Atp5f1a (ATP synthase F1 subunit alpha) - Rat Genome Database

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Gene: Atp5f1a (ATP synthase F1 subunit alpha) Rattus norvegicus
Analyze
Symbol: Atp5f1a
Name: ATP synthase F1 subunit alpha
RGD ID: 619993
Description: Enables ADP binding activity; ATP binding activity; and protease binding activity. Contributes to ATP hydrolysis activity. Involved in several processes, including cellular response to dexamethasone stimulus; cellular response to nitric oxide; and response to muscle activity. Located in cell surface; membrane raft; and mitochondrial inner membrane. Part of mitochondrial proton-transporting ATP synthase complex and proton-transporting ATP synthase complex, catalytic core F(1). Used to study metabolic dysfunction-associated steatotic liver disease and pulmonary hypertension. Biomarker of Alzheimer's disease and hypertension. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 22; mitochondrial complex V (ATP synthase) deficiency nuclear type 4A; and mitochondrial complex V (ATP synthase) deficiency nuclear type 4B. Orthologous to human ATP5F1A (ATP synthase F1 subunit alpha); PARTICIPATES IN electron transport chain pathway; Alzheimer's disease pathway; Huntington's disease pathway; INTERACTS WITH (R)-adrenaline; (S)-nicotine; 1,2,4-trimethylbenzene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ATP synthase subunit alpha, mitochondrial; ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle; ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit, isoform 1; atp synthase, h+ transporting, mitochondrial f1 complex, alpha subunit, isoform 1.; Atp5a1; mitochondrial H+-ATP synthase alpha subunit
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81873,567,537 - 73,575,473 (+)NCBIGRCr8
mRatBN7.21871,292,406 - 71,300,342 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1871,292,374 - 71,300,794 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1873,391,830 - 73,399,766 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01874,061,095 - 74,069,031 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01871,917,686 - 71,925,622 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01874,156,553 - 74,164,490 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1874,156,553 - 74,164,495 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01873,830,604 - 73,838,477 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41874,735,267 - 74,743,088 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11874,808,539 - 74,816,361 (+)NCBI
Celera1869,811,132 - 69,819,068 (+)NCBICelera
Cytogenetic Map18q12.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-dexrazoxane  (ISO)
(R)-adrenaline  (EXP)
(S)-nicotine  (EXP)
(Z)-3-butylidenephthalide  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2,2-tetramine  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2,5-hexanedione  (EXP)
2,6-dinitrotoluene  (EXP)
2-methoxyethanol  (EXP)
2-tert-butylhydroquinone  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3'-diindolylmethane  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxynon-2-enal  (ISO)
5-Hydroxythalidomide  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (EXP)
7H-xanthine  (EXP)
9H-xanthine  (EXP)
acrolein  (ISO)
actinomycin D  (ISO)
aldehydo-D-glucose  (EXP)
alpha-D-galactose  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
amphetamine  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenic trichloride  (ISO)
arsenous acid  (ISO)
atrazine  (EXP,ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
cadmium dichloride  (EXP)
calycosin  (EXP,ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloropicrin  (ISO)
chromium(6+)  (ISO)
cisplatin  (EXP)
clobetasol  (ISO)
cocaine  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
corosolic acid  (ISO)
D-glucose  (EXP)
decabromodiphenyl ether  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibenzo[a,l]pyrene  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
