Pgr (progesterone receptor) - Rat Genome Database

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Gene: Pgr (progesterone receptor) Rattus norvegicus
Symbol: Pgr
Name: progesterone receptor
RGD ID: 3317
Description: Enables several functions, including nuclear steroid receptor activity; sequence-specific DNA binding activity; and steroid binding activity. Involved in several processes, including cellular response to hormone stimulus; cellular response to wortmannin; and regulation of DNA-templated transcription. Located in axon terminus; dendritic spine; and perikaryon. Biomarker of endometriosis and polycystic ovary syndrome. Human ortholog(s) of this gene implicated in endometriosis; hyperprolactinemia; and obesity. Orthologous to human PGR (progesterone receptor); PARTICIPATES IN phosphatidylinositol 3-kinase-Akt signaling pathway; INTERACTS WITH (S)-naringenin; 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: nuclear receptor subfamily 3 group C member 3; PR; progestin receptor form A; progestin receptor form B
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Is Marker For: Strains:   SD-Pgrem1Soar  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.286,072,673 - 6,131,552 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl86,072,673 - 6,131,344 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx810,003,167 - 10,062,099 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.088,300,792 - 8,359,726 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.086,329,892 - 6,388,768 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.087,128,656 - 7,187,796 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl87,128,656 - 7,187,796 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.087,113,895 - 7,172,761 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.485,784,717 - 5,845,901 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.185,784,716 - 5,845,901 (+)NCBI
Celera87,609,728 - 7,668,047 (+)NCBICelera
Cytogenetic Map8q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(20S)-ginsenoside Rh1  (ISO)
(25R)-cholest-5-ene-3beta,26-diol  (ISO)
(R)-camphor  (ISO)
(R)-linalyl acetate  (ISO)
(S)-naringenin  (EXP,ISO)
(S)-nicotine  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP,ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (EXP)
1-(3-(trifluoromethyl)phenyl)piperazine  (ISO)
1-benzylpiperazine  (ISO)
1-Hydroxypyrene  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17alpha-hydroxyprogesterone  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,2-(2-Chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,3',4,4',5,5'-Heptachlorobiphenyl  (ISO)
2,3,4,5-Tetrachloro-4'-biphenylol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-Trimethylbenzaldehyde  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP,ISO)
2-hydroxybenzoic acid (3,3,5-trimethylcyclohexyl) ester  (ISO)
2-palmitoylglycerol  (ISO)
26-hydroxycholesterol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-1-decanol  (ISO)
3,5-di-tert-Butyl-4-hydroxybenzaldehyde  (ISO)
3,6-diaminoacridine  (ISO)
3,7-dihydropurine-6-thione  (EXP)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-methylcholanthrene  (EXP,ISO)
4'-epidoxorubicin  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxy-17beta-estradiol  (ISO)
4-nonylphenol  (EXP,ISO)
4-terpineol  (ISO)
4-tert-butylphenol  (ISO)
4-tert-Octylphenol  (EXP,ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-oxocampestanol  (ISO)
8-Br-cAMP  (ISO)
adefovir pivoxil  (ISO)
afimoxifene  (ISO)
alachlor  (ISO)
aldicarb  (ISO)
aldrin  (ISO)
