Nox4 (NADPH oxidase 4) - Rat Genome Database

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Gene: Nox4 (NADPH oxidase 4) Rattus norvegicus
Analyze
Symbol: Nox4
Name: NADPH oxidase 4
RGD ID: 620600
Description: Enables NAD(P)H oxidase H2O2-forming activity and superoxide-generating NAD(P)H oxidase activity. Involved in several processes, including cellular response to cAMP; cellular response to gamma radiation; and cellular response to mercury ion. Located in several cellular components, including endoplasmic reticulum; focal adhesion; and stress fiber. Part of NADPH oxidase complex. Used to study hypertension. Biomarker of hypertension; metabolic dysfunction-associated steatohepatitis; obesity; and steatotic liver disease. Orthologous to human NOX4 (NADPH oxidase 4); PARTICIPATES IN thyroid hormone biosynthetic pathway; INTERACTS WITH (-)-epigallocatechin 3-gallate; (R)-lipoic acid; 1,2-dimethylhydrazine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: kidney oxidase-1; kidney superoxide-producing NADPH oxidase; kox-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Nox4em2Mcwi   Nox4em1Mcwi  
Genetic Models: SS-Nox4em2Mcwi SS-Nox4em1Mcwi SS-Nox4em2Mcwi-/- SS-Nox4em2Mcwi-/+ SS-Nox4em2Ncf2em1Mcwi
Is Marker For: Strains:   FHH.BN-(D1Hmgc14-D1Hmgc15)/Mcwi  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81150,313,736 - 150,491,480 (+)NCBIGRCr8
mRatBN7.21140,900,886 - 141,078,844 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1140,901,097 - 141,077,406 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1148,877,339 - 149,042,590 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01156,047,993 - 156,213,233 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01148,921,890 - 149,087,126 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01150,796,359 - 150,976,186 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1150,797,084 - 150,976,194 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01157,106,652 - 157,196,482 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01157,246,099 - 157,285,107 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41143,415,816 - 143,603,554 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11143,494,221 - 143,681,960 (+)NCBI
Celera1139,242,883 - 139,407,667 (+)NCBICelera
Cytogenetic Map1q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Nox4RatAneurysm  IEP 2324659 RGD 
Nox4Ratbrain ischemia  ISONox4 (Mus musculus)1580980mRNA and protein:increased expression:cerebral cortex (human)RGD 
Nox4RatDiabetic Nephropathies  IEP 2324670associated with Diabetes Mellitus more ...RGD 
Nox4RatDiabetic Nephropathies  IMP 2324673associated with Diabetes Mellitus and ExperimentalRGD 
Nox4RatExperimental Diabetes Mellitus  IEP 2324658protein:increased expression:aortaRGD 
Nox4Rathypertension  IEP 2324669protein:increased expression:aorta and vascular associated smooth muscle cellRGD 
Nox4Rathypertension  IMP 11085830 RGD 
Nox4RatLeft Ventricular Hypertrophy  IEP 13703040associated with hypertensionRGD 
Nox4Ratmetabolic dysfunction-associated steatohepatitis susceptibilityIEP 21076282mRNA:increased expression:liver (rat)RGD 
Nox4Ratobesity treatmentIEP 401960083 RGD 
Nox4Ratpulmonary hypertension  ISONox4 (Mus musculus)4762683associated with Anoxia more ...RGD 
Nox4RatReperfusion Injury  IEP 2324666mRNA:increased expression:cerebral cortexRGD 
Nox4RatSpinal Cord Injuries  IEP 329853757mRNA and protein:increased expression:gastrocnemius muscleRGD 
Nox4Ratsteatotic liver disease treatmentIEP 401960083 RGD 
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Nox4Ratintellectual disability  ISONOX4 (Homo sapiens)8554872ClinVar Annotator: match by term: Intellectual disabilityClinVar 
Nox4Ratoculocutaneous albinism type IA  ISONOX4 (Homo sapiens)8554872ClinVar Annotator: match by term: Tyrosinase-negative oculocutaneous albinismClinVarPMID:25741868
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Nox4RatBrain Injuries  ISONOX4 (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:36762617
Nox4RatChemical and Drug Induced Liver Injury  ISONOX4 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25226513
Nox4RatColonic Neoplasms  ISONOX4 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20715105
Nox4Ratcongestive heart failure  ISONOX4 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20304815
Nox4Ratend stage renal disease  ISONOX4 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19420110
Nox4RatExperimental Liver Cirrhosis  ISONOX4 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25380136
Nox4Rathypertension  ISONOX4 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:27659729 more ...
Nox4Ratkidney failure  ISONOX4 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:23325087

