Ccnb1 (cyclin B1) - Rat Genome Database

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Gene: Ccnb1 (cyclin B1) Rattus norvegicus
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Symbol: Ccnb1
Name: cyclin B1
RGD ID: 2291
Description: Enables protein kinase binding activity. Involved in several processes, including cellular response to iron(III) ion; positive regulation of cardiac muscle cell proliferation; and regulation of macromolecule metabolic process. Predicted to be located in cytosol; membrane; and microtubule cytoskeleton. Predicted to be part of cyclin B1-CDK1 complex and outer kinetochore. Predicted to be active in cytoplasm; microtubule organizing center; and nucleus. Predicted to colocalize with mitochondrial matrix. Human ortholog(s) of this gene implicated in breast cancer and prostate cancer. Orthologous to human CCNB1 (cyclin B1); PARTICIPATES IN cell cycle pathway, mitotic; G1/S transition pathway; G2/M checkpoint pathway; INTERACTS WITH (-)-citrinin; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1,3-dichloropropan-2-ol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: G2/mitotic-specific cyclin-B1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8233,646,252 - 33,655,225 (-)NCBIGRCr8
mRatBN7.2231,912,190 - 31,921,163 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl231,912,193 - 31,921,172 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx239,046,390 - 39,055,360 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0237,087,590 - 37,096,347 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0231,945,688 - 31,954,752 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0230,782,133 - 30,791,106 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl230,783,915 - 30,791,221 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0249,941,586 - 49,948,770 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4231,574,600 - 31,581,784 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1231,493,947 - 31,502,123 (-)NCBI
Celera227,925,441 - 27,934,414 (-)NCBICelera
Cytogenetic Map2q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-Tetrandrine  (ISO)
(-)-citrinin  (EXP,ISO)
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(1S)-bornane-2,3-dione  (ISO)
(20R)-protopanaxadiol  (ISO)
(S)-(-)-perillyl alcohol  (ISO)
(S)-colchicine  (ISO)
(S)-naringenin  (ISO)
(S)-nicotine  (ISO)
(Z)-ligustilide  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dichloropropan-2-ol  (EXP)
1,4-dioxane  (ISO)
1-(4-methoxybenzyl)-3-(5-nitro-1,3-thiazol-2-yl)urea  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,4'-trichlorobiphenyl  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2-acetamidofluorene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (EXP)
2-methoxy-17beta-estradiol  (ISO)
2-nitrofluorene  (EXP)
2-palmitoylglycerol  (ISO)
3',4',5-trihydroxy-3,7-dimethoxyflavone  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,3'-diindolylmethane  (ISO)
3-[(4-anilinophenyl)diazenyl]benzene-1-sulfonic acid  (EXP)
3-chloropropane-1,2-diol  (EXP)
3-methylcholanthrene  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-amino-1,8-naphthalimide  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitroquinoline N-oxide  (ISO)
4-nonylphenol  (EXP)
4-phenylbutyric acid  (ISO)
5,7-dihydroxy-4'-methoxyflavone  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
5-fluorouracil  (ISO)
6-O-methylguanine  (ISO)
6-oxocampestanol  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
9-Methoxycamptothecin  (ISO)
acetamide  (EXP)
acetylleucyl-leucyl-norleucinal  (ISO)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
acrylamide  (EXP,ISO)
adenosine  (EXP)
aflatoxin B1  (EXP,ISO)
AICA ribonucleotide  (ISO)
alachlor  (EXP)
aldehydo-D-glucosamine  (EXP)
aldehydo-D-glucose  (ISO)
aldrin  (ISO)
all-trans-retinoic acid  (ISO)
alpha-hexylcinnamaldehyde  (ISO)
alpha-naphthoflavone  (ISO)
alpha-pinene  (ISO)
