RGD Reference Report - Expression profiling of cyclin B1 and D1 in cervical carcinoma. - Rat Genome Database

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Expression profiling of cyclin B1 and D1 in cervical carcinoma.

Authors: Zhao, M  Kim, YT  Yoon, BS  Kim, SW  Kang, MH  Kim, SH  Kim, JH  Kim, JW  Park, YW 
Citation: Zhao M, etal., Exp Oncol. 2006 Mar;28(1):44-8.
RGD ID: 2315938
Pubmed: PMID:16614707   (View Abstract at PubMed)

AIM: Cyclins are a family of regulatory proteins that play a key role in controlling the cell cycle. Abnormalities of cell cycle regulators, including cyclins and cyclin dependent kinases, have been reported in various malignant tumors. This study was undertaken to quantitatively detect cyclin B1 and D1 in cervical cancer. METHODS: A quantitative real-time reverse transcription polymerase chain reaction and Western blot assay were used to analyze the expression of cyclin B1/D1 mRNA and proteins, respectively, in fresh invasive cervical cancer (n = 41) and normal cervical tissues (n = 10). RESULTS: There was significantly greater cyclin B1 expression in invasive cervical cancer than in normal cervical tissue (P = 0.019). However, cyclin D1 expression was not significantly different. A Western blot assay yielded similar results. CONCLUSION: Our results were consistent with the concept that up-regulation of cyclin B1 expression occurred in cervical cancer and an aberrant expression of cyclin B1 might play an important role in cervical carcinogenesis.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
cervical cancer  IEP 2315938mRNA and protein:increased expression:uterine cervixRGD 
cervical cancer  ISOCCNB1 (Homo sapiens)2315938; 2315938mRNA and protein:increased expression:uterine cervixRGD 

Objects Annotated

Genes (Rattus norvegicus)
Ccnb1  (cyclin B1)

Genes (Mus musculus)
Ccnb1  (cyclin B1)

Genes (Homo sapiens)
CCNB1  (cyclin B1)


Additional Information