CCNB1 (cyclin B1) - Rat Genome Database

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Gene: CCNB1 (cyclin B1) Sus scrofa
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Symbol: CCNB1
Name: cyclin B1
RGD ID: 14154597
Description: ENCODES a protein that exhibits histone kinase activity; protein kinase binding (ortholog); protein-containing complex binding (ortholog); INVOLVED IN negative regulation of meiotic cell cycle process involved in oocyte maturation; positive regulation of histone phosphorylation; cellular response to fatty acid (ortholog); ASSOCIATED WITH breast cancer (ortholog); cervical cancer (ortholog); COVID-19 (ortholog); FOUND IN centrosome (ortholog); cytoplasm (ortholog); nucleus (ortholog); INTERACTS WITH copper(II) sulfate; dibromine; lead(0)
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: cyclin B; G2/mitotic-specific cyclin B1; G2/mitotic-specific cyclin-B1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1647,338,110 - 47,348,381 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11647,338,239 - 47,348,385 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21651,155,615 - 51,165,760 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to fatty acid  (ISO)
cellular response to hypoxia  (ISO)
cellular response to iron(III) ion  (ISO)
cellular response to organic cyclic compound  (ISO)
digestive tract development  (ISO)
histone H3-S10 phosphorylation involved in chromosome condensation  (IEA,ISO)
in utero embryonic development  (IEA,ISO)
mitotic cell cycle  (ISO)
mitotic cell cycle phase transition  (IBA)
mitotic metaphase plate congression  (IBA)
mitotic spindle organization  (IEA)
negative regulation of gene expression  (ISO)
negative regulation of meiotic cell cycle process involved in oocyte maturation  (IMP)
negative regulation of protein phosphorylation  (ISO)
oocyte maturation  (ISO)
positive regulation of attachment of spindle microtubules to kinetochore  (IEA)
positive regulation of cardiac muscle cell proliferation  (ISO)
positive regulation of cell cycle  (ISO)
positive regulation of cyclin-dependent protein serine/threonine kinase activity  (IEA)
positive regulation of fibroblast proliferation  (IEA,ISO)
positive regulation of G2/M transition of mitotic cell cycle  (IEA)
positive regulation of histone phosphorylation  (IMP,ISO)
positive regulation of mitochondrial ATP synthesis coupled electron transport  (IEA)
positive regulation of mitotic cell cycle  (ISO)
positive regulation of mRNA 3'-end processing  (ISO)
protein phosphorylation  (ISO)
protein-containing complex assembly  (ISO)
regulation of cell cycle  (ISO)
regulation of chromosome condensation  (ISO)
regulation of cyclin-dependent protein serine/threonine kinase activity  (IBA)
regulation of mitotic cell cycle spindle assembly checkpoint  (IEA)
response to DDT  (ISO)
response to drug  (ISO)
response to mechanical stimulus  (ISO)
response to toxic substance  (ISO)
spermatogenesis  (ISO)
tissue regeneration  (ISO)
ventricular cardiac muscle cell development  (ISO)

Cellular Component

References
Additional References at PubMed
PMID:14681463   PMID:15278898   PMID:16319287   PMID:19705412   PMID:24626152   PMID:27744448  


