Nox4<sup>em2Mcwi</sup> (NADPH oxidase 4; zinc finger nuclease induced mutant 2, Medical College of Wisconsin) - Rat Genome Database

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Gene: Nox4em2Mcwi (NADPH oxidase 4; zinc finger nuclease induced mutant 2, Medical College of Wisconsin) Rattus norvegicus
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Symbol: Nox4em2Mcwi
Name: NADPH oxidase 4; zinc finger nuclease induced mutant 2, Medical College of Wisconsin
RGD ID: 4139868
Description: This allele was made by zinc finger nuclease mutagenesis. The resulting mutation is an 8-bp frameshift deletion in exon 7 (del 586-593).
ASSOCIATED WITH decreased mean systemic arterial blood pressure; decreased susceptibility to hypertension; decreased urine albumin level
Type: allele  of Nox4  
Previously known as: Nox4^[em2Mcwi]; Nox4em2Mcwi
Is Marker For: Strains:   SS-Nox4em2Mcwi   SS-Nox4em2Mcwi-/-   SS-Nox4em2Mcwi-/+   SS-Nox4em2Ncf2em1Mcwi  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Cytogenetic Map1 RGD


Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Evidence of the Importance of Nox4 in Production of Hypertension in Dahl Salt-Sensitive Rats. Cowley AW Jr, etal., Hypertension. 2016 Feb;67(2):440-50. doi: 10.1161/HYPERTENSIONAHA.115.06280. Epub 2015 Dec 7.
2. Knockout rats via embryo microinjection of zinc-finger nucleases. Geurts AM, etal., Science. 2009 Jul 24;325(5939):433.
3. PhysGen Knockouts PhysGen Knockout strains
4. Role of Nox4 and p67phox subunit of Nox2 in ROS production in response to increased tubular flow in the mTAL of Dahl salt-sensitive rats. Zheleznova NN, etal., Am J Physiol Renal Physiol. 2016 Aug 1;311(2):F450-8. doi: 10.1152/ajprenal.00187.2016. Epub 2016 Jun 8.

Genomics

Allelic Variants
Name Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Assembly
Nox4em2Mcwi-var1 chr1 150861996 150862003 ACCTATGC - deletion Rnor_6.0

Related Rat Strains
The following Strains have been annotated to Nox4em2Mcwi


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_053524 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles


Additional Information