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Nox4Rat(-)-epigallocatechin 3-gallate decreases expressionEXP 6480464epigallocatechin gallate results in decreased expression of NOX4 mRNACTDPMID:27659729
Nox4Rat(R)-lipoic acid multiple interactionsEXP 6480464acetovanillone promotes the reaction [Thioctic Acid inhibits the reaction [Mitogens results in increased expression of NOX4 mRNA]] more ...CTDPMID:29760339 and PMID:33111558
Nox4Rat(R)-lipoic acid multiple interactionsISONox4 (Mus musculus)6480464Thioctic Acid inhibits the reaction [Bleomycin results in increased expression of NOX4 mRNA]CTDPMID:35187969
Nox4Rat(S)-nicotine increases expressionISONox4 (Mus musculus)6480464Nicotine results in increased expression of NOX4 proteinCTDPMID:20685820
Nox4Rat1,2-dichloroethane decreases expressionISONox4 (Mus musculus)6480464ethylene dichloride results in decreased expression of NOX4 mRNACTDPMID:28189721 and PMID:28960355
Nox4Rat1,2-dichloroethane multiple interactionsISONox4 (Mus musculus)6480464[ethylene dichloride co-treated with Ethanol] results in increased expression of NOX4 protein and allyl sulfide inhibits the reaction [[ethylene dichloride co-treated with Ethanol] results in increased expression of NOX4 protein]CTDPMID:37150348
Nox4Rat1,2-dimethylhydrazine decreases expressionEXP 64804641 and 2-Dimethylhydrazine results in decreased expression of NOX4 mRNACTDPMID:32387197
Nox4Rat1,4-benzoquinone decreases expressionISONOX4 (Homo sapiens)6480464quinone results in decreased expression of NOX4 proteinCTDPMID:30448556
Nox4Rat1,4-bis(2-ethylhexyl) sulfosuccinate increases expressionISONox4 (Mus musculus)6480464Dioctyl Sulfosuccinic Acid results in increased expression of NOX4 mRNACTDPMID:30728429
Nox4Rat1-naphthyl isothiocyanate decreases expressionEXP 64804641-Naphthylisothiocyanate results in decreased expression of NOX4 mRNACTDPMID:25380136 and PMID:30723492
Nox4Rat17beta-estradiol multiple interactionsISONOX4 (Homo sapiens)6480464[Estradiol co-treated with TGFB1 protein] results in increased expression of NOX4 mRNACTDPMID:30165855
Nox4Rat17beta-estradiol affects expressionISONox4 (Mus musculus)6480464Estradiol affects the expression of NOX4 mRNACTDPMID:39298647
Nox4Rat17beta-estradiol multiple interactionsEXP 6480464[estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of NOX4 mRNACTDPMID:32741896
Nox4Rat17beta-estradiol 3-benzoate multiple interactionsEXP 6480464[estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of NOX4 mRNACTDPMID:32741896
Nox4Rat2,2',4,4'-Tetrabromodiphenyl ether increases expressionISONOX4 (Homo sapiens)64804642 more ...CTDPMID:31622892
Nox4Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionISONox4 (Mus musculus)6480464Tetrachlorodibenzodioxin results in decreased expression of NOX4 mRNACTDPMID:19770486
Nox4Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISONox4 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of NOX4 mRNACTDPMID:28922406
Nox4Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of NOX4 mRNACTDPMID:21215274 and PMID:32109520
Nox4Rat2,3,7,8-Tetrachlorodibenzofuran decreases expressionEXP 64804642 more ...CTDPMID:32109520
Nox4Rat2,4-dibromophenyl 2,4,5-tribromophenyl ether increases expressionISONOX4 (Homo sapiens)64804642 more ...CTDPMID:31622892