all-trans-retinoic acid  (ISO)
alpha-hexachlorocyclohexane  (ISO)
alpha-Methylstyrene  (ISO)
alpha-naphthoflavone  (ISO)
alpha-Zearalanol  (ISO)
alternariol  (ISO)
aminoglutethimide  (ISO)
amlodipine  (ISO)
ammonium sulfate  (ISO)
amsacrine  (ISO)
anastrozole  (ISO)
androgen antagonist  (EXP)
apigenin  (ISO)
aprepitant  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
artesunate  (ISO)
atrazine  (EXP,ISO)
bendiocarb  (ISO)
benzo[a]pyrene  (ISO)
beta-hexachlorocyclohexane  (ISO)
bexarotene  (ISO)
bicalutamide  (ISO)
bifenthrin  (EXP,ISO)
biochanin A  (EXP,ISO)
biphenyl-2-ol  (ISO)
biphenyl-4-ol  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol A dimethacrylate  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
budesonide  (ISO)
buta-1,3-diene  (ISO)
butylated hydroxyanisole  (ISO)
Butylbenzyl phthalate  (EXP,ISO)
Butylparaben  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP)
camphor  (ISO)
camptothecin  (ISO)
carbaryl  (ISO)
carbon nanotube  (ISO)
carfilzomib  (ISO)
chlordecone  (EXP,ISO)
chlorogenic acid  (ISO)
chlorpyrifos  (EXP,ISO)
Chorionic gonadotropin  (ISO)
chrysen-6-ol  (ISO)
Ciclesonide  (ISO)
ciclopirox  (ISO)
clomiphene  (ISO)
cobalt dichloride  (ISO)
cocaine  (EXP)
colforsin daropate hydrochloride  (ISO)
copper(II) chloride  (ISO)
coumestrol  (EXP,ISO)
Cuprizon  (EXP)
cyclohexanone  (ISO)
cyfluthrin  (ISO)
cyhalothrin  (ISO)
cypermethrin  (ISO)
cyproterone acetate  (ISO)
daidzein  (ISO)
daidzein 7-O-beta-D-glucoside  (ISO)
danazol  (ISO)
delta-hexachlorocyclohexane  (ISO)
deoxynivalenol  (ISO)
desogestrel  (ISO)
diarylheptanoid  (ISO)
dibutyl phthalate  (EXP,ISO)
dichloroacetic acid  (ISO)
dieldrin  (EXP,ISO)
diethyl phthalate  (EXP,ISO)
diethylstilbestrol  (EXP,ISO)
difenoconazole  (ISO)
digitoxin  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (EXP,ISO)
dioxygen  (EXP,ISO)
disodium selenite  (ISO)
doxorubicin  (ISO)
dronedarone  (ISO)
drospirenone  (ISO)
dydrogesterone  (ISO)
elcometrine  (ISO)
emetine  (ISO)
endosulfan  (EXP,ISO)
endrin  (ISO)
enzacamene  (EXP,ISO)
epoxiconazole  (EXP)
erucamide  (ISO)
Estradiol dipropionate  (ISO)
estriol  (ISO)
estrogen  (EXP)
estrone  (ISO)
ethanol  (EXP)
ethyl myristate  (ISO)
ethylparaben  (ISO)
etonogestrel  (ISO)
etoposide phosphate  (ISO)
exemestane  (ISO)
ezetimibe  (ISO)
fenhexamid  (ISO)
fenpyroximate  (ISO)
fenvalerate  (ISO)
fludioxonil  (ISO)
flumethrin  (ISO)
flunisolide  (ISO)
fluoxastrobin  (ISO)
flutamide  (EXP,ISO)
fluticasone  (ISO)
flutolanil  (ISO)
fulvestrant  (EXP,ISO)
galaxolide  (ISO)
gamma-hexachlorocyclohexane  (ISO)
gamma-terpinene  (ISO)
geldanamycin  (ISO)
gemcitabine  (ISO)
genistein  (EXP,ISO)
gentamycin  (EXP)
geraniol  (EXP)
gestodene  (ISO)
ginsenoside Rb1  (ISO)
ginsenoside Re  (ISO)
ginsenoside Rg1  (ISO)
glutathione  (ISO)
glyceollin  (ISO)
glyphosate  (EXP,ISO)
Goserelin  (ISO)
heptachlor  (EXP,ISO)
Heptachlor epoxide  (ISO)
herbicide  (ISO)
hexachlorobenzene  (ISO)
hexestrol  (ISO)
hydrogen peroxide  (ISO)
icariin  (ISO)
Icaritin  (ISO)
ICI-164384  (ISO)
imidacloprid  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
irilone  (ISO)
Isobavachin  (ISO)
Isobutylparaben  (EXP)
isoflavones  (EXP)
isophorone  (ISO)
Isopropylparaben  (EXP)
isoprothiolane  (ISO)
kaempferol  (ISO)
ketoconazole  (ISO)
kresoxim-methyl  (ISO)
lasofoxifene  (EXP)
Laurolactam  (ISO)
lead(II) chloride  (ISO)
letrozole  (ISO)
levonorgestrel  (ISO)
limonene  (ISO)
linalool  (ISO)
linalyl acetate  (ISO)
linuron  (EXP)
loteprednol etabonate  (ISO)
medroxyprogesterone  (ISO)
medroxyprogesterone acetate  (ISO)
