Atp5f1a (ATP synthase F1 subunit alpha) - Rat Genome Database

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Gene: Atp5f1a (ATP synthase F1 subunit alpha) Rattus norvegicus
Analyze
Symbol: Atp5f1a
Name: ATP synthase F1 subunit alpha
RGD ID: 619993
Description: Exhibits ADP binding activity; ATP binding activity; and protease binding activity. Contributes to ATPase activity. Involved in several processes, including cellular response to dexamethasone stimulus; cellular response to nitric oxide; and response to muscle activity. Localizes to several cellular components, including cell surface; membrane raft; and mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1). Predicted to colocalize with COP9 signalosome. Used to study non-alcoholic fatty liver disease and pulmonary hypertension. Biomarker of Alzheimer's disease and hypertension. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 22 and mitochondrial complex V (ATP synthase) deficiency nuclear type 4. Orthologous to human ATP5F1A (ATP synthase F1 subunit alpha); PARTICIPATES IN electron transport chain pathway; Alzheimer's disease pathway; Huntington's disease pathway; INTERACTS WITH (R)-adrenaline; (S)-nicotine; 1,2,4-trimethylbenzene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: ATP synthase subunit alpha, mitochondrial; ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle; ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit, isoform 1; atp synthase, h+ transporting, mitochondrial f1 complex, alpha subunit, isoform 1.; Atp5a1; mitochondrial H+-ATP synthase alpha subunit
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21871,292,406 - 71,300,342 (+)NCBI
Rnor_6.0 Ensembl1874,156,553 - 74,164,495 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01874,156,553 - 74,164,490 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01873,830,604 - 73,838,477 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41874,735,267 - 74,743,088 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11874,808,539 - 74,816,361 (+)NCBI
Celera1869,811,132 - 69,819,068 (+)NCBICelera
Cytogenetic Map18q12.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-dexrazoxane  (ISO)
(R)-adrenaline  (EXP)
(S)-nicotine  (EXP)
(Z)-3-butylidenephthalide  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2,2-tetramine  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2,6-dinitrotoluene  (EXP)
2-tert-butylhydroquinone  (EXP)
3,3'-diindolylmethane  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4-hydroxynon-2-enal  (ISO)
5-Hydroxythalidomide  (ISO)
7,12-dimethyltetraphene  (EXP)
7H-xanthine  (EXP)
9H-xanthine  (EXP)
acrolein  (ISO)
aldehydo-D-glucose  (EXP)
alpha-D-galactose  (EXP)
ammonium chloride  (EXP)
amphetamine  (ISO)
arsenous acid  (ISO)
atrazine  (EXP,ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium dichloride  (EXP)
carbon nanotube  (ISO)
chloropicrin  (ISO)
chromium(6+)  (ISO)
cisplatin  (EXP)
clobetasol  (ISO)
cocaine  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
D-glucose  (EXP)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (EXP)
diclofenac  (EXP)
dihydroartemisinin  (ISO)
dioxygen  (ISO)
doxorubicin  (EXP,ISO)
enzyme inhibitor  (ISO)
ethanol  (EXP,ISO)
flavonoids  (EXP)
flutamide  (ISO)
folic acid  (ISO)
folpet  (ISO)
galactose  (EXP)
gentamycin  (EXP)
glucose  (EXP)
hyaluronic acid  (EXP)
hydrogen peroxide  (EXP,ISO)
indometacin  (ISO)
isoflavones  (EXP)
isoprenaline  (ISO)
maneb  (ISO)
methanol  (EXP)
minocycline  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosomorpholine  (EXP)
naphthalene  (ISO)
niclosamide  (ISO)
nicotine  (EXP)
nitroglycerin  (EXP)
ochratoxin A  (EXP)
okadaic acid  (ISO)
ouabain  (ISO)
oxybenzone  (EXP)
ozone  (EXP)
paracetamol  (ISO)
paraquat  (ISO)
PCB138  (EXP)
permethrin  (EXP)
phenobarbital  (ISO)
phlorizin  (ISO)
Pyridostigmine bromide  (EXP)
pyruvic acid  (EXP)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
streptozocin  (EXP)
sunitinib  (ISO)
T-2 toxin  (EXP)
tamoxifen  (ISO)
tanespimycin  (ISO)
tetrachloromethane  (EXP)
thapsigargin  (ISO)
toluene  (EXP)