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Biological Process
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Nox4Ratbone resorption acts_upstream_of_or_withinIEAUniProtKB:Q9JHI8 and ensembl:ENSMUSP000000327811600115GO_REF:0000107EnsemblGO_REF:0000107
Nox4Ratbone resorption acts_upstream_of_or_withinISONox4 (Mus musculus)1624291 PMID:11098048RGDPMID:11098048
Nox4Ratcardiac muscle cell differentiation acts_upstream_of_or_withinIEAUniProtKB:Q9JHI8 and ensembl:ENSMUSP000000327811600115GO_REF:0000107EnsemblGO_REF:0000107
Nox4Ratcardiac muscle cell differentiation acts_upstream_of_or_withinISONox4 (Mus musculus)1624291 PMID:16775014RGDPMID:16775014
Nox4Ratcell morphogenesis involved_inISSUniProtKB:Q9JHI81600115GO_REF:0000024UniProtGO_REF:0000024
Nox4Ratcell morphogenesis involved_inISONox4 (Mus musculus)1624291 PMID:10869423RGDPMID:10869423
Nox4Ratcell morphogenesis involved_inIEAUniProtKB:Q9JHI8 and ensembl:ENSMUSP000000327811600115GO_REF:0000107EnsemblGO_REF:0000107
Nox4Ratcellular response to cAMP  IEP 2324669 RGD 
Nox4Ratcellular response to gamma radiation  IEP 2317861 RGD 
Nox4Ratcellular response to glucose stimulus involved_inISONox4 (Mus musculus)1624291 PMID:18431508RGDPMID:18431508
Nox4Ratcellular response to glucose stimulus involved_inIEAUniProtKB:Q9JHI8 and ensembl:ENSMUSP000000327811600115GO_REF:0000107EnsemblGO_REF:0000107
Nox4Ratcellular response to interleukin-1  IEP 329961560 RGD 
Nox4Ratcellular response to mercury ion  IEP 329961577 RGD 
Nox4Ratcellular response to transforming growth factor beta stimulus  IEP 2324663 RGD 
Nox4Ratdefense response involved_inIBAFB:FBgn0283531 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Nox4Ratgene expression involved_inISONOX4 (Homo sapiens)1624291 PMID:23144758RGDPMID:23144758
Nox4Ratheart process involved_inISONOX4 (Homo sapiens)1624291UniProtKB:P06241 and PMID:27525436RGDPMID:27525436
Nox4Ratheart process involved_inIEAUniProtKB:Q9JHI8 and ensembl:ENSMUSP000000327811600115GO_REF:0000107EnsemblGO_REF:0000107
Nox4Ratheart process involved_inISONox4 (Mus musculus)1624291UniProtKB:P39688 and PMID:27525436RGDPMID:27525436
Nox4Rathomocysteine metabolic process involved_inISONOX4 (Homo sapiens)1624291 PMID:20031578RGDPMID:20031578
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Cellular Component
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Nox4Ratanchoring junction located_inIEAUniProtKB-KW:KW-09651600115GO_REF:0000043UniProtGO_REF:0000043
Nox4Ratapical plasma membrane  IDA 2317856 RGD 
Nox4Ratcell periphery located_inIEAUniProtKB:Q9JHI8 and ensembl:ENSMUSP000000327811600115GO_REF:0000107EnsemblGO_REF:0000107
Nox4Ratcell periphery located_inISONox4 (Mus musculus)1624291 PMID:18431508RGDPMID:18431508
Nox4Ratendoplasmic reticulum located_inIDA 1580287PMID:15322091UniProt 
Nox4Ratendoplasmic reticulum located_inIEAUniProtKB-KW:KW-02561600115GO_REF:0000043UniProtGO_REF:0000043
Nox4Ratendoplasmic reticulum located_inISONOX4 (Homo sapiens)1624291 PMID:21343298RGDPMID:21343298
Nox4Ratendoplasmic reticulum membrane located_inISONOX4 (Homo sapiens)1624291 PMID:15927447RGDPMID:15927447
Nox4Ratendoplasmic reticulum membrane located_inIEAUniProtKB-SubCell:SL-00971600115GO_REF:0000044UniProtGO_REF:0000044
Nox4Ratfocal adhesion located_inIEAUniProtKB-SubCell:SL-01181600115GO_REF:0000044UniProtGO_REF:0000044
