Foxp3 (forkhead box P3) - Rat Genome Database

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Gene: Foxp3 (forkhead box P3) Rattus norvegicus
Symbol: Foxp3
Name: forkhead box P3
RGD ID: 1562112
Description: Predicted to enable several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; NFAT protein binding activity; and enzyme binding activity. Involved in several processes, including establishment of endothelial blood-brain barrier; negative regulation of defense response to virus; and response to rapamycin. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Used to study intrahepatic cholangiocarcinoma. Biomarker of Korean hemorrhagic fever; bronchial disease (multiple); graft-versus-host disease; hypertension; and hypothyroidism. Human ortholog(s) of this gene implicated in Human papillomavirus infectious disease; colorectal cancer; immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome; pulmonary tuberculosis; and type 1 diabetes mellitus. Orthologous to human FOXP3 (forkhead box P3); INTERACTS WITH 1-naphthyl isothiocyanate; alpha-Zearalanol; amphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: forkhead box protein P3; LOC317382; RGD1562112; similar to scurfin
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr8X17,580,380 - 17,601,181 (-)NCBIGRCr8
mRatBN7.2X14,908,494 - 14,924,994 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX14,908,494 - 14,923,838 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX19,722,817 - 19,738,131 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X20,345,005 - 20,360,319 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X16,610,149 - 16,625,463 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X15,753,175 - 15,768,648 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX15,753,175 - 15,768,522 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X16,544,710 - 16,565,562 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X26,950,006 - 26,965,329 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX14,991,861 - 15,007,179 (-)NCBICelera
Cytogenetic MapXq12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
Acute-On-Chronic Liver Failure  (ISO)
adult T-cell leukemia/lymphoma  (ISO)
Airway Remodeling  (ISO)
allergic disease  (ISO)
anemia  (ISO)
Animal Toxoplasmosis  (ISO)
anogenital venereal wart  (ISO)
asthma  (IEP,ISO)
autistic disorder  (ISO)
bacterial pneumonia  (ISO)
bone marrow disease  (ISO)
Breast Neoplasms  (ISO)
bronchiolitis obliterans  (IEP)
cervical squamous cell carcinoma  (ISO)
chlamydia  (ISO)
Chronic Hepatitis B  (ISO)
Chronic Hepatitis C  (ISO)
colorectal cancer  (ISO)
congenital disorder of glycosylation type IIm  (ISO)
cutaneous leishmaniasis  (ISO)
dermatitis  (ISO)
diabetes mellitus  (ISO)
Dysbiosis  (IEP)
endometriosis  (ISO)
Endotoxemia  (IEP)
Epstein-Barr virus infectious disease  (ISO)
Experimental Arthritis  (IEP)
Experimental Autoimmune Myocarditis  (IEP)
Experimental Autoimmune Neuritis  (IEP)
Experimental Colitis  (IDA,ISO)
Experimental Diabetes Mellitus  (IEP)
genetic disease  (ISO)
graft-versus-host disease  (IEP)
hepatitis B  (ISO)
hepatitis C  (ISO)
hepatocellular carcinoma  (ISO)
Hydranencephaly with Renal Aplasia-Dysplasia  (ISO)
Hydrops Fetalis  (ISO)
hypertension  (IEP)
hypothyroidism  (IEP)
immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome  (ISO,ISS)
infectious mononucleosis  (ISO)
intrahepatic cholangiocarcinoma  (IDA)
Korean hemorrhagic fever  (IEP)
Lung Injury  (ISO)
Lung Neoplasms  (ISO)
malaria  (ISO)
multidrug-resistant tuberculosis  (ISO)
Neuralgia  (IEP,ISO)
neurodegeneration with brain iron accumulation 5  (ISO)
Neurodevelopmental Disorders  (ISO)
occupational dermatitis  (ISO)
pancytopenia  (ISO)
papillomavirus infectious disease  (ISO)
pleural tuberculosis  (ISO)
polycystic ovary syndrome  (ISO)
primary biliary cholangitis  (ISO)
pulmonary tuberculosis  (ISO)
Recurrent Respiratory Papillomatosis  (ISO)
rheumatoid arthritis  (ISO)
Sepsis  (ISO)
spermatogenic failure 3  (ISO)
Spinal Cord Injuries  (IEP)
Squamous Intraepithelial Lesions of the Cervix  (ISO)
syndromic X-linked intellectual disability Lubs type  (ISO)
syphilis  (ISO)
Transplant Rejection  (ISO)
tropical spastic paraparesis  (ISO)
type 1 diabetes mellitus  (ISO)
vaccinia  (ISO)
Wiskott-Aldrich syndrome  (ISS)
Wound Infection  (IEP)
X-linked epilepsy with variable learning disabilities and behavior disorders  (ISO)
X-linked severe congenital neutropenia  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-Tetrandrine  (ISO)
(S)-nicotine  (ISO)
1-Hydroxypyrene  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-palmitoylglycerol  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
aflatoxin B1  (ISO)
alloxan  (ISO)
alpha-naphthoflavone  (ISO)
alpha-Zearalanol  (EXP)
amiodarone  (ISO)