alpha-Zearalanol  (EXP)
alvocidib  (ISO)
amiloride  (ISO)
ammonium chloride  (EXP)
amsacrine  (ISO)
aniline  (EXP)
anthocyanin  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
anthracene-1,8,9-triol  (ISO)
antimycin A  (ISO)
apigenin  (ISO)
Archazolid B  (ISO)
aristolochic acid A  (EXP,ISO)
aristolochic acids  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
atrazine  (ISO)
azathioprine  (ISO)
baicalein  (ISO)
belinostat  (ISO)
benomyl  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
benzophenone  (EXP)
beta-D-glucosamine  (EXP)
beta-naphthoflavone  (EXP)
betulinic acid  (ISO)
bexarotene  (ISO)
bezafibrate  (ISO)
bicalutamide  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol A glycidylmethacrylate  (ISO)
Bisphenol B  (EXP)
bortezomib  (ISO)
brassinolide  (ISO)
bucladesine  (ISO)
buta-1,3-diene  (ISO)
butane-2,3-dione  (ISO)
butylated hydroxyanisole  (ISO)
cadmium acetate  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcitriol  (ISO)
calycosin  (ISO)
camptothecin  (ISO)
cannabidiol  (ISO)
capsaicin  (ISO)
carbendazim  (ISO)
carbon nanotube  (ISO)
casticin  (ISO)
cefaloridine  (EXP)
celecoxib  (ISO)
chenodeoxycholic acid  (ISO)
chloramphenicol  (ISO)
chlorendic acid  (EXP)
chloroethene  (ISO)
chloroprene  (ISO)
chlorpyrifos  (EXP,ISO)
choline  (ISO)
chromium(6+)  (EXP,ISO)
chrysin  (ISO)
ciprofloxacin  (EXP,ISO)
cisplatin  (EXP,ISO)
citric acid  (ISO)
clofibrate  (EXP)
cobalt dichloride  (EXP,ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
coptisine  (ISO)
cordycepin  (ISO)
corosolic acid  (ISO)
corticosterone  (EXP)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cryptolepine  (ISO)
CU-O LINKAGE  (ISO)
cucurbitacin I  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
cyclosporin A  (ISO)
cypermethrin  (EXP)
cytochalasin B  (ISO)
D-glucose  (ISO)
DDE  (ISO)
deguelin  (ISO)
DENSPM  (ISO)
deoxynivalenol  (ISO)
desferrioxamine B  (ISO)
desloratadine  (ISO)
dexamethasone  (EXP,ISO)
Diacetoxyscirpenol  (ISO)
diallyl disulfide  (ISO)
Diallyl sulfide  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (EXP,ISO)
dibenz[a,h]anthracene  (ISO)
dibenzofuran  (EXP)
dibutyl phthalate  (ISO)
dichloroacetic acid  (ISO)
dicrotophos  (ISO)
Didymin  (ISO)
dieldrin  (EXP)
diepoxybutane  (ISO)
diethyl sulfate  (ISO)
diethylstilbestrol  (EXP)
digitonin  (ISO)
digitoxin  (ISO)
dioscin  (ISO)
dioxygen  (EXP,ISO)
diquat  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
Echimidine  (ISO)
EHT 1864  (ISO)
elemental selenium  (ISO)
ellipticine  (ISO)
Enterolactone  (ISO)
enzalutamide  (ISO)
enzyme inhibitor  (ISO)
erlotinib hydrochloride  (ISO)
erythromycin estolate  (EXP)
estragole  (EXP,ISO)
estriol  (ISO)
etoposide  (ISO)
eugenol  (EXP)
Evodiamine  (ISO)
fangchinoline  (ISO)
farnesol  (ISO)
fenpyroximate  (ISO)
fipronil  (EXP)
fisetin  (ISO)
flavanones  (ISO)
flumequine  (ISO)
fluoxetine  (ISO)
flurbiprofen  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
formononetin  (EXP,ISO)
fructose  (ISO)
fulvestrant  (EXP,ISO)
furan  (EXP)
gefitinib  (ISO)
gemcitabine  (ISO)
genistein  (EXP,ISO)
geraniol  (ISO)
gingerol  (ISO)
glucose  (ISO)
glycidol  (EXP)
glyphosate  (ISO)
Goe 6976  (ISO)
gossypin  (ISO)
GSK-J4  (ISO)
guggulsterone  (ISO)
GW 4064  (ISO)
hellebrigenin  (ISO)
heptachlor  (EXP)
hydrazine  (ISO)
hydrogen peroxide  (ISO)
hydroxyurea  (ISO)
indole-3-methanol  (EXP)
indometacin  (ISO)
inuviscolide  (ISO)
iodoacetic acid  (ISO)
irinotecan  (EXP)
iron dichloride  (ISO)
iron trichloride  (ISO)
isosilybin A  (ISO)
ivermectin  (ISO)
kaempferol  (ISO)
kojic acid  (ISO)
L-ascorbic acid  (EXP)
L-methionine  (ISO)
lactucin  (ISO)
Lasiocarpine  (ISO)
lead(0)  (ISO)
leflunomide  (EXP,ISO)
Licochalcone A  (ISO)
Licochalcone B  (ISO)
lidocaine  (EXP,ISO)
lipopolysaccharide  (ISO)
lithocholic acid  (ISO)
Longikaurin A  (ISO)
lucanthone  (ISO)
luteolin  (ISO)
luteolin 7-O-beta-D-glucoside  (ISO)
LY294002  (ISO)
