Imported Disease Annotations - ClinVarTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | genetic disease | | ISO | RGD:68657 | 8554872 | ClinVar Annotator: match by term: Inborn genetic diseases | ClinVar | | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Imported Disease Annotations - CTD
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References
References - curated
| # | Reference Title | Reference Citation |
| 1. | Up-regulation of ORL-1 receptors in spinal tissue of allodynic rats after sciatic nerve injury. | Briscini L, etal., Eur J Pharmacol. 2002 Jun 28;447(1):59-65. |
| 2. | Molecular cloning and tissue distribution of a putative member of the rat opioid receptor gene family that is not a mu, delta or kappa opioid receptor type. | Bunzow JR, etal., FEBS Lett 1994 Jun 27;347(2-3):284-8. |
| 3. | Molecular cloning, tissue distribution and chromosomal localization of a novel member of the opioid receptor gene family. | Chen Y, etal., FEBS Lett 1994 Jun 27;347(2-3):279-83. |
| 4. | Pharmacological characterization of the nociceptin receptor which mediates reduction of alcohol drinking in rats. | Ciccocioppo R, etal., Peptides. 2002 Jan;23(1):117-25. |
| 5. | Reversal of stress- and CRF-induced anorexia in rats by the synthetic nociceptin/orphanin FQ receptor agonist, Ro 64-6198. | Ciccocioppo R, etal., Psychopharmacology (Berl). 2002 May;161(2):113-9. Epub 2002 Mar 22. |
| 6. | Activation of opioid receptor like-1 receptor in the spinal cord produces sex-specific antinociception in the rat: estrogen attenuates antinociception in the female, whereas testosterone is required for the expression of antinociception in the male. | Claiborne J, etal., J Neurosci. 2006 Dec 13;26(50):13048-53. |
| 7. | Molecular cloning of the orphanin FQ receptor gene and differential tissue expression of splice variants in rat. | Curro D, etal., Gene 2001 Mar 21;266(1-2):139-45. |
| 8. | Sex-related differences in the distribution of opioid receptor-like 1 receptor mRNA and colocalization with estrogen receptor mRNA in neurons of the spinal trigeminal nucleus caudalis in the rat. | Flores CA, etal., Neuroscience. 2003;118(3):769-78. |
| 9. | cDNA cloning and regional distribution of a novel member of the opioid receptor family. | Fukuda K, etal., FEBS Lett 1994 Apr 18;343(1):42-6. |
| 10. | Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. | Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27. |
| 11. | Rat ISS GO annotations from GOA human gene data--August 2006 | GOA data from the GO Consortium |
| 12. | Opioid receptor-like 1 stimulation in the collecting duct induces aquaresis through vasopressin-independent aquaporin-2 downregulation. | Hadrup N, etal., Am J Physiol Renal Physiol. 2004 Jul;287(1):F160-8. Epub 2004 Mar 9. |
| 13. | Gastric acid secretion stimulated by centrally injected nociceptin in urethane-anesthetized rats. | Ishihara S, etal., Eur J Pharmacol. 2002 Apr 19;441(1-2):105-14. |
| 14. | Nociceptin inhibits uterine contractions in term-pregnant rats by signaling through multiple pathways. | Klukovits A, etal., Biol Reprod. 2010 Jul;83(1):36-41. doi: 10.1095/biolreprod.109.082222. Epub 2010 Mar 17. |
| 15. | Molecular cloning of a novel G protein-coupled receptor related to the opiate receptor family. | Lachowicz JE, etal., J Neurochem 1995 Jan;64(1):34-40. |
| 16. | Orphan opioid receptor antisense probes block orphanin FQ-induced hyperphagia. | Leventhal L, etal., Eur J Pharmacol. 1998 May 15;349(1):R1-3. |
| 17. | Morphine-6beta-glucuronide-induced hyperphagia: characterization of opioid action by selective antagonists and antisense mapping in rats. | Leventhal L, etal., J Pharmacol Exp Ther. 1998 Nov;287(2):538-44. |
| 18. | Expression of ORL1 mRNA in some brain nuclei in neuropathic pain rats. | Ma F, etal., Brain Res. 2005 May 10;1043(1-2):214-7. |
| 19. | Nociceptin inhibits the neurogenic vasopressor response in the pithed rat via prejunctional ORL1 receptors. | Malinowska B, etal., Naunyn Schmiedebergs Arch Pharmacol. 2000 Jan;361(1):80-4. |
| 20. | Rat ISS GO annotations from MGI mouse gene data--August 2006 | MGD data from the GO Consortium |
| 21. | Acute and subchronic antinociceptive effects of nociceptin/orphanin FQ receptor agonists infused by intrathecal route in rats. | Micheli L, etal., Eur J Pharmacol. 2015 May 5;754:73-81. doi: 10.1016/j.ejphar.2015.02.020. Epub 2015 Feb 19. |
| 22. | Electronic Transfer of LocusLink and RefSeq Data | NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 23. | GOA pipeline | RGD automated data pipeline |