megestrol acetate  (ISO)
melatonin  (EXP,ISO)
mercaptopurine  (EXP)
mercury dichloride  (ISO)
mestranol  (ISO)
methimazole  (ISO)
methomyl  (ISO)
methotrexate  (ISO)
methoxyacetic acid  (EXP,ISO)
methoxychlor  (EXP,ISO)
methyl laurate  (ISO)
methylmercury chloride  (EXP)
methylparaben  (ISO)
methylseleninic acid  (ISO)
methyltestosterone  (EXP)
mifepristone  (EXP,ISO)
Mitotane  (ISO)
mometasone furoate  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
Monobutylphthalate  (EXP)
mycophenolic acid  (ISO)
mycotoxin  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
nandrolone  (ISO)
nebivolol  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
niclosamide  (ISO)
nicotine  (ISO)
nonane  (ISO)
Nonylphenol  (EXP,ISO)
norethisterone  (ISO)
Norethynodrel  (ISO)
norgestimate  (ISO)
okadaic acid  (ISO)
ormeloxifene  (EXP)
Osajin  (ISO)
oseltamivir  (ISO)
oxaliplatin  (ISO)
oxamyl  (ISO)
oxybenzone  (ISO)
oxymetholone  (ISO)
ozone  (ISO)
p-tert-Amylphenol  (EXP,ISO)
p-tolualdehyde  (ISO)
paracetamol  (EXP)
pazopanib  (ISO)
PCB138  (ISO)
pentachlorophenol  (ISO)
pentobarbital  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (ISO)
phenanthrene  (ISO)
phenol red  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phthalic acid  (ISO)
phytoestrogen  (ISO)
picene  (ISO)
picoxystrobin  (ISO)
plumbagin  (EXP)
Pomiferin  (ISO)
potassium chloride  (ISO)
prochloraz  (EXP)
procymidone  (EXP)
progesterone  (EXP,ISO)
promegestone  (EXP,ISO)
propoxur  (ISO)
propylparaben  (ISO)
pterostilbene  (ISO)
puerarin  (EXP,ISO)
purine-6-thiol  (EXP)
pyrene  (ISO)
pyridaben  (ISO)
quercetin  (ISO)
radicicol  (ISO)
raloxifene  (EXP,ISO)
resveratrol  (EXP,ISO)
Rosavin  (ISO)
rotenone  (ISO)
RU 58668  (ISO)
rubitecan  (ISO)
S-methyl methanethiosulfonate  (ISO)
Se-methyl-L-selenocysteine  (ISO)
Se-methylselenocysteine  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simazine  (EXP)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sodium fluoride  (EXP)
sophoraflavanone B  (EXP,ISO)
Sophoricoside  (ISO)
staurosporine  (ISO)
stilben-4-ol  (ISO)
stilbene-4,4'-diol  (ISO)
sulindac sulfide  (ISO)
sulindac sulfone  (ISO)
sunitinib  (ISO)
T-2 toxin  (ISO)
tamoxifen  (EXP,ISO)
tanespimycin  (ISO)
tea tree oil  (ISO)
tegaserod  (ISO)
Temsirolimus  (ISO)
teniposide  (ISO)
testosterone  (ISO)
Testosterone propionate  (EXP,ISO)
Tetrachlorobisphenol A  (ISO)
tetraphene  (ISO)
tibolone  (ISO)
ticlopidine  (ISO)
tolcapone  (ISO)
toxaphene  (EXP,ISO)
TRAM-34  (ISO)
trans-stilbene-4,4'-diol  (ISO)
triamcinolone  (ISO)
trichostatin A  (ISO)
trifloxystrobin  (ISO)
trimegestone  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
ursodeoxycholic acid  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP,ISO)
vorinostat  (ISO)
wortmannin  (EXP)
XL147  (ISO)
zearalenone  (ISO)
zidovudine  (ISO)
zinc oxide  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to estrogen stimulus  (IEP)
cellular response to follicle-stimulating hormone stimulus  (IEP)
cellular response to gonadotropin stimulus  (IEP)
cellular response to luteinizing hormone stimulus  (IEP)
cellular response to wortmannin  (IEP)
diterpenoid metabolic process  (IEP)
epithelial cell maturation  (ISO)
estrous cycle  (IEP)
female mating behavior  (IMP)
glandular epithelial cell maturation  (IEA,ISO)
intracellular steroid hormone receptor signaling pathway  (IBA)
lung alveolus development  (IEA,ISO)
luteinization  (IEP)
maintenance of protein location in nucleus  (IEA,ISO)
mammary gland development  (ISO)
negative regulation of apoptotic process  (IMP)
