Pnoc (prepronociceptin) - Rat Genome Database

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Gene: Pnoc (prepronociceptin) Rattus norvegicus
Analyze
Symbol: Pnoc
Name: prepronociceptin
RGD ID: 3362
Description: Predicted to enable opioid receptor binding activity and receptor ligand activity. Involved in chemical synaptic transmission; female pregnancy; and neuropeptide signaling pathway. Predicted to be located in extracellular region. Predicted to be active in several cellular components, including axon terminus; neuronal cell body; and synaptic membrane. Biomarker of fetal alcohol spectrum disorder. Human ortholog(s) of this gene implicated in neonatal abstinence syndrome. Orthologous to human PNOC (prepronociceptin); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: N23K; neuropeptide nociceptin 1; nociceptin; Npnc1; orphanin FQ; Prepronociceptin (neuropeptide nociceptin) (N23K)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81543,800,240 - 43,827,841 (-)NCBIGRCr8
mRatBN7.21539,624,635 - 39,652,463 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1539,624,641 - 39,651,867 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1541,488,469 - 41,501,440 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01542,638,659 - 42,651,630 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01541,085,000 - 41,097,863 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01548,805,841 - 48,833,071 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1548,805,228 - 48,833,285 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01552,547,677 - 52,574,687 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41544,822,635 - 44,835,637 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11544,838,334 - 44,851,337 (-)NCBI
Celera1539,298,658 - 39,311,512 (-)NCBICelera
Cytogenetic Map15p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Regulation of nociceptin/orphanin FQ gene expression in astrocytes by ceramide. Buzas B Neuroreport 2002 Oct 7;13(14):1707-10.
2. Inflammatory mediators increase the expression of nociceptin/orphanin FQ in rat astrocytes in culture. Buzas B, etal., Glia 2002 Sep;39(3):237-46.
3. Possible mechanism of hypothermia induced by intracerebroventricular injection of orphanin FQ/nociceptin. Chen X, etal., Brain Res 2001 Jun 22;904(2):252-8.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Nociceptin inhibits uterine contractions in term-pregnant rats by signaling through multiple pathways. Klukovits A, etal., Biol Reprod. 2010 Jul;83(1):36-41. doi: 10.1095/biolreprod.109.082222. Epub 2010 Mar 17.
7. Antioscillatory effects of nociceptin/orphanin FQ in synaptic networks of the rat thalamus. Meis S, etal., J Neurosci 2002 Feb 1;22(3):718-27.
8. Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor. Meunier JC, etal., Nature 1995 Oct 12;377(6549):532-5.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Structure, tissue distribution, and chromosomal localization of the prepronociceptin gene. Mollereau C, etal., Proc Natl Acad Sci U S A 1996 Aug 6;93(16):8666-70.
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. Primary structure and tissue distribution of the orphanin FQ precursor. Nothacker HP, etal., Proc Natl Acad Sci U S A 1996 Aug 6;93(16):8677-82.
13. Expression of orphanin FQ/nociceptin and its receptor in rat peripheral ganglia and spinal cord. Pettersson LM, etal., Brain Res 2002 Aug 2;945(2):266-75.
14. Effects of maternal separation on brain nociceptin/orphanin FQ peptide levels in male Wistar rats. Ploj K, etal., Pharmacol Biochem Behav 2002 Aug;73(1):123-9.
15. GOA pipeline RGD automated data pipeline
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Variations in opioid receptor genes in neonatal abstinence syndrome. Wachman EM, etal., Drug Alcohol Depend. 2015 Oct 1;155:253-9. doi: 10.1016/j.drugalcdep.2015.07.001. Epub 2015 Jul 8.
18. Prenatal ethanol induces an anxiety phenotype and alters expression of dynorphin & nociceptin/orphanin FQ genes. Wille-Bille A, etal., Prog Neuropsychopharmacol Biol Psychiatry. 2018 Jul 13;85:77-88. doi: 10.1016/j.pnpbp.2018.04.005. Epub 2018 Apr 18.
19. Immunomodulatory activity of orphanin FQ/nociceptin on traumatic rats. Zhao H, etal., Acta Pharmacol Sin. 2002 Apr;23(4):343-8.
Additional References at PubMed
PMID:11214319   PMID:12677331   PMID:12932825   PMID:14561874   PMID:14624331   PMID:15282268   PMID:15584926   PMID:15649868   PMID:15890775   PMID:15919744   PMID:16584812   PMID:16887913  
PMID:16935273   PMID:16935438   PMID:17202427   PMID:17274997   PMID:17382298   PMID:17478889   PMID:17493706   PMID:17499930   PMID:17640482   PMID:17681177   PMID:17766480   PMID:18027846  
PMID:18191820   PMID:18280651   PMID:18987291   PMID:19070636   PMID:19418633   PMID:19429134   PMID:19544046   PMID:19561314   PMID:19720395   PMID:19747494   PMID:20025627   PMID:20331962  
PMID:20427724   PMID:21095077   PMID:21162294   PMID:21191090   PMID:21215744   PMID:22075222   PMID:22120202   PMID:22153590   PMID:23082795   PMID:23219985   PMID:23264212   PMID:23735696  
PMID:25161013   PMID:25171201   PMID:30112574   PMID:30302539   PMID:38316167   PMID:38338936  


