Ccnb1 (cyclin B1) - Rat Genome Database

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Gene: Ccnb1 (cyclin B1) Mus musculus
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Symbol: Ccnb1
Name: cyclin B1
RGD ID: 735742
MGI Page MGI
Description: Predicted to enable cyclin-dependent protein serine/threonine kinase activator activity; enzyme binding activity; and patched binding activity. Acts upstream of or within several processes, including histone H3-S10 phosphorylation involved in chromosome condensation; in utero embryonic development; and positive regulation of fibroblast proliferation. Located in cytoplasm; membrane; and nucleus. Colocalizes with mitochondrial matrix. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; eye; and genitourinary system. Human ortholog(s) of this gene implicated in breast cancer and prostate cancer. Orthologous to human CCNB1 (cyclin B1); PARTICIPATES IN cell cycle pathway, mitotic; p53 signaling pathway; INTERACTS WITH (S)-nicotine; 1,2-dichloroethane; 1,2-dimethylhydrazine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Ccnb1-r; Ccnb1-rs1; Ccnb1-rs13; Cycb-4; Cycb-5; CycB1; Cycb1-rs1; cyclin B1, related sequence 1; cyclin B1, related sequence 13; G2/mitotic-specific cyclin B1; G2/mitotic-specific cyclin-B1; MGC18763; MGC90915
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Related Pseudogenes: Gm12856   Gm4870   Gm7067   Gm7483   Gm8416  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3913100,915,247 - 100,922,994 (-)NCBIGRCm39mm39
GRCm39 Ensembl13100,915,158 - 100,923,078 (-)Ensembl
GRCm3813100,778,739 - 100,786,486 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl13100,778,650 - 100,786,570 (-)EnsemblGRCm38mm10GRCm38
MGSCv3713101,548,694 - 101,556,441 (-)NCBIGRCm37mm9NCBIm37
MGSCv3613101,878,996 - 101,886,743 (-)NCBImm8
Celera13104,387,574 - 104,395,322 (-)NCBICelera
Cytogenetic Map13D1NCBI
cM Map1353.23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-Tetrandrine  (ISO)
(-)-citrinin  (ISO)
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(1S)-bornane-2,3-dione  (ISO)
(20R)-protopanaxadiol  (ISO)
(S)-(-)-perillyl alcohol  (ISO)
(S)-colchicine  (ISO)
(S)-nicotine  (EXP,ISO)
(Z)-ligustilide  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
1,4-dioxane  (EXP)
1-(4-methoxybenzyl)-3-(5-nitro-1,3-thiazol-2-yl)urea  (ISO)
1-chloro-2,4-dinitrobenzene  (EXP)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP)
1-naphthyl isothiocyanate  (EXP,ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoic acid  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,6-di-tert-butyl-4-methylphenol  (EXP)
2-acetamidofluorene  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-methoxy-17beta-estradiol  (ISO)
2-nitrofluorene  (ISO)
3',4',5-trihydroxy-3,7-dimethoxyflavone  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3'-diindolylmethane  (ISO)
3-[(4-anilinophenyl)diazenyl]benzene-1-sulfonic acid  (ISO)
