Nox4 (NADPH oxidase 4) - Rat Genome Database
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Gene: Nox4 (NADPH oxidase 4) Rattus norvegicus
Analyze
Symbol: Nox4
Name: NADPH oxidase 4
RGD ID: 620600
Description: Exhibits NAD(P)H oxidase H2O2-forming activity. Involved in several processes, including cellular response to cAMP; cellular response to gamma radiation; and positive regulation of stress fiber assembly. Localizes to several cellular components, including NADPH oxidase complex; focal adhesion; and perinuclear endoplasmic reticulum. Colocalizes with stress fiber. Used to study hypertension. Biomarker of hypertension and non-alcoholic steatohepatitis. Orthologous to human NOX4 (NADPH oxidase 4); PARTICIPATES IN thyroid hormone biosynthetic pathway; INTERACTS WITH (-)-epigallocatechin 3-gallate; (R)-lipoic acid; 1,2-dimethylhydrazine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: kidney oxidase-1; kidney superoxide-producing NADPH oxidase; kox-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Nox4em2Mcwi   Nox4em1Mcwi  
Genetic Models: SS-Nox4em2Ncf2em1Mcwi SS-Nox4em1Mcwi SS-Nox4em2Mcwi-/- SS-Nox4em2Mcwi-/+ SS-Nox4em2Mcwi
Is Marker For: Strains:   FHH.BN-(D1Hmgc14-D1Hmgc15)/Mcwi  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21140,900,886 - 141,078,844 (+)NCBI
Rnor_6.0 Ensembl1150,797,084 - 150,976,194 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01150,796,359 - 150,976,186 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01157,106,652 - 157,196,482 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01157,246,099 - 157,285,107 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41143,415,816 - 143,603,554 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11143,494,221 - 143,681,960 (+)NCBI
Celera1139,242,883 - 139,407,667 (+)NCBICelera
Cytogenetic Map1q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (EXP)
(R)-lipoic acid  (EXP)
(S)-nicotine  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (EXP)
1,4-benzoquinone  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3-chloropropane-1,2-diol  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
aflatoxin B2  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
amlodipine  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
apocynin  (EXP)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenous acid  (ISO)
atorvastatin calcium  (EXP,ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
beta-naphthoflavone  (EXP)
bezafibrate  (EXP,ISO)
bisphenol A  (EXP)
bisphenol F  (ISO)
bosentan  (ISO)
bromobenzene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (EXP,ISO)
candesartan  (EXP,ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP-42112A  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chromium atom  (ISO)
cisplatin  (EXP,ISO)
cobalt dichloride  (ISO)
crocidolite asbestos  (ISO)
curcumin  (EXP)
cyclosporin A  (EXP,ISO)
cypermethrin  (ISO)
cytarabine  (ISO)
D-glucose  (EXP,ISO)
dapsone  (ISO)
daunorubicin  (EXP)
decabromodiphenyl ether  (EXP,ISO)
Deoxycorticosterone acetate  (ISO)
dexamethasone  (ISO)
