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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3317
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pgr
Name: progesterone receptor
Acc ID: CHEBI:73390
Term: promegestone
Definition: A progestin consisting of 17beta-propionylestra-4,9-dien-3-one substituted at position 17 by a methyl group.
Chemical ID: MESH:D011397
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pgraffects localizationEXP 6480464CTDPromegestone affects the localization of PGR protein

PMID:16020483
Pgraffects bindingISORGD:7310816480464CTDPromegestone binds to PGR protein

PMID:23765520
Pgrincreases activityISORGD:7310816480464CTDPromegestone results in increased activity of PGR protein

PMID:15103026 PMID:20008677 PMID:30951782
Pgrincreases uptakeISORGD:7310816480464CTDPGR protein results in increased uptake of Promegestone

PMID:21795739
Pgrmultiple interactionsISORGD:110926480464CTDPGR protein promotes the reaction [Promegestone results in increased expression of FSHB mRNA]

PMID:16675544
Pgrmultiple interactionsISORGD:7310816480464CTD1 1-bis4-hydroxyphenylcyclohexane inhibits the reaction [Promegestone results in increased activity of PGR protein] Bortezomib inhibits the reaction [Promegestone results in increased activity of PGR protein] carfilzomib inhibits the reaction [Promegestone results in increased activity of PGR protein] Decitabine inhibits the reaction [Promegestone results in increased activity of PGR protein] fenpyroximate inhibits the reaction [Promegestone results in increased activity of PGR protein] fluoxastrobin inhibits the reaction [Promegestone results in increased activity of PGR protein] kresoxim-methyl inhibits the reaction [Promegestone results in increased activity of PGR protein] methoxyacetic acid promotes the reaction [Promegestone results in increased activity of PGR protein] metoprine inhibits the reaction [Promegestone results in increased activity of PGR protein] Mifepristone inhibits the reaction [methoxyacetic acid promotes the reaction [Promegestone results in increased activity of PGR protein]] picoxystrobin inhibits the reaction [Promegestone results in increased activity of PGR protein] Proflavine inhibits the reaction [Promegestone results in increased activity of PGR protein] Promegestone promotes the reaction [ARID1A protein binds to PGR protein] Promegestone promotes the reaction [SMARCE1 protein binds to PGR protein] pyrachlostrobin inhibits the reaction [Promegestone results in increased activity of PGR protein] pyridaben inhibits the reaction [Promegestone results in increased activity of PGR protein] Rotenone inhibits the reaction [Promegestone results in increased activity of PGR protein] ST 1481 inhibits the reaction [Promegestone results in increased activity of PGR protein] trifloxystrobin inhibits the reaction [Promegestone results in increased activity of PGR protein] U 0126 inhibits the reaction [methoxyacetic acid promotes the reaction [Promegestone results in increased activity of PGR protein]] Vorinostat inhibits the reaction [Promegestone results in increased activity of PGR protein] ZNF366 protein inhibits the reaction [Promegestone results in increased activity of PGR protein]

PMID:15103026 PMID:18486176 PMID:19609353 PMID:20008677 PMID:30818834 PMID:30951782
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