| 24. | ClinVar Automated Import and Annotation Pipeline | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
| 25. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
| 26. | Nociceptin/orphanin FQ receptor knockout rats: in vitro and in vivo studies. | Rizzi A, etal., Neuropharmacology. 2011 Mar;60(4):572-9. doi: 10.1016/j.neuropharm.2010.12.010. Epub 2010 Dec 22. |
| 27. | Methylation of OPRL1 mediates the effect of psychosocial stress on binge drinking in adolescents. | Ruggeri B, etal., J Child Psychol Psychiatry. 2018 Jun;59(6):650-658. doi: 10.1111/jcpp.12843. Epub 2017 Dec 2. |
| 28. | Modulation of Ca2+ channels by opioid receptor-like 1 receptors natively expressed in rat stellate ganglion neurons innervating cardiac muscle. | Ruiz-Velasco V, etal., J Pharmacol Exp Ther. 2005 Sep;314(3):987-94. Epub 2005 Jun 3. |
| 29. | Pharmacological blockade or genetic knockout of the NOP receptor potentiates the rewarding effect of morphine in rats. | Rutten K, etal., Drug Alcohol Depend. 2011 Apr 1;114(2-3):253-6. doi: 10.1016/j.drugalcdep.2010.10.004. Epub 2010 Nov 20. |
| 30. | Dynorphin A(1-17)-induced feeding: pharmacological characterization using selective opioid antagonists and antisense probes in rats. | Silva RM, etal., J Pharmacol Exp Ther. 2002 May;301(2):513-8. |
| 31. | Role of nociceptin and opioid receptor like 1 on entrainment function in the rat suprachiasmatic nucleus. | Sugino T, etal., Neuroscience. 2006;137(2):537-44. Epub 2005 Nov 28. |
| 32. | Tentative Sequence Identification Numbers | Tentative Sequence Data IDs. TIGR Gene Index, Rat Data |
| 33. | Two C-terminal amino acids, Ser(334) and Ser(335), are required for homologous desensitization and agonist-induced phosphorylation of opioid receptor-like 1 receptors. | Wang HL, etal., Cell Signal. 2006 May;18(5):670-8. Epub 2005 Jul 14. |
| 34. | Heterodimerization of opioid receptor-like 1 and mu-opioid receptors impairs the potency of micro receptor agonist. | Wang HL, etal., J Neurochem. 2005 Mar;92(6):1285-94. |
| 35. | cDNA cloning of an orphan opiate receptor gene family member and its splice variant. | Wang JB, etal., FEBS Lett 1994 Jul 4;348(1):75-9. |
| 36. | Isolation of a novel cDNA encoding a putative membrane receptor with high homology to the cloned mu, delta, and kappa opioid receptors. | Wick MJ, etal., Brain Res Mol Brain Res 1994 Nov;27(1):37-44. |
| 37. | Buprenorphine activates mu and opioid receptor like-1 receptors simultaneously, but the analgesic effect is mainly mediated by mu receptor activation in the rat formalin test. | Yamamoto T, etal., J Pharmacol Exp Ther. 2006 Jul;318(1):206-13. Epub 2006 Mar 24. |
| 38. | Immunomodulatory activity of orphanin FQ/nociceptin on traumatic rats. | Zhao H, etal., Acta Pharmacol Sin. 2002 Apr;23(4):343-8. |
Additional References at PubMed
| PMID:8137918 | PMID:9915326 | PMID:10571060 | PMID:10814826 | PMID:11726686 | PMID:11973003 | PMID:12217419 | PMID:12568343 | PMID:12842128 | PMID:12842289 | PMID:14660000 | PMID:15282268 |
| PMID:15890775 | PMID:15948180 | PMID:16483692 | PMID:17493706 | PMID:17499882 | PMID:17512052 | PMID:17681177 | PMID:17766480 | PMID:18987291 | PMID:19527777 | PMID:19720395 | PMID:19765615 |
| PMID:19887453 | PMID:20159949 | PMID:21925513 | PMID:22074385 | PMID:22075222 | PMID:22120202 | PMID:22371475 | PMID:23219985 | PMID:23337899 | PMID:23669068 | PMID:23869704 | PMID:24452062 |
| PMID:24978951 | PMID:25013167 | PMID:25161013 | PMID:25875798 | PMID:26387568 | PMID:26935148 | PMID:27127846 | PMID:27238748 | PMID:27562376 | PMID:28280884 | PMID:28906039 | PMID:34285372 |
Genomics
Comparative Map Data
| Oprl1 (Rattus norvegicus - Norway rat) |
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| OPRL1 (Homo sapiens - human) |
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| Oprl1 (Mus musculus - house mouse) |
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| Oprl1 (Chinchilla lanigera - long-tailed chinchilla) |
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| OPRL1 (Pan paniscus - bonobo/pygmy chimpanzee) |
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| OPRL1 (Canis lupus familiaris - dog) |
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| Oprl1 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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| OPRL1 (Sus scrofa - pig) |
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| Oprl1 (Heterocephalus glaber - naked mole-rat) |
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Variants
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Variants in Oprl1
14 total Variants 
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