CCNB1 (cyclin B1) - Rat Genome Database
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Gene: CCNB1 (cyclin B1) Homo sapiens
Analyze
Symbol: CCNB1
Name: cyclin B1
RGD ID: 733179
HGNC Page HGNC
Description: Exhibits cyclin-dependent protein serine/threonine kinase activator activity; enzyme binding activity; and patched binding activity. Involved in several processes, including mitotic metaphase plate congression; positive regulation of mitochondrial ATP synthesis coupled electron transport; and regulation of cell cycle process. Localizes to several cellular components, including condensed nuclear chromosome outer kinetochore; cyclin B1-CDK1 complex; and microtubule cytoskeleton. Colocalizes with mitochondrial matrix. Implicated in breast cancer and prostate cancer. Biomarker of breast cancer; in situ carcinoma; renal cell carcinoma; and reproductive organ cancer (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CCNB; G2/mitotic-specific cyclin B1; G2/mitotic-specific cyclin-B1
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl569,167,135 - 69,178,245 (+)EnsemblGRCh38hg38GRCh38
GRCh38569,167,150 - 69,178,245 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37568,462,977 - 68,474,072 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36568,498,669 - 68,509,828 (+)NCBINCBI36hg18NCBI36
Build 34568,498,668 - 68,509,824NCBI
Celera565,462,166 - 65,473,328 (+)NCBI
Cytogenetic Map5q13.2NCBI
HuRef565,418,249 - 65,429,485 (+)NCBIHuRef
CHM1_1568,462,558 - 68,473,793 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (EXP)
(+)-Tetrandrine  (EXP)
(-)-citrinin  (EXP,ISO)
(-)-demecolcine  (EXP)
(-)-epigallocatechin 3-gallate  (EXP)
(1S)-bornane-2,3-dione  (EXP)
(20R)-protopanaxadiol  (EXP)
(S)-(-)-perillyl alcohol  (EXP)
(S)-colchicine  (EXP)
(S)-nicotine  (EXP,ISO)
(Z)-ligustilide  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-dioxane  (ISO)
1-(4-methoxybenzyl)-3-(5-nitro-1,3-thiazol-2-yl)urea  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoic acid  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2-acetamidofluorene  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-methoxy-17beta-estradiol  (EXP)
2-nitrofluorene  (ISO)
3',4',5-trihydroxy-3,7-dimethoxyflavone  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3'-diindolylmethane  (EXP)
3-[(4-anilinophenyl)diazenyl]benzene-1-sulfonic acid  (ISO)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-amino-1,8-naphthalimide  (EXP)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitroquinoline N-oxide  (ISO)
4-nonylphenol  (ISO)
5-aza-2'-deoxycytidine  (EXP,ISO)
5-azacytidine  (EXP)
5-fluorouracil  (EXP)
6-O-methylguanine  (EXP)
6-oxocampestanol  (EXP)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
acetamide  (ISO)
acetylleucyl-leucyl-norleucinal  (EXP)
acetylsalicylic acid  (EXP)
acrolein  (EXP)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
AICA ribonucleotide  (EXP)
alachlor  (ISO)
aldehydo-D-glucosamine  (ISO)
aldrin  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-hexylcinnamaldehyde  (ISO)
alpha-naphthoflavone  (EXP)
alpha-pinene  (EXP)
alvocidib  (EXP)
amiloride  (EXP)
ammonium chloride  (ISO)
amsacrine  (EXP)
anthocyanin  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
anthracene-1,8,9-triol  (ISO)
antimycin A  (EXP)
apigenin  (EXP)
aristolochic acid  (ISO)
arsane  (EXP)
arsenic atom  (EXP)
arsenite(3-)  (EXP,ISO)
arsenous acid  (EXP,ISO)
atrazine  (EXP)
azathioprine  (EXP)
baicalein  (EXP)
belinostat  (EXP)
benomyl  (EXP)
benzene  (EXP,ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP)
benzo[b]fluoranthene  (ISO)
benzophenone  (ISO)
beta-D-glucosamine  (ISO)
beta-naphthoflavone  (ISO)
bexarotene  (EXP)
bezafibrate  (ISO)
bicalutamide  (EXP)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A glycidylmethacrylate  (EXP)
bortezomib  (EXP)
brassinolide  (EXP)
bucladesine  (EXP)
buta-1,3-diene  (ISO)
butylated hydroxyanisole  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP,ISO)
calcitriol  (EXP)
calycosin  (EXP)
camptothecin  (EXP)
capsaicin  (EXP)
carbon nanotube  (ISO)
casticin  (EXP)
cefaloridine  (ISO)
celecoxib  (EXP)
chloramphenicol  (ISO)
chlorendic acid  (ISO)
chloroethene  (ISO)
chloroprene  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chromium(6+)  (EXP,ISO)
chrysin  (EXP)
ciprofloxacin  (EXP,ISO)
cisplatin  (EXP,ISO)
citric acid  (EXP)
