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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3317
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pgr
Name: progesterone receptor
Acc ID: CHEBI:27563
Term: arsenic atom
Definition: A pnictogen that has formula As.
Chemical ID: MESH:D001151
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pgraffects expressionISOPGR (Homo sapiens)6480464CTDArsenic affects the expression of PGR mRNAPMID:33047385
Pgrdecreases expressionISOPGR (Homo sapiens)6480464CTDArsenic results in decreased expression of PGR protein; Arsenic results in decreased expression of PGR protein alternative formPMID:33047385
Pgrmultiple interactionsISOPGR (Homo sapiens)6480464CTD[Metals, Heavy results in increased abundance of Arsenic] which results in increased expression of PGR mRNA; Arsenic inhibits the reaction [Estradiol results in increased expression of PGR mRNA]; Arsenic inhibits the reaction [Estradiol results in increased expression of PGR protein]; Estradiol affects the reaction [Arsenic affects the expression of PGR mRNA]PMID:29111618 PMID:33047385
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