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Strain Registration

Strain: SS-Nox4em2Mcwi-/-

Symbol: SS-Nox4em2Mcwi-/-
Strain: SS-Nox4em2-/Nox4em2-
Substrain: Mcwi
Full Name: SS-Nox4em2Mcwi-/Nox4em2Mcwi-
RGD ID: 5688074
Citation ID: RRID:RGD_5688074
Ontology ID: RS:0003150
Alleles: Nox4em2Mcwi
Also Known As: SS-Nox4em2Mcwi-/-; SS-Nox4em2Mcwi/1Mcwi; SS-Nox4em2Mcwi/1Mcwi; SS-Nox4em2Mcwi-/Nox4em2Mcwi-; SS-Nox4^[em2Mcwi-/-]
Type: mutant
Available Source: Not Available
Origination: PhysGen Knockouts
Description: ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. This homozygous mutant carries an 8-bp frameshift deletion in exon 7 of rat Nox4.
Genetic Status: Homozygous
Last Known Status: Live Animals; Cryopreserved Sperm (as of 2019-01-03)
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81150,313,736 - 150,491,480RGD_MAPPER_PIPELINE
mRatBN7.21140,900,886 - 141,078,844RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01150,861,996 - 150,862,003RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01157,106,652 - 157,285,107RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.41143,415,816 - 143,603,554RGD_MAPPER_PIPELINERGSC3.4





References

References - curated
# Reference Title Reference Citation
1. Evidence of the Importance of Nox4 in Production of Hypertension in Dahl Salt-Sensitive Rats. Cowley AW Jr, etal., Hypertension. 2016 Feb;67(2):440-50. doi: 10.1161/HYPERTENSIONAHA.115.06280. Epub 2015 Dec 7.
2. Knockout rats via embryo microinjection of zinc-finger nucleases. Geurts AM, etal., Science. 2009 Jul 24;325(5939):433.
3. PhysGen Knockouts PhysGen Knockout strains
4. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region

Allelic Variants
Name Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Assembly
Nox4em2Mcwi-var1 chr1 150861996 150862003 ACCTATGC - deletion Rnor_6.0

Additional Information


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-03-31 SS-Nox4em2Mcwi-/-  SS-Nox4em2Mcwi-/Nox4em2Mcwi-  SS-Nox4em2Mcwi-/-  SS-Nox4em2Mcwi-/Nox4em2Mcwi-  Symbol and/or name change 68913 APPROVED