negative regulation of DNA-templated transcription  (IEP)
negative regulation of gene expression  (IEA,ISO)
negative regulation of granulosa cell apoptotic process  (IMP)
negative regulation of phosphorylation  (IEA,ISO)
ovulation from ovarian follicle  (IEA,ISO)
paracrine signaling  (IEA,ISO)
positive regulation of cell population proliferation  (IDA)
positive regulation of DNA-templated transcription  (IDA,ISO)
positive regulation of smooth muscle cell migration  (IMP)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
progesterone receptor signaling pathway  (IEA,ISO)
regulation of DNA-templated transcription  (ISO)
regulation of epithelial cell proliferation  (IEA,ISO)
regulation of transcription by RNA polymerase II  (IBA)
response to cocaine  (IDA)
response to estrogen  (IEP)
response to progesterone  (IEP)
smooth muscle relaxation of the bladder outlet  (ISO)
tertiary branching involved in mammary gland duct morphogenesis  (IEA,ISO)

Cellular Component
axon  (IDA)
axon terminus  (IDA)
cytoplasm  (IEA)
dendrite  (IDA)
dendritic spine  (IDA)
nucleus  (IEA,ISO)
perikaryon  (IDA)
plasma membrane  (IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. Differential responses of progesterone receptor membrane component-1 (Pgrmc1) and the classical progesterone receptor (Pgr) to 17beta-estradiol and progesterone in hippocampal subregions that support synaptic remodeling and neurogenesis. Bali N, etal., Endocrinology. 2012 Feb;153(2):759-69. doi: 10.1210/en.2011-1699. Epub 2011 Dec 6.
2. Role of the progesterone receptor in restrained glutamic acid decarboxylase gene expression in the hypothalamus during the preovulatory luteinizing hormone surge. Brann DW, etal., Neuroendocrinology 2002 Nov;76(5):283-9.
3. Progestin receptors mediate progesterone suppression of epileptiform activity in tetanized hippocampal slices in vitro. Edwards HE, etal., Neuroscience. 2000;101(4):895-906.
4. Dominant role of nuclear progesterone receptor in the control of rat periovulatory granulosa cell apoptosis. Friberg PA, etal., Biol Reprod. 2009 Jun;80(6):1160-7. doi: 10.1095/biolreprod.108.073932. Epub 2009 Feb 4.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Antagonists of the protein kinase A and mitogen-activated protein kinase systems and of the progestin receptor block the ability of vaginocervical/flank-perineal stimulation to induce female rat sexual behaviour. Gonzalez-Flores O, etal., J Neuroendocrinol. 2008 Dec;20(12):1361-7. doi: 10.1111/j.1365-2826.2008.01794.x.
8. Sex differences in the regulation of progesterone receptor isoforms expression in the rat brain. Guerra-Araiza C, etal., Brain Res Bull 2002 Oct 30;59(2):105-9.
9. Changes in alpha-estradiol receptor and progesterone receptor expression in the locus coeruleus and preoptic area throughout the rat estrous cycle. Helena CV, etal., J Endocrinol. 2006 Feb;188(2):155-65.
10. PROGINS Alu sequence insertion is associated with hyperprolactinaemia but not leiomyoma susceptibility. Hsieh YY, etal., Clin Endocrinol (Oxf). 2005 Apr;62(4):492-7.
11. Extra-nuclear activation of progesterone receptor in regulating arterial smooth muscle cell migration. Hsu SP, etal., Atherosclerosis. 2011 Jul;217(1):83-9. doi: 10.1016/j.atherosclerosis.2011.02.051. Epub 2011 Mar 10.
12. Estrogen-induced activation of hypoxia-inducible factor-1alpha, vascular endothelial growth factor expression, and edema in the uterus are mediated by the phosphatidylinositol 3-kinase/Akt pathway. Kazi AA and Koos RD, Endocrinology. 2007 May;148(5):2363-74. doi: 10.1210/en.2006-1394. Epub 2007 Feb 1.