3-methylcholanthrene  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-amino-1,8-naphthalimide  (ISO)
4-hydroxynon-2-enal  (EXP)
4-hydroxyphenyl retinamide  (EXP)
4-nitroquinoline N-oxide  (EXP)
4-nonylphenol  (ISO)
5-aza-2'-deoxycytidine  (EXP,ISO)
5-azacytidine  (ISO)
5-fluorouracil  (ISO)
6-O-methylguanine  (ISO)
6-oxocampestanol  (ISO)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (EXP)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (EXP)
acetamide  (ISO)
acetylleucyl-leucyl-norleucinal  (ISO)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
acrylamide  (EXP,ISO)
aflatoxin B1  (EXP,ISO)
AICA ribonucleotide  (ISO)
alachlor  (ISO)
aldehydo-D-glucosamine  (ISO)
aldrin  (EXP)
all-trans-retinoic acid  (EXP,ISO)
alpha-hexylcinnamaldehyde  (EXP)
alpha-naphthoflavone  (ISO)
alpha-pinene  (ISO)
alvocidib  (ISO)
amiloride  (ISO)
ammonium chloride  (ISO)
amsacrine  (ISO)
anthocyanin  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
anthracene-1,8,9-triol  (EXP)
antimycin A  (ISO)
apigenin  (ISO)
aristolochic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (ISO)
atrazine  (ISO)
azathioprine  (ISO)
baicalein  (ISO)
belinostat  (ISO)
benomyl  (ISO)
benzene  (EXP,ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (EXP)
benzophenone  (ISO)
beta-D-glucosamine  (ISO)
beta-naphthoflavone  (ISO)
betulinic acid  (ISO)
bexarotene  (ISO)
bezafibrate  (EXP)
bicalutamide  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol A glycidylmethacrylate  (ISO)
bortezomib  (ISO)
brassinolide  (ISO)
bucladesine  (ISO)
buta-1,3-diene  (EXP)
butylated hydroxyanisole  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP,ISO)
calcitriol  (ISO)
calycosin  (ISO)
camptothecin  (ISO)
capsaicin  (ISO)
carbon nanotube  (EXP)
casticin  (ISO)
cefaloridine  (ISO)
celecoxib  (ISO)
chloramphenicol  (EXP)
chlorendic acid  (ISO)
chloroethene  (EXP)
chloroprene  (EXP)
chlorpyrifos  (EXP,ISO)
choline  (EXP)
chromium(6+)  (EXP,ISO)
chrysin  (ISO)
ciprofloxacin  (ISO)
cisplatin  (EXP,ISO)
citric acid  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
corticosterone  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cryptolepine  (ISO)
CU-O LINKAGE  (ISO)
cucurbitacin I  (ISO)
curcumin  (ISO)
cyclosporin A  (EXP,ISO)
cytochalasin B  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (ISO)
Diacetoxyscirpenol  (EXP)
diallyl disulfide  (ISO)
Diallyl sulfide  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (EXP)
dibenzofuran  (ISO)
dibutyl phthalate  (EXP,ISO)
dichloroacetic acid  (EXP)
dicrotophos  (ISO)
Didymin  (ISO)
dieldrin  (ISO)
diepoxybutane  (EXP)
diethyl sulfate  (ISO)
diethylstilbestrol  (ISO)
digitoxin  (ISO)
dioscin  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
Echimidine  (ISO)
elemental selenium  (ISO)
ellipticine  (ISO)
Enterolactone  (ISO)
enzalutamide  (ISO)
enzyme inhibitor  (ISO)
erlotinib hydrochloride  (ISO)
erythromycin estolate  (ISO)
Estragole  (EXP,ISO)
estriol  (EXP)
etoposide  (ISO)
eugenol  (ISO)
farnesol  (ISO)
fipronil  (ISO)
fisetin  (ISO)