clofibrate  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (EXP)
corticosterone  (ISO)
coumestrol  (EXP)
crocidolite asbestos  (EXP)
cryptolepine  (EXP)
CU-O LINKAGE  (EXP)
cucurbitacin I  (EXP)
curcumin  (EXP)
cyclosporin A  (EXP,ISO)
cytochalasin B  (EXP)
desferrioxamine B  (EXP)
dexamethasone  (EXP,ISO)
Diacetoxyscirpenol  (ISO)
diallyl disulfide  (EXP)
Diallyl sulfide  (EXP)
diallyl trisulfide  (EXP)
diarsenic trioxide  (EXP,ISO)
dibenz[a,h]anthracene  (ISO)
dibenzofuran  (ISO)
dibutyl phthalate  (EXP,ISO)
dichloroacetic acid  (ISO)
dicrotophos  (EXP)
dieldrin  (ISO)
diepoxybutane  (ISO)
diethyl sulfate  (EXP)
diethylstilbestrol  (ISO)
digitoxin  (EXP)
dioscin  (EXP)
dioxygen  (EXP,ISO)
disodium selenite  (EXP)
dorsomorphin  (EXP)
doxorubicin  (EXP,ISO)
elemental selenium  (EXP)
ellipticine  (EXP)
Enterolactone  (EXP)
enzyme inhibitor  (EXP)
erlotinib hydrochloride  (EXP)
erythromycin estolate  (ISO)
Estragole  (ISO)
estriol  (ISO)
etoposide  (EXP)
eugenol  (ISO)
farnesol  (EXP)
fipronil  (ISO)
fisetin  (EXP)
flavanones  (EXP)
flumequine  (ISO)
fluoxetine  (ISO)
flurbiprofen  (EXP)
folic acid  (EXP,ISO)
formaldehyde  (EXP)
formononetin  (EXP,ISO)
fulvestrant  (EXP,ISO)
furan  (ISO)
gemcitabine  (EXP)
genistein  (EXP,ISO)
geraniol  (EXP)
gingerol  (EXP)
glycidol  (ISO)
glyphosate  (EXP)
Goe 6976  (EXP)
guggulsterone  (ISO)
GW 4064  (EXP)
hellebrigenin  (EXP)
heptachlor  (ISO)
hydrazine  (ISO)
hydrogen peroxide  (EXP)
hydroxyurea  (EXP,ISO)
indole-3-methanol  (ISO)
indometacin  (EXP)
inuviscolide  (EXP)
iodoacetic acid  (ISO)
irinotecan  (ISO)
iron dichloride  (ISO)
iron trichloride  (ISO)
kaempferol  (EXP)
kojic acid  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
lead(0)  (EXP)
lead(2+)  (EXP)
leflunomide  (EXP,ISO)
lidocaine  (ISO)
lipopolysaccharide  (ISO)
lithocholic acid  (ISO)
Longikaurin A  (EXP)
lucanthone  (EXP)
luteolin  (EXP)
malachite green cation  (ISO)
malathion  (EXP)
mangiferin  (EXP)
Manumycin A  (EXP)
mechlorethamine  (EXP)
medroxyprogesterone acetate  (EXP)
MeIQx  (ISO)
melatonin  (EXP)
metformin  (EXP)
methamphetamine  (ISO)
methapyrilene  (ISO)
methotrexate  (EXP)
methyl methanesulfonate  (EXP)
methyl salicylate  (ISO)
methylmercury chloride  (ISO)
methylparaben  (EXP)
methylseleninic acid  (EXP)
Mezerein  (ISO)
mirex  (ISO)
mitomycin C  (EXP,ISO)
Mitotane  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
monobenzyl phthalate  (ISO)
monoethyl phthalate  (ISO)
morin  (EXP)
myricetin  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
N-Nitrosopyrrolidine  (EXP)
nickel atom  (EXP)
nickel dichloride  (ISO)
nickel subsulfide  (ISO)
niclosamide  (EXP)
nicotine  (EXP,ISO)
nocodazole  (EXP)
nonanoic acid  (ISO)
NS-398  (EXP)
O-methyleugenol  (EXP)
obeticholic acid  (ISO)
ochratoxin A  (EXP,ISO)
oligomycin A  (ISO)
omacetaxine mepesuccinate  (EXP)
osthole  (EXP)
oxaliplatin  (EXP,ISO)
ozone  (EXP,ISO)
paclitaxel  (EXP)
palbociclib  (EXP)
palytoxin  (ISO)
Panduratin A  (EXP)
paracetamol  (EXP,ISO)
paraquat  (ISO)
PCB138  (ISO)
Pentoxifylline  (EXP)
perfluorononanoic acid  (EXP)
perfluorooctanoic acid  (EXP,ISO)
perillyl alcohol  (EXP)
phenethyl caffeate  (EXP)
phenethyl isothiocyanate  (EXP)
phenformin  (ISO)
phenobarbital  (ISO)
PhIP  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
phthalaldehyde  (ISO)
pioglitazone  (EXP)
piperine  (ISO)
piperonyl butoxide  (ISO)
Pirarubicin  (EXP)
pirinixic acid  (EXP,ISO)
piroxicam  (EXP)
potassium bromate  (EXP)
potassium chromate  (EXP)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (EXP,ISO)
propanal  (EXP)
propofol  (EXP)
propylparaben  (EXP)
quercetin  (EXP,ISO)
quinoline  (EXP)
quinolines  (EXP)
raloxifene  (EXP)
resveratrol  (EXP,ISO)
riboflavin  (EXP)
rimonabant  (EXP)
ritonavir  (EXP)
romidepsin  (EXP)
rotenone  (ISO)
SB 203580  (EXP)
selenium atom  (EXP)
selumetinib  (ISO)
silibinin  (EXP)
silicon dioxide  (EXP,ISO)
silver atom  (EXP)
silver(0)  (EXP)
silver(1+) nitrate  (EXP)
simazine  (ISO)
sodium arsenite  (EXP,ISO)
sodium azide  (EXP)
sodium dichromate  (ISO)
sodium nitrite  (ISO)
Soman  (ISO)
sorafenib  (ISO)
sterigmatocystin  (EXP)
sulfadimethoxine  (ISO)
sulforaphane  (EXP)
sulindac  (EXP)
sunitinib  (EXP)
tamoxifen  (ISO)
temozolomide  (EXP)
testosterone  (EXP,ISO)
tetrachloromethane  (ISO)
thalidomide  (EXP)
thapsigargin  (EXP)
thimerosal  (EXP)
thioacetamide  (ISO)
thymoquinone  (EXP)
titanium dioxide  (EXP,ISO)