trichloroethene  (EXP)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
1. Bertrand J, etal., Proteomics. 2015 Jul;15(13):2198-210. doi: 10.1002/pmic.201400304. Epub 2015 Mar 17.
2. Bianchet M, etal., J Biol Chem. 1991 Nov 5;266(31):21197-201.
3. Brulé C, etal., Biochimie. 2010 Dec;92(12):1923-33. doi: 10.1016/j.biochi.2010.09.003. Epub 2010 Sep 17.
4. Capitanio D, etal., Proteomics. 2016 Feb;16(4):645-56. doi: 10.1002/pmic.201500395.
5. Chen J, etal., OMICS. 2012 Mar;16(3):98-104. doi: 10.1089/omi.2011.0023.
6. Chomova M, etal., Mol Cell Biochem. 2017 Nov;435(1-2):109-131. doi: 10.1007/s11010-017-3061-6. Epub 2017 May 19.
7. Datta A, etal., J Proteomics. 2014 Mar 17;99:54-67. doi: 10.1016/j.jprot.2014.01.011. Epub 2014 Jan 19.
8. de Souza AP, etal., Proteome Sci. 2015 Dec 2;13:32. doi: 10.1186/s12953-015-0088-z. eCollection 2015.
9. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. GOA data from the GO Consortium
11. Jungebluth P, etal., Cell Transplant. 2011;20(10):1561-74. doi: 10.3727/096368910X557254. Epub 2011 Mar 7.
12. KEGG
13. Ko YH, etal., J Biol Chem. 2000 Oct 20;275(42):32931-9.
14. Kumar V, etal., Sci Rep. 2019 Sep 11;9(1):13170. doi: 10.1038/s41598-019-49666-0.
15. Ledesma MD, etal., Brain Res. 2003 Oct 10;987(1):107-16.
16. Lee JH, etal., J Biol Chem 1990 Mar 15;265(8):4664-9.
17. Mailloux RJ, etal., PLoS One. 2014 Sep 15;9(9):e106832. doi: 10.1371/journal.pone.0106832. eCollection 2014.
18. Meyer B, etal., Mol Cell Proteomics. 2007 Oct;6(10):1690-9. Epub 2007 Jun 17.
19. MGD data from the GO Consortium
20. NCBI rat LocusLink and RefSeq merged data July 26, 2002
21. Nicoletti VG, etal., Neurochem Res. 2005 Jun-Jul;30(6-7):737-52.
22. OMIM Disease Annotation Pipeline
23. Osanai T, etal., Cardiovasc Res. 2009 Mar 1;81(4):780-7. doi: 10.1093/cvr/cvn356. Epub 2008 Dec 22.
24. Pedersen PL, etal., Biochemistry. 1987 Dec 29;26(26):8631-7.
25. Pipeline to import KEGG annotations from KEGG into RGD
26. Pipeline to import SMPDB annotations from SMPDB into RGD
27. Ramm S, etal., Toxicology. 2015 May 4;331:100-11. doi: 10.1016/j.tox.2015.03.004. Epub 2015 Mar 13.
28. Reed TT, etal., Brain Res. 2009 Jun 5;1274:66-76. doi: 10.1016/j.brainres.2009.04.009. Epub 2009 Apr 15.
29. RGD automated data pipeline
30. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
31. RGD automated import pipeline for gene-chemical interactions
32. Severino V, etal., J Proteome Res. 2011 Jul 1;10(7):3212-24. Epub 2011 Jun 1.
33. Singh S and Khar A, Apoptosis. 2005 Dec;10(6):1469-82. doi: 10.1007/s10495-005-1394-1.
34. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
35. Sun B, etal., Comp Biochem Physiol Part D Genomics Proteomics. 2008 Mar;3(1):108-17. doi: 10.1016/j.cbd.2007.11.001. Epub 2007 Dec 3.