amphetamine  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzalkonium chloride  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (ISO)
calcitriol  (ISO)
carbon monoxide  (ISO)
carbon nanotube  (ISO)
chloroquine  (ISO)
chlorpyrifos  (ISO)
chrysin  (ISO)
cisplatin  (ISO)
cyclophosphamide  (ISO)
deoxynivalenol  (ISO)
dextran sulfate  (EXP,ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dorsomorphin  (ISO)
fingolimod hydrochloride  (ISO)
fragrance  (ISO)
fulvestrant  (ISO)
fumonisin B1  (ISO)
gentamycin  (EXP)
hydralazine  (ISO)
hydroxysafflor yellow A  (ISO)
iron dichloride  (ISO)
lead diacetate  (EXP,ISO)
lead(0)  (ISO)
leflunomide  (ISO)
levamisole  (ISO)
lipopolysaccharide  (ISO)
methimazole  (EXP)
mevalonic acid  (ISO)
N-acetyl-L-cysteine  (ISO)
nickel atom  (ISO)
nicotine  (ISO)
nitrogen dioxide  (ISO)
obeticholic acid  (ISO)
ozone  (EXP,ISO)
paracetamol  (EXP)
phenanthrene  (EXP)
phenytoin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
platycodin D  (ISO)
procainamide  (ISO)
progesterone  (ISO)
quinacrine  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP,ISO)
silicon dioxide  (ISO)
simvastatin  (EXP,ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
testosterone  (ISO)
thioacetamide  (EXP)
toluene  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
Triptolide  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
alpha-beta T cell proliferation  (ISO)
B cell homeostasis  (ISO)
CD4-positive, alpha-beta T cell differentiation  (ISO)
CD4-positive, alpha-beta T cell proliferation  (ISO)
CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation  (ISO)
chromatin remodeling  (ISO)
DNA-templated transcription  (ISO)
establishment of endothelial blood-brain barrier  (IEP)
gene expression  (ISO)
immature T cell proliferation in thymus  (ISO)
inflammatory response  (ISO)
isotype switching to IgE isotypes  (ISO)
lymphocyte proliferation  (ISO)
myeloid cell homeostasis  (ISO)
negative regulation of alpha-beta T cell proliferation  (ISO)
negative regulation of CD4-positive, alpha-beta T cell proliferation  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of chronic inflammatory response  (ISO)
negative regulation of cytokine production  (ISO)
negative regulation of defense response to virus  (IMP)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of immune response  (ISO)
negative regulation of inflammatory response  (ISO)
negative regulation of interleukin-10 production  (ISO)
negative regulation of interleukin-17 production  (ISO)
negative regulation of interleukin-2 production  (ISO)
negative regulation of interleukin-4 production  (ISO)
negative regulation of interleukin-5 production  (ISO)
negative regulation of interleukin-6 production  (ISO)
negative regulation of isotype switching to IgE isotypes  (ISO)
negative regulation of lymphocyte proliferation  (ISO)
negative regulation of T cell cytokine production  (ISO)
negative regulation of T cell proliferation  (ISO)
negative regulation of T-helper 17 cell differentiation  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of tumor necrosis factor production  (ISO)
negative regulation of type II interferon production  (ISO)
positive regulation of CD4-positive, alpha-beta T cell differentiation  (ISO)
positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of immature T cell proliferation in thymus  (ISO)
positive regulation of interleukin-4 production  (ISO)
positive regulation of peripheral T cell tolerance induction  (ISO)
positive regulation of regulatory T cell differentiation  (ISO)
positive regulation of T cell anergy  (ISO)
positive regulation of T cell tolerance induction  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transforming growth factor beta1 production  (ISO)
regulation of immunoglobulin production  (ISO)
regulation of isotype switching to IgG isotypes  (ISO)
regulation of T cell anergy  (ISO)
regulation of transcription by RNA polymerase II  (IBA,ISO)
regulatory T cell differentiation  (ISO)
response to lipopolysaccharide  (IEP)
response to rapamycin  (IEP)
response to virus  (ISO)
T cell activation  (ISO)
T cell anergy  (ISO)
T cell mediated immunity  (ISO)
T cell proliferation  (ISO)
T cell receptor signaling pathway  (ISO)
T cell tolerance induction  (ISO)
tolerance induction  (ISO)
tolerance induction to self antigen  (ISO)
transcription by RNA polymerase II  (ISO)
transforming growth factor beta1 production  (ISO)

Cellular Component
cytoplasm  (ISO)
cytosol  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,ISO)


References - curated
# Reference Title Reference Citation
1. Spironolactone decreases DOCA-salt-induced organ damage by blocking the activation of T helper 17 and the downregulation of regulatory T lymphocytes. Amador CA, etal., Hypertension. 2014 Apr;63(4):797-803. doi: 10.1161/HYPERTENSIONAHA.113.02883. Epub 2014 Jan 13.