flavanones  (ISO)
flumequine  (EXP)
fluoxetine  (EXP)
flurbiprofen  (ISO)
folic acid  (EXP,ISO)
formaldehyde  (ISO)
formononetin  (ISO)
fulvestrant  (ISO)
furan  (ISO)
gefitinib  (EXP)
gemcitabine  (ISO)
genistein  (EXP,ISO)
geraniol  (ISO)
gingerol  (ISO)
glycidol  (ISO)
glyphosate  (ISO)
Goe 6976  (ISO)
guggulsterone  (EXP)
GW 4064  (ISO)
hellebrigenin  (ISO)
heptachlor  (ISO)
hydrazine  (EXP)
hydrogen peroxide  (ISO)
hydroxyurea  (EXP,ISO)
indole-3-methanol  (ISO)
indometacin  (ISO)
inuviscolide  (ISO)
iodoacetic acid  (EXP)
irinotecan  (ISO)
iron dichloride  (EXP)
iron trichloride  (EXP)
kaempferol  (ISO)
kojic acid  (EXP)
L-ascorbic acid  (ISO)
L-methionine  (EXP)
Lasiocarpine  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
leflunomide  (ISO)
Licochalcone A  (ISO)
lidocaine  (EXP)
lipopolysaccharide  (EXP)
lithocholic acid  (EXP)
Longikaurin A  (ISO)
lucanthone  (ISO)
luteolin  (ISO)
LY294002  (ISO)
malachite green cation  (ISO)
malathion  (ISO)
mangiferin  (ISO)
Manumycin A  (ISO)
mechlorethamine  (ISO)
medroxyprogesterone acetate  (ISO)
MeIQx  (EXP)
melatonin  (ISO)
metformin  (ISO)
methamphetamine  (ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methyl salicylate  (EXP)
methylmercury chloride  (EXP)
methylparaben  (EXP,ISO)
methylseleninic acid  (ISO)
Mezerein  (EXP)
mirex  (ISO)
mitomycin C  (EXP,ISO)
Mitotane  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
monobenzyl phthalate  (EXP)
monocrotaline  (ISO)
monoethyl phthalate  (EXP)
morin  (ISO)
myricetin  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP,ISO)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (ISO)
N-Nitrosopyrrolidine  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel subsulfide  (ISO)
niclosamide  (ISO)
nicotine  (EXP,ISO)
nocodazole  (ISO)
nonanoic acid  (EXP)
NS-398  (ISO)
O-methyleugenol  (ISO)
obeticholic acid  (EXP)
ochratoxin A  (ISO)
oligomycin A  (EXP)
omacetaxine mepesuccinate  (ISO)
osthole  (ISO)
oxaliplatin  (ISO)
ozone  (EXP,ISO)
paclitaxel  (ISO)
palbociclib  (ISO)
palytoxin  (EXP)
Panduratin A  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
PCB138  (EXP)
Pentoxifylline  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
perillyl alcohol  (ISO)
phenethyl caffeate  (ISO)
phenethyl isothiocyanate  (ISO)
phenformin  (ISO)
phenobarbital  (EXP,ISO)
PhIP  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
phthalaldehyde  (EXP)
pioglitazone  (ISO)
piperine  (EXP)
piperonyl butoxide  (ISO)
Pirarubicin  (ISO)
pirinixic acid  (EXP,ISO)
piroxicam  (ISO)
potassium bromate  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
progesterone  (EXP,ISO)
propanal  (ISO)
propofol  (ISO)
propylparaben  (EXP,ISO)
quercetin  (EXP,ISO)
quinoline  (ISO)
quinolines  (ISO)
raloxifene  (ISO)
resveratrol  (EXP,ISO)
riboflavin  (ISO)
riddelliine  (ISO)
rimonabant  (ISO)
ritonavir  (ISO)
romidepsin  (ISO)
rotenone  (ISO)
SB 203580  (ISO)
selenium atom  (ISO)
selumetinib  (EXP)
silibinin  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