Diallyl sulfide  (EXP)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibenziodolium  (ISO)
dichloroacetic acid  (ISO)
dihydrogen  (ISO)
dioxygen  (EXP,ISO)
diprotium  (ISO)
doxorubicin  (EXP,ISO)
doxycycline  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
erlotinib hydrochloride  (ISO)
ethanol  (EXP,ISO)
ethoxyquin  (EXP)
farrerol  (EXP)
ferric oxide  (ISO)
fisetin  (EXP)
flavonoids  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fructose  (EXP)
furan  (EXP)
ginkgolide B  (ISO)
glucose  (EXP,ISO)
GW 6471  (EXP)
hesperetin  (ISO)
homocysteine  (ISO)
hydrazine  (ISO)
hydrochlorothiazide  (EXP)
hydrogen peroxide  (ISO)
hydrogen sulfide  (EXP)
hydroxylamine  (EXP)
indoxyl sulfate  (ISO)
isoprenaline  (ISO)
kaempferol  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
lead(0)  (EXP)
lead(2+)  (EXP)
lead(II) chloride  (ISO)
Leonurine  (EXP,ISO)
lipoic acid  (EXP)
lipopolysaccharide  (ISO)
loganin  (ISO)
lutein  (ISO)
LY294002  (ISO)
mancozeb  (ISO)
manidipine  (EXP)
menadione  (ISO)
mercury atom  (ISO)
mercury dichloride  (EXP,ISO)
mercury(0)  (ISO)
methapyrilene  (ISO)
microcystin-LR  (ISO)
mitogen  (EXP)
monocrotaline  (EXP)
N-acetyl-L-cysteine  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
naringin  (ISO)
nicotinamide  (EXP)
nicotine  (ISO)
nicotinic acid  (EXP)
nitroglycerin  (EXP)
paracetamol  (EXP,ISO)
paraquat  (ISO)
PD123319  (ISO)
phenethyl caffeate  (ISO)
phenobarbital  (EXP,ISO)
PhIP  (EXP)
phosphatidylcholine  (ISO)
pioglitazone  (EXP)
pirfenidone  (ISO)
pirinixic acid  (EXP,ISO)
potassium chromate  (ISO)
probenecid  (ISO)
reactive oxygen species  (ISO)
resveratrol  (EXP,ISO)
rotenone  (EXP,ISO)
salubrinal  (ISO)
saxagliptin  (EXP)
SB 203580  (EXP)
selenium atom  (ISO)
silibinin  (EXP)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sirtinol  (EXP)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sodium dichromate  (EXP)
sodium fluoride  (EXP)
streptozocin  (EXP,ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
superoxide  (ISO)
telmisartan  (EXP)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
thioacetamide  (EXP)
thymoquinone  (EXP)
torcetrapib  (ISO)
trans-piceid  (EXP)
trichloroethene  (ISO)
triclosan  (ISO)
triphenyl phosphate  (EXP)
troglitazone  (ISO)
tyrphostin AG 1478  (EXP)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
zinc atom  (ISO)
zinc dichloride  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
1. Ambasta RK, etal., J Biol Chem. 2004 Oct 29;279(44):45935-41. Epub 2004 Aug 18.
2. Block K, etal., Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14385-90. Epub 2009 Aug 17.
3. Carmona-Cuenca I, etal., J Hepatol. 2008 Dec;49(6):965-76. Epub 2008 Sep 19.
4. Collins-Underwood JR, etal., Free Radic Biol Med. 2008 Sep 15;45(6):929-38. Epub 2008 Jun 30.
5. Colston JT, etal., FEBS Lett. 2005 Apr 25;579(11):2533-40.
6. Cowley AW Jr, etal., Hypertension. 2016 Feb;67(2):440-50. doi: 10.1161/HYPERTENSIONAHA.115.06280. Epub 2015 Dec 7.
7. Cutz E, etal., Adv Exp Med Biol. 2009;648:427-38.
8. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. GOA data from the GO Consortium