diclofenac  (EXP)
dihydroartemisinin  (ISO)
dioxygen  (ISO)
doxorubicin  (EXP,ISO)
enzyme inhibitor  (ISO)
ethanol  (EXP,ISO)
fenvalerate  (EXP)
flavonoids  (EXP)
flutamide  (ISO)
folic acid  (ISO)
folpet  (ISO)
galactose  (EXP)
gentamycin  (EXP)
glucose  (EXP)
hyaluronic acid  (EXP)
hydrogen peroxide  (EXP,ISO)
indometacin  (ISO)
isoflavones  (EXP)
isopimaric acid  (ISO)
isoprenaline  (EXP,ISO)
ivermectin  (ISO)
lenvatinib  (EXP)
maneb  (ISO)
methanol  (EXP)
methimazole  (EXP)
minocycline  (ISO)
mitoxantrone  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-acetyl-L-cysteine  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosomorpholine  (EXP)
naphthalene  (ISO)
niclosamide  (ISO)
nicotine  (EXP)
nitroglycerin  (EXP)
Nivalenol  (ISO)
Nutlin-3  (ISO)
ochratoxin A  (EXP)
okadaic acid  (ISO)
ouabain  (ISO)
oxybenzone  (EXP)
ozone  (EXP)
paracetamol  (ISO)
paraquat  (ISO)
PCB138  (EXP)
permethrin  (EXP)
phenobarbital  (ISO)
phlorizin  (ISO)
pinostrobin  (ISO)
pramipexole  (EXP)
Pyridostigmine bromide  (EXP)
pyruvic acid  (EXP)
quercetin  (ISO)
regorafenib  (EXP)
resveratrol  (ISO)
rotenone  (EXP)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
streptozocin  (EXP)
sulfadimethoxine  (EXP)
sulfasalazine  (EXP)
sunitinib  (ISO)
T-2 toxin  (EXP)
tamoxifen  (ISO)
tanespimycin  (ISO)
tetrachloromethane  (EXP)
thapsigargin  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
toluene  (EXP)
trichloroethene  (EXP)
Triptolide  (EXP,ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Glutamine enema regulates colonic ubiquitinated proteins but not proteasome activities during TNBS-induced colitis leading to increased mitochondrial activity. Bertrand J, etal., Proteomics. 2015 Jul;15(13):2198-210. doi: 10.1002/pmic.201400304. Epub 2015 Mar 17.
2. Mitochondrial ATP synthase. Quaternary structure of the F1 moiety at 3.6 A determined by x-ray diffraction analysis. Bianchet M, etal., J Biol Chem. 1991 Nov 5;266(31):21197-201.
3. Proteomic study of calpain interacting proteins during skeletal muscle aging. Brulé C, etal., Biochimie. 2010 Dec;92(12):1923-33. doi: 10.1016/j.biochi.2010.09.003. Epub 2010 Sep 17.
4. Specific protein changes contribute to the differential muscle mass loss during ageing. Capitanio D, etal., Proteomics. 2016 Feb;16(4):645-56. doi: 10.1002/pmic.201500395.
5. Hypoxia affects mitochondrial protein expression in rat skeletal muscle. Chen J, etal., OMICS. 2012 Mar;16(3):98-104. doi: 10.1089/omi.2011.0023.
6. Diabetes-induced abnormalities of mitochondrial function in rat brain cortex: the effect of n-3 fatty acid diet. Chomova M, etal., Mol Cell Biochem. 2017 Nov;435(1-2):109-131. doi: 10.1007/s11010-017-3061-6. Epub 2017 May 19.
7. Novel pathophysiological markers are revealed by iTRAQ-based quantitative clinical proteomics approach in vascular dementia. Datta A, etal., J Proteomics. 2014 Mar 17;99:54-67. doi: 10.1016/j.jprot.2014.01.011. Epub 2014 Jan 19.
8. Gender-specific effects of intrauterine growth restriction on the adipose tissue of adult rats: a proteomic approach. de Souza AP, etal., Proteome Sci. 2015 Dec 2;13:32. doi: 10.1186/s12953-015-0088-z. eCollection 2015.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
11. Mesenchymal stem cells restore lung function by recruiting resident and nonresident proteins. Jungebluth P, etal., Cell Transplant. 2011;20(10):1561-74. doi: 10.3727/096368910X557254. Epub 2011 Mar 7.
12. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
13. Mitochondrial F(0)F(1) ATP synthase. Subunit regions on the F1 motor shielded by F(0), Functional significance, and evidence for an involvement of the unique F(0) subunit F(6). Ko YH, etal., J Biol Chem. 2000 Oct 20;275(42):32931-9.
14. Chronic Pressure Overload Results in Deficiency of Mitochondrial Membrane Transporter ABCB7 Which Contributes to Iron Overload, Mitochondrial Dysfunction, Metabolic Shift and Worsens Cardiac Function. Kumar V, etal., Sci Rep. 2019 Sep 11;9(1):13170. doi: 10.1038/s41598-019-49666-0.