malachite green cation  (EXP)
malathion  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
mangiferin  (ISO)
manumycin A  (ISO)
mechlorethamine  (ISO)
medroxyprogesterone acetate  (ISO)
MeIQx  (ISO)
melatonin  (ISO)
metformin  (ISO)
methamphetamine  (EXP)
methapyrilene  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methyl salicylate  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
methylseleninic acid  (ISO)
Mezerein  (ISO)
mirex  (EXP)
mitomycin C  (ISO)
Mitotane  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monobenzyl phthalate  (ISO)
monocrotaline  (ISO)
monoethyl phthalate  (ISO)
morin  (ISO)
myricetin  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP,ISO)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
N-Nitrosopyrrolidine  (ISO)
nickel atom  (ISO)
nickel dichloride  (EXP)
nickel subsulfide  (EXP)
niclosamide  (ISO)
nicotine  (ISO)
nocodazole  (ISO)
nonanoic acid  (ISO)
NORCANTHARIDIN  (ISO)
norwogonin  (ISO)
NS-398  (ISO)
O-methyleugenol  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (EXP,ISO)
okadaic acid  (ISO)
oligomycin A  (ISO)
omacetaxine mepesuccinate  (ISO)
osthole  (ISO)
oxaliplatin  (EXP,ISO)
oxcarbazepine  (EXP)
ozone  (ISO)
paclitaxel  (ISO)
palbociclib  (ISO)
palytoxin  (ISO)
Panduratin A  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
patulin  (ISO)
PCB138  (ISO)
Pentoxifylline  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
perillyl alcohol  (ISO)
phenethyl caffeate  (ISO)
phenethyl isothiocyanate  (ISO)
phenformin  (EXP)
phenobarbital  (EXP,ISO)
PhIP  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phthalaldehyde  (ISO)
phytosphingosine  (ISO)
picoxystrobin  (ISO)
pifithrin-alpha hydrobromide  (ISO)
pioglitazone  (ISO)
piperine  (ISO)
piperonyl butoxide  (EXP)
Pirarubicin  (ISO)
pirinixic acid  (EXP,ISO)
piroxicam  (ISO)
potassium bromate  (ISO)
potassium chromate  (ISO)
potassium dichromate  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
progesterone  (EXP,ISO)
propanal  (ISO)
propofol  (ISO)
propylparaben  (ISO)
pyrimidifen  (ISO)
quercetin  (EXP,ISO)
quinoline  (ISO)
quinolines  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
riboflavin  (ISO)
riddelliine  (ISO)
rimonabant  (ISO)
ritonavir  (ISO)
romidepsin  (ISO)
rotenone  (EXP,ISO)
Salinomycin  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
selumetinib  (ISO)
silibinin  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
silver(1+) nitrate  (ISO)
simazine  (ISO)
sodium arsenite  (ISO)
sodium azide  (ISO)
sodium chromate  (ISO)
sodium dichromate  (EXP)
sodium nitrite  (ISO)
Soman  (EXP)
sorafenib  (ISO)
sterigmatocystin  (ISO)
sulfadimethoxine  (ISO)
sulforaphane  (ISO)
sulindac  (ISO)
sunitinib  (ISO)
tamoxifen  (EXP)
temozolomide  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (ISO)
tetrathiomolybdate(2-)  (ISO)
thalidomide  (ISO)
thapsigargin  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
thymoquinone  (ISO)
titanium dioxide  (EXP,ISO)
Tomentosin  (ISO)
topotecan  (EXP,ISO)
trabectedin  (ISO)
triazoles  (ISO)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
Triptolide  (EXP,ISO)
triptonide  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
Tryptanthrine  (ISO)
tungsten  (ISO)
tunicamycin  (ISO)
Tylophorine  (ISO)
tyrphostin AG 1478  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vemurafenib  (ISO)
verteporfin  (ISO)
vincaleukoblastine  (ISO)
vinclozolin  (EXP,ISO)
vincristine  (ISO)
vorinostat  (ISO)
wortmannin  (ISO)
Xanthatin  (ISO)
xanthohumol  (ISO)
Yangonin  (ISO)
zaragozic acid A  (EXP,ISO)
zearalenone  (ISO)
zidovudine  (ISO)
zinc acetate  (ISO)
zinc atom  (EXP,ISO)
zinc dichloride  (ISO)
zinc(0)  (EXP,ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cell division  (IEA)
cellular response to fatty acid  (IEP)
cellular response to hypoxia  (IEP)
cellular response to iron(III) ion  (IEP)
chromatin remodeling  (IEA)