2. Novel biomarkers for the detection of wound infection by wound fluid RT-PCR in rats. Asada M, etal., Exp Dermatol. 2012 Feb;21(2):118-22. doi: 10.1111/j.1600-0625.2011.01404.x. Epub 2011 Dec 6.
3. G allele at -924 A > G position of FoxP3 gene promoter as a risk factor for tuberculosis. Beiranvand E, etal., BMC Infect Dis. 2017 Oct 11;17(1):673. doi: 10.1186/s12879-017-2762-5.
4. FOXP3 immunoregulatory gene variants are independent predictors of human papillomavirus infection and cervical cancer precursor lesions. Cezar-Dos-Santos F, etal., J Cancer Res Clin Oncol. 2019 Aug;145(8):2013-2025. doi: 10.1007/s00432-019-02951-x. Epub 2019 Jun 8.
5. Expression of the T regulatory cell transcription factor FoxP3 in peri-implantation phase endometrium in infertile women with endometriosis. Chen S, etal., Reprod Biol Endocrinol. 2012 Apr 27;10:34. doi: 10.1186/1477-7827-10-34.
6. Co-transplantation of Xenogeneic Bone Marrow-derived Mesenchymal Stem Cells Alleviates Rejection of Pancreatic Islets in Non-obese Diabetic Mice. Corradi-Perini C, etal., Transplant Proc. 2017 May;49(4):902-905. doi: 10.1016/j.transproceed.2017.01.064.
7. Intrahepatic detection of FOXP3 gene expression after liver transplantation using minimally invasive aspiration biopsy. Demirkiran A, etal., Transplantation. 2007 Mar 27;83(6):819-23. doi: 10.1097/
8. Regulatory T cell activity is partly inhibited in a mouse model of chronic Pseudomonas aeruginosa lung infection. Ding FM, etal., Exp Lung Res. 2015 Feb;41(1):44-55. doi: 10.3109/01902148.2014.964351. Epub 2014 Nov 14.
9. Regulatory T cells enhance persistence of the zoonotic pathogen Seoul virus in its reservoir host. Easterbrook JD, etal., Proc Natl Acad Sci U S A. 2007 Sep 25;104(39):15502-7. Epub 2007 Sep 18.
10. G protein-coupled receptor kinase 6 controls chronicity and severity of dextran sodium sulphate-induced colitis in mice. Eijkelkamp N, etal., Gut. 2007 Jun;56(6):847-54. doi: 10.1136/gut.2006.107094. Epub 2007 Jan 17.
11. Homeostatic regulation of T effector to Treg ratios in an area of seasonal malaria transmission. Finney OC, etal., Eur J Immunol. 2009 May;39(5):1288-300. doi: 10.1002/eji.200839112.
12. Skin inflammation arising from cutaneous regulatory T cell deficiency leads to impaired viral immune responses. Freyschmidt EJ, etal., J Immunol. 2010 Jul 15;185(2):1295-302. doi: 10.4049/jimmunol.0903144. Epub 2010 Jun 14.
13. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
14. Evaluation of T Regulatory Lymphocytes Transcription Factors in HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) Patients. Ghezeldasht SA, etal., Appl Biochem Biotechnol. 2017 Aug;182(4):1403-1414. doi: 10.1007/s12010-017-2406-7. Epub 2017 Jan 18.
15. Zhenbao Pill reduces Treg cell proportion in acute spinal cord injury rats by regulating TUG1/miR-214/HSP27 axis. He Y, etal., Biosci Rep. 2018 Nov 7;38(6). pii: BSR20180895. doi: 10.1042/BSR20180895. Print 2018 Dec 21.