15. Proteomic characterisation of neuronal sphingolipid-cholesterol microdomains: role in plasminogen activation. Ledesma MD, etal., Brain Res. 2003 Oct 10;987(1):107-16.
16. Mitochondrial ATP synthase. cDNA cloning, amino acid sequence, overexpression, and properties of the rat liver alpha subunit. Lee JH, etal., J Biol Chem 1990 Mar 15;265(8):4664-9.
17. Exposure to a northern contaminant mixture (NCM) alters hepatic energy and lipid metabolism exacerbating hepatic steatosis in obese JCR rats. Mailloux RJ, etal., PLoS One. 2014 Sep 15;9(9):e106832. doi: 10.1371/journal.pone.0106832. eCollection 2014.
18. Identification of two proteins associated with mammalian ATP synthase. Meyer B, etal., Mol Cell Proteomics. 2007 Oct;6(10):1690-9. Epub 2007 Jun 17.
19. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
20. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
21. Effect of antioxidant diets on mitochondrial gene expression in rat brain during aging. Nicoletti VG, etal., Neurochem Res. 2005 Jun-Jul;30(6-7):737-52.
22. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
23. Coupling factor 6 enhances Src-mediated responsiveness to angiotensin II in resistance arterioles and cells. Osanai T, etal., Cardiovasc Res. 2009 Mar 1;81(4):780-7. doi: 10.1093/cvr/cvn356. Epub 2008 Dec 22.
24. Mitochondrial ATP synthase: dramatic Mg2+-induced alterations in the structure and function of the F1-ATPase moiety. Pedersen PL, etal., Biochemistry. 1987 Dec 29;26(26):8631-7.
25. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
26. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
27. Application of a discovery to targeted LC-MS proteomics approach to identify deregulated proteins associated with idiosyncratic liver toxicity in a rat model of LPS/diclofenac co-administration. Ramm S, etal., Toxicology. 2015 May 4;331:100-11. doi: 10.1016/j.tox.2015.03.004. Epub 2015 Mar 13.
28. Proteomic identification of HNE-bound proteins in early Alzheimer disease: Insights into the role of lipid peroxidation in the progression of AD. Reed TT, etal., Brain Res. 2009 Jun 5;1274:66-76. doi: 10.1016/j.brainres.2009.04.009. Epub 2009 Apr 15.
29. GOA pipeline RGD automated data pipeline
30. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
31. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
32. Proteomic characterization of early changes induced by triiodothyronine in rat liver. Severino V, etal., J Proteome Res. 2011 Jul 1;10(7):3212-24. Epub 2011 Jun 1.
33. Differential gene expression during apoptosis induced by a serum factor: role of mitochondrial F0-F1 ATP synthase complex. Singh S and Khar A, Apoptosis. 2005 Dec;10(6):1469-82. doi: 10.1007/s10495-005-1394-1.
34. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
35. Proteomic adaptation to chronic high intensity swimming training in the rat heart. Sun B, etal., Comp Biochem Physiol Part D Genomics Proteomics. 2008 Mar;3(1):108-17. doi: 10.1016/j.cbd.2007.11.001. Epub 2007 Dec 3.
36. Compromised mitochondrial remodeling in compensatory hypertrophied myocardium of spontaneously hypertensive rat. Tang Y, etal., Cardiovasc Pathol. 2013 Nov 14. pii: S1054-8807(13)00200-7. doi: 10.1016/j.carpath.2013.11.002.
37. Impact of exposure to low concentrations of nitric oxide on protein profile in murine and human pancreatic islet cells. Tapia-Limonchi R, etal., Islets. 2014;6(5-6):e995997. doi: 10.1080/19382014.2014.995997.
38. Protein Drug Targets of Lavandula angustifolia on treatment of Rat Alzheimer's Disease. Zali H, etal., Iran J Pharm Res. 2015 Winter;14(1):291-302.
39. Changes in the brain mitochondrial proteome of male Sprague-Dawley rats treated with manganese chloride. Zhang S, etal., Toxicol Appl Pharmacol. 2005 Jan 1;202(1):13-7.