digestive tract development  (IEP)
G1/S transition of mitotic cell cycle  (IBA)
in utero embryonic development  (IEA,ISO)
mitotic cell cycle phase transition  (IEA)
mitotic metaphase chromosome alignment  (IBA,IEA,ISO)
mitotic spindle organization  (IEA,ISO)
negative regulation of gene expression  (IMP)
negative regulation of meiotic cell cycle process involved in oocyte maturation  (ISO)
negative regulation of protein phosphorylation  (IMP)
oocyte maturation  (IMP)
positive regulation of attachment of spindle microtubules to kinetochore  (IEA,ISO)
positive regulation of cardiac muscle cell proliferation  (IDA)
positive regulation of cell cycle  (IEA,ISO)
positive regulation of fibroblast proliferation  (IEA,ISO)
positive regulation of G2/M transition of mitotic cell cycle  (IEA,ISO)
positive regulation of mitochondrial ATP synthesis coupled electron transport  (IEA,ISO)
positive regulation of mitotic cell cycle  (IEA,ISO)
positive regulation of mRNA 3'-end processing  (IMP)
positive regulation of protein kinase activity  (IMP)
protein phosphorylation  (ISO)
protein-containing complex assembly  (IDA)
regulation of chromosome condensation  (IMP)
regulation of mitotic cell cycle spindle assembly checkpoint  (IEA,ISO)
response to DDT  (IEP)
response to mechanical stimulus  (IEP)
response to toxic substance  (IEP)
response to xenobiotic stimulus  (IEP)
spermatogenesis  (IEP)
tissue regeneration  (IEP)
ventricular cardiac muscle cell development  (IEP)

Cellular Component
centrosome  (IEA,ISO,ISS)
cyclin B1-CDK1 complex  (IBA,IEA,ISO)
cytoplasm  (IBA,IEA,ISO)
cytoskeleton  (IEA)
cytosol  (IEA,ISO)
membrane  (IEA,ISO)
microtubule organizing center  (IBA)
mitochondrial matrix  (IBA,IEA,ISO)
nucleus  (IBA,IEA,ISO)
outer kinetochore  (IEA,ISO)
spindle pole  (IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Forced expression of the cyclin B1-CDC2 complex induces proliferation in adult rat cardiomyocytes. Bicknell KA, etal., Biochem J. 2004 Sep 1;382(Pt 2):411-6.
2. Forkhead box M1B is a determinant of rat susceptibility to hepatocarcinogenesis and sustains ERK activity in human HCC. Calvisi DF, etal., Gut. 2009 May;58(5):679-87. Epub 2009 Jan 9.
3. The expression of cyclins in neurons of rats after focal cerebral ischemia. Chen B and Wang W, J Huazhong Univ Sci Technolog Med Sci. 2008 Feb;28(1):60-4.
4. Okadaic acid induced cyclin B1 expression and mitotic catastrophe in rat cortex. Chen B, etal., Neurosci Lett. 2006 Oct 9;406(3):178-82. Epub 2006 Aug 21.
5. Differential gene expression in mouse mammary adenocarcinomas in the presence and absence of wild type p53. Cui XS and Donehower LA, Oncogene. 2000 Dec 7;19(52):5988-96.
6. Minichromosome maintenance (Mcm) proteins, cyclin B1 and D1, phosphohistone H3 and in situ DNA replication for functional analysis of vulval intraepithelial neoplasia. Davidson EJ, etal., Br J Cancer. 2003 Jan 27;88(2):257-62.
7. Celecoxib leads to G2/M arrest by induction of p21 and down-regulation of cyclin B1 expression in a p53-independent manner. Dvory-Sobol H, etal., Eur J Cancer. 2006 Feb;42(3):422-6. Epub 2006 Jan 19.
8. Cyclin-dependent kinase 1 plays a critical role in DNA replication control during rat liver regeneration. Garnier D, etal., Hepatology. 2009 Dec;50(6):1946-56.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
11. Developmental changes in cyclin B1 and cyclin-dependent kinase 1 (CDK1) levels in the different populations of spermatogenic cells of the post-natal rat testis. Godet M, etal., Eur J Cell Biol. 2000 Nov;79(11):816-23.
12. Single perivascular delivery of mitomycin C stimulates p21 expression and inhibits neointima formation in rat arteries. Granada JF, etal., Arterioscler Thromb Vasc Biol. 2005 Nov;25(11):2343-8. Epub 2005 Sep 1.
13. Progressive derailment of cell cycle regulators in endometrial carcinogenesis. Horree N, etal., J Clin Pathol. 2008 Jan;61(1):36-42. Epub 2007 May 4.
