

RefSeq Acc Id:

NM_031574 ⟹ NP_113762

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	16	75,855,360 - 75,969,349 (+)	NCBI
Rnor_6.0	16	81,320,090 - 81,434,239 (-)	NCBI
Rnor_5.0	16	80,808,492 - 80,922,641 (-)	NCBI
RGSC_v3.4	16	80,710,463 - 80,824,220 (+)	RGD
Celera	16	73,663,562 - 73,777,478 (+)	RGD

Sequence:

show sequence

GTCGACGAGCAGCATGGCGGTGGAGGAAGAGGGACTGCGGGTCTTCCAGAGCGTGAGGATCAAG
ATTGGTGAAGCCAAGAATCTCCCTTCCTACCCGGGGCCAAACAAGATGAGGGACTGCTACTGCA
CTGTGAACCTGGACCAGGAGGAGGTTTTCCGGACCAAAATCGTAGAGAAGTCACTCTGCCCCTT
TTACGGAGAGGACTTTTACTGTGAAATTCCTCGGAGTTTCCGCCACCTGTCCTTTTACATTTTT
GATAGAGACGTTTTCCGAAGGGATTCCATCATAGGCAAGGTGGCCATCCAGAAGGAAGACTTGC
AAAGGTACCACAACAGGGACACATGGTTCCAGCTCCAGCATGTGGATGCTGACTCAGAGGTGCA
GGGCAAGGTCCACCTGGAGCTGAGACTGAGTGAGGTCATTACAGACACTGGTGTTGTCTGTCAC
AAACTCGCTGCACGCATCTTCGAGTGCCAGGGACTCCCCATTGTGAACGGGCAGTGCGACCCTT
ACGCCACCGTGACATTGGCCGGACCCTTCAGGTCTGAAGCGAAGAAAACCAAGGTGAAGAAGAA
AACCAACAACCCCCAGTTCGATGAGGTGTTTTATTTTGAGGTGACCAGACCCTGCAGCTACAGC
AAAAAGTCCCACTTCGACTTCGAGGAGGAGGACGTTGACAAACTTGAAATCCGAGTTGACCTCT
GGAACGCCAGCAACCTGAAGTTTGGGGATGAGTTTCTCGGGGAGTTGAGGATCCCTCTCCATGT
GCTGCGATACGCCAGTTCTTACGAAGCCTGGTACTTCCTCCAGCCCCGAGACAATGGCAGTAAG
AGCGTGAAGCCAGATGACTTAGGGTCGCTGAGGTTAAATGTAGTTTACACAGAAGACCACGTCT
TCTCCTCTGAGTACTACAGCCCACTACGTGACCTGTTACTGAAGTCTGCGGATGTGGAGCCTGT
CTCAGCTTCAGCAGCGCACATCCTCGGGGAGGTGTGCAGAGATAAGCAAGAGGCAGCCATCCCG
CTGGTACGGCTCCTGCTGCACTATGGCAGGGTAGTGCCCTTCATCAGTGCCATCGCTAGCGCAG
AGGTGAAGAGGACCCAGGACCCCAATACCATCTTCCGAGGAAACTCACTGACCTCTAAGTGCAT
AGATGAGACAATGAAGCTGGCGGGCATGCACTATCTCCACGTGACCCTGAAGCCCACCATTGAG
GAGATCTGCCAGAGCCATAAGTCCTGTGAGATCGACCCTGTGAAACTGAAAGATGGCGAAAACC
TTGAGAACAACATGGAGAGCCTGAGGCAGTATGTGGATCGAATATTCAGTGTCATCACTAAGTC
AGGGGTGAGCTGCCCCACCGTCATGTGTGACATCTTCTTCTCCCTGCGGGAGGCAGCTGCCAAG
CGCTTCCAAGATGACTTGGATGTGAGGTATACCGCCGTGAGCAGCTTCATCTTCCTGAGGTTCT
TCGCTCCCGCTATCCTGTCCCCGAACCTTTTCCAGCTGACGCCCCACCATACGGATCCACAGAC
TTCTAGAACCCTGACGCTTATCTCAAAGACCATCCAGACCCTTGGCAGCTTGTCCAAGTCCAAG
TCTGCCAGTTTTAAGGAGTCATACATGGCGACGTTCTATGAATTCTTCAATGAGCAGAAGTATG
CAGATGCCGTAAAGAATTTCCTGGATTTGATCTCATCCTCCGGGAGAAGGGACCCCAAGAGCAT
AGAGCAGCCCATCCTGCTTAAAGAAGGCTTCATGATCAAGCGGGCCCAAGGAAGGAAACGCTTT
GGAATGAAGAATTTCAAGAAGAGGTGGTTTCGCCTCACGAACCACGAGTTCACCTACCAGAAAA
GCAAAGGTGATCAGCCGCTCTGCAACATCCCCATCGAGAACATCTTGGCCGTGGAGAGGTTAGA
GGAGGAGTCCTTCCGAATGAAAAATATGTTCCAGGTCATCCAGCCAGAGCGTGCACTGTACATC
CAGGCCAACAACTGTGTGGAGGCCAAGGACTGGATTGACATCCTCACAAAAGTGAGTCAGTGCA
ACCAGAAGCGGCTCACAGTCTTCCACCCATCGGCCTACCTGAACGGCCACTGGCTTTGCTGCAG
GGCCTCTTCAGACACCGCTATTGGCTGCACTCCCTGCACTGGTGGGCTCCCAGCAAACATCCAG
CTGGACATTGATGGGGACCGTGAAACAGAGCGCATCTACTCTCTCTTTAACCTGTACATGGGCA
AGTTGGAAAAGATGCAGGAGGCCTGCGGCAGCAAGTCCGTATACGATGGCCCTGAGCAGGAGGA
ATACTCAACATTCATCATCGATGACCCCCAGGAGACGTACAGGACGCTGAAGCAGGTCATCGCT
GGGGTGGGGACCCTTGAGCAGGAGCACGCGCAGTACAGGAGGAACAAGTTCAAGAAGACGAGAT
ACGGGAGCCAGGAGCACCCTATTGGAGACAAGAGCTTCCAGAACTACATCAGGCAGCAGTCTGA
GATCTCAACCCATTCCATTTAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_113762	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	BAA78368	(Get FASTA)	NCBI Sequence Viewer
	BAA81903	(Get FASTA)	NCBI Sequence Viewer
	BAA89032	(Get FASTA)	NCBI Sequence Viewer
	BAA89047	(Get FASTA)	NCBI Sequence Viewer
	BAF31891	(Get FASTA)	NCBI Sequence Viewer
	EDM08909	(Get FASTA)	NCBI Sequence Viewer
	Q9QYJ2	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_113762 ⟸ NM_031574