silver(1+) nitrate  (ISO)
simazine  (EXP)
sodium arsenite  (EXP,ISO)
sodium azide  (ISO)
sodium dichromate  (ISO)
sodium nitrite  (EXP)
Soman  (ISO)
sorafenib  (EXP)
sterigmatocystin  (ISO)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
sulindac  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
thalidomide  (ISO)
thapsigargin  (ISO)
thimerosal  (ISO)
thioacetamide  (ISO)
thymoquinone  (ISO)
titanium dioxide  (EXP,ISO)
Tomentosin  (ISO)
topotecan  (ISO)
trabectedin  (ISO)
triazoles  (ISO)
tributylstannane  (ISO)
Tributyltin oxide  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (EXP)
Triptolide  (ISO)
triptonide  (EXP)
troglitazone  (ISO)
tungsten  (EXP)
tunicamycin  (ISO)
Tylophorine  (ISO)
tyrphostin AG 1478  (ISO)
urethane  (EXP)
valproic acid  (EXP,ISO)
vemurafenib  (ISO)
verteporfin  (EXP)
vincaleukoblastine  (ISO)
vinclozolin  (ISO)
vincristine  (ISO)
vorinostat  (ISO)
wortmannin  (ISO)
Xanthatin  (ISO)
Yangonin  (EXP)
zaragozic acid A  (EXP,ISO)
zearalenone  (EXP)
zidovudine  (ISO)
zinc atom  (ISO)
zinc dichloride  (EXP)
zinc(0)  (ISO)
zoledronic acid  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cell division  (IEA)
cellular response to fatty acid  (ISO)
cellular response to hypoxia  (ISO)
cellular response to iron(III) ion  (ISO)
cellular response to organic cyclic compound  (ISO)
digestive tract development  (ISO)
histone H3-S10 phosphorylation involved in chromosome condensation  (IDA)
in utero embryonic development  (IMP)
mitotic cell cycle  (ISO)
mitotic cell cycle phase transition  (IBA)
mitotic metaphase plate congression  (IBA,ISO)
mitotic spindle organization  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of meiotic cell cycle process involved in oocyte maturation  (ISO)
negative regulation of protein phosphorylation  (ISO)
oocyte maturation  (ISO)
positive regulation of attachment of spindle microtubules to kinetochore  (ISO)
positive regulation of cardiac muscle cell proliferation  (ISO)
positive regulation of cell cycle  (IDA)
positive regulation of fibroblast proliferation  (IMP)
positive regulation of G2/M transition of mitotic cell cycle  (ISO)
positive regulation of histone phosphorylation  (ISO)
positive regulation of mitochondrial ATP synthesis coupled electron transport  (ISO)
positive regulation of mitotic cell cycle  (ISO)
positive regulation of mRNA 3'-end processing  (ISO)
protein phosphorylation  (IDA)
protein-containing complex assembly  (ISO)
regulation of cell cycle  (ISO)
regulation of chromosome condensation  (ISO)
regulation of cyclin-dependent protein serine/threonine kinase activity  (IBA)
regulation of mitotic cell cycle spindle assembly checkpoint  (ISO)
response to DDT  (ISO)
response to mechanical stimulus  (ISO)
response to toxic substance  (ISO)
response to xenobiotic stimulus  (ISO)
spermatogenesis  (ISO)
tissue regeneration  (ISO)
ventricular cardiac muscle cell development  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