16. Therapeutic effects of acupuncture with MOK, a polyherbal medicine, on PTU-induced hypothyroidism in rats. Hwang JH, etal., Exp Ther Med. 2018 Jul;16(1):310-320. doi: 10.3892/etm.2018.6190. Epub 2018 May 18.
17. The effects of vasoactive intestinal peptide in the rat model of experimental autoimmune neuritis and the implications for treatment of acute inflammatory demyelinating polyradiculoneuropathy or Guillain-Barré syndrome. Jiao H and Ren H, Drug Des Devel Ther. 2018 Nov 6;12:3817-3824. doi: 10.2147/DDDT.S175331. eCollection 2018.
18. A model of chronic lung allograft rejection in the rat. Jungraithmayr W, etal., Eur Respir J. 2010 Jun;35(6):1354-63. Epub 2009 Oct 19.
19. The relationship of FOXP3 expression and clinicopathological characteristics in adult T-cell leukemia/lymphoma. Karube K, etal., Mod Pathol. 2008 May;21(5):617-25. doi: 10.1038/modpathol.2008.25. Epub 2008 Feb 8.
20. Associations of FoxP3 gene polymorphisms with severe recurrent respiratory papillomatosis in Korean patients. Kwon TK, etal., J Otolaryngol Head Neck Surg. 2017 Mar 15;46(1):21. doi: 10.1186/s40463-017-0197-z.
21. Alterations of T helper lymphocyte subpopulations in sepsis, severe sepsis, and septic shock: a prospective observational study. Li J, etal., Inflammation. 2015;38(3):995-1002. doi: 10.1007/s10753-014-0063-3.
22. Placenta‑derived mesenchymal stem cells improve airway hyperresponsiveness and inflammation in asthmatic rats by modulating the Th17/Treg balance. Li Y, etal., Mol Med Rep. 2017 Dec;16(6):8137-8145. doi: 10.3892/mmr.2017.7605. Epub 2017 Sep 25.
23. [Significance and effect of Glucosidorum Tripterygii tororum on expressions of Foxp3 in regulatory T cells in type 1 diabetic rat model]. Liang CL and Wang J, Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2008 Mar;24(3):270-3.
24. Changes in intestinal mucosal immune barrier in rats with endotoxemia. Liu C, etal., World J Gastroenterol. 2009 Dec 14;15(46):5843-50. doi: 10.3748/wjg.15.5843.
25. Anti-inflammatory effects of Lactobacillus brevis K65 on RAW 264.7 cells and in mice with dextran sulphate sodium-induced ulcerative colitis. Liu YW, etal., Benef Microbes. 2016 Jun;7(3):387-96. doi: 10.3920/BM2015.0109. Epub 2016 Mar 1.
26. Extremely Low Frequency Electromagnetic Fields Decrease Serum Levels of Interleukin-17, Transforming Growth Factor-β and Downregulate Foxp3 Expression in the Spleen. Mahdavinejad L, etal., J Interferon Cytokine Res. 2018 Oct;38(10):457-462. doi: 10.1089/jir.2018.0048.
27. Study of liver-targeted regulatory T cells in hepatitis B and C virus in chronically infected patients. Miyaaki H, etal., Liver Int. 2009 May;29(5):702-7. doi: 10.1111/j.1478-3231.2008.01842.x. Epub 2008 Jul 30.
28. Increased Th17 functions are accompanied by Tregs activities in lupoid leishmaniasis. Nabavi NS, etal., Parasite Immunol. 2018 Jan;40(1). doi: 10.1111/pim.12507. Epub 2017 Dec 17.
29. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
30. Adenovirus-mediated Foxp3 expression in lung epithelial cells reduces airway inflammation in ovalbumin and cockroach-induced asthma model. Park S, etal., Exp Mol Med. 2016 Sep 16;48(9):e259. doi: 10.1038/emm.2016.83.
31. The Influence of Metformin to the Transcriptional Activity of the mTOR and FOX3 Genes in Parapancreatic Adipose Tissue of Streptozotocin-Induced Diabetic Rats. Putilin DA, etal., J Med Life. 2020 Jan-Mar;13(1):50-55. doi: 10.25122/jml-2020-0029.
32. In vivo fluctuation of Tax, Foxp3, CTLA-4, and GITR mRNA expression in CD4(+)CD25(+) T cells of patients with human T-lymphotropic virus type 1-associated myelopathy. Ramirez E, etal., Braz J Med Biol Res. 2010 Nov;43(11):1109-15. doi: 10.1590/s0100-879x2010007500107. Epub 2010 Oct 8.
33. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
34. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
35. Comprehensive gene review and curation RGD comprehensive gene curation
36. MyD88 is critically involved in immune tolerance breakdown at environmental interfaces of Foxp3-deficient mice. Rivas MN, etal., J Clin Invest. 2012 May;122(5):1933-47. doi: 10.1172/JCI40591. Epub 2012 Apr 2.
37. Naturally-occurring regulatory T cells are increased in inflamed portal tracts with cholangiopathy in primary biliary cirrhosis. Sasaki M, etal., J Clin Pathol. 2007 Oct;60(10):1102-7. doi: 10.1136/jcp.2006.044776. Epub 2006 Dec 8.
38. FoxP3 demethylation is increased in human colorectal cancer and rat cholangiocarcinoma tissue. Schultze FC, etal., Clin Biochem. 2014 Feb;47(3):201-5. doi: 10.1016/j.clinbiochem.2013.11.013. Epub 2013 Nov 26.
39. Protective Effect of Norcantharidin on Collagen-Induced Arthritis Rats. Shen HB, etal., Chin J Integr Med. 2018 Apr;24(4):278-283. doi: 10.1007/s11655-017-2792-2. Epub 2017 Dec 21.
40. Mechanistic investigation of immunosuppression in patients with condyloma acuminata. Shi YJ, etal., Mol Med Rep. 2013 Aug;8(2):480-6. doi: 10.3892/mmr.2013.1511. Epub 2013 Jun 6.
41. Foxp3 plasmid-encapsulated PLGA nanoparticles attenuate pain behavior in rats with spinal nerve ligation. Shin J, etal., Nanomedicine. 2019 Jun;18:90-100. doi: 10.1016/j.nano.2019.02.023. Epub 2019 Mar 8.
42. Bupi Hewei decoction ameliorates 5-fluorouracil-induced intestinal dysbiosis in rats through T helper 17/T regulatory cell signaling pathway. Sun Z, etal., J Tradit Chin Med. 2020 Feb;40(1):38-48.
43. Distinct cytokine and regulatory T cell profile at pleural sites of dual HIV/tuberculosis infection compared to that in the systemic circulation. Toossi Z, etal., Clin Exp Immunol. 2011 Mar;163(3):333-8. doi: 10.1111/j.1365-2249.2010.04269.x.
44. Upregulation of TGF-beta, FOXP3, and CD4+CD25+ regulatory T cells correlates with more rapid parasite growth in human malaria infection. Walther M, etal., Immunity. 2005 Sep;23(3):287-96. doi: 10.1016/j.immuni.2005.08.006.
45. [The reduced pulmonary function is related to the decreased expression of Treg and Foxp3 in adjuvant-induced arthritis rats]. Wan L, etal., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2013 Mar;29(3):251-5.
46. Spontaneous acceptance of mouse kidney allografts is associated with increased Foxp3 expression and differences in the B and T cell compartments. Wang C, etal., Transpl Immunol. 2011 Apr 15;24(3):149-56. doi: 10.1016/j.trim.2010.12.004. Epub 2011 Jan 1.
47. Activated IL-23/IL-17 pathway closely correlates with increased Foxp3 expression in livers of chronic hepatitis B patients. Wang Q, etal., BMC Immunol. 2011 Apr 14;12:25. doi: 10.1186/1471-2172-12-25.
48. [Changes of FoxP3, CD4(+)CD25(+) regulatory T cells, TLR2 and TLR9 in children with infectious mononucleosis]. Wang Q, etal., Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2013 Apr;21(2):469-73. doi: 10.7534/j.issn.1009-2137.2013.02.044.
49. Treatment and prevention of experimental autoimmune myocarditis with CD28 superagonists. Wang S, etal., Cardiology. 2010;115(2):107-13. doi: 10.1159/000256660. Epub 2009 Nov 10.
50. FOXP3 expression and clinical characteristics of hepatocellular carcinoma. Wang WH, etal., World J Gastroenterol. 2010 Nov 21;16(43):5502-9. doi: 10.3748/wjg.v16.i43.5502.
51. X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy. Wildin RS, etal., Nat Genet. 2001 Jan;27(1):18-20.
52. Effective expansion of forkhead box P3⁺ regulatory T cells via early secreted antigenic target 6 and antigen 85 complex B from Mycobacterium tuberculosis. Wu YE, etal., Mol Med Rep. 2015 Apr;11(4):3134-42. doi: 10.3892/mmr.2014.3033. Epub 2014 Dec 3.