14. Alteration of subcellular and cellular expression patterns of cyclin B1 in renal cell carcinoma is significantly related to clinical progression and survival of patients. Ikuerowo SO, etal., Int J Cancer. 2006 Aug 15;119(4):867-74.
15. The prognostic significance of proliferation-associated nucleolar protein p120 expression in prostate adenocarcinoma: a comparison with cyclins A and B1, Ki-67, proliferating cell nuclear antigen, and p34cdc2. Kallakury BV, etal., Cancer. 1999 Apr 1;85(7):1569-76.
16. Analysis of gene expression in different stages of MeIQx-induced rat hepatocarcinogenesis. Kang JS, etal., Oncol Rep. 2007 Apr;17(4):747-52.
17. o,p'-DDT elicits PXR/CAR-, not ER-, mediated responses in the immature ovariectomized rat liver. Kiyosawa N, etal., Toxicol Sci. 2008 Feb;101(2):350-63. Epub 2007 Nov 5.
18. Selective degradation of cyclin B1 mRNA in rat oocytes by RNA interference (RNAi). Lazar S, etal., J Mol Endocrinol. 2004 Aug;33(1):73-85.
19. Induction of cell cycle arrest in prostate cancer cells by the dietary compound isoliquiritigenin. Lee YM, etal., J Med Food. 2009 Feb;12(1):8-14.
20. Mechanical stretch induces mitochondria-dependent apoptosis in neonatal rat cardiomyocytes and G2/M accumulation in cardiac fibroblasts. Liao XD, etal., Cell Res. 2004 Feb;14(1):16-26.
21. Different fibrillar Abeta 1-42 concentrations induce adult hippocampal neurons to reenter various phases of the cell cycle. Majd S, etal., Brain Res. 2008 Jul 7;1218:224-9. Epub 2008 Apr 27.
22. Neoplastic transformation of rat liver epithelial cells is enhanced by non-transferrin-bound iron. Messner DJ and Kowdley KV, BMC Gastroenterol. 2008 Feb 6;8:2.
23. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
24. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
25. Cyclin B1 is a prognostic proliferation marker with a high reproducibility in a population-based lymph node negative breast cancer cohort. Nimeus-Malmstrom E, etal., Int J Cancer. 2009 Dec 2.
26. Induction of histone acetylation on the CRBPII gene in perinatal rat small intestine. Ogura Y, etal., Biochim Biophys Acta. 2007 Sep;1770(9):1289-96. Epub 2007 Jul 4.
27. Pentylenetetrazole kindling induces neuronal cyclin B1 expression in rat hippocampus. Pavlova T, etal., Neurosci Lett. 2006 Jan 9;392(1-2):154-8. Epub 2005 Oct 18.
28. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
29. Borna disease virus nucleoprotein interacts with the CDC2-cyclin B1 complex. Planz O, etal., J Virol. 2003 Oct;77(20):11186-92.
30. Dietary feeding of silibinin inhibits prostate tumor growth and progression in transgenic adenocarcinoma of the mouse prostate model. Raina K, etal., Cancer Res. 2007 Nov 15;67(22):11083-91.
31. Gene expression profile of butyrate-inhibited vascular smooth muscle cell proliferation. Ranganna K, etal., Mol Cell Biochem. 2003 Dec;254(1-2):21-36.
32. Reactome: A Knowledgebase of Biological Processes Reactome
33. GOA pipeline RGD automated data pipeline
34. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
35. Comprehensive gene review and curation RGD comprehensive gene curation
36. Expression of the F-box protein SKP2 induces hyperplasia, dysplasia, and low-grade carcinoma in the mouse prostate. Shim EH, etal., Cancer Res. 2003 Apr 1;63(7):1583-8.
37. CD8 T-cell responses against cyclin B1 in breast cancer patients with tumors overexpressing p53. Sorensen RB, etal., Clin Cancer Res. 2009 Mar 1;15(5):1543-9. Epub 2009 Feb 17.
38. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
39. Cyclin G: a new mammalian cyclin with homology to fission yeast Cig1. Tamura K, etal., Oncogene 1993 Aug;8(8):2113-8.
40. Posttranscriptional regulation of cyclin B messenger RNA expression in the regenerating rat liver. Trembley JH, etal., Cell Growth Differ 1994 Jan;5(1):99-108.
41. Significance of Insulin Signaling in Liver Regeneration Triggered by Portal Vein Ligation. Tseng JH, etal., J Surg Res. 2009 Jul 30.