1. Chen B and Wang W, J Huazhong Univ Sci Technolog Med Sci. 2008 Feb;28(1):60-4.
2. Cui XS and Donehower LA, Oncogene. 2000 Dec 7;19(52):5988-96.
3. Davidson EJ, etal., Br J Cancer. 2003 Jan 27;88(2):257-62.
4. Horree N, etal., J Clin Pathol. 2008 Jan;61(1):36-42. Epub 2007 May 4.
5. Ikuerowo SO, etal., Int J Cancer. 2006 Aug 15;119(4):867-74.
6. Kallakury BV, etal., Cancer. 1999 Apr 1;85(7):1569-76.
7. Kang JS, etal., Oncol Rep. 2007 Apr;17(4):747-52.
8. Ko MS, etal., Development 2000 Apr;127(8):1737-49.
9. MGD and Homologene mouse data transfer
10. MGD data from the GO Consortium
11. MGD IEA
12. Nimeus-Malmstrom E, etal., Int J Cancer. 2009 Dec 2.
13. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
14. Pavlova T, etal., Neurosci Lett. 2006 Jan 9;392(1-2):154-8. Epub 2005 Oct 18.
15. Pipeline to import KEGG annotations from KEGG into RGD
16. Raina K, etal., Cancer Res. 2007 Nov 15;67(22):11083-91.
17. RGD automated import pipeline
18. RGD automated import pipeline for gene-chemical interactions
19. Shim EH, etal., Cancer Res. 2003 Apr 1;63(7):1583-8.
20. Sorensen RB, etal., Clin Cancer Res. 2009 Mar 1;15(5):1543-9. Epub 2009 Feb 17.
21. Suzumori N, etal., Proc Natl Acad Sci U S A 2003 Jan 21;100(2):550-5. Epub 2003 Jan 13.
22. Tetzlaff MT, etal., Mol Cell Biol 2004 Mar;24(6):2487-98.
23. Tseng JH, etal., J Surg Res. 2009 Jul 30.
24. Vella LA, etal., Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):14010-5. Epub 2009 Aug 3.
25. Woo GH, etal., Cancer Sci. 2009 Apr;100(4):617-25. Epub 2009 Feb 25.
26. Zhao M, etal., Exp Oncol. 2006 Mar;28(1):44-8.
27. Zheng H, etal., Am J Obstet Gynecol. 2009 Oct;201(4):367.e1-6. Epub 2009 Jul 15.
Additional References at PubMed
PMID:1280449   PMID:1386686   PMID:1387105   PMID:1535334   PMID:1722210   PMID:1836195   PMID:7624053   PMID:8375336   PMID:8552401   PMID:8975718   PMID:9247342   PMID:9371520  
PMID:9539739   PMID:9856457   PMID:10049595   PMID:10231856   PMID:10349636   PMID:10433265   PMID:10480350   PMID:10559244   PMID:10605025   PMID:10708519   PMID:10716937   PMID:10885754  
PMID:10922068   PMID:11042159   PMID:11076861   PMID:11095619   PMID:11217851   PMID:11331587   PMID:11389549   PMID:11501764   PMID:12121977   PMID:12124778   PMID:12424202   PMID:12477932  
PMID:12904583   PMID:12934012   PMID:14593421   PMID:14610273   PMID:14742445   PMID:14749395   PMID:15159393   PMID:15214576   PMID:15280554   PMID:15327787   PMID:15489334   PMID:15531365  
PMID:15548709   PMID:15580572   PMID:15707957   PMID:15716349   PMID:15730892   PMID:15735755   PMID:15838522   PMID:15984162   PMID:16007079   PMID:16054035   PMID:16102754   PMID:16107646  
PMID:16109376   PMID:16141072   PMID:16141073   PMID:16489008   PMID:16724106   PMID:16782087   PMID:17098733   PMID:17160696   PMID:17213798   PMID:17274640   PMID:17276355   PMID:17283331  
PMID:17320365   PMID:17325031   PMID:17362983   PMID:17366632   PMID:17475776   PMID:17893320   PMID:18022836   PMID:18048386   PMID:18206965   PMID:18232736   PMID:18265020   PMID:18364031  
PMID:18364698   PMID:18425394   PMID:18592162   PMID:18603407   PMID:18725516   PMID:19001847   PMID:19015276   PMID:19139267   PMID:19154723   PMID:19160489   PMID:19265663   PMID:19376971  
PMID:19474320   PMID:19553603   PMID:19748123   PMID:19769738   PMID:19877281   PMID:19898483   PMID:20105280   PMID:20846384   PMID:20927403   PMID:21074523   PMID:21241890   PMID:21267068  
PMID:21346194   PMID:21398609   PMID:21440680   PMID:21613325   PMID:21677750   PMID:21731673   PMID:21737879   PMID:21779394   PMID:21873635   PMID:22053081   PMID:22125605   PMID:22154697  
PMID:22206758   PMID:22302686   PMID:22442484   PMID:22444557   PMID:22513370   PMID:22516201   PMID:22560297   PMID:22649246   PMID:22696294   PMID:22808246   PMID:22837015   PMID:22922362  
PMID:22957921   PMID:23048031   PMID:23060211   PMID:23223288   PMID:23322385   PMID:23835136   PMID:23948252   PMID:24009519   PMID:24073291   PMID:24123312   PMID:24194600   PMID:24301385  
PMID:24415942   PMID:24453338   PMID:24553289   PMID:24706806   PMID:24746669   PMID:24886500   PMID:25131634   PMID:25196150   PMID:25246615   PMID:25349079   PMID:25422376   PMID:25515659  
PMID:25631042   PMID:25651564   PMID:25956904   PMID:26021489   PMID:26410627   PMID:26542706   PMID:26633882   PMID:27141870   PMID:27626380   PMID:27693251   PMID:27694478   PMID:27862528  
