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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3317
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pgr
Name: progesterone receptor
Acc ID: CHEBI:10106
Term: zearalenone
Definition: A macrolide comprising a fourteen-membered lactone fused to 1,3-dihydroxybenzene; a potent estrogenic metabolite produced by some Giberella species.
Chemical ID: MESH:D015025
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pgrincreases expressionISOPGR (Homo sapiens)6480464CTDZearalenone results in increased expression of PGR mRNA; Zearalenone results in increased expression of PGR proteinPMID:19371625 PMID:21803136 PMID:28807876 PMID:28965971 PMID:35588983
Pgrmultiple interactionsISOPGR (Homo sapiens)6480464CTDdeoxynivalenol promotes the reaction [Zearalenone results in increased expression of PGR mRNA]; Fulvestrant inhibits the reaction [Zearalenone results in increased expression of PGR protein]; PPARG inhibits the reaction [Zearalenone results in increased expression of PGR mRNA]; Zearalenone inhibits the reaction [Progesterone binds to and results in increased activity of PGR protein]PMID:21803136 PMID:35588983
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