Genomics

Comparative Map Data
Pnoc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81543,800,240 - 43,827,841 (-)NCBIGRCr8
mRatBN7.21539,624,635 - 39,652,463 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1539,624,641 - 39,651,867 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1541,488,469 - 41,501,440 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01542,638,659 - 42,651,630 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01541,085,000 - 41,097,863 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01548,805,841 - 48,833,071 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1548,805,228 - 48,833,285 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01552,547,677 - 52,574,687 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41544,822,635 - 44,835,637 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11544,838,334 - 44,851,337 (-)NCBI
Celera1539,298,658 - 39,311,512 (-)NCBICelera
Cytogenetic Map15p12NCBI
PNOC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38828,316,988 - 28,343,351 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl828,316,986 - 28,343,355 (+)EnsemblGRCh38hg38GRCh38
GRCh37828,174,785 - 28,200,868 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36828,230,568 - 28,256,787 (+)NCBINCBI36Build 36hg18NCBI36
Build 34828,230,567 - 28,256,786NCBI
Celera827,134,504 - 27,160,720 (+)NCBICelera
Cytogenetic Map8p21.1NCBI
HuRef826,719,942 - 26,746,164 (+)NCBIHuRef
CHM1_1828,376,658 - 28,402,833 (+)NCBICHM1_1
T2T-CHM13v2.0828,595,062 - 28,621,518 (+)NCBIT2T-CHM13v2.0
Pnoc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391465,638,931 - 65,662,908 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1465,638,122 - 65,662,921 (-)EnsemblGRCm39 Ensembl
GRCm381465,400,673 - 65,425,564 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1465,400,673 - 65,425,472 (-)EnsemblGRCm38mm10GRCm38
MGSCv371466,019,510 - 66,044,046 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361464,354,783 - 64,379,319 (-)NCBIMGSCv36mm8
Celera1463,152,191 - 63,176,787 (-)NCBICelera
Cytogenetic Map14D1NCBI
cM Map1434.33NCBI
Pnoc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540350,735,390 - 50,755,902 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540350,735,567 - 50,755,892 (+)NCBIChiLan1.0ChiLan1.0
PNOC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2746,856,738 - 46,883,138 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1822,571,113 - 22,597,566 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0827,596,413 - 27,622,844 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1824,796,490 - 24,822,764 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl824,796,638 - 24,822,758 (+)Ensemblpanpan1.1panPan2
PNOC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12529,223,758 - 29,246,487 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2529,224,092 - 29,245,851 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2529,873,540 - 29,896,041 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02529,382,377 - 29,404,891 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2529,382,715 - 29,404,498 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12529,342,437 - 29,364,950 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02529,226,990 - 29,249,199 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02529,393,029 - 29,415,545 (-)NCBIUU_Cfam_GSD_1.0
Pnoc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049437,451,235 - 7,473,199 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366751,113,435 - 1,134,910 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366751,113,435 - 1,134,916 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PNOC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1412,101,698 - 12,133,778 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11412,101,223 - 12,134,174 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21413,256,659 - 13,288,651 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PNOC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1826,418,473 - 26,444,689 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl826,418,815 - 26,444,677 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605215,687,564 - 15,713,855 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pnoc
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475823,007,573 - 23,028,704 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475823,007,530 - 23,026,962 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pnoc
140 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:260
Count of miRNA genes:175
Interacting mature miRNAs:195
Transcripts:ENSRNOT00000019117
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15141686771Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15142356671Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)151985656646187442Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152211793367117933Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)152803066582262678Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)152803066582262678Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)152803066582262678Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
2293691Bmd37Bone mineral density QTL 376.60.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)153361105871477291Rat
2293686Bmd36Bone mineral density QTL 367.40.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)153361105871477291Rat
1598828Glom14Glomerulus QTL 142.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)153405413979054139Rat