36. Tang Y, etal., Cardiovasc Pathol. 2013 Nov 14. pii: S1054-8807(13)00200-7. doi: 10.1016/j.carpath.2013.11.002.
37. Tapia-Limonchi R, etal., Islets. 2014;6(5-6):e995997. doi: 10.1080/19382014.2014.995997.
38. Zali H, etal., Iran J Pharm Res. 2015 Winter;14(1):291-302.
39. Zhang S, etal., Toxicol Appl Pharmacol. 2005 Jan 1;202(1):13-7.
Additional References at PubMed
PMID:7916601   PMID:9736690   PMID:10077593   PMID:12110673   PMID:12865426   PMID:14651853   PMID:15489334   PMID:16778019   PMID:16854843   PMID:17387143   PMID:17612527   PMID:17634366  
PMID:17643490   PMID:18614015   PMID:18850735   PMID:19016746   PMID:19056867   PMID:19808025   PMID:19946888   PMID:20080761   PMID:20833797   PMID:21106936   PMID:21950801   PMID:22082260  
PMID:22658674   PMID:23376485   PMID:23533145   PMID:23979707   PMID:24625528   PMID:25931508   PMID:26767982   PMID:26769832   PMID:29476059   PMID:29867124  


Genomics

Comparative Map Data
Atp5f1a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21871,292,406 - 71,300,342 (+)NCBI
Rnor_6.0 Ensembl1874,156,553 - 74,164,495 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01874,156,553 - 74,164,490 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01873,830,604 - 73,838,477 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41874,735,267 - 74,743,088 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11874,808,539 - 74,816,361 (+)NCBI
Celera1869,811,132 - 69,819,068 (+)NCBICelera
Cytogenetic Map18q12.3NCBI
ATP5F1A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1846,080,248 - 46,104,334 (-)EnsemblGRCh38hg38GRCh38
GRCh381846,080,248 - 46,104,227 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371843,660,214 - 43,684,193 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361841,918,108 - 41,938,197 (-)NCBINCBI36hg18NCBI36
Build 341841,918,107 - 41,932,285NCBI
Celera1840,472,298 - 40,486,450 (-)NCBI
Cytogenetic Map18q21.1NCBI
HuRef1840,521,726 - 40,541,788 (-)NCBIHuRef
CHM1_11843,591,321 - 43,611,335 (-)NCBICHM1_1
Atp5a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391877,861,468 - 77,870,569 (+)NCBIGRCm39mm39
GRCm39 Ensembl1877,861,429 - 77,870,569 (+)Ensembl
GRCm381877,773,768 - 77,782,869 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1877,773,729 - 77,782,869 (+)EnsemblGRCm38mm10GRCm38
MGSCv371878,012,507 - 78,021,608 (+)NCBIGRCm37mm9NCBIm37
MGSCv361877,978,093 - 77,986,942 (+)NCBImm8
Celera1878,959,749 - 78,968,850 (+)NCBICelera
Cytogenetic Map18E3NCBI
cM Map1852.38NCBI
Atp5f1a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540231,651,960 - 31,662,762 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540231,652,226 - 31,662,114 (-)NCBIChiLan1.0ChiLan1.0
ATP5F1A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11842,904,136 - 42,918,626 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1842,904,136 - 42,923,326 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01839,366,384 - 39,380,514 (-)NCBIMhudiblu_PPA_v0panPan3
ATP5F1A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1745,118,188 - 45,127,048 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl745,117,657 - 45,127,048 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha744,600,134 - 44,608,995 (+)NCBI
ROS_Cfam_1.0745,071,120 - 45,079,950 (+)NCBI
UMICH_Zoey_3.1744,770,243 - 44,779,076 (+)NCBI
UNSW_CanFamBas_1.0744,823,645 - 44,832,526 (+)NCBI
UU_Cfam_GSD_1.0745,108,044 - 45,116,902 (+)NCBI
Atp5f1a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494441,415,655 - 41,425,434 (+)NCBI
SpeTri2.0NW_004936517743,036 - 752,836 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ATP5F1A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl195,625,800 - 95,750,875 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1195,738,789 - 95,750,835 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21105,944,306 - 105,955,798 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ATP5F1A
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11834,815,924 - 34,828,052 (+)NCBI
ChlSab1.1 Ensembl1834,816,027 - 34,830,924 (+)Ensembl
Atp5f1a
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247789,773,365 - 9,784,564 (-)NCBI

Position Markers
D16S2555E  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map18q12.3UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181569587287080053Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181569587287080053Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)182028575887080053Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182260373687074531Rat