13. Cloning of the rat progesterone receptor gene 5'-region and identification of two functionally distinct promoters. Kraus WL, etal., Mol Endocrinol 1993 Dec;7(12):1603-16.
14. Immunocytochemical evidence for a progesterone receptor in neurons and glial cells of the rat spinal cord. Labombarda F, etal., Neurosci Lett. 2000 Jul 7;288(1):29-32.
15. Distribution of membrane progesterone receptor alpha in the male mouse and rat brain and its regulation after traumatic brain injury. Meffre D, etal., Neuroscience. 2013 Feb 12;231:111-24. doi: 10.1016/j.neuroscience.2012.11.039. Epub 2012 Dec 2.
16. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
17. Site-specific decrease of progesterone receptor mRNA expression in the hypothalamus of middle-aged persistently estrus rats. Mills RH, etal., Brain Res 2002 Nov 15;955(1-2):200-6.
18. Hormonal regulation, localization, and functional activity of the progesterone receptor in granulosa cells of rat preovulatory follicles. Natraj U and Richards JS, Endocrinology. 1993 Aug;133(2):761-9.
19. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
20. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
21. Regulation of the progesterone receptor gene by gonadotropins and cyclic adenosine 3',5'-monophosphate in rat granulosa cells. Park-Sarge OK and Mayo KE, Endocrinology 1994 Feb;134(2):709-18.
22. Biological markers that predict clinical recurrence in ductal carcinoma in situ of the breast. Provenzano E, etal., Eur J Cancer. 2003 Mar;39(5):622-30.
23. Sex differences in progesterone receptor expression: a potential mechanism for estradiol-mediated sexual differentiation. Quadros PS, etal., Endocrinology 2002 Oct;143(10):3727-39.
24. GOA pipeline RGD automated data pipeline
25. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
26. Association between polymorphisms in the progesterone receptor gene and endometriosis. Treloar SA, etal., Mol Hum Reprod. 2005 Sep;11(9):641-7. Epub 2005 Aug 26.
27. Progesterone regulation of the progesterone receptor in rat gonadotropes. Turgeon JL and Waring DW, Endocrinology. 2000 Sep;141(9):3422-9.
28. Progestin activation of nongenomic pathways via cross talk of progesterone receptor with estrogen receptor beta induces proliferation of endometrial stromal cells. Vallejo G, etal., Mol Endocrinol. 2005 Dec;19(12):3023-37. Epub 2005 Jul 14.
29. Correlates of obesity in postmenopausal women with breast cancer: comparison of genetic, demographic, disease-related, life history and dietary factors. Wasserman L, etal., Int J Obes Relat Metab Disord. 2004 Jan;28(1):49-56.
30. Ultrastructural localization of extranuclear progestin receptors in the rat hippocampal formation. Waters EM, etal., J Comp Neurol. 2008 Nov 1;511(1):34-46. doi: 10.1002/cne.21826.
31. Progesterone receptors activation after acute cocaine administration. Wu HB, etal., Brain Res. 2006 Dec 18;1126(1):188-92. Epub 2006 Nov 15.
32. [The changes of estrogen receptor (ER) and progesterone receptor (PR) mRNAs in endometrium with endometriosis]. Zheng H, etal., Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2004 May;20(2):194-6.
33. Distribution and estrogen regulation of membrane progesterone receptor-beta in the female rat brain. Zuloaga DG, etal., Endocrinology. 2012 Sep;153(9):4432-43. doi: 10.1210/en.2012-1469. Epub 2012 Jul 9.
34. Disruption in the expression and immunolocalisation of steroid receptors and steroidogenic enzymes in letrozole-induced polycystic ovaries in rat. Zurvarra FM, etal., Reprod Fertil Dev. 2009;21(7):827-39.