PMID:27986432   PMID:28340616   PMID:28527696   PMID:28535371   PMID:28768199   PMID:28808066   PMID:28923932   PMID:29058287   PMID:29072697   PMID:29074707   PMID:29074977   PMID:29215012  
PMID:29632206   PMID:29911914   PMID:29950673   PMID:30093551   PMID:30097513   PMID:30302808   PMID:30368232   PMID:30389914   PMID:30558467   PMID:30566624   PMID:30635284   PMID:30700550  
PMID:31024075   PMID:31064784   PMID:31097699   PMID:31358751   PMID:31598710   PMID:31704793   PMID:31806625   PMID:32152291   PMID:32232159   PMID:32325033   PMID:32341029   PMID:32439164  
PMID:32518258   PMID:32703236   PMID:33147210  


Genomics

Comparative Map Data
Ccnb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3913100,915,247 - 100,922,994 (-)NCBIGRCm39mm39
GRCm39 Ensembl13100,915,158 - 100,923,078 (-)Ensembl
GRCm3813100,778,739 - 100,786,486 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl13100,778,650 - 100,786,570 (-)EnsemblGRCm38mm10GRCm38
MGSCv3713101,548,694 - 101,556,441 (-)NCBIGRCm37mm9NCBIm37
MGSCv3613101,878,996 - 101,886,743 (-)NCBImm8
Celera13104,387,574 - 104,395,322 (-)NCBICelera
Cytogenetic Map13D1NCBI
cM Map1353.23NCBI
CCNB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl569,167,135 - 69,178,245 (+)EnsemblGRCh38hg38GRCh38
GRCh38569,167,150 - 69,178,245 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37568,462,977 - 68,474,072 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36568,498,669 - 68,509,828 (+)NCBINCBI36hg18NCBI36
Build 34568,498,668 - 68,509,824NCBI
Celera565,462,166 - 65,473,328 (+)NCBI
Cytogenetic Map5q13.2NCBI
HuRef565,418,249 - 65,429,485 (+)NCBIHuRef
CHM1_1568,462,558 - 68,473,793 (+)NCBICHM1_1
Ccnb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2231,912,190 - 31,921,163 (-)NCBImRatBN7.2
Rnor_6.0 Ensembl230,783,915 - 30,791,221 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0230,782,133 - 30,791,106 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0249,941,586 - 49,948,770 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4231,574,600 - 31,581,784 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1231,493,947 - 31,502,123 (-)NCBI
Celera227,925,441 - 27,934,414 (-)NCBICelera
Cytogenetic Map2q12NCBI
Ccnb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955446140,093 - 149,500 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955446140,661 - 149,500 (-)NCBIChiLan1.0ChiLan1.0
CCNB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1546,394,362 - 46,405,332 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl546,394,362 - 46,405,332 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0544,826,103 - 44,836,832 (-)NCBIMhudiblu_PPA_v0panPan3
CCNB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1254,256,957 - 54,264,749 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha251,223,809 - 51,231,591 (+)NCBI
ROS_Cfam_1.0254,767,756 - 54,775,584 (+)NCBI
UMICH_Zoey_3.1251,827,069 - 51,834,879 (+)NCBI
UNSW_CanFamBas_1.0252,602,043 - 52,609,862 (+)NCBI
UU_Cfam_GSD_1.0253,489,618 - 53,497,458 (+)NCBI
Ccnb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213191,463,462 - 191,471,154 (-)NCBI
SpeTri2.0NW_004936480400,287 - 407,677 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CCNB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1647,338,110 - 47,348,381 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11647,338,239 - 47,348,385 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21651,155,615 - 51,165,760 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CCNB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1465,265,798 - 65,276,465 (+)NCBI
ChlSab1.1 Ensembl465,265,844 - 65,277,085 (+)Ensembl
Vero_WHO_p1.0NW_02366604913,995,123 - 14,005,792 (+)NCBI

Position Markers
Ccnb1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map13D1UniSTS
cM Map1356.0UniSTS
D4Ertd639e  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv37149,242,471 - 9,242,692UniSTSGRCm37
MGSCv374118,614,683 - 118,614,904UniSTSGRCm37
Celera144,030,106 - 4,030,327UniSTS
Celera4117,665,957 - 117,666,178UniSTS
Cytogenetic Map13D1UniSTS
Cytogenetic Map14A1UniSTS
cM Map454.4UniSTS
PMC212738P2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7B3UniSTS
Cytogenetic Map13D1UniSTS
cM Map1356.0UniSTS