Additional References at PubMed
PMID:7916601   PMID:9736690   PMID:10077593   PMID:12110673   PMID:12865426   PMID:14651853   PMID:15489334   PMID:16778019   PMID:16854843   PMID:17387143   PMID:17612527   PMID:17634366  
PMID:17643490   PMID:18614015   PMID:18850735   PMID:19016746   PMID:19056867   PMID:19808025   PMID:19946888   PMID:20080761   PMID:20833797   PMID:21106936   PMID:21950801   PMID:22082260  
PMID:22658674   PMID:23376485   PMID:23533145   PMID:23979707   PMID:24625528   PMID:25931508   PMID:26767982   PMID:26769832   PMID:29476059   PMID:29867124   PMID:32357304   PMID:34894202  
PMID:35352799   PMID:36755387  


Genomics

Comparative Map Data
Atp5f1a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81873,567,537 - 73,575,473 (+)NCBIGRCr8
mRatBN7.21871,292,406 - 71,300,342 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1871,292,374 - 71,300,794 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1873,391,830 - 73,399,766 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01874,061,095 - 74,069,031 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01871,917,686 - 71,925,622 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01874,156,553 - 74,164,490 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1874,156,553 - 74,164,495 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01873,830,604 - 73,838,477 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41874,735,267 - 74,743,088 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11874,808,539 - 74,816,361 (+)NCBI
Celera1869,811,132 - 69,819,068 (+)NCBICelera
Cytogenetic Map18q12.3NCBI
ATP5F1A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381846,080,248 - 46,104,227 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1846,080,248 - 46,104,334 (-)EnsemblGRCh38hg38GRCh38
GRCh371843,660,214 - 43,684,193 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361841,918,108 - 41,938,197 (-)NCBINCBI36Build 36hg18NCBI36
Build 341841,918,107 - 41,932,285NCBI
Celera1840,472,298 - 40,486,450 (-)NCBICelera
Cytogenetic Map18q21.1NCBI
HuRef1840,521,726 - 40,541,788 (-)NCBIHuRef
CHM1_11843,591,321 - 43,611,335 (-)NCBICHM1_1
T2T-CHM13v2.01846,271,209 - 46,295,188 (-)NCBIT2T-CHM13v2.0
Atp5f1a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391877,861,468 - 77,870,569 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1877,861,429 - 77,870,569 (+)EnsemblGRCm39 Ensembl
GRCm381877,773,768 - 77,782,869 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1877,773,729 - 77,782,869 (+)EnsemblGRCm38mm10GRCm38
MGSCv371878,012,507 - 78,021,608 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361877,978,093 - 77,986,942 (+)NCBIMGSCv36mm8
Celera1878,959,749 - 78,968,850 (+)NCBICelera
Cytogenetic Map18E3NCBI
cM Map1852.38NCBI
Atp5f1a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540231,651,960 - 31,662,762 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540231,652,226 - 31,662,114 (-)NCBIChiLan1.0ChiLan1.0
ATP5F1A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21763,508,983 - 63,523,359 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11849,201,584 - 49,215,960 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01839,366,384 - 39,380,514 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11842,904,136 - 42,918,626 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1842,904,136 - 42,923,326 (-)Ensemblpanpan1.1panPan2
ATP5F1A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1745,118,188 - 45,127,048 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl745,117,657 - 45,127,048 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha744,600,134 - 44,608,995 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0745,071,120 - 45,079,950 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl745,071,075 - 45,079,951 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1744,770,243 - 44,779,076 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0744,823,645 - 44,832,526 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0745,108,044 - 45,116,902 (+)NCBIUU_Cfam_GSD_1.0
Atp5f1a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494441,415,655 - 41,425,434 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936517742,791 - 753,336 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936517743,036 - 752,836 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ATP5F1A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl195,733,090 - 95,750,841 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1195,738,789 - 95,750,835 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21105,944,306 - 105,955,798 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ATP5F1A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11834,815,924 - 34,828,052 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1834,816,027 - 34,830,924 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660509,183,131 - 9,195,639 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Atp5f1a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247789,773,064 - 9,784,533 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247789,773,365 - 9,784,564 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Atp5f1a