1331733Bp233Blood pressure QTL 2333.97196arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182596102681761656Rat
2300157Bmd66Bone mineral density QTL 6613.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)183053361475533614Rat
2300177Bmd65Bone mineral density QTL 6519.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)183053361475533614Rat
2293704Bss35Bone structure and strength QTL 354.590.0002femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)183053361475533614Rat
9590318Scort22Serum corticosterone level QTL 227.640.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)183136134176361341Rat
1331754Bp230Blood pressure QTL 2304.61609arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183136134176361341Rat
9589816Gluco68Glucose level QTL 687.250.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)183136134176361341Rat
8694378Bw157Body weight QTL 1573.590.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)183136134176361341Rat
738005Anxrr11Anxiety related response QTL 113.4exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)183160842476608424Rat
2303120Mamtr8Mammary tumor resistance QTL 80.001mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)183267035287080053Rat
631274Sprol1Serum protein level QTL 15.3blood total protein amount (VT:0005567)serum total protein level (CMO:0000661)183270402280696226Rat
631518Bw11Body weight QTL 112.8body mass (VT:0001259)body weight (CMO:0000012)183822191983221919Rat
61367Iddm4Insulin dependent diabetes mellitus QTL 42.330.0074blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)184037576985375769Rat
6893683Bw110Body weight QTL 1102.70.002body mass (VT:0001259)body weight (CMO:0000012)184500219488201929Rat
1598826Anxrr20Anxiety related response QTL 203.04body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)184631947688201929Rat
9589041Epfw12Epididymal fat weight QTL 1217.080.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)184913092088201929Rat
8694432Bw165Body weight QTL 1653.810.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)184913092088201929Rat
8694366Abfw8Abdominal fat weight QTL 86.380.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)184913092088201929Rat
2303571Bw92Body weight QTL 923body mass (VT:0001259)body weight (CMO:0000012)185137581688201929Rat
2303584Gluco55Glucose level QTL 552blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)185137581688201929Rat
738008Hcar14Hepatocarcinoma resistance QTL 144.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion number (CMO:0001462)185303349487080053Rat
1359020Ppulsi2Prepulse inhibition QTL 22.71prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)185386125277151443Rat
2301417Bp319Blood pressure QTL 3190.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)185410837579575348Rat
12880368Bw187Body weight QTL 1870.045body mass (VT:0001259)body weight (CMO:0000012)185410837579575348Rat
12904067Cm122Cardiac mass QTL 1220.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)185410837579575348Rat
12904069Cm123Cardiac mass QTL 1230.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)185410837579575348Rat
12904070Cm124Cardiac mass QTL 1240.01heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)185410837579575348Rat
12904071Am18Aortic mass QTL 180.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)185410837579575348Rat
12904073Kidm71Kidney mass QTL 710.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)185410837579575348Rat
1558649Bw58Body weight QTL 583.40.0005body mass (VT:0001259)body weight (CMO:0000012)185744867888201929Rat
6893359Bw103Body weight QTL 1031.20.12body mass (VT:0001259)body weight (CMO:0000012)185744867888201929Rat
6893368Bw107Body weight QTL 1070.30.5body mass (VT:0001259)body weight (CMO:0000012)185744867888201929Rat
1298072Cia26Collagen induced arthritis QTL 263.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)185819630088201929Rat
70185BpQTLcluster15Blood pressure QTL cluster 154.61arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)186190135479948616Rat
70185BpQTLcluster15Blood pressure QTL cluster 154.61arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)186190135479948616Rat
70185BpQTLcluster15Blood pressure QTL cluster 154.61arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)186190135479948616Rat