Ccnb1-rs1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map13D1UniSTS
cM Map582.0UniSTS
Ccnb1-rs13  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7B3UniSTS
Cytogenetic Map13D1UniSTS
cM Map1356.0UniSTS
Ccnb1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map13D1UniSTS
Cytogenetic Map7B3UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142147Mvwf4_mmodifier of von Willebrand factor 4 (mouse)Not determined20293442112761890Mouse
4142241Tailq3_mtail length QTL 3 (mouse)Not determined55572541112294569Mouse
4141992W6q16_mweight 6 weeks QTL 16 (mouse)Not determined55572541112294569Mouse
4142314Tailaq3_mtail length adjusted QTL 3 (mouse)Not determined55572541112294569Mouse
4140959W10q17_mweight 10 weeks QTL 17 (mouse)Not determined55572541112294569Mouse
10402414Sgp5_mserum gp70 production 5 (mouse)Not determined1356322643105285678Mouse
1301593Heal8_mwound healing/regeneration 8 (mouse)Not determined1367905880101906000Mouse
14696726Kidrq3_mkidney weight, right QTL 3 (mouse)1368068947102068947Mouse
14747007Mancz11_mmandible centroid size 11 (mouse)1369963165103963165Mouse
4141266Mol3_mmodifier of LPS-response 3 (mouse)Not determined75984481112294569Mouse
12880414V125Dq10_mvitamin D active form serum level QTL 10 (mouse)1377900000111900000Mouse
10045623Heal18_mwound healing regeneration 18 (mouse)Not determined1379102537113102654Mouse
1558741Ses10_msalmonella enteritidis susceptibility 10 (mouse)Not determined1382603460116603598Mouse
4142465Pbwg17_mpostnatal body weight growth 17 (mouse)Not determined1383739552117739748Mouse
14700691Cisaq1_mcoxsackieviral infection serum ALT QTL 1 (mouse)1386000000120000000Mouse
4140995Fbtq6_mfemoral bone trait QTL 6 (mouse)Not determined1386205109120205250Mouse
4141728Egaq4_mearly growth adjusted QTL 4 (mouse)Not determined87753866112294569Mouse
1300939Hrtfm6_mheart failure modifier 6 (mouse)Not determined1391247158120421639Mouse
1300876Tanidd2_mtally ho associated non-insulin dependednt diabetes mellitus 2 (mouse)Not determined1391828769120421639Mouse
1301142Heal2_mwound healing/regeneration 2 (mouse)Not determined1393738733120421639Mouse
4142338Skmw18_mskeletal muscle weight 18 (mouse)Not determined1394391865120421639Mouse
1558763Gct9_mgranulosa cell tumorigenesis 9 (mouse)Not determined1394900290120421639Mouse
1357468Rplag_mreduced platelet aggregation (mouse)Not determined1395365596120421639Mouse
14746974Manh75_mmandible shape 75 (mouse)1399250111120421639Mouse
4141102Sod1m_msuperoxide dismutase 1, soluble, modifier (mouse)Not determined99603460110563377Mouse
12879496Fexq2_mfear expression QTL 2 (mouse)13100604983120421639Mouse

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir93mmu-miR-93-5pOncomiRDBexternal_infoNANA22581829

Predicted Target Of
Summary Value
Count of predictions:3299
Count of miRNA genes:692
Interacting mature miRNAs:910
Transcripts:ENSMUST00000072119, ENSMUST00000091295, ENSMUST00000128279, ENSMUST00000134080, ENSMUST00000142056, ENSMUST00000147790, ENSMUST00000174038
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_172301 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC112701 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK088816 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK136259 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK143597 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK163259 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK166686 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK167950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK168441 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK168502 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK168993 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC011478 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC080202 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC085238 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466567 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ931532 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HH771232 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S43105 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X58708 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X64713 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000072119   ⟹   ENSMUSP00000071989