54 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:31
Count of miRNA genes:31
Interacting mature miRNAs:31
Transcripts:ENSRNOT00000022892
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331733Bp233Blood pressure QTL 2333.97196arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182479697779788953Rat
12904069Cm123Cardiac mass QTL 1230.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)185253976376104388Rat
12904070Cm124Cardiac mass QTL 1240.01heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)185253976376104388Rat
2303584Gluco55Glucose level QTL 552blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)184852004483828827Rat
12904071Am18Aortic mass QTL 180.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)185253976376104388Rat
12904067Cm122Cardiac mass QTL 1220.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)185253976376104388Rat
61384Bp48Blood pressure QTL 4819.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)186062231177209844Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182137289383213037Rat
2301417Bp319Blood pressure QTL 3190.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)185253976376104388Rat
1298072Cia26Collagen induced arthritis QTL 263.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)185470976983828827Rat
12904073Kidm71Kidney mass QTL 710.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)185253976376104388Rat
6903353Bp353Blood pressure QTL 3532.8arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)185979647883828827Rat
738008Hcar14Hepatocarcinoma resistance QTL 144.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion number (CMO:0001462)185146473383218561Rat
6903356Bp354Blood pressure QTL 3544.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)185979647883828827Rat
631518Bw11Body weight QTL 112.8body mass (VT:0001259)body weight (CMO:0000012)183587072380870723Rat
6893683Bw110Body weight QTL 1102.70.002body mass (VT:0001259)body weight (CMO:0000012)184334502283828827Rat
8694366Abfw8Abdominal fat weight QTL 86.380.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)184664067583828827Rat
2300157Bmd66Bone mineral density QTL 6613.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)182896485373964853Rat
738005Anxrr11Anxiety related response QTL 113.4exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)183003981375039813Rat
631274Sprol1Serum protein level QTL 15.3blood total protein amount (VT:0005567)serum total protein level (CMO:0000661)183139332077209694Rat
9589041Epfw12Epididymal fat weight QTL 1217.080.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)184664067583828827Rat
8694432Bw165Body weight QTL 1653.810.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)184664067583828827Rat
70185BpQTLcluster15Blood pressure QTL cluster 154.61arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)185971241776477814Rat
2293704Bss35Bone structure and strength QTL 354.590.0002femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)182896485373964853Rat
9589816Gluco68Glucose level QTL 687.250.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)182979296574792965Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)181927890183218561Rat
8694378Bw157Body weight QTL 1573.590.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)182979296574792965Rat
1331770Bp234Blood pressure QTL 2343.807arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)185979647871893566Rat
2303571Bw92Body weight QTL 923body mass (VT:0001259)body weight (CMO:0000012)184852004483828827Rat
2300177Bmd65Bone mineral density QTL 6519.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)182896485373964853Rat
1598826Anxrr20Anxiety related response QTL 203.04body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)184143297183828827Rat
2301969Bp324Blood pressure QTL 3244.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)185971241776477814Rat
631675Iddm15Insulin dependent diabetes mellitus QTL 15urine glucose amount (VT:0001758)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)186062231177209844Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181179151883218561Rat
2303120Mamtr8Mammary tumor resistance QTL 80.001mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)183135940883218561Rat
12880368Bw187Body weight QTL 1870.045body mass (VT:0001259)body weight (CMO:0000012)185253976376104388Rat
724542Kidm2Kidney mass QTL 22.6kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)185917211583828827Rat
61367Iddm4Insulin dependent diabetes mellitus QTL 42.330.0074blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)183819245583192455Rat
1359020Ppulsi2Prepulse inhibition QTL 22.71prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)185229287573997283Rat
9590318Scort22Serum corticosterone level QTL 227.640.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)182979296574792965Rat
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181179151883218561Rat
1331754Bp230Blood pressure QTL 2304.61609arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182979296574792965Rat

Markers in Region