10. Gojo A, etal., Eur J Pharmacol. 2007 Jul 30;568(1-3):242-7. Epub 2007 Apr 20.
11. Gorin Y, etal., J Biol Chem. 2005 Nov 25;280(47):39616-26. Epub 2005 Aug 31.
12. He L, etal., J Appl Physiol. 2010 May;108(5):1304-10. Epub 2010 Feb 25.
13. Lassegue B, etal., Circ Res 2001 May 11;88(9):888-94.
14. Matsunami T, etal., Int J Clin Exp Pathol. 2010 May 22;3(5):472-81.
15. Matsushima S, etal., J Clin Invest. 2016 Sep 1;126(9):3403-16. doi: 10.1172/JCI85624. Epub 2016 Aug 15.
16. McCann SK, etal., J Neurosci Res. 2008 Aug 15;86(11):2524-34.
17. McCrann DJ, etal., Cell Cycle. 2009 Mar 15;8(6):902-8. Epub 2009 Mar 21.
18. Meng D, etal., Cardiovasc Res. 2008 Nov 1;80(2):299-308. Epub 2008 Jun 20.
19. MGD data from the GO Consortium
20. NCBI rat LocusLink and RefSeq merged data July 26, 2002
21. Nisbet RE, etal., Am J Respir Cell Mol Biol. 2009 May;40(5):601-9. Epub 2008 Oct 23.
22. Pipeline to import SMPDB annotations from SMPDB into RGD
23. RGD automated data pipeline
24. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
25. RGD automated import pipeline for gene-chemical interactions
26. Saha S, etal., Can J Physiol Pharmacol. 2008 Apr;86(4):190-8.
27. Sancho P, etal., Biochim Biophys Acta. 2009 Feb;1793(2):253-63. Epub 2008 Sep 24.
28. Tada Y, etal., Hypertension. 2009 Sep;54(3):552-7. Epub 2009 Jul 20.
29. Vallet P, etal., Neuroscience. 2005;132(2):233-8.
30. Wang C, etal., Eur J Pharmacol. 2009 Oct 12;620(1-3):131-7. Epub 2009 Aug 15.
31. Zeng SY, etal., Can J Cardiol. 2013 Oct;29(10):1310-9. doi: 10.1016/j.cjca.2013.04.026. Epub 2013 Jul 11.
Additional References at PubMed
PMID:10869423   PMID:11032835   PMID:11098048   PMID:12842860   PMID:14670934   PMID:16150729   PMID:16775014   PMID:17082491   PMID:17283869   PMID:17324585   PMID:17698723   PMID:17942966  
PMID:18431508   PMID:18474828   PMID:18554521   PMID:18559349   PMID:18624925   PMID:18760347   PMID:19038868   PMID:19056645   PMID:19204183   PMID:19574552   PMID:19910702   PMID:19926889  
PMID:20016382   PMID:20031578   PMID:20185797   PMID:20686447   PMID:20715105   PMID:20724704   PMID:21071935   PMID:21419746   PMID:21646815   PMID:21940672   PMID:22031600   PMID:22063193  
PMID:22195989   PMID:22566500   PMID:22873349   PMID:22875785   PMID:23022406   PMID:23033809   PMID:23144758   PMID:23225244   PMID:23271793   PMID:23393389   PMID:23624625   PMID:23722270  
PMID:23884197   PMID:23940049   PMID:24041960   PMID:24480752   PMID:24623966   PMID:24636100   PMID:24872317   PMID:24947524   PMID:25203114   PMID:25410908   PMID:25681565   PMID:26088607  
PMID:26136558   PMID:26279425   PMID:26387612   PMID:26631573   PMID:26945889   PMID:27033446   PMID:27279484   PMID:27558234   PMID:27665186   PMID:27847553   PMID:27913300   PMID:27923787  
PMID:27929749   PMID:28011270   PMID:28063381   PMID:28078487   PMID:28330417   PMID:28431936   PMID:28447737   PMID:28634073   PMID:28751569   PMID:28805491   PMID:29087944   PMID:29147462  
PMID:29672130   PMID:29723859   PMID:29793963   PMID:30316800   PMID:30354218   PMID:30551445   PMID:30610956   PMID:30953402   PMID:31179339   PMID:31216444   PMID:31541678   PMID:32183375  
PMID:32233792  


Genomics

Comparative Map Data
Nox4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21140,900,886 - 141,078,844 (+)NCBI
Rnor_6.0 Ensembl1150,797,084 - 150,976,194 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01150,796,359 - 150,976,186 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01157,106,652 - 157,196,482 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01157,246,099 - 157,285,107 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41143,415,816 - 143,603,554 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11143,494,221 - 143,681,960 (+)NCBI
Celera1139,242,883 - 139,407,667 (+)NCBICelera
Cytogenetic Map1q32NCBI
NOX4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1189,324,353 - 89,498,187 (-)EnsemblGRCh38hg38GRCh38
GRCh381189,324,353 - 89,589,557 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371189,057,521 - 89,322,725 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361188,699,160 - 88,864,301 (-)NCBINCBI36hg18NCBI36
Build 341188,699,159 - 88,864,301NCBI
Celera1185,399,612 - 85,574,418 (+)NCBI
Cytogenetic Map11q14.3NCBI
HuRef1185,294,642 - 85,559,923 (-)NCBIHuRef
CHM1_11188,940,465 - 89,205,767 (-)NCBICHM1_1
Nox4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39786,893,638 - 87,047,918 (+)NCBIGRCm39mm39
GRCm39 Ensembl786,895,304 - 87,047,918 (+)Ensembl
GRCm38787,244,430 - 87,398,710 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl787,246,096 - 87,398,710 (+)EnsemblGRCm38mm10GRCm38
MGSCv37794,395,305 - 94,547,116 (+)NCBIGRCm37mm9NCBIm37
MGSCv36787,122,556 - 87,274,367 (+)NCBImm8
Celera784,613,741 - 84,757,901 (+)NCBICelera
Cytogenetic Map7D3NCBI
Nox4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554144,062,081 - 4,212,746 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554144,062,337 - 4,220,032 (+)NCBIChiLan1.0ChiLan1.0
NOX4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11187,911,335 - 88,171,535 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v01184,330,362 - 84,496,755 (-)NCBIMhudiblu_PPA_v0panPan3
NOX4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2110,615,970 - 10,775,277 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12110,615,153 - 10,782,927 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Nox4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936736230,465 - 394,859 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NOX4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl922,624,195 - 22,776,554 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1922,622,105 - 22,776,691 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2925,234,530 - 25,427,884 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NOX4