Tomentosin  (EXP)
topotecan  (EXP,ISO)
trabectedin  (EXP)
triazoles  (EXP)
tributylstannane  (EXP)
Tributyltin oxide  (ISO)
trichloroethene  (ISO)
trichostatin A  (EXP)
trimellitic anhydride  (ISO)
Triptolide  (EXP,ISO)
troglitazone  (EXP)
tungsten  (ISO)
tunicamycin  (EXP)
Tylophorine  (EXP)
tyrphostin AG 1478  (EXP)
urethane  (ISO)
valproic acid  (EXP,ISO)
vemurafenib  (EXP)
verteporfin  (ISO)
vincaleukoblastine  (EXP)
vinclozolin  (ISO)
vincristine  (EXP)
vorinostat  (EXP)
wortmannin  (EXP)
Xanthatin  (EXP)
Yangonin  (ISO)
zaragozic acid A  (ISO)
zearalenone  (ISO)
zidovudine  (EXP)
zinc atom  (ISO)
zinc dichloride  (ISO)
zinc(0)  (ISO)
zoledronic acid  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anaphase-promoting complex-dependent catabolic process  (TAS)
cell division  (IEA)
cellular response to fatty acid  (IEA,ISO)
cellular response to hypoxia  (IEA,ISO)
cellular response to iron(III) ion  (IEA,ISO)
cellular response to organic cyclic compound  (IEA,ISO)
digestive tract development  (IEA,ISO)
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest  (TAS)
G2/M transition of mitotic cell cycle  (TAS)
histone H3-S10 phosphorylation involved in chromosome condensation  (IEA,ISO)
in utero embryonic development  (IEA,ISO)
mitotic cell cycle  (ISO)
mitotic cell cycle phase transition  (IBA)
mitotic chromosome condensation  (TAS)
mitotic metaphase plate congression  (IBA,IMP)
mitotic nuclear envelope disassembly  (TAS)
mitotic nuclear envelope reassembly  (TAS)
mitotic spindle organization  (IMP)
negative regulation of gene expression  (IEA,ISO)
negative regulation of meiotic cell cycle process involved in oocyte maturation  (ISO)
negative regulation of protein phosphorylation  (IEA,ISO)
oocyte maturation  (IEA,ISO)
positive regulation of attachment of spindle microtubules to kinetochore  (IMP)
positive regulation of cardiac muscle cell proliferation  (IEA,ISO)
positive regulation of cell cycle  (ISO)
positive regulation of cyclin-dependent protein serine/threonine kinase activity  (IEA)
positive regulation of fibroblast proliferation  (IEA,ISO)
positive regulation of G2/M transition of mitotic cell cycle  (IDA)
positive regulation of histone phosphorylation  (IEA,ISO)
positive regulation of mitochondrial ATP synthesis coupled electron transport  (IDA)
positive regulation of mitotic cell cycle  (IMP)
positive regulation of mRNA 3'-end processing  (IEA,ISO)
protein phosphorylation  (ISO)
protein-containing complex assembly  (IEA,ISO)
regulation of cell cycle  (ISO,TAS)
regulation of chromosome condensation  (IEA,ISO)
regulation of cyclin-dependent protein serine/threonine kinase activity  (IBA)
regulation of mitotic cell cycle phase transition  (TAS)
regulation of mitotic cell cycle spindle assembly checkpoint  (IMP)
regulation of transcription initiation from RNA polymerase II promoter  (TAS)
response to DDT  (IEA,ISO)
response to drug  (IEA,ISO)
response to mechanical stimulus  (IEA,ISO)
response to toxic substance  (ISO)
spermatogenesis  (IEA,ISO)
tissue regeneration  (IEA,ISO)
ventricular cardiac muscle cell development  (IEA,ISO)

Cellular Component

References

Additional References at PubMed
PMID:1384126   PMID:1386342   PMID:1387877   PMID:1717476   PMID:1828290   PMID:1836978   PMID:2570636   PMID:7474080   PMID:7474100   PMID:7494303   PMID:7666531   PMID:7737117  
PMID:7769006   PMID:7799941   PMID:7843284   PMID:7876309   PMID:7903056   PMID:8070405   PMID:8101826   PMID:8397206   PMID:8397207   PMID:8402895   PMID:8463339   PMID:8475101  
PMID:8524869   PMID:8662825   PMID:8756624   PMID:8889548   PMID:9001210   PMID:9053846   PMID:9094673   PMID:9244350   PMID:9315635   PMID:9499405   PMID:9515786   PMID:9520381  
PMID:9560267   PMID:9679058   PMID:9813064   PMID:9885575   PMID:9891079   PMID:9926943   PMID:10339564   PMID:10362260   PMID:10373560   PMID:10395539   PMID:10421840   PMID:10581175  
PMID:10716937   PMID:10793135   PMID:10864927   PMID:10958988   PMID:10973963   PMID:10995390   PMID:11113184   PMID:11242082   PMID:11259605   PMID:11260656   PMID:11278247   PMID:11285280  
PMID:11310559   PMID:11331587   PMID:11444800   PMID:11531413   PMID:11559705   PMID:11562349   PMID:11572993   PMID:11598127   PMID:11642719   PMID:11691994   PMID:11732576   PMID:11739784  
PMID:11779217   PMID:11809526   PMID:11836499   PMID:11878934   PMID:11960377   PMID:12009577   PMID:12054478   PMID:12068134   PMID:12097298   PMID:12115375   PMID:12124778   PMID:12200597  
