Gene: P3h3 (prolyl 3-hydroxylase 3) Rattus norvegicus
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Symbol: P3h3
Name: prolyl 3-hydroxylase 3
Description: ENCODES a protein that exhibits iron ion binding (inferred); L-ascorbic acid binding (inferred); INVOLVED IN collagen biosynthetic process (ortholog); negative regulation of cell population proliferation (ortholog); peptidyl-lysine hydroxylation (ortholog); ASSOCIATED WITH hyperphosphatemic familial tumoral calcinosis (ortholog); osteoarthritis (ortholog); FOUND IN catalytic complex (ortholog); INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 17alpha-ethynylestradiol; 6-propyl-2-thiouracil
AGR Description: Predicted to have procollagen-proline 3-dioxygenase activity; predicted to be involved in collagen biosynthetic process, negative regulation of cell population proliferation, and peptidyl-lysine hydroxylation; predicted to localize to the catalytic complex and endoplasmic reticulum; orthologous to human P3H3 (prolyl 3-hydroxylase 3).
Merged Description: Predicted to have procollagen-proline 3-dioxygenase activity; predicted to be involved in collagen biosynthetic process, negative regulation of cell population proliferation, and peptidyl-lysine hydroxylation; predicted to localize to the catalytic complex and endoplasmic reticulum; orthologous to human P3H3 (prolyl 3-hydroxylase 3); INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 17alpha-ethynylestradiol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: leprecan-like 2; Leprel2; LOC297595; MGC189333
Orthologs:
Homo sapiens (human) : P3H3 (prolyl 3-hydroxylase 3)  HGNC  Alliance
Mus musculus (house mouse) : P3h3 (prolyl 3-hydroxylase 3)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : P3h3 (prolyl 3-hydroxylase 3)
Pan paniscus (bonobo/pygmy chimpanzee) : P3H3 (prolyl 3-hydroxylase 3)
Canis lupus familiaris (dog) : P3H3 (prolyl 3-hydroxylase 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : P3h3 (prolyl 3-hydroxylase 3)
Sus scrofa (pig) : P3H3 (prolyl 3-hydroxylase 3)
more info ...
Allele / Splice: P3h3Tn(sb-T2/Bart3)2.310Mcwi  
Genetic Models: F344-P3h3Tn(sb-T2/Bart3)2.310Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.04157,359,331 - 157,375,186 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04224,377,005 - 224,392,881 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44160,964,297 - 160,978,321 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14161,209,590 - 161,225,134 (-)NCBI
Celera4146,384,156 - 146,397,672 (-)NCBICelera
Cytogenetic Map4q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
 
More on P3h3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1305699
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-04-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.