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Gene: Alox5 (arachidonate 5-lipoxygenase) Rattus norvegicus
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Symbol: Alox5
Name: arachidonate 5-lipoxygenase
Description: Predicted to have arachidonate 5-lipoxygenase activity and iron ion binding activity. Involved in several processes, including positive regulation of cytochrome-c oxidase activity; positive regulation of vasoconstriction; and response to hyperoxia. Localizes to several cellular components, including the dendrite; nuclear envelope; and sarcolemma. Used to study several diseases, including brain ischemia; hypertension (multiple); pleurisy; portal hypertension; and pulmonary edema. Human ortholog(s) of this gene implicated in arteriosclerosis; asthma; pancreatic cancer; and pulmonary tuberculosis. Orthologous to human ALOX5 (arachidonate 5-lipoxygenase); PARTICIPATES IN lipoxygenase mediated pathway of arachidonic acid metabolism; acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid; 4-hydroxycyclophosphamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 5 - Lipoxygenase; 5-lipoxygenase; 5-LO; LOX5A
Orthologs:
Homo sapiens (human) : ALOX5 (arachidonate 5-lipoxygenase)  HGNC  Alliance
Mus musculus (house mouse) : Alox5 (arachidonate 5-lipoxygenase)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Alox5 (arachidonate 5-lipoxygenase)
Pan paniscus (bonobo/pygmy chimpanzee) : ALOX5 (arachidonate 5-lipoxygenase)
Canis lupus familiaris (dog) : ALOX5 (arachidonate 5-lipoxygenase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Alox5 (arachidonate 5-lipoxygenase)
Sus scrofa (pig) : ALOX5 (arachidonate 5-lipoxygenase)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.04148,398,004 - 148,446,308 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04214,345,956 - 214,393,337 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44152,610,283 - 152,657,891 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14152,855,123 - 152,902,732 (-)NCBI
Celera4138,415,564 - 138,454,485 (-)NCBICelera
Cytogenetic Map4q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Alox5
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2096
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.