D16S2555E  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map18q12.3UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000022892   ⟹   ENSRNOP00000022892
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1871,292,374 - 71,300,794 (+)Ensembl
Rnor_6.0 Ensembl1874,156,553 - 74,164,495 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000102563   ⟹   ENSRNOP00000084192
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1871,293,956 - 71,300,794 (+)Ensembl
RefSeq Acc Id: NM_023093   ⟹   NP_075581
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81873,567,537 - 73,575,473 (+)NCBI
mRatBN7.21871,292,406 - 71,300,342 (+)NCBI
Rnor_6.01874,156,553 - 74,164,490 (+)NCBI
Rnor_5.01873,830,604 - 73,838,477 (+)NCBI
RGSC_v3.41874,735,267 - 74,743,088 (+)RGD
Celera1869,811,132 - 69,819,068 (+)RGD
Sequence:
RefSeq Acc Id: NP_075581   ⟸   NM_023093
- Peptide Label: precursor
- UniProtKB: Q6P753 (UniProtKB/Swiss-Prot),   P15999 (UniProtKB/Swiss-Prot),   A6KMW0 (UniProtKB/TrEMBL),   F1LP05 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000022892   ⟸   ENSRNOT00000022892
Ensembl Acc Id: ENSRNOP00000084192   ⟸   ENSRNOT00000102563
Protein Domains
ATP synthase alpha subunit C-terminal   ATPase F1/V1/A1 complex alpha/beta subunit   ATPase F1/V1/A1 complex alpha/beta subunit N-

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P15999-F1-model_v2 AlphaFold P15999 1-553 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700881
Promoter ID:EPDNEW_R11403
Type:initiation region
Name:Atp5f1a_1
Description:ATP synthase F1 subunit alpha
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01874,156,549 - 74,156,609EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619993 AgrOrtholog
BioCyc Gene G2FUF-6929 BioCyc
BioCyc Pathway PWY-7980 [ATP biosynthesis] BioCyc
BioCyc Pathway Image PWY-7980 BioCyc
Ensembl Genes ENSRNOG00000017032 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055014298 UniProtKB/Swiss-Prot
  ENSRNOG00060015154 UniProtKB/Swiss-Prot
  ENSRNOG00065023837 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000022892 UniProtKB/TrEMBL
  ENSRNOT00000022892.6 UniProtKB/Swiss-Prot
  ENSRNOT00000102563.1 UniProtKB/TrEMBL
  ENSRNOT00055024562 UniProtKB/Swiss-Prot
  ENSRNOT00060026011 UniProtKB/Swiss-Prot
  ENSRNOT00065040892 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.150.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.40.30.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5599635 IMAGE-MGC_LOAD
InterPro ATP_synth_asu-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATP_synth_asu_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATP_synth_asu_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATP_synth_F1_a UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATP_synth_F1_asu UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATPase_a/bsu_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATPase_F1/V1/A1_a/bsu_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATPase_F1/V1/A1_a/bsu_N_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATPase_F1/V1/A1_a/bsu_nucl-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:65262 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:72613 IMAGE-MGC_LOAD
NCBI Gene 65262 ENTREZGENE
PANTHER ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL UniProtKB/Swiss-Prot
  ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL UniProtKB/Swiss-Prot
  ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL UniProtKB/TrEMBL
  ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL UniProtKB/TrEMBL
Pfam ATP-synt_ab UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATP-synt_ab_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATP-synt_ab_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Atp5f1a PhenoGen
PIRSF F_ATPase_subunit_alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ATPASE_ALPHA_BETA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000017032 RatGTEx
  ENSRNOG00055014298 RatGTEx
  ENSRNOG00060015154 RatGTEx
  ENSRNOG00065023837 RatGTEx
Superfamily-SCOP C-terminal domain of alpha and beta subunits of F1 ATP synthase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50615 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZXA2_RAT UniProtKB/TrEMBL
  A6KMW0 ENTREZGENE, UniProtKB/TrEMBL
  ATPA_RAT UniProtKB/Swiss-Prot
  F1LP05 ENTREZGENE, UniProtKB/TrEMBL
  P15999 ENTREZGENE
  Q6P753 ENTREZGENE
UniProt Secondary Q6P753 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-11-30 Atp5f1a  ATP synthase F1 subunit alpha  Atp5a1  ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-06-27 Atp5a1  ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle  Atp5a1  ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit, isoform 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Atp5a1  ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit, isoform 1.    mitochondrial H+-ATP synthase alpha subunit  Name updated 1299863 APPROVED
2002-08-07 Atp5a1  mitochondrial H+-ATP synthase alpha subunit      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_protein 510 amino acids (mature protein); 55.2 kDa; pI 8.8 727262