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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3317
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pgr
Name: progesterone receptor
Acc ID: CHEBI:81584
Term: 2,2',4,4'-Tetrabromodiphenyl ether
Definition: An organobromine compound that has formula C12H6Br4O.
Chemical ID: MESH:C511295
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pgrincreases expressionISOPGR (Homo sapiens)6480464CTD2,2',4,4'-tetrabromodiphenyl ether results in increased expression of PGR mRNAPMID:30796839
Pgrmultiple interactionsISOPGR (Homo sapiens)6480464CTD2,2',4,4'-tetrabromodiphenyl ether analog binds to and results in decreased activity of PGR protein; 2,2',4,4'-tetrabromodiphenyl ether binds to and results in decreased activity of PGR protein; [2,2',4,4'-tetrabromodiphenyl ether co-treated with hexabrominated diphenyl ether 153 co-treated with pentabrominated diphenyl ether 100] results in increased expression of PGR mRNA; Fulvestrant inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased expression of PGR mRNA]PMID:16601080 PMID:23398518 PMID:30796839
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