PMID:12379461   PMID:12397081   PMID:12424202   PMID:12447691   PMID:12468530   PMID:12477932   PMID:12483522   PMID:12515609   PMID:12524548   PMID:12586340   PMID:12612082   PMID:12676926  
PMID:12684677   PMID:12738867   PMID:12775724   PMID:12791267   PMID:12839990   PMID:12865421   PMID:12956947   PMID:14645578   PMID:14701726   PMID:14760118   PMID:14993212   PMID:15016823  
PMID:15024056   PMID:15181148   PMID:15215233   PMID:15251430   PMID:15265780   PMID:15489334   PMID:15541388   PMID:15592520   PMID:15635413   PMID:15654331   PMID:15710382   PMID:15749827  
PMID:15767402   PMID:15790566   PMID:15916961   PMID:15931389   PMID:15989971   PMID:16009132   PMID:16082198   PMID:16109376   PMID:16142332   PMID:16159883   PMID:16221667   PMID:16226712  
PMID:16237118   PMID:16273239   PMID:16322753   PMID:16407259   PMID:16474839   PMID:16478538   PMID:16479161   PMID:16751065   PMID:16784539   PMID:16799550   PMID:16880739   PMID:16921029  
PMID:17098733   PMID:17167975   PMID:17242184   PMID:17242210   PMID:17274640   PMID:17283331   PMID:17327911   PMID:17359284   PMID:17359356   PMID:17360335   PMID:17373649   PMID:17386261  
PMID:17388661   PMID:17389604   PMID:17408621   PMID:17431037   PMID:17445807   PMID:17466630   PMID:17472438   PMID:17495531   PMID:17495533   PMID:17513602   PMID:17533373   PMID:17586317  
PMID:17598982   PMID:17655707   PMID:17668170   PMID:17679094   PMID:17850284   PMID:17881737   PMID:18048386   PMID:18195732   PMID:18281511   PMID:18337751   PMID:18353325   PMID:18372919  
PMID:18408012   PMID:18408765   PMID:18414058   PMID:18445273   PMID:18471975   PMID:18491248   PMID:18591933   PMID:18593994   PMID:18652313   PMID:18671143   PMID:18692784   PMID:18799590  
PMID:18820706   PMID:19028417   PMID:19107194   PMID:19134343   PMID:19162005   PMID:19275580   PMID:19275586   PMID:19293801   PMID:19344781   PMID:19369249   PMID:19458171   PMID:19470724  
PMID:19475398   PMID:19502428   PMID:19505905   PMID:19609944   PMID:19614764   PMID:19724852   PMID:19738611   PMID:19763267   PMID:19786724   PMID:19820702   PMID:19825974   PMID:19826003  
PMID:19855194   PMID:19879842   PMID:19968870   PMID:20080579   PMID:20095356   PMID:20097574   PMID:20103625   PMID:20126263   PMID:20160477   PMID:20169205   PMID:20171170   PMID:20228808  
PMID:20334896   PMID:20360007   PMID:20360068   PMID:20367638   PMID:20368335   PMID:20383333   PMID:20404109   PMID:20412769   PMID:20453000   PMID:20467437   PMID:20508983   PMID:20526282  
PMID:20660152   PMID:20661218   PMID:20725088   PMID:20733051   PMID:20733055   PMID:20808790   PMID:20810654   PMID:20890132   PMID:20927403   PMID:20937773   PMID:20956543   PMID:20965177  
PMID:20974803   PMID:21120602   PMID:21145461   PMID:21148318   PMID:21174181   PMID:21241890   PMID:21264543   PMID:21276999   PMID:21336306   PMID:21379580   PMID:21488187   PMID:21489275  
PMID:21504622   PMID:21525341   PMID:21540187   PMID:21569376   PMID:21596315   PMID:21700221   PMID:21871181   PMID:21873635   PMID:21900495   PMID:21900748   PMID:21925791   PMID:21952639  
PMID:21965721   PMID:22014574   PMID:22024040   PMID:22024133   PMID:22071694   PMID:22137483   PMID:22157815   PMID:22158041   PMID:22163316   PMID:22193957   PMID:22253775   PMID:22266860  
PMID:22286100   PMID:22391203   PMID:22482362   PMID:22508987   PMID:22529100   PMID:22532137   PMID:22552851   PMID:22580043   PMID:22682366   PMID:22726437   PMID:22898364   PMID:22905155  
PMID:22939629   PMID:22949227   PMID:22965228   PMID:23007861   PMID:23091007   PMID:23114644   PMID:23239745   PMID:23246971   PMID:23253261   PMID:23288039   PMID:23383273   PMID:23397142  
PMID:23414517   PMID:23430691   PMID:23443559   PMID:23455922   PMID:23460259   PMID:23505570   PMID:23602568   PMID:23670162   PMID:23708605   PMID:23775624   PMID:23791783   PMID:23799914  
PMID:23874748   PMID:23979597   PMID:24058555   PMID:24145166   PMID:24151075   PMID:24163370   PMID:24248602   PMID:24324638   PMID:24324728   PMID:24358021   PMID:24386390   PMID:24395923  
PMID:24415942   PMID:24416725   PMID:24488334   PMID:24508230   PMID:24574517   PMID:24623419   PMID:24705021   PMID:24714775   PMID:24746669   PMID:24840883   PMID:24971465   PMID:25044212  