Additional References at PubMed
PMID:1840636   PMID:8274433   PMID:10733525   PMID:11282275   PMID:11814428   PMID:11920725   PMID:12039952   PMID:12058073   PMID:12193379   PMID:12354672   PMID:12372000   PMID:12638125  
PMID:12771131   PMID:12897242   PMID:12952366   PMID:14671656   PMID:14681235   PMID:14763995   PMID:14764628   PMID:14765981   PMID:15189328   PMID:15219413   PMID:16176985   PMID:17277083  
PMID:17332059   PMID:17614295   PMID:17785366   PMID:17850461   PMID:17982270   PMID:18081559   PMID:18208546   PMID:18308846   PMID:18310454   PMID:18635654   PMID:18712784   PMID:18958180  
PMID:19506349   PMID:19818377   PMID:20375746   PMID:20535645   PMID:20555290   PMID:20660062   PMID:20702577   PMID:21119048   PMID:21695196   PMID:21981076   PMID:22326965   PMID:23153933  
PMID:23817898   PMID:23994211   PMID:24190884   PMID:24246438   PMID:24296318   PMID:24339918   PMID:24859236   PMID:24909783   PMID:25612677   PMID:30069875   PMID:31926947   PMID:34740365  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.286,072,673 - 6,131,552 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl86,072,673 - 6,131,344 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx810,003,167 - 10,062,099 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.088,300,792 - 8,359,726 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.086,329,892 - 6,388,768 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.087,128,656 - 7,187,796 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl87,128,656 - 7,187,796 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.087,113,895 - 7,172,761 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.485,784,717 - 5,845,901 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.185,784,716 - 5,845,901 (+)NCBI
Celera87,609,728 - 7,668,047 (+)NCBICelera
Cytogenetic Map8q11NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh3811101,029,624 - 101,129,813 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11101,029,624 - 101,129,813 (-)EnsemblGRCh38hg38GRCh38
GRCh3711100,900,355 - 101,000,544 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611100,414,313 - 100,506,465 (-)NCBINCBI36Build 36hg18NCBI36
Build 3411100,414,312 - 100,506,465NCBI
Celera1198,069,715 - 98,169,894 (-)NCBICelera
Cytogenetic Map11q22.1NCBI
HuRef1196,837,449 - 96,937,628 (-)NCBIHuRef
CHM1_111100,783,609 - 100,883,736 (-)NCBICHM1_1
T2T-CHM13v2.011101,039,187 - 101,139,328 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm3998,890,017 - 8,968,612 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl98,899,834 - 8,968,612 (+)EnsemblGRCm39 Ensembl
GRCm3898,898,900 - 8,968,611 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl98,899,833 - 8,968,611 (+)EnsemblGRCm38mm10GRCm38
MGSCv3798,899,833 - 8,968,611 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3698,862,303 - 8,926,995 (+)NCBIMGSCv36mm8
Celera96,279,529 - 6,348,253 (+)NCBICelera
Cytogenetic Map9A1NCBI
cM Map92.46NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0NW_0049554124,643,839 - 4,693,478 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan111102,925,904 - 103,028,120 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01195,997,677 - 96,098,866 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11199,508,571 - 99,598,020 (-)NCBIpanpan1.1PanPan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.121447,197 - 552,511 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl21447,319 - 552,511 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha21461,376 - 566,187 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.021609,104 - 717,242 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl21609,104 - 742,638 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.121392,996 - 497,928 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.021478,480 - 583,792 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.021532,736 - 637,643 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440494784,948,508 - 85,038,416 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365516,498,553 - 6,573,222 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365516,498,553 - 6,573,212 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl932,035,684 - 32,129,221 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1932,035,684 - 32,129,776 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2936,044,789 - 36,138,540 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap9p13-p11NCBI
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1192,420,970 - 92,519,128 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl192,430,453 - 92,517,296 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604333,353,079 - 33,447,583 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046248781,714,559 - 1,762,421 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248781,714,196 - 1,769,302 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Pgr
245 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:135
Count of miRNA genes:109
Interacting mature miRNAs:125
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590084Insglur5Insulin/glucose ratio QTL 518.540.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)8124597739Rat
