RGD Reference Report - Borna disease virus nucleoprotein interacts with the CDC2-cyclin B1 complex. - Rat Genome Database

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Borna disease virus nucleoprotein interacts with the CDC2-cyclin B1 complex.

Authors: Planz, O  Pleschka, S  Oesterle, K  Berberich-Siebelt, F  Ehrhardt, C  Stitz, L  Ludwig, S 
Citation: Planz O, etal., J Virol. 2003 Oct;77(20):11186-92.
RGD ID: 2316351
Pubmed: PMID:14512566   (View Abstract at PubMed)
PMCID: PMC224960   (View Article at PubMed Central)

Transition from G(2) to M phase, a cell cycle checkpoint, is regulated by the Cdc2-cyclin B1 complex. Here, we report that persistent infection with Borna disease virus (BDV), a noncytolytic RNA virus infecting the central nervous system, results in decelerated proliferation of infected host cells due to a delayed G(2)-to-M transition. Persistent BDV-infected rat fibroblast cells showed reduced proliferation compared to uninfected cells. In pull-down assays we observed an interaction of the viral nucleoprotein with the Cdc2-cyclin B1 complex. Transfection of the viral nucleoprotein but not of the phosphoprotein also results in decelerated proliferation. This phenomenon was found in BDV-susceptible primary rat fibroblast cells and also in primary mouse cells, which are not susceptible to BDV infection. This is the first evidence that the noncytolytic Borna disease virus can manipulate host cell functions via interaction of the viral nucleoprotein with mitotic entry regulators. BDV preferentially infects and persists in nondividing neurons. The present report could give an explanation for this selective choice of host cell by BDV.



Gene Ontology Annotations    Click to see Annotation Detail View

Molecular Function

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Ccnb1Ratprotein-containing complex binding  IPICdk1 (Rattus norvegicus) and UniProtKB:Q01552 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ccnb1  (cyclin B1)


Additional Information