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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3317
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pgr
Name: progesterone receptor
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pgrincreases methylationISOPGR (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of PGR exon; Benzo(a)pyrene results in increased methylation of PGR promoterPMID:27901495
Pgrmultiple interactionsISOPGR (Homo sapiens)6480464CTDBenzo(a)pyrene inhibits the reaction [16 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3,20-dione results in increased activity of PGR protein]; Benzo(a)pyrene inhibits the reaction [Estradiol results in increased expression of PGR mRNA]PMID:10822009 PMID:26022396
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