53. Mesenchymal stem cells administered after liver transplantation prevent acute graft-versus-host disease in rats. Xia X, etal., Liver Transpl. 2012 Jun;18(6):696-706. doi: 10.1002/lt.23414.
54. Impact of astrocyte and lymphocyte interactions on the blood-brain barrier in multiple sclerosis. Yan XB, etal., Rev Neurol (Paris). 2019 Jun;175(6):396-402. doi: 10.1016/j.neurol.2018.12.006. Epub 2019 Apr 23.
55. Elevated IL-23R Expression and Foxp3+Rorgt+ Cells in Intestinal Mucosa During Acute and Chronic Colitis. Yang J and Xu L, Med Sci Monit. 2016 Aug 8;22:2785-92. doi: 10.12659/msm.896827.
56. Loss of Foxp3 is associated with CD30 expression in the anaplastic large cell subtype of adult T-cell leukemia/lymphoma (ATLL) in US/Caribbean patients: potential therapeutic implications for CD30 antibody-mediated therapy. Yao J, etal., Am J Surg Pathol. 2013 Sep;37(9):1407-12. doi: 10.1097/PAS.0b013e31828f2322.
57. The regulatory impact of immune inhibitors on T cells of SD rats. Zhang CH, etal., Asian Pac J Trop Med. 2014 Apr;7(4):305-8. doi: 10.1016/S1995-7645(14)60044-4.
58. The Treg/Th17 imbalance in Toxoplasma gondii-infected pregnant mice. Zhang H, etal., Am J Reprod Immunol. 2012 Feb;67(2):112-21. doi: 10.1111/j.1600-0897.2011.01065.x. Epub 2011 Sep 19.
59. Bifidobacterium longum affects the methylation level of forkhead box P3 promoter in 2, 4, 6-trinitrobenzenesulphonic acid induced colitis in rats. Zhang M, etal., Microb Pathog. 2017 Sep;110:426-430. doi: 10.1016/j.micpath.2017.07.029. Epub 2017 Jul 18.
60. Equilibrium of Treg/Th17 cells of peripheral blood in syphilitic patients with sero-resistance. Zhao J, etal., Exp Ther Med. 2016 Jun;11(6):2300-2304. doi: 10.3892/etm.2016.3178. Epub 2016 Mar 23.
61. Negative immune factors might predominate local tumor immune status and promote carcinogenesis in cervical carcinoma. Zhao M, etal., Virol J. 2017 Jan 13;14(1):5. doi: 10.1186/s12985-016-0670-8.
62. Fibrinogen-like protein-2 causes deterioration in cardiac function in experimental autoimmune myocarditis rats through regulation of programmed death-1 and inflammatory cytokines. Zheng Z, etal., Immunology. 2018 Feb;153(2):246-252. doi: 10.1111/imm.12837. Epub 2017 Oct 16.
63. High expression of IDO1 and TGF-β1 during recurrence and post infection clearance with Chlamydia trachomatis, are independent of host IFN-γ response. Ziklo N, etal., BMC Infect Dis. 2019 Mar 4;19(1):218. doi: 10.1186/s12879-019-3843-4.
Additional References at PubMed
PMID:7930593   PMID:8566060   PMID:10072494   PMID:11265635   PMID:11483607   PMID:11714795   PMID:12522256   PMID:12612578   PMID:15100250   PMID:15466453   PMID:15652505   PMID:15780990  
PMID:15790681   PMID:15809349   PMID:16203996   PMID:16227984   PMID:16230479   PMID:16275384   PMID:16301745   PMID:16532000   PMID:16652169   PMID:16769892   PMID:16873067   PMID:16920951  
PMID:16945588   PMID:17028180   PMID:17360565   PMID:17377532   PMID:18368049   PMID:18573908   PMID:18665051   PMID:18997793   PMID:19015308   PMID:19100737   PMID:19276356   PMID:19956764  
PMID:20583921   PMID:20706986   PMID:20944002   PMID:20979845   PMID:21304439   PMID:21458306   PMID:21948080   PMID:22079196   PMID:22564625   PMID:22588919   PMID:22678915   PMID:23169781  
PMID:24012345   PMID:24501220   PMID:25001933   PMID:25066760   PMID:25598450   PMID:26684623   PMID:28396406   PMID:28469165   PMID:31314754   PMID:32599120   PMID:33993340   PMID:36273134  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr8X17,580,380 - 17,601,181 (-)NCBIGRCr8
mRatBN7.2X14,908,494 - 14,924,994 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX14,908,494 - 14,923,838 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX19,722,817 - 19,738,131 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X20,345,005 - 20,360,319 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X16,610,149 - 16,625,463 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X15,753,175 - 15,768,648 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX15,753,175 - 15,768,522 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X16,544,710 - 16,565,562 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X26,950,006 - 26,965,329 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX14,991,861 - 15,007,179 (-)NCBICelera