Nox4Ratfocal adhesion  IDA 2324670 RGD 
Nox4Ratmembrane located_inIEAInterPro:IPR0007781600115GO_REF:0000002InterProGO_REF:0000002
Nox4Ratmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
Nox4Ratmembrane located_inIEAUniProtKB-SubCell:SL-01621600115GO_REF:0000044UniProtGO_REF:0000044
Nox4Ratmitochondrion located_inIDA 13601987PMID:27525436ARUK-UCL 
Nox4Ratmitochondrion part_ofIEAUniProtKB:Q9JHI8 and ensembl:ENSMUSP000000327811600115GO_REF:0000107EnsemblGO_REF:0000107
Nox4Ratmitochondrion located_inISONox4 (Mus musculus)1624291 PMID:23624625RGDPMID:23624625
Nox4RatNADPH oxidase complex  IDA 1580287 RGD 
Nox4RatNADPH oxidase complex part_ofIBAMGI:2681162 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Nox4Ratnucleolus located_inISONOX4 (Homo sapiens) and UniProtKB:Q9NPH5-41624291 PMID:23393389RGDPMID:23393389
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Molecular Function
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Nox4Ratheme binding enablesISSUniProtKB:Q9NPH51600115GO_REF:0000024UniProtGO_REF:0000024
Nox4Ratheme binding enablesISONOX4 (Homo sapiens)1624291 PMID:25062272RGDPMID:25062272
Nox4Ratmodified amino acid binding enablesISONOX4 (Homo sapiens)1624291 PMID:20031578RGDPMID:20031578
Nox4RatNAD(P)H oxidase H2O2-forming activity  IDA 632514 RGD 
Nox4RatNAD(P)H oxidase H2O2-forming activity enablesISONOX4 (Homo sapiens)1624291 PMID:14966267 more ...RGDPMID:14966267 more ...
Nox4RatNADPH oxidase H202-forming activity enablesIEARHEA:112601600115GO_REF:0000116RHEAGO_REF:0000116
Nox4Ratoxidoreductase activity enablesIEAUniProtKB-KW:KW-05601600115GO_REF:0000043UniProtGO_REF:0000043
Nox4Ratoxidoreductase activity enablesIEAInterPro:IPR000778 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Nox4Ratoxidoreductase activity enablesIEAARBA:ARBA000287471600115GO_REF:0000117UniProtGO_REF:0000117
Nox4Ratoxidoreductase activity, acting on NAD(P)H, oxygen as acceptor  IDA 1580287 RGD 
Nox4Ratprotein binding  IPICyba (Rattus norvegicus)1580287 RGD 
Nox4Ratprotein binding enablesISONOX4 (Homo sapiens)1624291UniProtKB:O00206 more ...RGDPMID:15356101 and PMID:17064675
Nox4Ratprotein tyrosine kinase binding enablesISONox4 (Mus musculus)1624291UniProtKB:P06241 and PMID:27525436RGDPMID:27525436
Nox4Ratprotein tyrosine kinase binding enablesIEAUniProtKB:Q9JHI8 and ensembl:ENSMUSP000000327811600115GO_REF:0000107EnsemblGO_REF:0000107
Nox4Ratsuperoxide-generating NAD(P)H oxidase activity enablesISONox4 (Mus musculus)1624291 PMID:11098048 more ...RGDPMID:11098048 more ...
Nox4Ratsuperoxide-generating NAD(P)H oxidase activity enablesIEAUniProtKB:Q9JHI8 and ensembl:ENSMUSP000000327811600115GO_REF:0000107EnsemblGO_REF:0000107
Nox4Ratsuperoxide-generating NAD(P)H oxidase activity enablesIBAFB:FBgn0283531 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Nox4Ratsuperoxide-generating NAD(P)H oxidase activity NOT|enablesISONOX4 (Homo sapiens) and UniProtKB:Q9NPH5-31624291 PMID:15721269RGDPMID:15721269
Nox4Ratsuperoxide-generating NAD(P)H oxidase activity enablesISONOX4 (Homo sapiens)1624291 PMID:10869423 more ...RGDPMID:10869423 more ...
Nox4Ratsuperoxide-generating NAD(P)H oxidase activity enablesISONOX4 (Homo sapiens) and UniProtKB:Q9NPH5-41624291 PMID:15721269 and PMID:23393389RGDPMID:15721269 and PMID:23393389
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Imported Annotations - SMPDB