70185BpQTLcluster15Blood pressure QTL cluster 154.61arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)186190135479948616Rat
2301969Bp324Blood pressure QTL 3244.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)186190135479948616Rat
6903356Bp354Blood pressure QTL 3544.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)186198564888201929Rat
631675Iddm15Insulin dependent diabetes mellitus QTL 15urine glucose amount (VT:0001758)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)186280540680696375Rat
61384Bp48Blood pressure QTL 4819.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)186280540680696375Rat
724542Kidm2Kidney mass QTL 22.6kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)186300981288201929Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:31
Count of miRNA genes:31
Interacting mature miRNAs:31
Transcripts:ENSRNOT00000022892
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 1 49 8 11 2 29 8
Medium 2 57 41 19 41 72 6 41 11
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000022892   ⟹   ENSRNOP00000022892
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1874,156,553 - 74,164,495 (+)Ensembl
RefSeq Acc Id: NM_023093   ⟹   NP_075581
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21871,292,406 - 71,300,342 (+)NCBI
Rnor_6.01874,156,553 - 74,164,490 (+)NCBI
Rnor_5.01873,830,604 - 73,838,477 (+)NCBI
RGSC_v3.41874,735,267 - 74,743,088 (+)RGD
Celera1869,811,132 - 69,819,068 (+)RGD
Sequence:
Reference Sequences
RefSeq Acc Id: NP_075581   ⟸   NM_023093
- Peptide Label: precursor
- UniProtKB: P15999 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000022892   ⟸   ENSRNOT00000022892
Protein Domains
ATP-synt_ab   ATP-synt_ab_C   ATP-synt_ab_N

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700881
Promoter ID:EPDNEW_R11403
Type:initiation region
Name:Atp5f1a_1
Description:ATP synthase F1 subunit alpha
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01874,156,549 - 74,156,609EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619993 AgrOrtholog
Ensembl Genes ENSRNOG00000017032 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000022892 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000022892 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 1.20.150.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.40.30.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5599635 IMAGE-MGC_LOAD
InterPro ATP_synth_asu-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATP_synth_asu_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATP_synth_asu_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATP_synth_F1_a UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATP_synth_F1_asu UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATPase_a/bsu_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATPase_F1/V1/A1_a/bsu_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATPase_F1/V1/A1_a/bsu_N_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATPase_F1/V1/A1_a/bsu_nucl-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:65262 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72613 IMAGE-MGC_LOAD
NCBI Gene 65262 ENTREZGENE
Pfam ATP-synt_ab UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATP-synt_ab_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATP-synt_ab_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Atp5f1a PhenoGen
PIRSF F_ATPase_subunit_alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ATPASE_ALPHA_BETA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50615 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs atpA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt ATPA_RAT UniProtKB/Swiss-Prot
  F1LP05_RAT UniProtKB/TrEMBL
  P15999 ENTREZGENE
UniProt Secondary Q6P753 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-11-30 Atp5f1a  ATP synthase F1 subunit alpha  Atp5a1  ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-06-27 Atp5a1  ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle  Atp5a1  ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit, isoform 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Atp5a1  ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit, isoform 1.    mitochondrial H+-ATP synthase alpha subunit  Name updated 1299863 APPROVED
2002-08-07 Atp5a1  mitochondrial H+-ATP synthase alpha subunit      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_protein 510 amino acids (mature protein); 55.2 kDa; pI 8.8 727262