Cytogenetic MapXq12NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38X49,250,438 - 49,264,710 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX49,250,438 - 49,264,800 (-)EnsemblGRCh38hg38GRCh38
GRCh37X49,106,899 - 49,121,172 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X48,994,354 - 49,008,232 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X48,863,780 - 48,877,659NCBI
CeleraX52,543,105 - 52,557,472 (+)NCBICelera
Cytogenetic MapXp11.23NCBI
HuRefX46,763,332 - 46,777,541 (-)NCBIHuRef
CHM1_1X49,139,199 - 49,153,588 (-)NCBICHM1_1
T2T-CHM13v2.0X48,662,300 - 48,676,549 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39X7,445,915 - 7,461,482 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX7,439,883 - 7,461,484 (+)EnsemblGRCm39 Ensembl
GRCm38X7,579,676 - 7,595,243 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX7,573,644 - 7,595,245 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X7,156,819 - 7,172,360 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X6,736,652 - 6,752,193 (+)NCBIMGSCv36mm8
CeleraX3,876,537 - 3,892,077 (-)NCBICelera
Cytogenetic MapXA1.1NCBI
cM MapX3.41NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_004955543731,707 - 742,606 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955543731,707 - 742,606 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v2X50,742,581 - 50,759,396 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X50,745,946 - 50,762,762 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X41,550,462 - 41,567,492 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X49,402,652 - 49,417,029 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX49,402,652 - 49,417,029 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1X42,331,229 - 42,362,841 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX42,344,108 - 42,350,758 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX16,722,772 - 16,729,421 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X42,484,818 - 42,504,672 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX42,482,908 - 42,492,386 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X42,469,693 - 42,476,343 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X42,457,152 - 42,463,801 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X42,552,106 - 42,558,755 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2X34,877,987 - 34,897,169 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367211,118,782 - 1,132,308 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367211,118,376 - 1,125,282 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 EnsemblX43,303,785 - 43,322,968 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X43,303,777 - 43,328,164 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X48,151,901 - 48,175,580 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1X46,349,890 - 46,365,133 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607611,912,136 - 11,927,083 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_004624893995,182 - 1,008,679 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624893995,145 - 1,008,492 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Foxp3
24 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:560
Count of miRNA genes:275
Interacting mature miRNAs:359
Prediction methods:Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X143491017Rat
634325Bw13Body weight QTL 130body mass (VT:0001259)body weight (CMO:0000012)X144797220991088Rat
70165Bp64Blood pressure QTL 645.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X144812931706553Rat
631204Gluco15Glucose level QTL 150.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)X162371522646544Rat
1298071Edpm12Estrogen-dependent pituitary mass QTL 123.2pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)X292789847927898Rat
10755455Coatc13Coat color QTL 130coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7440600049406000Rat
631666Iddm5Insulin dependent diabetes mellitus QTL 5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X449454949494549Rat
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X14,909,682 - 14,909,827 (+)MAPPERmRatBN7.2
Rnor_6.0X15,754,364 - 15,754,508NCBIRnor6.0
Rnor_5.0X16,545,899 - 16,546,043UniSTSRnor5.0
RGSC_v3.4X26,951,195 - 26,951,339UniSTSRGSC3.4
CeleraX14,993,050 - 14,993,194UniSTS
RH 3.4 MapX167.4UniSTS
Cytogenetic MapXq13UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X14,911,941 - 14,912,081 (+)MAPPERmRatBN7.2