2317882Alcrsp24Alcohol response QTL 243.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)8125902202Rat
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)8209764047097640Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)8209764047097640Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)8209764047097640Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)8209764047097640Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)8470581049705810Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)8470581049705810Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)8470581049705810Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.286,118,296 - 6,118,502 (+)MAPPERmRatBN7.2
Rnor_6.087,174,420 - 7,174,625NCBIRnor6.0
Rnor_5.087,159,385 - 7,159,590UniSTSRnor5.0
RGSC_v3.485,832,646 - 5,832,851UniSTSRGSC3.4
Celera87,654,792 - 7,654,997UniSTS
RH 3.4 Map80.0UniSTS
Cytogenetic Map8q11UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.286,131,303 - 6,131,491 (+)MAPPERmRatBN7.2
Rnor_6.087,187,548 - 7,187,735NCBIRnor6.0
Rnor_5.087,172,513 - 7,172,700UniSTSRnor5.0
RGSC_v3.485,845,653 - 5,845,840UniSTSRGSC3.4
Celera87,667,799 - 7,667,986UniSTS
Cytogenetic Map8q11UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.286,113,844 - 6,113,968 (+)MAPPERmRatBN7.2
Rnor_6.087,169,968 - 7,170,091NCBIRnor6.0
Rnor_5.087,154,933 - 7,155,056UniSTSRnor5.0
RGSC_v3.485,828,194 - 5,828,317UniSTSRGSC3.4
Celera87,650,340 - 7,650,463UniSTS
Cytogenetic Map8q11UniSTS

Related Rat Strains
The following Strains have been annotated to Pgr


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 8 7
Low 14 8 56 34 23 9
Below cutoff 16 11 9 8 9 6 6 8 1 5 2 6


RefSeq Acc Id: ENSRNOT00000038313   ⟹   ENSRNOP00000032053
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl86,072,673 - 6,131,344 (+)Ensembl
Rnor_6.0 Ensembl87,128,656 - 7,187,796 (+)Ensembl
RefSeq Acc Id: NM_022847   ⟹   NP_074038
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
mRatBN7.286,072,673 - 6,131,552 (+)NCBI
Rnor_6.087,128,656 - 7,187,796 (+)NCBI
Rnor_5.087,113,895 - 7,172,761 (+)NCBI
RGSC_v3.485,784,717 - 5,845,901 (+)RGD
Celera87,609,728 - 7,668,047 (+)RGD
RefSeq Acc Id: NP_074038   ⟸   NM_022847
- UniProtKB: Q63449 (UniProtKB/Swiss-Prot),   F7FA48 (UniProtKB/TrEMBL),   E0YJE7 (UniProtKB/TrEMBL),   E0YJE6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000032053   ⟸   ENSRNOT00000038313
Protein Domains
NR LBD   Nuclear receptor

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63449-F1-model_v2 AlphaFold Q63449 1-923 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3317 AgrOrtholog
BioCyc Gene G2FUF-31749 BioCyc
Ensembl Genes ENSRNOG00000006831 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000038313 ENTREZGENE
  ENSRNOT00000038313.5 UniProtKB/TrEMBL
Gene3D-CATH 1.10.565.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro NHR-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nucl_hrmn_rcpt_lig-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nuclear_hrmn_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Progest_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_hrmn_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_NHR/GATA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25154 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Hormone_recep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prog_receptor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  zf-C4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pgr PhenoGen
  NUCLEAR_REC_DBD_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NUCLEAR_REC_DBD_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000006831 RatGTEx
SMART HOLI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZnF_C4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48508 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt Secondary F7FA48 UniProtKB/TrEMBL

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Pgr  Progesterone receptor      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains promoter region +461 to +675 contains an estrogen responsive element-like region 625704
gene_drugs aromatase inhibitor 1,4,6-androstatriene-3,17-dione reduces PRir in fetal males 625704
gene_expression immunoreactivity higher in new born males than females in the anteroventral periventricular nucleus (AVPv) and medial preoptic nucleus(MPN) regions 625704
gene_function nuclear hormone receptor and transcription factor 625704
gene_process reduces glutamic acid decarboxylase-67 (GAD(67)) mRNA in the hypothalamus 729543
gene_process involved in the regulation of gene expression 625704
gene_process may contribute to the sex differences in brain affecting gene expression in nervous system 625704
gene_regulation prenatal exposure to either testosterone propionate or synthetic estrogen increases progesterone receptor expression (PRir) in fetal females; aromatization of testosterone to estrogen important for sex difference in PR expression 625704
gene_transcript multiple mRNA transcripts are transcribed from the gene with two isoforms found expressed in rat 625704
gene_transcript gene contains two distinct promoter regions from -131 to +65 and from +461 to +675 625704