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Nox4Ratthyroid hormone biosynthetic pathway  ISONOX4 (Homo sapiens)10402751 SMPDBSMP:00716

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#
Reference Title
Reference Citation
1. Hu antigen R is required for NOX-1 but not NOX-4 regulation by inflammatory stimuli in vascular smooth muscle cells. Aguado A, etal., J Hypertens. 2016 Feb;34(2):253-65. doi: 10.1097/HJH.0000000000000801.
2. Direct interaction of the novel Nox proteins with p22phox is required for the formation of a functionally active NADPH oxidase. Ambasta RK, etal., J Biol Chem. 2004 Oct 29;279(44):45935-41. Epub 2004 Aug 18.
3. Subcellular localization of Nox4 and regulation in diabetes. Block K, etal., Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14385-90. Epub 2009 Aug 17.
4. Upregulation of the NADPH oxidase NOX4 by TGF-beta in hepatocytes is required for its pro-apoptotic activity. Carmona-Cuenca I, etal., J Hepatol. 2008 Dec;49(6):965-76. Epub 2008 Sep 19.
5. NADPH oxidase mediates radiation-induced oxidative stress in rat brain microvascular endothelial cells. Collins-Underwood JR, etal., Free Radic Biol Med. 2008 Sep 15;45(6):929-38. Epub 2008 Jun 30.
6. H2O2 activates Nox4 through PLA2-dependent arachidonic acid production in adult cardiac fibroblasts. Colston JT, etal., FEBS Lett. 2005 Apr 25;579(11):2533-40.
7. Evidence of the Importance of Nox4 in Production of Hypertension in Dahl Salt-Sensitive Rats. Cowley AW Jr, etal., Hypertension. 2016 Feb;67(2):440-50. doi: 10.1161/HYPERTENSIONAHA.115.06280. Epub 2015 Dec 7.
8. The role of NOX2 and "novel oxidases" in airway chemoreceptor O(2) sensing. Cutz E, etal., Adv Exp Med Biol. 2009;648:427-38.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
11. The Rho-kinase inhibitor, fasudil, attenuates diabetic nephropathy in streptozotocin-induced diabetic rats. Gojo A, etal., Eur J Pharmacol. 2007 Jul 30;568(1-3):242-7. Epub 2007 Apr 20.
12. Nox4 NAD(P)H oxidase mediates hypertrophy and fibronectin expression in the diabetic kidney. Gorin Y, etal., J Biol Chem. 2005 Nov 25;280(47):39616-26. Epub 2005 Aug 31.
13. Modulation of chronic hypoxia-induced chemoreceptor hypersensitivity by NADPH oxidase subunits in rat carotid body. He L, etal., J Appl Physiol. 2010 May;108(5):1304-10. Epub 2010 Feb 25.
14. Novel gp91(phox) homologues in vascular smooth muscle cells : nox1 mediates angiotensin II-induced superoxide formation and redox-sensitive signaling pathways. Lassegue B, etal., Circ Res 2001 May 11;88(9):888-94.
15. Spinal Cord Injury Leads to Hyperoxidation and Nitrosylation of Skeletal Muscle Ryanodine Receptor-1 Associated with Upregulation of Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4. Liu XH, etal., J Neurotrauma. 2017 Jun 15;34(12):2069-2074. doi: 10.1089/neu.2016.4763. Epub 2017 Feb 27.
16. Regulation of oxidative stress and inflammation by hepatic adiponectin receptor 2 in an animal model of nonalcoholic steatohepatitis. Matsunami T, etal., Int J Clin Exp Pathol. 2010 May 22;3(5):472-81.
17. Tyrosine kinase FYN negatively regulates NOX4 in cardiac remodeling. Matsushima S, etal., J Clin Invest. 2016 Sep 1;126(9):3403-16. doi: 10.1172/JCI85624. Epub 2016 Aug 15.
18. Early increase of Nox4 NADPH oxidase and superoxide generation following endothelin-1-induced stroke in conscious rats. McCann SK, etal., J Neurosci Res. 2008 Aug 15;86(11):2524-34.
19. Upregulation of Nox4 in the aging vasculature and its association with smooth muscle cell polyploidy. McCrann DJ, etal., Cell Cycle. 2009 Mar 15;8(6):902-8. Epub 2009 Mar 21.
20. Insulin-like growth factor-I induces reactive oxygen species production and cell migration through Nox4 and Rac1 in vascular smooth muscle cells. Meng D, etal., Cardiovasc Res. 2008 Nov 1;80(2):299-308. Epub 2008 Jun 20.
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PMID:10869423   PMID:11032835   PMID:11098048   PMID:12842860   PMID:14670934   PMID:16150729   PMID:16775014   PMID:17082491   PMID:17283869   PMID:17324585   PMID:17698723   PMID:17942966  
PMID:18431508   PMID:18474828   PMID:18554521   PMID:18559349   PMID:18624925   PMID:18760347   PMID:19038868   PMID:19056645   PMID:19204183   PMID:19574552   PMID:19910702   PMID:19926889  
PMID:20016382   PMID:20031578   PMID:20185797   PMID:20686447   PMID:20715105   PMID:20724704   PMID:21071935   PMID:21419746   PMID:21646815   PMID:21940672   PMID:22031600   PMID:22063193  
PMID:22195989   PMID:22566500   PMID:22873349   PMID:22875785   PMID:23022406   PMID:23033809   PMID:23144758   PMID:23225244   PMID:23271793   PMID:23393389   PMID:23624625   PMID:23722270  
PMID:23884197   PMID:23940049   PMID:24041960   PMID:24480752   PMID:24623966   PMID:24636100   PMID:24872317   PMID:24947524   PMID:25203114   PMID:25410908   PMID:25681565   PMID:26088607  
PMID:26136558   PMID:26279425   PMID:26387612   PMID:26631573   PMID:26945889   PMID:27033446   PMID:27558234   PMID:27665186   PMID:27847553   PMID:27913300   PMID:27923787   PMID:27929749  
PMID:28011270   PMID:28063381   PMID:28078487   PMID:28330417   PMID:28431936   PMID:28447737   PMID:28634073   PMID:28751569   PMID:28805491   PMID:29087944   PMID:29147462   PMID:29672130  
PMID:29723859   PMID:29793963   PMID:30316800   PMID:30354218   PMID:30551445   PMID:30610956   PMID:30953402   PMID:31065679   PMID:31179339   PMID:31216444   PMID:31541678   PMID:32182821  
PMID:32183375   PMID:32233792   PMID:32311288   PMID:32776539   PMID:32799394   PMID:33001475   PMID:33273999   PMID:33470533   PMID:33515385   PMID:34396450   PMID:34435888   PMID:34834085  
PMID:35029280   PMID:35935259   PMID:36043333   PMID:36166507   PMID:36662655   PMID:37002575   PMID:37501791   PMID:37985134   PMID:37985248   PMID:38237016  
1 to 10 of 10 rows