Rnor_6.0X15,756,623 - 15,756,762NCBIRnor6.0
Rnor_5.0X16,548,158 - 16,548,297UniSTSRnor5.0
RGSC_v3.4X26,953,454 - 26,953,593UniSTSRGSC3.4
CeleraX14,995,309 - 14,995,448UniSTS
RH 3.4 MapX166.6UniSTS
Cytogenetic MapXq13UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Low 2 9 17 1 19 1 8 11 12 8 14 11 8
Below cutoff 1 24 23 23 23 62 23 23


RefSeq Acc Id: ENSRNOT00000015641   ⟹   ENSRNOP00000015641
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX14,908,494 - 14,917,167 (-)Ensembl
Rnor_6.0 EnsemblX15,753,175 - 15,761,932 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000077391   ⟹   ENSRNOP00000073801
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX14,910,646 - 14,923,838 (-)Ensembl
Rnor_6.0 EnsemblX15,755,327 - 15,768,522 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000091146   ⟹   ENSRNOP00000071307
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX14,910,646 - 14,917,193 (-)Ensembl
Rnor_6.0 EnsemblX15,755,327 - 15,761,932 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000098091   ⟹   ENSRNOP00000080390
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX14,910,646 - 14,923,838 (-)Ensembl
RefSeq Acc Id: NM_001108250   ⟹   NP_001101720
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
GRCr8X17,580,380 - 17,595,700 (-)NCBI
mRatBN7.2X14,908,494 - 14,923,814 (-)NCBI
Rnor_6.0X15,753,175 - 15,768,498 (-)NCBI
Rnor_5.0X16,544,710 - 16,565,562 (-)NCBI
RGSC_v3.4X26,950,006 - 26,965,329 (-)RGD
CeleraX14,991,861 - 15,007,179 (-)RGD
RefSeq Acc Id: XM_039099794   ⟹   XP_038955722
Rat AssemblyChrPosition (strand)Source
GRCr8X17,581,732 - 17,601,181 (-)NCBI
mRatBN7.2X14,909,846 - 14,917,495 (-)NCBI
RefSeq Acc Id: XM_063280054   ⟹   XP_063136124
Rat AssemblyChrPosition (strand)Source
GRCr8X17,581,732 - 17,601,181 (-)NCBI
RefSeq Acc Id: XM_063280055   ⟹   XP_063136125
Rat AssemblyChrPosition (strand)Source
GRCr8X17,581,732 - 17,601,180 (-)NCBI
RefSeq Acc Id: XM_063280056   ⟹   XP_063136126
Rat AssemblyChrPosition (strand)Source
GRCr8X17,581,732 - 17,601,180 (-)NCBI
RefSeq Acc Id: NP_001101720   ⟸   NM_001108250
- UniProtKB: D4Q8I1 (UniProtKB/TrEMBL),   A0A8I6G4G9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000073801   ⟸   ENSRNOT00000077391
RefSeq Acc Id: ENSRNOP00000071307   ⟸   ENSRNOT00000091146
RefSeq Acc Id: ENSRNOP00000015641   ⟸   ENSRNOT00000015641
RefSeq Acc Id: XP_038955722   ⟸   XM_039099794
- Peptide Label: isoform X1
RefSeq Acc Id: ENSRNOP00000080390   ⟸   ENSRNOT00000098091
RefSeq Acc Id: XP_063136124   ⟸   XM_063280054
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063136125   ⟸   XM_063280055
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063136126   ⟸   XM_063280056
- Peptide Label: isoform X2
Protein Domains
C2H2-type   Fork-head

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4Q8I2-F1-model_v2 AlphaFold D4Q8I2 1-488 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13701753
Promoter ID:EPDNEW_R12274
Type:single initiation site
Description:forkhead box P3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X15,768,517 - 15,768,577EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1562112 AgrOrtholog
BioCyc Gene G2FUF-2904 BioCyc
Ensembl Genes ENSRNOG00000011702 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000015641 ENTREZGENE
  ENSRNOT00000015641.7 UniProtKB/TrEMBL
  ENSRNOT00000077391.2 UniProtKB/TrEMBL
  ENSRNOT00000091146.2 UniProtKB/TrEMBL
  ENSRNOT00000098091.1 UniProtKB/TrEMBL
InterPro FH_FOXP3 UniProtKB/TrEMBL
  TF_fork_head UniProtKB/TrEMBL
  TF_fork_head_CS_2 UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/TrEMBL
  WH_DNA-bd_sf UniProtKB/TrEMBL
  Znf_C2H2/integrase_DNA-bd UniProtKB/TrEMBL
KEGG Report rno:317382 UniProtKB/TrEMBL
Pfam Fork_head UniProtKB/TrEMBL
PhenoGen Foxp3 PhenoGen
RatGTEx ENSRNOG00000011702 RatGTEx
Superfamily-SCOP SSF46785 UniProtKB/TrEMBL

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Foxp3  forkhead box P3   Foxp3_predicted  forkhead box P3 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Foxp3_predicted  forkhead box P3 (predicted)  RGD1562112_predicted  similar to scurfin (predicted)  Symbol and Name updated 1299863 APPROVED
2006-03-07 RGD1562112_predicted  similar to scurfin (predicted)  LOC317382  similar to scurfin  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC317382  similar to scurfin      Symbol and Name status set to provisional 70820 PROVISIONAL