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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2291
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccnb1
Name: cyclin B1
Acc ID: CHEBI:15368
Term: acrolein
Definition: An enal that is prop-2-ene with an oxo group at position 1.
Chemical ID: MESH:D000171
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccnb1decreases expressionISOCCNB1 (Homo sapiens)6480464CTDAcrolein results in decreased expression of CCNB1 proteinPMID:34958888
Ccnb1multiple interactionsISOCCNB1 (Homo sapiens)6480464CTD[Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of CCNB1 mRNA; [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of CCNB1 mRNA; [TP53 protein affects the susceptibility to Acrolein] which affects the localization of CCNB1 proteinPMID:29964147 PMID:32699268
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