Nox4 (NADPH oxidase 4) - Rat Genome Database

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Gene: Nox4 (NADPH oxidase 4) Heterocephalus glaber
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Symbol: Nox4
Name: NADPH oxidase 4
RGD ID: 18918706
Description: ENCODES a protein that exhibits heme binding (ortholog); modified amino acid binding (ortholog); NAD(P)H oxidase H2O2-forming activity (ortholog); INVOLVED IN bone resorption (ortholog); cardiac muscle cell differentiation (ortholog); cell morphogenesis (ortholog); PARTICIPATES IN thyroid hormone biosynthetic pathway; ASSOCIATED WITH Aneurysm (ortholog); Brain Injuries (ortholog); brain ischemia (ortholog); FOUND IN apical plasma membrane (ortholog); cell periphery (ortholog); endoplasmic reticulum (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624845669,902 - 827,834 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624845669,880 - 829,471 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:21993625   PMID:30032202  


Genomics

Comparative Map Data
Nox4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624845669,902 - 827,834 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624845669,880 - 829,471 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
NOX4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381189,324,353 - 89,589,557 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1189,324,353 - 89,498,187 (-)EnsemblGRCh38hg38GRCh38
GRCh371189,057,521 - 89,322,725 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361188,699,160 - 88,864,301 (-)NCBINCBI36Build 36hg18NCBI36
Build 341188,699,159 - 88,864,301NCBI
Celera1185,399,612 - 85,574,418 (+)NCBICelera
Cytogenetic Map11q14.3NCBI
HuRef1185,294,642 - 85,559,923 (-)NCBIHuRef
CHM1_11188,940,465 - 89,205,767 (-)NCBICHM1_1
T2T-CHM13v2.01189,244,014 - 89,509,286 (-)NCBIT2T-CHM13v2.0
Nox4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39786,893,638 - 87,047,918 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl786,895,304 - 87,047,918 (+)EnsemblGRCm39 Ensembl
GRCm38787,244,430 - 87,398,710 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl787,246,096 - 87,398,710 (+)EnsemblGRCm38mm10GRCm38
MGSCv37794,395,305 - 94,547,116 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36787,122,556 - 87,274,367 (+)NCBIMGSCv36mm8
Celera784,613,741 - 84,757,901 (+)NCBICelera
Cytogenetic Map7D3NCBI
cM Map748.96NCBI
Nox4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81150,313,736 - 150,491,480 (+)NCBIGRCr8
mRatBN7.21140,900,886 - 141,078,844 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1140,901,097 - 141,077,406 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1148,877,339 - 149,042,590 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01156,047,993 - 156,213,233 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01148,921,890 - 149,087,126 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01150,796,359 - 150,976,186 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1150,797,084 - 150,976,194 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01157,106,652 - 157,196,482 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01157,246,099 - 157,285,107 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41143,415,816 - 143,603,554 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11143,494,221 - 143,681,960 (+)NCBI
Celera1139,242,883 - 139,407,667 (+)NCBICelera
Cytogenetic Map1q32NCBI
Nox4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554144,062,081 - 4,212,746 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554144,062,337 - 4,220,032 (+)NCBIChiLan1.0ChiLan1.0
NOX4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2990,148,233 - 90,362,455 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11191,239,494 - 91,406,480 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01184,330,362 - 84,496,755 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11187,911,335 - 88,171,535 (-)NCBIpanpan1.1PanPan1.1panPan2
NOX4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12110,615,153 - 10,782,927 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2110,615,970 - 10,775,277 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2110,465,855 - 10,632,710 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02110,796,288 - 10,963,304 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2110,795,550 - 10,960,296 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12110,584,756 - 10,745,644 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02110,643,276 - 10,811,261 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02110,699,999 - 10,861,437 (+)NCBIUU_Cfam_GSD_1.0
Nox4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494774,947,435 - 75,112,097 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936736230,476 - 396,708 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936736230,465 - 394,859 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NOX4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl922,624,212 - 22,776,534 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1922,622,105 - 22,776,691 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2925,234,530 - 25,427,884 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NOX4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1180,470,418 - 80,642,513 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl180,470,826 - 80,642,722 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604345,091,781 - 45,259,250 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000000926   ⟹   ENSHGLP00000000885
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_004624845669,902 - 827,834 (+)Ensembl
Ensembl Acc Id: ENSHGLT00000000927   ⟹   ENSHGLP00000000886
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_004624845670,052 - 826,187 (+)Ensembl
RefSeq Acc Id: XM_004868204   ⟹   XP_004868261
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624845669,885 - 829,471 (+)NCBI
RefSeq Acc Id: XM_021247197   ⟹   XP_021102856
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624845669,882 - 829,471 (+)NCBI
RefSeq Acc Id: XM_021247198   ⟹   XP_021102857
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624845669,880 - 813,301 (+)NCBI
RefSeq Acc Id: XM_021247199   ⟹   XP_021102858
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624845670,070 - 829,471 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004868261 (Get FASTA)   NCBI Sequence Viewer  
  XP_021102856 (Get FASTA)   NCBI Sequence Viewer  
  XP_021102857 (Get FASTA)   NCBI Sequence Viewer  
  XP_021102858 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHB08690 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000000885
RefSeq Acc Id: XP_021102857   ⟸   XM_021247198
- Peptide Label: isoform X3
RefSeq Acc Id: XP_021102856   ⟸   XM_021247197
- Peptide Label: isoform X2
- UniProtKB: G5BHC9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004868261   ⟸   XM_004868204
- Peptide Label: isoform X1
- UniProtKB: G5BHC9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021102858   ⟸   XM_021247199
- Peptide Label: isoform X4
- UniProtKB: G5BHC9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000000885   ⟸   ENSHGLT00000000926
Ensembl Acc Id: ENSHGLP00000000886   ⟸   ENSHGLT00000000927


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000000730 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000000926 ENTREZGENE
Gene3D-CATH Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module UniProtKB/TrEMBL
InterPro Cyt_b245_heavy_chain UniProtKB/TrEMBL
  FAD-bd_8 UniProtKB/TrEMBL
  FAD-bd_FR_type UniProtKB/TrEMBL
  Fe3_Rdtase_TM_dom UniProtKB/TrEMBL
  Fe_red_NAD-bd_6 UniProtKB/TrEMBL
  FNR_nucleotide-bd UniProtKB/TrEMBL
  RBOH/FRE UniProtKB/TrEMBL
  Riboflavin_synthase-like_b-brl UniProtKB/TrEMBL
NCBI Gene Nox4 ENTREZGENE
PANTHER NADPH OXIDASE UniProtKB/TrEMBL
  NADPH OXIDASE 4 UniProtKB/TrEMBL
Pfam FAD_binding_8 UniProtKB/TrEMBL
  Ferric_reduct UniProtKB/TrEMBL
  NAD_binding_6 UniProtKB/TrEMBL
PRINTS GP91PHOX UniProtKB/TrEMBL
PROSITE FAD_FR UniProtKB/TrEMBL
Superfamily-SCOP Ferredoxin reductase-like, C-terminal NADP-linked domain UniProtKB/TrEMBL
  Riboflavin synthase domain-like UniProtKB/TrEMBL
UniProt G5BHC9 ENTREZGENE, UniProtKB/TrEMBL