Nox4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81150,313,736 - 150,491,480 (+)NCBIGRCr8
mRatBN7.21140,900,886 - 141,078,844 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1140,901,097 - 141,077,406 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1148,877,339 - 149,042,590 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01156,047,993 - 156,213,233 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01148,921,890 - 149,087,126 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01150,796,359 - 150,976,186 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1150,797,084 - 150,976,194 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01157,106,652 - 157,196,482 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01157,246,099 - 157,285,107 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41143,415,816 - 143,603,554 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11143,494,221 - 143,681,960 (+)NCBI
Celera1139,242,883 - 139,407,667 (+)NCBICelera
Cytogenetic Map1q32NCBI
NOX4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381189,324,353 - 89,589,557 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1189,324,353 - 89,498,187 (-)EnsemblGRCh38hg38GRCh38
GRCh371189,057,521 - 89,322,725 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361188,699,160 - 88,864,301 (-)NCBINCBI36Build 36hg18NCBI36
Build 341188,699,159 - 88,864,301NCBI
Celera1185,399,612 - 85,574,418 (+)NCBICelera
Cytogenetic Map11q14.3NCBI
HuRef1185,294,642 - 85,559,923 (-)NCBIHuRef
CHM1_11188,940,465 - 89,205,767 (-)NCBICHM1_1
T2T-CHM13v2.01189,244,014 - 89,509,286 (-)NCBIT2T-CHM13v2.0
Nox4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39786,893,638 - 87,047,918 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl786,895,304 - 87,047,918 (+)EnsemblGRCm39 Ensembl
GRCm38787,244,430 - 87,398,710 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl787,246,096 - 87,398,710 (+)EnsemblGRCm38mm10GRCm38
MGSCv37794,395,305 - 94,547,116 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36787,122,556 - 87,274,367 (+)NCBIMGSCv36mm8
Celera784,613,741 - 84,757,901 (+)NCBICelera
Cytogenetic Map7D3NCBI
cM Map748.96NCBI
Nox4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554144,062,081 - 4,212,746 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554144,062,337 - 4,220,032 (+)NCBIChiLan1.0ChiLan1.0
NOX4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2990,148,233 - 90,362,455 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11191,239,494 - 91,406,480 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01184,330,362 - 84,496,755 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11187,911,335 - 88,171,535 (-)NCBIpanpan1.1PanPan1.1panPan2
NOX4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12110,615,153 - 10,782,927 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2110,615,970 - 10,775,277 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2110,465,855 - 10,632,710 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02110,796,288 - 10,963,304 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2110,795,550 - 10,960,296 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12110,584,756 - 10,745,644 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02110,643,276 - 10,811,261 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02110,699,999 - 10,861,437 (+)NCBIUU_Cfam_GSD_1.0
Nox4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494774,947,435 - 75,112,097 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936736230,476 - 396,708 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936736230,465 - 394,859 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NOX4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl922,624,212 - 22,776,534 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1922,622,105 - 22,776,691 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2925,234,530 - 25,427,884 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NOX4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1180,470,418 - 80,642,513 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl180,470,826 - 80,642,722 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604345,091,781 - 45,259,250 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nox4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624845669,902 - 827,834 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624845669,880 - 829,471 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Nox4
1041 total Variants


