CCNB1 (cyclin B1) - Rat Genome Database

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Gene: CCNB1 (cyclin B1) Canis lupus familiaris
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Symbol: CCNB1
Name: cyclin B1
RGD ID: 12274567
Description: ENCODES a protein that exhibits cyclin-dependent protein serine/threonine kinase activator activity (ortholog); histone kinase activity (ortholog); patched binding (ortholog); INVOLVED IN cellular response to fatty acid (ortholog); cellular response to hypoxia (ortholog); cellular response to iron(III) ion (ortholog); ASSOCIATED WITH breast cancer (ortholog); cervical cancer (ortholog); COVID-19 (ortholog); FOUND IN centrosome (ortholog); cyclin B1-CDK1 complex (ortholog); cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: G2/mitotic-specific cyclin-B1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Related Pseudogenes: LOC485338  
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1254,256,957 - 54,264,749 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha251,223,809 - 51,231,591 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0254,767,756 - 54,775,584 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1251,827,069 - 51,834,879 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0252,602,043 - 52,609,862 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0253,489,618 - 53,497,458 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cell division  (IEA)
cellular response to fatty acid  (ISO)
cellular response to hypoxia  (ISO)
cellular response to iron(III) ion  (ISO)
cellular response to organic cyclic compound  (ISO)
digestive tract development  (ISO)
in utero embryonic development  (ISO)
mitotic cell cycle phase transition  (IEA)
mitotic metaphase chromosome alignment  (ISO)
mitotic spindle organization  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of meiotic cell cycle process involved in oocyte maturation  (ISO)
negative regulation of protein phosphorylation  (ISO)
oocyte maturation  (ISO)
positive regulation of attachment of spindle microtubules to kinetochore  (ISO)
positive regulation of cardiac muscle cell proliferation  (ISO)
positive regulation of cell cycle  (ISO)
positive regulation of fibroblast proliferation  (ISO)
positive regulation of G2/M transition of mitotic cell cycle  (ISO)
positive regulation of mitochondrial ATP synthesis coupled electron transport  (ISO)
positive regulation of mitotic cell cycle  (ISO)
positive regulation of mRNA 3'-end processing  (ISO)
positive regulation of protein kinase activity  (ISO)
protein-containing complex assembly  (ISO)
regulation of chromosome condensation  (ISO)
regulation of mitotic cell cycle spindle assembly checkpoint  (ISO)
response to DDT  (ISO)
response to mechanical stimulus  (ISO)
response to toxic substance  (ISO)
response to xenobiotic stimulus  (ISO)
spermatogenesis  (ISO)
tissue regeneration  (ISO)
ventricular cardiac muscle cell development  (ISO)

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
CCNB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1254,256,957 - 54,264,749 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha251,223,809 - 51,231,591 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0254,767,756 - 54,775,584 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1251,827,069 - 51,834,879 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0252,602,043 - 52,609,862 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0253,489,618 - 53,497,458 (+)NCBIUU_Cfam_GSD_1.0
CCNB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38569,167,150 - 69,178,245 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl569,167,135 - 69,178,245 (+)EnsemblGRCh38hg38GRCh38
GRCh37568,462,977 - 68,474,072 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36568,498,669 - 68,509,828 (+)NCBINCBI36Build 36hg18NCBI36
Build 34568,498,668 - 68,509,824NCBI
Celera565,462,166 - 65,473,328 (+)NCBICelera
Cytogenetic Map5q13.2NCBI
HuRef565,418,249 - 65,429,485 (+)NCBIHuRef
CHM1_1568,462,558 - 68,473,793 (+)NCBICHM1_1
T2T-CHM13v2.0569,989,760 - 70,000,851 (+)NCBIT2T-CHM13v2.0
Ccnb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3913100,915,247 - 100,922,994 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl13100,915,158 - 100,923,078 (-)EnsemblGRCm39 Ensembl
GRCm3813100,778,739 - 100,786,486 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl13100,778,650 - 100,786,570 (-)EnsemblGRCm38mm10GRCm38
MGSCv3713101,548,694 - 101,556,441 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3613101,878,996 - 101,886,743 (-)NCBIMGSCv36mm8
Celera13104,387,574 - 104,395,322 (-)NCBICelera
Cytogenetic Map13D1NCBI
cM Map1353.23NCBI
Ccnb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8233,646,252 - 33,655,225 (-)NCBIGRCr8
mRatBN7.2231,912,190 - 31,921,163 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl231,912,193 - 31,921,172 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx239,046,390 - 39,055,360 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0237,087,590 - 37,096,347 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0231,945,688 - 31,954,752 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0230,782,133 - 30,791,106 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl230,783,915 - 30,791,221 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0249,941,586 - 49,948,770 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4231,574,600 - 31,581,784 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1231,493,947 - 31,502,123 (-)NCBI
Celera227,925,441 - 27,934,414 (-)NCBICelera
Cytogenetic Map2q12NCBI
Ccnb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955446140,093 - 149,500 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955446140,661 - 149,500 (-)NCBIChiLan1.0ChiLan1.0
CCNB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2444,745,330 - 44,756,107 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1542,898,956 - 42,909,733 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0544,826,103 - 44,836,832 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1546,394,362 - 46,405,332 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl546,394,362 - 46,405,332 (-)Ensemblpanpan1.1panPan2
Ccnb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213191,463,462 - 191,471,154 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936480399,224 - 407,704 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936480400,287 - 407,677 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CCNB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1647,338,110 - 47,348,377 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11647,338,239 - 47,348,385 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21651,155,615 - 51,165,760 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CCNB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1465,265,798 - 65,276,465 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl465,265,844 - 65,277,085 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604913,995,123 - 14,005,792 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in CCNB1
116 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 3 3 8
Low 2 14 6 3 9 9 3
Below cutoff 5 8 6 6 6 3 1 3