PMID:25106528   PMID:25149538   PMID:25161877   PMID:25217616   PMID:25241761   PMID:25246557   PMID:25306923   PMID:25315186   PMID:25362646   PMID:25398907   PMID:25415322   PMID:25482201  
PMID:25483188   PMID:25486360   PMID:25490258   PMID:25501285   PMID:25505175   PMID:25603287   PMID:25651564   PMID:25659430   PMID:25698537   PMID:25750436   PMID:25825779   PMID:25849598  
PMID:25852190   PMID:25885523   PMID:25962181   PMID:25982682   PMID:26029996   PMID:26125663   PMID:26136431   PMID:26186194   PMID:26221070   PMID:26270673   PMID:26344197   PMID:26349943  
PMID:26387543   PMID:26387737   PMID:26389696   PMID:26474281   PMID:26496610   PMID:26506418   PMID:26555753   PMID:26555773   PMID:26638075   PMID:26673895   PMID:26706989   PMID:26709398  
PMID:26752685   PMID:26834014   PMID:26912231   PMID:26942677   PMID:27030811   PMID:27074503   PMID:27114510   PMID:27114546   PMID:27183908   PMID:27259151   PMID:27297620   PMID:27432908  
PMID:27462423   PMID:27486754   PMID:27522463   PMID:27542221   PMID:27609421   PMID:27626412   PMID:27634302   PMID:27663664   PMID:27669826   PMID:27726420   PMID:27903976   PMID:27927753  
PMID:28115489   PMID:28296622   PMID:28514442   PMID:28601573   PMID:28675297   PMID:28678347   PMID:28821558   PMID:28927264   PMID:29229926   PMID:29395067   PMID:29507755   PMID:29700288  
PMID:29705704   PMID:29844126   PMID:29908998   PMID:29973362   PMID:30021884   PMID:30069972   PMID:30327455   PMID:30481564   PMID:30518842   PMID:30556321   PMID:30629673   PMID:30674582  
PMID:30726872   PMID:30782840   PMID:30833792   PMID:30974121   PMID:31073040   PMID:31091453   PMID:31230944   PMID:31350353   PMID:31387191   PMID:31455778   PMID:31469407   PMID:31474315  
PMID:31492965   PMID:31527303   PMID:31585531   PMID:31588029   PMID:31605132   PMID:31630568   PMID:31746372   PMID:31767812   PMID:31814919   PMID:31822694   PMID:31870357   PMID:31906456  
PMID:32152539   PMID:32231148   PMID:32632220   PMID:32877691   PMID:33037310  


Genomics

Comparative Map Data
CCNB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl569,167,135 - 69,178,245 (+)EnsemblGRCh38hg38GRCh38
GRCh38569,167,150 - 69,178,245 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37568,462,977 - 68,474,072 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36568,498,669 - 68,509,828 (+)NCBINCBI36hg18NCBI36
Build 34568,498,668 - 68,509,824NCBI
Celera565,462,166 - 65,473,328 (+)NCBI
Cytogenetic Map5q13.2NCBI
HuRef565,418,249 - 65,429,485 (+)NCBIHuRef
CHM1_1568,462,558 - 68,473,793 (+)NCBICHM1_1
Ccnb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3913100,915,247 - 100,922,994 (-)NCBIGRCm39mm39
GRCm39 Ensembl13100,915,158 - 100,923,078 (-)Ensembl
GRCm3813100,778,739 - 100,786,486 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl13100,778,650 - 100,786,570 (-)EnsemblGRCm38mm10GRCm38
MGSCv3713101,548,694 - 101,556,441 (-)NCBIGRCm37mm9NCBIm37
MGSCv3613101,878,996 - 101,886,743 (-)NCBImm8
Celera13104,387,574 - 104,395,322 (-)NCBICelera
Cytogenetic Map13D1NCBI
cM Map1353.23NCBI
Ccnb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2231,912,190 - 31,921,163 (-)NCBI
Rnor_6.0 Ensembl230,783,915 - 30,791,221 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0230,782,133 - 30,791,106 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0249,941,586 - 49,948,770 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4231,574,600 - 31,581,784 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1231,493,947 - 31,502,123 (-)NCBI
Celera227,925,441 - 27,934,414 (-)NCBICelera
Cytogenetic Map2q12NCBI
Ccnb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955446140,093 - 149,500 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955446140,661 - 149,500 (-)NCBIChiLan1.0ChiLan1.0
CCNB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1546,394,362 - 46,405,332 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl546,394,362 - 46,405,332 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0544,826,103 - 44,836,832 (-)NCBIMhudiblu_PPA_v0panPan3
CCNB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1254,256,957 - 54,264,749 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Ccnb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936480400,287 - 407,677 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CCNB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1647,338,110 - 47,348,381 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11647,338,239 - 47,348,385 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21651,155,615 - 51,165,760 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CCNB1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1465,265,798 - 65,276,465 (+)NCBI