Assembly: RGSC_v3.4
Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain Variant Page
1 143490643 143490644 G T snv ACI/EurMcwi (MCW), SS/JrHsdMcwi (MCW), SR/JrHsd (MCW), FHH/EurMcwi (MCW) View more Information

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir92brno-miR-92b-3pMirtarbaseexternal_infoLuciferase reporter assay//Microarray//qRT-PCR//WeNon-Functional MTI21071935
Mir25rno-miR-25-3pMirtarbaseexternal_infoLuciferase reporter assay//Microarray//qRT-PCR//WeFunctional MTI21071935

Predicted Target Of
Summary Value
Count of predictions:215
Count of miRNA genes:148
Interacting mature miRNAs:162
Transcripts:ENSRNOT00000018990
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 64 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1121767634166767634Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
1598866Bp287Blood pressure QTL 2875.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1123350408182418476Rat
9590300Scort16Serum corticosterone level QTL 164.390.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1103111621148111621Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1115585465172949803Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat

1 to 10 of 64 rows
AU047304  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21140,980,579 - 140,980,729 (+)MAPPERmRatBN7.2
Rnor_6.01150,876,500 - 150,876,649NCBIRnor6.0
Rnor_5.01157,185,521 - 157,185,670UniSTSRnor5.0
RGSC_v3.41143,496,029 - 143,496,178UniSTSRGSC3.4
Celera1139,323,472 - 139,323,621UniSTS
Cytogenetic Map1q32UniSTS


The following Strains have been annotated to Nox4
FHH.BN-(D1Hmgc14-D1Hmgc15)/Mcwi    


This gene Nox4 is modified in the following models/strains:
SS-Nox4em2Mcwi     SS-Nox4em1Mcwi     SS-Nox4em2Mcwi-/-     SS-Nox4em2Mcwi-/+     SS-Nox4em2Ncf2em1Mcwi    




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 111 72 71 40 25 40 6 199 97 91 45 55 31



Ensembl Acc Id: ENSRNOT00000018990   ⟹   ENSRNOP00000018990
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1140,901,097 - 141,076,106 (+)Ensembl
Rnor_6.0 Ensembl1150,797,084 - 150,976,194 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000102096   ⟹   ENSRNOP00000085650
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1140,901,173 - 141,077,406 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000116153   ⟹   ENSRNOP00000079906
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1140,901,173 - 141,077,406 (+)Ensembl
RefSeq Acc Id: NM_053524   ⟹   NP_445976
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81150,313,889 - 150,490,031 (+)NCBI
mRatBN7.21140,901,243 - 141,077,395 (+)NCBI
Rnor_6.01150,797,202 - 150,974,737 (+)NCBI
Rnor_5.01157,106,652 - 157,196,482 (+)NCBI
Rnor_5.01157,246,099 - 157,285,107 (+)NCBI
RGSC_v3.41143,415,816 - 143,603,554 (+)RGD
Celera1139,242,883 - 139,407,667 (+)RGD
Sequence:
RefSeq Acc Id: XM_008759643   ⟹   XP_008757865
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81150,313,736 - 150,491,480 (+)NCBI
mRatBN7.21140,900,886 - 141,078,844 (+)NCBI
Rnor_6.01150,797,084 - 150,976,186 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039092943   ⟹   XP_038948871
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81150,313,738 - 150,491,480 (+)NCBI
mRatBN7.21140,900,888 - 141,078,844 (+)NCBI
RefSeq Acc Id: XM_039092944   ⟹   XP_038948872
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81150,313,952 - 150,491,480 (+)NCBI
mRatBN7.21140,901,316 - 141,078,844 (+)NCBI
RefSeq Acc Id: NP_445976   ⟸   NM_053524
- UniProtKB: Q99M78 (UniProtKB/Swiss-Prot),   Q924V1 (UniProtKB/Swiss-Prot),   A6I5Y4 (UniProtKB/TrEMBL),   A0A8I5ZPH8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008757865   ⟸   XM_008759643
- Peptide Label: isoform X3
- UniProtKB: A6I5Y3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000018990   ⟸   ENSRNOT00000018990
RefSeq Acc Id: XP_038948871   ⟸   XM_039092943
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZPH8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038948872   ⟸   XM_039092944
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZPH8 (UniProtKB/TrEMBL)
FAD-binding FR-type   Ferric oxidoreductase