42. Healthy individuals have T-cell and antibody responses to the tumor antigen cyclin B1 that when elicited in mice protect from cancer. Vella LA, etal., Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):14010-5. Epub 2009 Aug 3.
43. Cellular distributions of molecules with altered expression specific to thyroid proliferative lesions developing in a rat thyroid carcinogenesis model. Woo GH, etal., Cancer Sci. 2009 Apr;100(4):617-25. Epub 2009 Feb 25.
44. [Influence of aerosols on the expression of cyclin B1, cyclin C and proliferating cell nuclear antigen in wound tissue healing of burned rat models] Zhang T, etal., Zhonghua Wai Ke Za Zhi. 2005 Oct 1;43(19):1280-3.
45. Expression profiling of cyclin B1 and D1 in cervical carcinoma. Zhao M, etal., Exp Oncol. 2006 Mar;28(1):44-8.
46. Gender-related differences in basal and hypoxia-induced activation of signal transduction pathways controlling cell cycle progression and apoptosis, in cardiac fibroblasts. Zhao X and Eghbali-Webb M, Endocrine. 2002 Jul;18(2):137-45.
47. Nuclear cyclin B1 is overexpressed in low-malignant-potential ovarian tumors but not in epithelial ovarian cancer. Zheng H, etal., Am J Obstet Gynecol. 2009 Oct;201(4):367.e1-6. Epub 2009 Jul 15.
Additional References at PubMed
PMID:8270434   PMID:9539739   PMID:11331587   PMID:12124778   PMID:12399820   PMID:12524548   PMID:12954723   PMID:14993286   PMID:15489334   PMID:15749827   PMID:16109376   PMID:16237118  
PMID:16489008   PMID:17325031   PMID:17850284   PMID:18195732   PMID:18438935   PMID:18775106   PMID:18818692   PMID:19376971   PMID:20725088   PMID:20969598   PMID:21865454   PMID:22053081  
PMID:22180637   PMID:24746669   PMID:25651564   PMID:26109654   PMID:31585531  


Genomics

Comparative Map Data
Ccnb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8233,646,252 - 33,655,225 (-)NCBIGRCr8
mRatBN7.2231,912,190 - 31,921,163 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl231,912,193 - 31,921,172 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx239,046,390 - 39,055,360 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0237,087,590 - 37,096,347 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0231,945,688 - 31,954,752 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0230,782,133 - 30,791,106 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl230,783,915 - 30,791,221 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0249,941,586 - 49,948,770 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4231,574,600 - 31,581,784 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1231,493,947 - 31,502,123 (-)NCBI
Celera227,925,441 - 27,934,414 (-)NCBICelera
Cytogenetic Map2q12NCBI
CCNB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38569,167,150 - 69,178,245 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl569,167,135 - 69,178,245 (+)EnsemblGRCh38hg38GRCh38
GRCh37568,462,977 - 68,474,072 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36568,498,669 - 68,509,828 (+)NCBINCBI36Build 36hg18NCBI36
Build 34568,498,668 - 68,509,824NCBI
Celera565,462,166 - 65,473,328 (+)NCBICelera
Cytogenetic Map5q13.2NCBI
HuRef565,418,249 - 65,429,485 (+)NCBIHuRef
CHM1_1568,462,558 - 68,473,793 (+)NCBICHM1_1
T2T-CHM13v2.0569,989,760 - 70,000,851 (+)NCBIT2T-CHM13v2.0
Ccnb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3913100,915,247 - 100,922,994 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl13100,915,158 - 100,923,078 (-)EnsemblGRCm39 Ensembl
GRCm3813100,778,739 - 100,786,486 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl13100,778,650 - 100,786,570 (-)EnsemblGRCm38mm10GRCm38
MGSCv3713101,548,694 - 101,556,441 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3613101,878,996 - 101,886,743 (-)NCBIMGSCv36mm8
Celera13104,387,574 - 104,395,322 (-)NCBICelera
Cytogenetic Map13D1NCBI
cM Map1353.23NCBI
Ccnb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955446140,093 - 149,500 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955446140,661 - 149,500 (-)NCBIChiLan1.0ChiLan1.0
CCNB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2444,745,330 - 44,756,107 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1542,898,956 - 42,909,733 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0544,826,103 - 44,836,832 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1546,394,362 - 46,405,332 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl546,394,362 - 46,405,332 (-)Ensemblpanpan1.1panPan2
CCNB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1254,256,957 - 54,264,749 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha251,223,809 - 51,231,591 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0254,767,756 - 54,775,584 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1251,827,069 - 51,834,879 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0252,602,043 - 52,609,862 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0253,489,618 - 53,497,458 (+)NCBIUU_Cfam_GSD_1.0