- UniProtKB:

Q9QYJ2 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MAVEEEGLRVFQSVRIKIGEAKNLPSYPGPNKMRDCYCTVNLDQEEVFRTKIVEKSLCPFYGED
FYCEIPRSFRHLSFYIFDRDVFRRDSIIGKVAIQKEDLQRYHNRDTWFQLQHVDADSEVQGKVH
LELRLSEVITDTGVVCHKLAARIFECQGLPIVNGQCDPYATVTLAGPFRSEAKKTKVKKKTNNP
QFDEVFYFEVTRPCSYSKKSHFDFEEEDVDKLEIRVDLWNASNLKFGDEFLGELRIPLHVLRYA
SSYEAWYFLQPRDNGSKSVKPDDLGSLRLNVVYTEDHVFSSEYYSPLRDLLLKSADVEPVSASA
AHILGEVCRDKQEAAIPLVRLLLHYGRVVPFISAIASAEVKRTQDPNTIFRGNSLTSKCIDETM
KLAGMHYLHVTLKPTIEEICQSHKSCEIDPVKLKDGENLENNMESLRQYVDRIFSVITKSGVSC
PTVMCDIFFSLREAAAKRFQDDLDVRYTAVSSFIFLRFFAPAILSPNLFQLTPHHTDPQTSRTL
TLISKTIQTLGSLSKSKSASFKESYMATFYEFFNEQKYADAVKNFLDLISSSGRRDPKSIEQPI
LLKEGFMIKRAQGRKRFGMKNFKKRWFRLTNHEFTYQKSKGDQPLCNIPIENILAVERLEEESF
RMKNMFQVIQPERALYIQANNCVEAKDWIDILTKVSQCNQKRLTVFHPSAYLNGHWLCCRASSD
TAIGCTPCTGGLPANIQLDIDGDRETERIYSLFNLYMGKLEKMQEACGSKSVYDGPEQEEYSTF
IIDDPQETYRTLKQVIAGVGTLEQEHAQYRRNKFKKTRYGSQEHPIGDKSFQNYIRQQSEISTH
SI

hide sequence

RefSeq Acc Id:

ENSRNOP00000061587 ⟸ ENSRNOT00000067508

RefSeq Acc Id:

ENSRNOP00000069783 ⟸ ENSRNOT00000080963

Protein Domains

C2 PH Ras-GAP

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13700226

Promoter ID:

EPDNEW_R10750

Type:

initiation region

Name:

Rasa3_1

Description:

RAS p21 protein activator 3

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	16	81,434,363 - 81,434,423	EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)

ACI/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

ACI/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

ACI/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

BBDP/Wor (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

BN/SsN (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Buf/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

COP/CrCrl (MCW & UW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob) University of Wisconsin (Dr. James Shull)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Charles River Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)

F344/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

F344/NRrrc (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

FHH/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHH/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

FHL/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHL/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

GH/OmrMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

GK/Ox (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LE/Stm (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/Crl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/NCrlBR (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LH/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LL/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LN/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

M520/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

MHS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MNS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MR/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

SBH/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBH/Ygl sequenced by MCW

SBH/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SBN/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBN/Ygl sequenced by MCW

SBN/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHR/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHRSP/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SR/JrHsd (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Harlan Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SR/JrHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/Jr (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/JrHsdMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SS/JrHsdMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WAG/Rij (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

WKY/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WN/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:69365	AgrOrtholog
Ensembl Genes	ENSRNOG00000017671	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000061587	UniProtKB/TrEMBL
	ENSRNOP00000069783	ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000067508	UniProtKB/TrEMBL
	ENSRNOT00000080963	ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH	2.30.29.30	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	2.60.40.150	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	C2_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	C2_domain_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PH-like_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PH_domain	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ras_GTPase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	RASA3_PH	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	RasGAP_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	RasGAP_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Rho_GTPase_activation_prot	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Znf_Btk_motif	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:29372	UniProtKB/Swiss-Prot
NCBI Gene	29372	ENTREZGENE
PANTHER	PTHR10194	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	BTK	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PF00168	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PF00169	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	RasGAP	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Rasa3	PhenoGen
PROSITE	PH_DOMAIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PS50004	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	RAS_GTPASE_ACTIV_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	RAS_GTPASE_ACTIV_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ZF_BTK	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	BTK	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	RasGAP	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SM00233	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SM00239	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF48350	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR	TC206671
UniProt	A0A0G2JW85_RAT	UniProtKB/TrEMBL
	F1LSI5_RAT	UniProtKB/TrEMBL
	Q9QYJ2	ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary	Q09YN9	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2002-06-10	Rasa3	RAS p21 protein activator 3			Name updated	70584	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_expression	expressed in the developing brain	634611

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - MGI

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - MGI