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1180,470,418 - 80,642,513 (-)NCBI
ChlSab1.1 Ensembl180,470,826 - 80,642,722 (-)Ensembl
Nox4
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624845669,880 - 829,471 (+)NCBI

Position Markers
AU047304  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01150,876,500 - 150,876,649NCBIRnor6.0
Rnor_5.01157,185,521 - 157,185,670UniSTSRnor5.0
RGSC_v3.41143,496,029 - 143,496,178UniSTSRGSC3.4
Celera1139,323,472 - 139,323,621UniSTS
Cytogenetic Map1q32UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)199983293216325819Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134993530173445086Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1124603592188289386Rat
631202Gluco13Glucose level QTL 130.0001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1139523928170246858Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1126240667217054291Rat
631206Niddm40Non-insulin dependent diabetes mellitus QTL 40blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1144723107174343537Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)158354072161711996Rat
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1133946489178946489Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)194201400184846632Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)190804143161321256Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1137787261236763528Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)195304961156446783Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)199983293216213510Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)199983293198656062Rat
631570Bp94Blood pressure QTL 940.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1130917121152871103Rat
631654Bp107Blood pressure QTL 107arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1133076978178076978Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)199983293188289386Rat
2303591Gluco41Glucose level QTL 412blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1109634374154634374Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149578577169852184Rat
2317833Alcrsp19Alcohol response QTL 1912.40.001response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1108417193153417193Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1100131562236763528Rat
738006Anxrr14Anxiety related response QTL 1440.00035locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1141296374186296374Rat
738028Anxrr12Anxiety related response QTL 124.90.00001locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1141296374186296374Rat
631496Bp97Blood pressure QTL 973.08arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1113593576158593576Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1130779148198585664Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1130779320219238476Rat
1300153Bp171Blood pressure QTL 1713.37arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194364073153076991Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1130779148199254774Rat
1641897Alcrsp1Alcohol response QTL 1response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1108417193153417193Rat
1598850Bp297Blood pressure QTL 2972.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1131334152176334152Rat
1598866Bp287Blood pressure QTL 2875.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1131334152176334152Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149578693217054291Rat
634348Bp138Blood pressure QTL 138arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1133076978184188922Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1130779148199254774Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)182788437239853971Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)149147799156446783Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1122614824201146953Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1108986301219232156Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1108986301238830534Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1108986301219232156Rat
1354623Rf46Renal function QTL 463.8blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)1108986301161784422Rat
1558645Bw55Body weight QTL 553.20.004body mass (VT:0001259)body weight (CMO:0000012)1144395993189395993Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1130779148199254774Rat
2313060Bss71Bone structure and strength QTL 712.60.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)1124090312169090312Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)194201400197187904Rat
2293140Bp313Blood pressure QTL 313arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1129208943174208943Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1137787261236763528Rat
61346Rf2Renal disease susceptibility QTL 23.7urine protein amount (VT:0005160)urine protein level (CMO:0000591)1111446783156446783Rat
61370Mcs3Mammary carcinoma susceptibility QTL 32.15mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1108057233167517487Rat
61399Tcat1Tongue tumor resistance QTL 13.3tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 5 mm (CMO:0001879)1111446783156446783Rat
6893347Bw98Body weight QTL 980.20.53body mass (VT:0001259)body weight (CMO:0000012)1144395993189395993Rat
6893361Bw104Body weight QTL 1040.590.27body mass (VT:0001259)body weight (CMO:0000012)1144395993189395993Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1106002252202571904Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1122614824262664716Rat
9685799Bp375Blood pressure QTL 375arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1133076978178076978Rat