ChlSab1.1 Ensembl465,265,844 - 65,277,085 (+)Ensembl

Position Markers
csnpccnb1-pcr3-1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37568,463,884 - 68,464,303UniSTSGRCh37
Build 36568,499,640 - 68,500,059RGDNCBI36
Celera565,463,137 - 65,463,556RGD
Cytogenetic Map5q12UniSTS
HuRef565,419,296 - 65,419,715UniSTS
csnpccnb1-pcr6-1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37568,470,583 - 68,471,017UniSTSGRCh37
Build 36568,506,339 - 68,506,773RGDNCBI36
Celera565,469,835 - 65,470,273RGD
Cytogenetic Map5q12UniSTS
HuRef565,425,994 - 65,426,432UniSTS
csnpccnb1-pcr7-1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37568,471,100 - 68,471,458UniSTSGRCh37
Build 36568,506,856 - 68,507,214RGDNCBI36
Celera565,470,356 - 65,470,714RGD
Cytogenetic Map5q12UniSTS
HuRef565,426,515 - 65,426,873UniSTS
csnpccnb1-pcr9-1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37568,473,235 - 68,473,564UniSTSGRCh37
Build 36568,508,991 - 68,509,320RGDNCBI36
Celera565,472,491 - 65,472,820RGD
Cytogenetic Map5q12UniSTS
HuRef565,428,648 - 65,428,977UniSTS
PMC138289P1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37568,462,849 - 68,463,089UniSTSGRCh37
Build 36568,498,605 - 68,498,845RGDNCBI36
Celera565,462,102 - 65,462,342RGD
Cytogenetic Map5q12UniSTS
HuRef565,418,261 - 65,418,501UniSTS
PMC31860P1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37568,463,759 - 68,463,887UniSTSGRCh37
Build 36568,499,515 - 68,499,643RGDNCBI36
Celera565,463,012 - 65,463,140RGD
Cytogenetic Map5q12UniSTS
HuRef565,419,171 - 65,419,299UniSTS
PMC31860P2  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37568,463,795 - 68,463,887UniSTSGRCh37
Build 36568,499,551 - 68,499,643RGDNCBI36
Celera565,463,048 - 65,463,140RGD
Cytogenetic Map5q12UniSTS
HuRef565,419,207 - 65,419,299UniSTS
CCNB1_1683  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37568,473,414 - 68,474,265UniSTSGRCh37
Build 36568,509,170 - 68,510,021RGDNCBI36
Celera565,472,670 - 65,473,521RGD
HuRef565,428,827 - 65,429,678UniSTS
G31135  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37568,473,875 - 68,474,001UniSTSGRCh37
Build 36568,509,631 - 68,509,757RGDNCBI36
Celera565,473,131 - 65,473,257RGD
Cytogenetic Map5q12UniSTS
HuRef565,429,288 - 65,429,414UniSTS
CCNB1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37568,470,097 - 68,470,796UniSTSGRCh37
Celera565,469,349 - 65,470,052UniSTS
HuRef565,425,508 - 65,426,211UniSTS

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR93hsa-miR-93-5pOncomiRDBexternal_infoNANA22581829

Predicted Target Of
Summary Value
Count of predictions:1133
Count of miRNA genes:607
Interacting mature miRNAs:676
Transcripts:ENST00000256442, ENST00000503507, ENST00000505500, ENST00000506572, ENST00000507798, ENST00000508407, ENST00000513102
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 1
Medium 500 52 263 146 888 124 620 64 282 157 752 480 35 18 166 4
Low 1929 2761 1403 419 1016 282 3705 1998 3375 259 704 1131 139 1 1186 2591 1 2
Below cutoff 7 174 60 59 46 59 31 133 73 3 2 1 31 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001354844 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001354845 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_031966 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC010273 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC022107 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI972071 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK289431 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AM851053 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY027761 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY027762 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY027763 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY027764 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY027765 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY027767 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY027768 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY027769 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY027770 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY338491 