Ccnb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213191,463,462 - 191,471,154 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936480399,224 - 407,704 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936480400,287 - 407,677 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CCNB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1647,338,110 - 47,348,377 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11647,338,239 - 47,348,385 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21651,155,615 - 51,165,760 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CCNB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1465,265,798 - 65,276,465 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl465,265,844 - 65,277,085 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604913,995,123 - 14,005,792 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Ccnb1
133 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:100
Count of miRNA genes:90
Interacting mature miRNAs:94
Transcripts:ENSRNOT00000025297
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10755430Coatc6Coat color QTL 60.02576coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)21159110056591100Rat
7387318Stl32Serum triglyceride level QTL 323.20.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)22238462767384627Rat
631682Bp115Blood pressure QTL 1154.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2137410502Rat
10755434Coatc7Coat color QTL 70.04794coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23064806575648065Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)218960362228801039Rat
738010Lnnr3Liver neoplastic nodule remodeling QTL 32.94liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)2141244106Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1300160Hrtrt3Heart rate QTL 33.62heart pumping trait (VT:2000009)absolute change in heart rate (CMO:0000534)22997159351729300Rat
731167Glom4Glomerulus QTL 42.40.0082kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)22030467265304672Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
738012Anxrr3Anxiety related response QTL 33.8exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)2902351954023519Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat
10402051Gdil2Gastrointestinal dilation QTL 2enteric ganglion morphology trait (VT:0001045)length of intestine affected by colonic aganglionosis to total length of colon ratio (CMO:0001836)22490385374786777Rat
9590095Sffal3Serum free fatty acids level QTL 36.780.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)22715716072157160Rat
1331764Bp205Blood pressure QTL 2053.476arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)22699957143154682Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1600379Mcs18Mammary carcinoma susceptibility QTL 182.6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)2788777242804738Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1643006Pain1Pain QTL 13.630.005mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)22699957148268661Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)25873687102844969Rat
2300168Bmd47Bone mineral density QTL 476.60.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)22066244865662448Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22691781781754745Rat
1578664Bmd9Bone mineral QTL density 95femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)21185206249003364Rat
1357990Ael1Aortic elastin QTL 13.10.00091aorta elastin amount (VT:0003905)aortic elastin21907682564076825Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)226917817136917119Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)228484589169504100Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
731184Mamtr4Mammary tumor resistance QTL 40.0003mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)21649174061491740Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)228484589169504100Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)226917817127469484Rat

Markers in Region
D2Ulb3  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2q12UniSTS
RH129097  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2231,913,458 - 31,913,614 (+)MAPPERmRatBN7.2
Rnor_6.0230,783,402 - 30,783,557NCBIRnor6.0
Rnor_5.0249,941,075 - 49,941,230UniSTSRnor5.0
RGSC_v3.4231,573,793 - 31,573,948UniSTSRGSC3.4
Celera227,926,710 - 27,926,865UniSTS
RH 3.4 Map264.4UniSTS
Cytogenetic Map2q12UniSTS
RH139214  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2231,913,479 - 31,913,623 (+)MAPPERmRatBN7.2
Rnor_6.0230,783,423 - 30,783,566NCBIRnor6.0
Rnor_5.0249,941,096 - 49,941,239UniSTSRnor5.0