Markers in Region
RH130731  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21539,624,790 - 39,624,975 (+)MAPPERmRatBN7.2
Rnor_6.01548,806,029 - 48,806,213NCBIRnor6.0
Rnor_5.01552,547,836 - 52,548,020UniSTSRnor5.0
RGSC_v3.41544,822,791 - 44,822,975UniSTSRGSC3.4
Celera1539,298,814 - 39,298,998UniSTS
Cytogenetic Map15p12UniSTS
RH94661  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21539,624,778 - 39,624,970 (+)MAPPERmRatBN7.2
Rnor_6.01548,806,017 - 48,806,208NCBIRnor6.0
Rnor_5.01552,547,824 - 52,548,015UniSTSRnor5.0
RGSC_v3.41544,822,779 - 44,822,970UniSTSRGSC3.4
Celera1539,298,802 - 39,298,993UniSTS
Cytogenetic Map15p12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 1 22 6 17 6 2 2 33 8 10 9 2
Low 2 21 13 13 2 13 6 8 41 13 29 2 6
Below cutoff 21 18 18 18 1 14 2

Sequence


RefSeq Acc Id: ENSRNOT00000019117   ⟹   ENSRNOP00000019117
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1539,624,641 - 39,651,867 (-)Ensembl
Rnor_6.0 Ensembl1548,805,228 - 48,833,285 (-)Ensembl
RefSeq Acc Id: NM_013007   ⟹   NP_037139
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81543,800,240 - 43,813,103 (-)NCBI
mRatBN7.21539,624,635 - 39,637,500 (-)NCBI
Rnor_6.01548,805,873 - 48,818,594 (-)NCBI
Rnor_5.01552,547,677 - 52,574,687 (-)NCBI
RGSC_v3.41544,822,635 - 44,835,637 (-)RGD
Celera1539,298,658 - 39,311,512 (-)RGD
Sequence:
RefSeq Acc Id: XM_006252196   ⟹   XP_006252258
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81543,800,240 - 43,827,592 (-)NCBI
mRatBN7.21539,624,639 - 39,651,943 (-)NCBI
Rnor_6.01548,805,841 - 48,833,071 (-)NCBI
Rnor_5.01552,547,677 - 52,574,687 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039093010   ⟹   XP_038948938
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81543,800,240 - 43,827,841 (-)NCBI
mRatBN7.21539,624,639 - 39,652,463 (-)NCBI
RefSeq Acc Id: XM_063273998   ⟹   XP_063130068
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81543,803,623 - 43,827,546 (-)NCBI
RefSeq Acc Id: NP_037139   ⟸   NM_013007
- Peptide Label: precursor
- UniProtKB: Q64162 (UniProtKB/Swiss-Prot),   Q62923 (UniProtKB/Swiss-Prot),   A6K6J8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006252258   ⟸   XM_006252196
- Peptide Label: isoform X1
- UniProtKB: A6K6J7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000019117   ⟸   ENSRNOT00000019117
RefSeq Acc Id: XP_038948938   ⟸   XM_039093010
- Peptide Label: isoform X1
- UniProtKB: A6K6J7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063130068   ⟸   XM_063273998
- Peptide Label: isoform X2
- UniProtKB: Q64162 (UniProtKB/Swiss-Prot),   Q62923 (UniProtKB/Swiss-Prot),   A6K6J8 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62923-F1-model_v2 AlphaFold Q62923 1-181 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3362 AgrOrtholog
BioCyc Gene G2FUF-13356 BioCyc
Ensembl Genes ENSRNOG00000014231 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055006648 UniProtKB/Swiss-Prot
  ENSRNOG00060010866 UniProtKB/Swiss-Prot
  ENSRNOG00065018612 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000019117.8 UniProtKB/Swiss-Prot
  ENSRNOT00055010837 UniProtKB/Swiss-Prot
  ENSRNOT00060018417 UniProtKB/Swiss-Prot
  ENSRNOT00065031257 UniProtKB/Swiss-Prot
InterPro Nociceptin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Opioid_neupept UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25516 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 25516 ENTREZGENE
PANTHER PREPRONOCICEPTIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11438 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Opiods_neuropep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pnoc PhenoGen
PRINTS OPIOIDPRCRSR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ORPHNNPRCRSR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE OPIOIDS_PRECURSOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROKAR_LIPOPROTEIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000014231 RatGTEx
  ENSRNOG00055006648 RatGTEx
  ENSRNOG00060010866 RatGTEx
  ENSRNOG00065018612 RatGTEx
UniProt A6K6J7 ENTREZGENE, UniProtKB/TrEMBL
  A6K6J8 ENTREZGENE, UniProtKB/TrEMBL
  PNOC_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q64162 ENTREZGENE
  Q99NQ1_RAT UniProtKB/TrEMBL
UniProt Secondary Q64162 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Pnoc  Prepronociceptin (neuropeptide nociceptin) (N23K)      Symbol and Name status set to approved 70586 APPROVED