Genomics

Comparative Map Data
CCNB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1647,338,110 - 47,348,381 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11647,338,239 - 47,348,385 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21651,155,615 - 51,165,760 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CCNB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl569,167,135 - 69,178,245 (+)EnsemblGRCh38hg38GRCh38
GRCh38569,167,150 - 69,178,245 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37568,462,977 - 68,474,072 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36568,498,669 - 68,509,828 (+)NCBINCBI36hg18NCBI36
Build 34568,498,668 - 68,509,824NCBI
Celera565,462,166 - 65,473,328 (+)NCBI
Cytogenetic Map5q13.2NCBI
HuRef565,418,249 - 65,429,485 (+)NCBIHuRef
CHM1_1568,462,558 - 68,473,793 (+)NCBICHM1_1
Ccnb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3913100,915,247 - 100,922,994 (-)NCBIGRCm39mm39
GRCm39 Ensembl13100,915,158 - 100,923,078 (-)Ensembl
GRCm3813100,778,739 - 100,786,486 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl13100,778,650 - 100,786,570 (-)EnsemblGRCm38mm10GRCm38
MGSCv3713101,548,694 - 101,556,441 (-)NCBIGRCm37mm9NCBIm37
MGSCv3613101,878,996 - 101,886,743 (-)NCBImm8
Celera13104,387,574 - 104,395,322 (-)NCBICelera
Cytogenetic Map13D1NCBI
cM Map1353.23NCBI
Ccnb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2231,912,190 - 31,921,163 (-)NCBI
Rnor_6.0 Ensembl230,783,915 - 30,791,221 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0230,782,133 - 30,791,106 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0249,941,586 - 49,948,770 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4231,574,600 - 31,581,784 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1231,493,947 - 31,502,123 (-)NCBI
Celera227,925,441 - 27,934,414 (-)NCBICelera
Cytogenetic Map2q12NCBI
Ccnb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955446140,093 - 149,500 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955446140,661 - 149,500 (-)NCBIChiLan1.0ChiLan1.0
CCNB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1546,394,362 - 46,405,332 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl546,394,362 - 46,405,332 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0544,826,103 - 44,836,832 (-)NCBIMhudiblu_PPA_v0panPan3
CCNB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1254,256,957 - 54,264,749 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha251,223,809 - 51,231,591 (+)NCBI
ROS_Cfam_1.0254,767,756 - 54,775,584 (+)NCBI
UMICH_Zoey_3.1251,827,069 - 51,834,879 (+)NCBI
UNSW_CanFamBas_1.0252,602,043 - 52,609,862 (+)NCBI
UU_Cfam_GSD_1.0253,489,618 - 53,497,458 (+)NCBI
Ccnb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213191,463,462 - 191,471,154 (-)NCBI
SpeTri2.0NW_004936480400,287 - 407,677 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CCNB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1465,265,798 - 65,276,465 (+)NCBI
ChlSab1.1 Ensembl465,265,844 - 65,277,085 (+)Ensembl
Vero_WHO_p1.0NW_02366604913,995,123 - 14,005,792 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 3 1 3 1
Low 7 3 3 2 2 22 2 3 2
Below cutoff 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000024108   ⟹   ENSSSCP00000023163
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1647,338,110 - 47,348,381 (+)Ensembl
RefSeq Acc Id: NM_001170768   ⟹   NP_001164239
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11647,338,239 - 47,348,385 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001164239   ⟸   NM_001170768
- UniProtKB: D2IE28 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000023163   ⟸   ENSSSCT00000024108
Protein Domains
CYCLIN   Cyclin N-terminal


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000029326 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070017445 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000023163 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00070028768 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000024108 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00070034444 UniProtKB/TrEMBL
InterPro Cyclin UniProtKB/TrEMBL
  Cyclin-like UniProtKB/TrEMBL
  Cyclin-like_sf UniProtKB/TrEMBL
  Cyclin_C-dom UniProtKB/TrEMBL
  Cyclin_N UniProtKB/TrEMBL
KEGG Report ssc:397662 UniProtKB/TrEMBL
NCBI Gene CCNB1 ENTREZGENE
PANTHER PTHR10177 UniProtKB/TrEMBL
Pfam Cyclin_C UniProtKB/TrEMBL
  Cyclin_N UniProtKB/TrEMBL
PIRSF Cyclin_A_B_D_E UniProtKB/TrEMBL
PROSITE CYCLINS UniProtKB/TrEMBL
SMART CYCLIN UniProtKB/TrEMBL
  Cyclin_C UniProtKB/TrEMBL
Superfamily-SCOP SSF47954 UniProtKB/TrEMBL
UniProt A0A4X1UFG8_PIG UniProtKB/TrEMBL
  D2IE28 ENTREZGENE, UniProtKB/TrEMBL
  H2AM22_PIG UniProtKB/TrEMBL
  H2AM23_PIG UniProtKB/TrEMBL
VGNC ID VGNC:86349 ENTREZGENE