RGSC_v3.4231,573,814 - 31,573,957UniSTSRGSC3.4
Celera227,926,731 - 27,926,874UniSTS
RH 3.4 Map263.7UniSTS
Cytogenetic Map2q12UniSTS
Ccnb1-rs1  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8233,648,190 - 33,648,507 (+)Marker Load Pipeline
mRatBN7.2231,914,127 - 31,914,445 (+)MAPPERmRatBN7.2
Rnor_6.0230,784,071 - 30,784,388NCBIRnor6.0
Rnor_5.0249,941,741 - 49,942,058UniSTSRnor5.0
RGSC_v3.4231,574,755 - 31,575,072UniSTSRGSC3.4
Celera227,927,379 - 27,927,696UniSTS
Cytogenetic Map2q12UniSTS
D4Ertd639e  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8233,648,169 - 33,649,015 (+)Marker Load Pipeline
mRatBN7.2231,914,107 - 31,914,953 (+)MAPPERmRatBN7.2
Rnor_6.0230,784,051 - 30,784,896NCBIRnor6.0
Rnor_5.0249,941,721 - 49,942,566UniSTSRnor5.0
RGSC_v3.4231,574,735 - 31,575,580UniSTSRGSC3.4
Celera227,927,359 - 27,928,204UniSTS
Cytogenetic Map2q12UniSTS
UniSTS:498737  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8233,648,108 - 33,648,463 (+)Marker Load Pipeline
mRatBN7.2231,914,046 - 31,914,401 (+)MAPPERmRatBN7.2
Rnor_6.0230,783,990 - 30,784,344NCBIRnor6.0
Rnor_5.0249,941,660 - 49,942,014UniSTSRnor5.0
RGSC_v3.4231,574,674 - 31,575,028UniSTSRGSC3.4
Celera227,927,298 - 27,927,652UniSTS
Cytogenetic Map2q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000082846   ⟹   ENSRNOP00000075114
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl231,914,090 - 31,921,172 (-)Ensembl
Rnor_6.0 Ensembl230,783,915 - 30,791,221 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000103969   ⟹   ENSRNOP00000095719
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl231,913,447 - 31,921,159 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000104772   ⟹   ENSRNOP00000082369
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl231,912,193 - 31,921,148 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000116076   ⟹   ENSRNOP00000079855
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl231,913,447 - 31,921,159 (-)Ensembl
RefSeq Acc Id: NM_171991   ⟹   NP_741988
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8233,646,252 - 33,655,225 (-)NCBI
mRatBN7.2231,912,190 - 31,921,163 (-)NCBI
Rnor_6.0230,782,133 - 30,791,106 (-)NCBI
Rnor_5.0249,941,586 - 49,948,770 (-)NCBI
RGSC_v3.4231,574,600 - 31,581,784 (-)RGD
Celera227,925,441 - 27,934,414 (-)NCBI
Sequence:
RefSeq Acc Id: NP_741988   ⟸   NM_171991
- UniProtKB: P30277 (UniProtKB/Swiss-Prot),   A6I5B4 (UniProtKB/TrEMBL),   A0A8I6G7B8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000075114   ⟸   ENSRNOT00000082846
Ensembl Acc Id: ENSRNOP00000082369   ⟸   ENSRNOT00000104772
Ensembl Acc Id: ENSRNOP00000079855   ⟸   ENSRNOT00000116076
Ensembl Acc Id: ENSRNOP00000095719   ⟸   ENSRNOT00000103969
Protein Domains
Cyclin C-terminal   Cyclin-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P30277-F1-model_v2 AlphaFold P30277 1-423 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691113
Promoter ID:EPDNEW_R1637
Type:initiation region
Name:Ccnb1_1
Description:cyclin B1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0230,791,099 - 30,791,159EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2291 AgrOrtholog
BioCyc Gene G2FUF-54647 BioCyc
Ensembl Genes ENSRNOG00000058539 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000103969.1 UniProtKB/Swiss-Prot
  ENSRNOT00000104772 ENTREZGENE
Gene3D-CATH Cyclin-like UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:6922392 IMAGE-MGC_LOAD
InterPro CCNB1_first_cyclin-box UniProtKB/Swiss-Prot
  Cyclin UniProtKB/Swiss-Prot
  Cyclin-like UniProtKB/Swiss-Prot
  Cyclin-like_sf UniProtKB/Swiss-Prot
  Cyclin_A/B-like UniProtKB/Swiss-Prot
  Cyclin_C-dom UniProtKB/Swiss-Prot
  Cyclin_N UniProtKB/Swiss-Prot
  Cyclins_cyclin-box UniProtKB/Swiss-Prot
KEGG Report rno:25203 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72670 IMAGE-MGC_LOAD
NCBI Gene 25203 ENTREZGENE
PANTHER PTHR10177 UniProtKB/Swiss-Prot
Pfam Cyclin_C UniProtKB/Swiss-Prot
  Cyclin_N UniProtKB/Swiss-Prot
PharmGKB CCNB1 RGD
PhenoGen Ccnb1 PhenoGen
PIRSF Cyclin_A_B_D_E UniProtKB/Swiss-Prot
PROSITE CYCLINS UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000058539 RatGTEx
SMART CYCLIN UniProtKB/Swiss-Prot
  Cyclin_C UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47954 UniProtKB/Swiss-Prot
UniProt A0A8I5ZPE0_RAT UniProtKB/TrEMBL
  A0A8I6G7B8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2RB82_RAT UniProtKB/TrEMBL
  A6I5B2_RAT UniProtKB/TrEMBL
  A6I5B3_RAT UniProtKB/TrEMBL
  A6I5B4 ENTREZGENE, UniProtKB/TrEMBL
  CCNB1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Ccnb1  Cyclin B1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in regenerating liver 1299843
gene_process may be involved in growth stimulation 68222
gene_transcript two mRNA species found in regenerating liver, 1.6 kb and 2.4 kb in length 1299843