Sequence


RefSeq Acc Id: XM_038469964   ⟹   XP_038325892
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1251,827,069 - 51,834,879 (+)NCBI
RefSeq Acc Id: XM_038530772   ⟹   XP_038386700
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0253,489,618 - 53,497,458 (+)NCBI
RefSeq Acc Id: XM_038594994   ⟹   XP_038450922
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0252,602,043 - 52,609,862 (+)NCBI
RefSeq Acc Id: XM_038659070   ⟹   XP_038514998
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0254,767,756 - 54,775,584 (+)NCBI
RefSeq Acc Id: XM_845305   ⟹   XP_850398
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1254,256,957 - 54,264,749 (+)NCBI
Dog10K_Boxer_Tasha251,223,809 - 51,231,591 (+)NCBI
Sequence:
RefSeq Acc Id: XP_850398   ⟸   XM_845305
- UniProtKB: A0A8C0M337 (UniProtKB/TrEMBL),   A0A8P0NLU4 (UniProtKB/TrEMBL),   A0A8P0SW93 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_038325892   ⟸   XM_038469964
RefSeq Acc Id: XP_038450922   ⟸   XM_038594994
RefSeq Acc Id: XP_038514998   ⟸   XM_038659070
- UniProtKB: A0A8P0SW93 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038386700   ⟸   XM_038530772
- UniProtKB: A0A8C0M337 (UniProtKB/TrEMBL),   A0A8P0NLU4 (UniProtKB/TrEMBL),   A0A8P0SW93 (UniProtKB/TrEMBL)
Protein Domains
Cyclin C-terminal   Cyclin-like


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000006595 UniProtKB/TrEMBL
  ENSCAFG00000007705 UniProtKB/TrEMBL
  ENSCAFG00030003413 UniProtKB/TrEMBL
  ENSCAFG00040003710 UniProtKB/TrEMBL
  ENSCAFG00845011909 ENTREZGENE
Ensembl Transcript ENSCAFT00000010650.5 UniProtKB/TrEMBL
  ENSCAFT00000012556.5 UniProtKB/TrEMBL
  ENSCAFT00030006385.1 UniProtKB/TrEMBL
  ENSCAFT00040007084.1 UniProtKB/TrEMBL
  ENSCAFT00845021157 ENTREZGENE
Gene3D-CATH Cyclin-like UniProtKB/TrEMBL
InterPro CCNB1_first_cyclin-box UniProtKB/TrEMBL
  Cyclin UniProtKB/TrEMBL
  Cyclin-like UniProtKB/TrEMBL
  Cyclin-like_sf UniProtKB/TrEMBL
  Cyclin_A/B-like UniProtKB/TrEMBL
  Cyclin_C-dom UniProtKB/TrEMBL
  Cyclin_N UniProtKB/TrEMBL
  Cyclins_cyclin-box UniProtKB/TrEMBL
KEGG Report cfa:608420 UniProtKB/TrEMBL
NCBI Gene CCNB1 ENTREZGENE
PANTHER G2/MITOTIC-SPECIFIC CYCLIN-B1 UniProtKB/TrEMBL
  PTHR10177 UniProtKB/TrEMBL
Pfam Cyclin_C UniProtKB/TrEMBL
  Cyclin_N UniProtKB/TrEMBL
PIRSF Cyclin_A_B_D_E UniProtKB/TrEMBL
PROSITE CYCLINS UniProtKB/TrEMBL
SMART CYCLIN UniProtKB/TrEMBL
  Cyclin_C UniProtKB/TrEMBL
Superfamily-SCOP SSF47954 UniProtKB/TrEMBL
UniProt A0A8C0M337 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0NLU4 ENTREZGENE
  A0A8P0SW93 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A0A8P0NLU4 UniProtKB/TrEMBL