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC006510 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BI253686 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM979016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT020128 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471137 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HH771226 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M25753 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S74452 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U22364 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U36838 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000256442   ⟹   ENSP00000256442
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl569,167,150 - 69,178,245 (+)Ensembl
RefSeq Acc Id: ENST00000503507   ⟹   ENSP00000425103
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl569,167,266 - 69,174,255 (+)Ensembl
RefSeq Acc Id: ENST00000505500   ⟹   ENSP00000424588
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl569,167,263 - 69,177,630 (+)Ensembl
RefSeq Acc Id: ENST00000506572   ⟹   ENSP00000423387
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl569,167,135 - 69,177,358 (+)Ensembl
RefSeq Acc Id: ENST00000507798   ⟹   ENSP00000426230
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl569,174,257 - 69,177,700 (+)Ensembl
RefSeq Acc Id: ENST00000508407   ⟹   ENSP00000426092
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl569,167,216 - 69,175,063 (+)Ensembl
RefSeq Acc Id: ENST00000513102
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl569,177,061 - 69,177,697 (+)Ensembl
RefSeq Acc Id: NM_001354844   ⟹   NP_001341773
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38569,167,150 - 69,178,245 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001354845   ⟹   NP_001341774
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38569,167,150 - 69,178,245 (+)NCBI
Sequence:
RefSeq Acc Id: NM_031966   ⟹   NP_114172
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38569,167,150 - 69,178,245 (+)NCBI
GRCh37568,462,837 - 68,474,072 (+)NCBI
Build 36568,498,669 - 68,509,828 (+)NCBI Archive
HuRef565,418,249 - 65,429,485 (+)NCBI
CHM1_1568,462,558 - 68,473,793 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_114172   ⟸   NM_031966
- Peptide Label: isoform 1
- UniProtKB: P14635 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001341773   ⟸   NM_001354844
- Peptide Label: isoform 2
- Sequence:
RefSeq Acc Id: NP_001341774   ⟸   NM_001354845
- Peptide Label: isoform 3
- Sequence:
RefSeq Acc Id: ENSP00000425103   ⟸   ENST00000503507
RefSeq Acc Id: ENSP00000424588   ⟸   ENST00000505500
RefSeq Acc Id: ENSP00000256442   ⟸   ENST00000256442
RefSeq Acc Id: ENSP00000423387   ⟸   ENST00000506572
RefSeq Acc Id: ENSP00000426230   ⟸   ENST00000507798
RefSeq Acc Id: ENSP00000426092   ⟸   ENST00000508407
Protein Domains
CYCLIN   Cyclin N-terminal

Promoters
RGD ID:6802940
Promoter ID:HG_KWN:50303
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:OTTHUMT00000215084,   UC003JVL.1,   UC010IXB.1
Position:
Human AssemblyChrPosition (strand)Source
Build 36568,498,386 - 68,498,886 (+)MPROMDB
RGD ID:6852698
Promoter ID:EP74161
Type:initiation region
Name:HS_CCNB1
Description:Cyclin B1.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Mammalian gene collection (MGC) full-length cDNA cloning
Position:
Human AssemblyChrPosition (strand)Source
Build 36568,498,765 - 68,498,825EPD
RGD ID:6869814
Promoter ID:EPDNEW_H8054
Type:initiation region
Name:CCNB1_2
Description:cyclin B1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H8055  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38569,167,045 - 69,167,105EPDNEW
RGD ID:6869780
Promoter ID:EPDNEW_H8055
Type:initiation region
Name:CCNB1_1
Description:cyclin B1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H8054  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38569,167,150 - 69,167,210EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 5q12.3-13.2(chr5:64932763-69495504)x1 copy number loss See cases [RCV000051223] Chr5:64932763..69495504 [GRCh38]
Chr5:64228590..68791331 [GRCh37]
Chr5:64264346..68827087 [NCBI36]
Chr5:5q12.3-13.2
pathogenic
GRCh38/hg38 5q12.1-13.2(chr5:63207112-71291191)x3 copy number gain See cases [RCV000135640] Chr5:63207112..71291191 [GRCh38]
Chr5:62502939..70587018 [GRCh37]
Chr5:62538695..70622774 [NCBI36]
Chr5:5q12.1-13.2