Name Modeler Protein Id AA Range Protein Structure
AF-Q924V1-F1-model_v2 AlphaFold Q924V1 1-578 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13690176
Promoter ID:EPDNEW_R701
Type:initiation region
Name:Nox4_1
Description:NADPH oxidase 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R702  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01150,797,096 - 150,797,156EPDNEW
RGD ID:13690177
Promoter ID:EPDNEW_R702
Type:initiation region
Name:Nox4_2
Description:NADPH oxidase 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R701  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01150,797,201 - 150,797,261EPDNEW


1 to 36 of 36 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-58588 BioCyc
Ensembl Genes ENSRNOG00000013925 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000102096 ENTREZGENE
  ENSRNOT00000102096.1 UniProtKB/Swiss-Prot
  ENSRNOT00000131019 ENTREZGENE
Gene3D-CATH 3.40.50.80 UniProtKB/Swiss-Prot
  Translation factors UniProtKB/Swiss-Prot
InterPro Cyt_b245_heavy_chain UniProtKB/Swiss-Prot
  FAD-bd_8 UniProtKB/Swiss-Prot
  FAD-bd_FR_type UniProtKB/Swiss-Prot
  Fe3_Rdtase_TM_dom UniProtKB/Swiss-Prot
  Fe_red_NAD-bd_6 UniProtKB/Swiss-Prot
  FNR_nucleotide-bd UniProtKB/Swiss-Prot
  RBOH/FRE UniProtKB/Swiss-Prot
  Riboflavin_synthase-like_b-brl UniProtKB/Swiss-Prot
KEGG Report rno:85431 UniProtKB/Swiss-Prot
NCBI Gene 85431 ENTREZGENE
PANTHER NADPH OXIDASE UniProtKB/Swiss-Prot
  NADPH OXIDASE 4 UniProtKB/Swiss-Prot
Pfam FAD_binding_8 UniProtKB/Swiss-Prot
  Ferric_reduct UniProtKB/Swiss-Prot
  NAD_binding_6 UniProtKB/Swiss-Prot
PhenoGen Nox4 PhenoGen
PRINTS GP91PHOX UniProtKB/Swiss-Prot
PROSITE FAD_FR UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000013925 RatGTEx
Superfamily-SCOP SSF52343 UniProtKB/Swiss-Prot
  SSF63380 UniProtKB/Swiss-Prot
UniProt A0A8I5ZPH8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2Q9R0_RAT UniProtKB/TrEMBL
  A6I5Y3 ENTREZGENE, UniProtKB/TrEMBL
  A6I5Y4 ENTREZGENE, UniProtKB/TrEMBL
  A6I5Y5_RAT UniProtKB/TrEMBL
  NOX4_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q99M78 ENTREZGENE
UniProt Secondary Q99M78 UniProtKB/Swiss-Prot
1 to 36 of 36 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Nox4  NADPH oxidase 4      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Nox4  NADPH oxidase 4      Symbol and Name status set to provisional 70820 PROVISIONAL

Note Type Note Reference
gene_expression highly expressed in vascular smooth muscle cells 632514
gene_regulation expression is downregulated by platelet-derived growth factor (PDGF) and Ang II 632514