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Gene: CCNB1 (cyclin B1) Homo sapiens
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Symbol: CCNB1
Name: cyclin B1
Description: Exhibits cyclin-dependent protein serine/threonine kinase activator activity; enzyme binding activity; and patched binding activity. Predicted to contribute to protein kinase activity. Involved in several processes, including mitotic metaphase plate congression; positive regulation of mitochondrial ATP synthesis coupled electron transport; and regulation of cell cycle process. Localizes to several cellular components, including the condensed nuclear chromosome outer kinetochore; cyclin B1-CDK1 complex; and microtubule cytoskeleton. Colocalizes with the mitochondrial matrix. Implicated in breast cancer and prostate cancer. Biomarker of breast cancer; in situ carcinoma; renal cell carcinoma; and reproductive organ cancer (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CCNB; G2/mitotic-specific cyclin B1; G2/mitotic-specific cyclin-B1
Orthologs:
Mus musculus (house mouse) : Ccnb1 (cyclin B1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ccnb1 (cyclin B1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ccnb1 (cyclin B1)
Pan paniscus (bonobo/pygmy chimpanzee) : CCNB1 (cyclin B1)
Canis lupus familiaris (dog) : CCNB1 (cyclin B1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ccnb1 (cyclin B1)
Sus scrofa (pig) : CCNB1 (cyclin B1)
Chlorocebus sabaeus (African green monkey) : CCNB1 (cyclin B1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl569,167,135 - 69,178,245 (+)EnsemblGRCh38hg38GRCh38
GRCh38569,167,010 - 69,178,245 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37568,462,837 - 68,474,072 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36568,498,669 - 68,509,828 (+)NCBINCBI36hg18NCBI36
Build 34568,498,668 - 68,509,824NCBI
Celera565,462,166 - 65,473,328 (+)NCBI
Cytogenetic Map5q13.2NCBI
HuRef565,418,249 - 65,429,485 (+)NCBIHuRef
CHM1_1568,462,558 - 68,473,793 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on CCNB1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 733179
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-03-24
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.