9590300Scort16Serum corticosterone level QTL 164.390.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1110620749155620749Rat
9685802Bp376Blood pressure QTL 376arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1134089429179089429Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1144634295241482368Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1125875758262433692Rat
8694370Bw154Body weight QTL 1548.910.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)1110620749155620749Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)135377692217372257Rat


Related Rat Strains
The following Strains have been annotated to Nox4


Genetic Models
This gene Nox4 is modified in the following models/strains
miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir92brno-miR-92b-3pMirtarbaseexternal_infoLuciferase reporter assay//Microarray//qRT-PCR//WeNon-Functional MTI21071935
Mir25rno-miR-25-3pMirtarbaseexternal_infoLuciferase reporter assay//Microarray//qRT-PCR//WeFunctional MTI21071935

Predicted Target Of
Summary Value
Count of predictions:215
Count of miRNA genes:148
Interacting mature miRNAs:162
Transcripts:ENSRNOT00000018990
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 3 3 23 11
Low 1 43 24 11 9 11 8 10 58 12 34 8
Below cutoff 2 14 11 10 11 1 16 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000018990   ⟹   ENSRNOP00000018990
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1150,797,084 - 150,976,194 (+)Ensembl
RefSeq Acc Id: NM_053524   ⟹   NP_445976
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21140,901,243 - 141,077,395 (+)NCBI
Rnor_6.01150,797,202 - 150,974,737 (+)NCBI
Rnor_5.01157,106,652 - 157,196,482 (+)NCBI
Rnor_5.01157,246,099 - 157,285,107 (+)NCBI
RGSC_v3.41143,415,816 - 143,603,554 (+)RGD
Celera1139,242,883 - 139,407,667 (+)RGD
Sequence:
RefSeq Acc Id: XM_008759640   ⟹   XP_008757862
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01150,796,359 - 150,976,186 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008759641   ⟹   XP_008757863
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01150,797,631 - 150,976,186 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008759642   ⟹   XP_008757864
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01150,797,871 - 150,976,186 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008759643   ⟹   XP_008757865
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21140,900,886 - 141,078,844 (+)NCBI
Rnor_6.01150,797,084 - 150,976,186 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039092943   ⟹   XP_038948871
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21140,900,888 - 141,078,844 (+)NCBI
RefSeq Acc Id: XM_039092944   ⟹   XP_038948872
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21140,901,316 - 141,078,844 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_445976   ⟸   NM_053524
- UniProtKB: Q924V1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_008757862   ⟸   XM_008759640
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_008757865   ⟸   XM_008759643
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_008757863   ⟸   XM_008759641
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_008757864   ⟸   XM_008759642
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSRNOP00000018990   ⟸   ENSRNOT00000018990
RefSeq Acc Id: XP_038948871   ⟸   XM_039092943
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038948872   ⟸   XM_039092944
- Peptide Label: isoform X2
Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690176
Promoter ID:EPDNEW_R701
Type:initiation region
Name:Nox4_1
Description:NADPH oxidase 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R702  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01150,797,096 - 150,797,156EPDNEW
RGD ID:13690177
Promoter ID:EPDNEW_R702
Type:initiation region
Name:Nox4_2
Description:NADPH oxidase 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R701  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01150,797,201 - 150,797,261EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Damaging Variants


Assembly: RGSC_v3.4

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
1 143490643 143490644 G T snv ACI/EurMcwi (MCW), SS/JrHsdMcwi (MCW), SR/JrHsd (MCW), FHH/EurMcwi (MCW)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620600 AgrOrtholog
Ensembl Genes ENSRNOG00000013925 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000018990 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000018990 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.80 UniProtKB/Swiss-Prot
InterPro Cyt_b245_heavy_chain UniProtKB/Swiss-Prot
  FAD-bd_8 UniProtKB/Swiss-Prot
  FAD-bd_FR_type UniProtKB/Swiss-Prot
  Fe3_Rdtase_TM_dom UniProtKB/Swiss-Prot
  Fe_red_NAD-bd_6 UniProtKB/Swiss-Prot
  FNR_nucleotide-bd UniProtKB/Swiss-Prot
  Riboflavin_synthase-like_b-brl UniProtKB/Swiss-Prot
KEGG Report rno:85431 UniProtKB/Swiss-Prot
NCBI Gene 85431 ENTREZGENE
Pfam FAD_binding_8 UniProtKB/Swiss-Prot
  Ferric_reduct UniProtKB/Swiss-Prot
  NAD_binding_6 UniProtKB/Swiss-Prot
PhenoGen Nox4 PhenoGen
PRINTS GP91PHOX UniProtKB/Swiss-Prot
PROSITE FAD_FR UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52343 UniProtKB/Swiss-Prot
  SSF63380 UniProtKB/Swiss-Prot
UniProt NOX4_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q99M78 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Nox4  NADPH oxidase 4      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Nox4  NADPH oxidase 4      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression highly expressed in vascular smooth muscle cells 632514
gene_regulation expression is downregulated by platelet-derived growth factor (PDGF) and Ang II 632514