likely pathogenic
GRCh38/hg38 5p15.33-q13.3(chr5:22149-74412725)x3 copy number gain See cases [RCV000138780] Chr5:22149..74412725 [GRCh38]
Chr5:22149..73708550 [GRCh37]
Chr5:75149..73744306 [NCBI36]
Chr5:5p15.33-q13.3
pathogenic
GRCh38/hg38 5q12.3-13.2(chr5:65976124-71317474)x3 copy number gain See cases [RCV000142796] Chr5:65976124..71317474 [GRCh38]
Chr5:65271952..70613301 [GRCh37]
Chr5:65307708..70649057 [NCBI36]
Chr5:5q12.3-13.2
uncertain significance
GRCh37/hg19 5q12.1-13.2(chr5:60722469-70792199)x1 copy number loss See cases [RCV000447549] Chr5:60722469..70792199 [GRCh37]
Chr5:5q12.1-13.2
pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:113577-180719789) copy number gain See cases [RCV000510723] Chr5:113577..180719789 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
GRCh37/hg19 5p15.1-q35.2(chr5:17628741-176575720)x1 copy number loss See cases [RCV000511978] Chr5:17628741..176575720 [GRCh37]
Chr5:5p15.1-q35.2
pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:113577-180719789)x3 copy number gain See cases [RCV000512039] Chr5:113577..180719789 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
GRCh37/hg19 5q12.1-13.2(chr5:58966132-68847066)x4 copy number gain See cases [RCV000510792] Chr5:58966132..68847066 [GRCh37]
Chr5:5q12.1-13.2
likely pathogenic
GRCh37/hg19 5q13.1-13.2(chr5:68313021-68847066)x4 copy number gain See cases [RCV000512580] Chr5:68313021..68847066 [GRCh37]
Chr5:5q13.1-13.2
uncertain significance
GRCh37/hg19 5q12.3-13.2(chr5:65315606-68755816)x1 copy number loss not provided [RCV000682564] Chr5:65315606..68755816 [GRCh37]
Chr5:5q12.3-13.2
likely pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:25328-180693344)x3 copy number gain not provided [RCV000744323] Chr5:25328..180693344 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:13648-180905029)x3 copy number gain not provided [RCV000744317] Chr5:13648..180905029 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
GRCh37/hg19 5q13.1-13.2(chr5:68278453-70369959)x3 copy number gain not provided [RCV000754758] Chr5:68278453..70369959 [GRCh37]
Chr5:5q13.1-13.2
uncertain significance
Single allele deletion Neurodevelopmental disorder [RCV000787436] Chr5:14685137..149511942 [GRCh37]
Chr5:5p15.2-q32
uncertain significance
GRCh38/hg38 5q11.2-13.2(chr5:58785203-73519962)x1 copy number loss Intellectual disability [RCV000984869] Chr5:58785203..73519962 [GRCh38]
Chr5:5q11.2-13.2
likely pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:1579 AgrOrtholog
COSMIC CCNB1 COSMIC
Ensembl Genes ENSG00000134057 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000256442 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000423387 UniProtKB/TrEMBL
  ENSP00000424588 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000425103 UniProtKB/TrEMBL
  ENSP00000426092 UniProtKB/TrEMBL
  ENSP00000426230 UniProtKB/TrEMBL
Ensembl Transcript ENST00000256442 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000503507 UniProtKB/TrEMBL
  ENST00000505500 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000506572 UniProtKB/TrEMBL
  ENST00000507798 UniProtKB/TrEMBL
  ENST00000508407 UniProtKB/TrEMBL
GTEx ENSG00000134057 GTEx
HGNC ID HGNC:1579 ENTREZGENE
Human Proteome Map CCNB1 Human Proteome Map
InterPro Cyclin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyclin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyclin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyclin_C-dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyclin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:891 UniProtKB/Swiss-Prot
NCBI Gene 891 ENTREZGENE
OMIM 123836 OMIM
PANTHER PTHR10177 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Cyclin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyclin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB CCNB1 RGD, PharmGKB
PIRSF Cyclin_A_B_D_E UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CYCLINS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART CYCLIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyclin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47954 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt CCNB1_HUMAN UniProtKB/Swiss-Prot
  D6RHI0_HUMAN UniProtKB/TrEMBL
  E9PC90_HUMAN UniProtKB/TrEMBL
  H0Y9U8_HUMAN UniProtKB/TrEMBL
  H0YA62_HUMAN UniProtKB/TrEMBL
  P14635 ENTREZGENE
UniProt Secondary A8K066 UniProtKB/Swiss-Prot
  Q5TZP9 UniProtKB/Swiss-Prot