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Strain Registration

Strain: FHH.BN-(D1Hmgc14-D1Hmgc15)/Mcwi

Symbol: FHH.BN-(D1Hmgc14-D1Hmgc15)/Mcwi
Strain: FHH.BN-(D1Hmgc14-D1Hmgc15)
Substrain: Mcwi
RGD ID: 1357959
Citation ID: RRID:RGD_1357959
Ontology ID: RS:0000341
Alleles: Ctsc;   Grm5;   Tyr;   Rab38;   Nox4
Previously known as: FHH.BN-(Rab38); FHH.BN-(Rab38)/Mcwi; FHH.BN-(D1Hmgc14-D1Hmgc15)/Mcwi
Type: congenic
Source: Department of Physiology, Medical College of Wisconsin, Milwaukee Wisconsin
Origin: The Rf-2 region of chromosome 1 is transferred from BN to the genomic background of FHH.
Last Known Status: Live Animals
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21140,879,679 - 142,314,355RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01150,775,310 - 152,202,960RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01157,084,760 - 158,516,775RGD_MAPPER_PIPELINERnor5.0





Disease Annotations     Click to see Annotation Detail View
Albuminuria  (IAGP)
proteinuria  (IAGP)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

Phenotype Values via PhenoMiner     Click to see Annotation Detail View
Options:  View chart  |  Download data table  |  View expanded data table


References

References - curated
# Reference Title Reference Citation
1. RF-2 gene modulates proteinuria and albuminuria independently of changes in glomerular permeability in the fawn-hooded hypertensive rat. Rangel-Filho A, etal., J Am Soc Nephrol 2005 Apr;16(4):852-6. Epub 2005 Mar 9.
2. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region

Position Markers

Flank 1 / 1 (D1Hmgc14)
Rat AssemblyChrPosition (strand)Source
mRatBN7.21140,879,679 - 140,879,943 (+)MAPPER
Rnor_6.01150,775,310 - 150,775,573NCBI
Rnor_5.01157,084,760 - 157,085,023UniSTS
Celera1139,221,291 - 139,221,554UniSTS
Cytogenetic Map1 RGD

Flank 2 / 1 (D1Hmgc15)
Rat AssemblyChrPosition (strand)Source
mRatBN7.21142,314,155 - 142,314,355 (+)MAPPER
Rnor_6.01152,202,761 - 152,202,960NCBI
Rnor_5.01158,516,576 - 158,516,775UniSTS
Celera1140,610,789 - 140,610,988UniSTS
Cytogenetic Map1 RGD

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics This strain covers 11 cM of the Rf-2 region which contains the Rab38 gene which modulates tubular processing of filtered proteins without affecting the barriers of glomerular filtration. 1357409
strain_characteristics These have the Rab38 gene from BN, as FHH Rab38 gene has a protein null mutation. 1357409
strain_life_disease Have significantly low proteinuria (UPV) and albuminuria (UAV) than FHH. 1357409

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-08-12 FHH.BN-(D1Hmgc14-D1Hmgc15)/Mcwi    FHH.BN-(D1Hmgc14-D1Hmgc15)/Mcwi    Name updated 68913 APPROVED
2013-08-12 FHH.BN-(D1Hmgc14-D1Hmgc15)/Mcwi    FHH.BN-(D1Hmgc14-D1Hmgc15)/Mcwi    Name updated 68913 APPROVED
2012-02-17 FHH.BN-(D1Hmgc14-D1Hmgc15)/Mcwi    FHH.BN-(Rab38)/Mcwi    Symbol updated 68687 APPROVED
2012-02-17 FHH.BN-(D1Hmgc14-D1Hmgc15)/Mcwi    FHH.BN-(Rab38)/Mcwi    Symbol updated 68687 APPROVED
2012-02-17 FHH.BN-(D1Hmgc14-D1Hmgc15)/Mcwi    FHH.BN-(Rab38)/Mcwi    Name updated 68913 APPROVED
2012-02-17 FHH.BN-(D1Hmgc14-D1Hmgc15)/Mcwi    FHH.BN-(Rab38)/Mcwi    Name updated 68913 APPROVED
2008-07-25 FHH.BN-(Rab38ab38)/Mcwi    FHH.BN-(Rab38)/Mcwi    gene nomenclature is perpetuated to the strain symbol 2293819 APPROVED
2008-07-25 FHH.BN-(Rab38)/Mcwi    FHH.BN-(Rab38)/Mcwi    gene nomenclature is perpetuated to the strain symbol 2293819 APPROVED
2008-07-18 FHH.BN-(Rab38ab38)/Mcwi    FHH.BN-(Rab38)/Mcwi    gene nomenclature is perpetuated to the strain symbol 2293819 APPROVED
2008-07-18 FHH.BN-(Rab38)/Mcwi    FHH.BN-(Rab38)/Mcwi    gene nomenclature is perpetuated to the strain symbol 2293819 APPROVED
2008-07-11 FHH.BN-(Rab38ab38)/Mcwi    FHH.BN-(Rab38)/Mcwi    gene nomenclature is perpetuated to the strain symbol 2293819 APPROVED
2008-07-04 FHH.BN-(Rab38ab38)/Mcwi    FHH.BN-(Rab38)/Mcwi    gene nomenclature is perpetuated to the strain symbol 2293819 APPROVED
2008-06-27 FHH.BN-(Rab38ab38)/Mcwi    FHH.BN-(Rab38)/Mcwi    gene nomenclature is perpetuated to the strain symbol 2293819 APPROVED
2008-06-16 FHH.BN-(Rab38ab38)/Mcwi    FHH.BN-(Rab38)/Mcwi    gene nomenclature is perpetuated to the strain symbol 2293819 APPROVED