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl13100,778,650 - 100,786,570 (-)Ensembl
RefSeq Acc Id: ENSMUST00000091295   ⟹   ENSMUSP00000088841
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl13100,778,732 - 100,786,486 (-)Ensembl
RefSeq Acc Id: ENSMUST00000128279
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl13100,783,044 - 100,785,603 (-)Ensembl
RefSeq Acc Id: ENSMUST00000134080
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl13100,779,609 - 100,782,033 (-)Ensembl
RefSeq Acc Id: ENSMUST00000142056
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl13100,785,537 - 100,786,475 (-)Ensembl
RefSeq Acc Id: ENSMUST00000147790
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl13100,778,747 - 100,781,453 (-)Ensembl
RefSeq Acc Id: ENSMUST00000174038   ⟹   ENSMUSP00000133962
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl13100,779,678 - 100,786,402 (-)Ensembl
RefSeq Acc Id: NM_172301   ⟹   NP_758505
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3913100,915,247 - 100,922,994 (-)NCBI
GRCm3813100,778,739 - 100,786,486 (-)NCBI
MGSCv3713101,548,694 - 101,556,441 (-)RGD
Celera13104,387,574 - 104,395,322 (-)RGD
cM Map13 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_758505   ⟸   NM_172301
- UniProtKB: P24860 (UniProtKB/Swiss-Prot),   Q3TQW9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000071989   ⟸   ENSMUST00000072119
RefSeq Acc Id: ENSMUSP00000088841   ⟸   ENSMUST00000091295
RefSeq Acc Id: ENSMUSP00000133962   ⟸   ENSMUST00000174038
Protein Domains
Cyclin N-terminal

Promoters
RGD ID:8681196
Promoter ID:EPDNEW_M18626
Type:initiation region
Name:Ccnb1_1
Description:Mus musculus cyclin B1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3813100,786,510 - 100,786,570EPDNEW
RGD ID:6823758
Promoter ID:MM_KWN:15095
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:ES_Cell
Transcripts:OTTMUST00000049584,   OTTMUST00000049587
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3613101,550,496 - 101,552,847 (-)MPROMDB
RGD ID:6823759
Promoter ID:MM_KWN:15096
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:ES_Cell
Transcripts:OTTMUST00000049586
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3613101,554,826 - 101,555,326 (-)MPROMDB
RGD ID:6823757
Promoter ID:MM_KWN:15097
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   ES_Cell,   Liver,   MEF_B4,   MEF_B6
Transcripts:OTTMUST00000049582,   OTTMUST00000049583,   OTTMUST00000049585
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3613101,556,356 - 101,556,856 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:88302 AgrOrtholog
Ensembl Genes ENSMUSG00000041431 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000071989 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000088841 UniProtKB/TrEMBL
  ENSMUSP00000133962 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000072119 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000091295 UniProtKB/TrEMBL
  ENSMUST00000174038 UniProtKB/TrEMBL
InterPro Cyclin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyclin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyclin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyclin_C-dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyclin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:268697 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:88302 ENTREZGENE
NCBI Gene 268697 ENTREZGENE
PANTHER PTHR10177 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Cyclin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyclin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB CCNB1 RGD
PhenoGen Ccnb1 PhenoGen
PIRSF Cyclin_A_B_D_E UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CYCLINS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART CYCLIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyclin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47954 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt C5IGX4_MOUSE UniProtKB/TrEMBL
  CCNB1_MOUSE UniProtKB/Swiss-Prot
  G3UY65_MOUSE UniProtKB/TrEMBL
  P24860 ENTREZGENE
  Q3TFV6_MOUSE UniProtKB/TrEMBL
  Q3TQW9 ENTREZGENE, UniProtKB/TrEMBL
  Q3UWL3_MOUSE UniProtKB/TrEMBL
  Q68EM3_MOUSE UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-22 Ccnb1  cyclin B1  Ccnb1-rs1  cyclin B1, related sequence 1  Data Merged 737654 PROVISIONAL