RGD Reference Report - Compromised mitochondrial remodeling in compensatory hypertrophied myocardium of spontaneously hypertensive rat. - Rat Genome Database

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Compromised mitochondrial remodeling in compensatory hypertrophied myocardium of spontaneously hypertensive rat.

Authors: Tang, Y  Mi, C  Liu, J  Gao, F  Long, J 
Citation: Tang Y, etal., Cardiovasc Pathol. 2013 Nov 14. pii: S1054-8807(13)00200-7. doi: 10.1016/j.carpath.2013.11.002.
RGD ID: 7800726
Pubmed: PMID:24388463   (View Abstract at PubMed)
DOI: DOI:10.1016/j.carpath.2013.11.002   (Journal Full-text)

BACKGROUND: Hypertension leads to cardiac hypertrophy as an adaptive response to increased workload. While initial development of hypertrophy is compensatory when contractile function is maintained, persistent stress on heart leads to deteriorated cardiac function and onset of heart failure. Mitochondrial dysfunction develops in the failing heart; however, whether it presents in compensatory cardiac hypertrophy is controversial. METHODS: Spontaneously hypertensive rats (SHRs) and age-matched normotensive Wistar Kyoto rats were used in the study. Mitochondrial function and remodeling-related mechanisms in the left ventricles were measured by enzyme activity tests, Western blots, and reverse transcriptase polymerase chain reaction. RESULTS: Compensatory cardiac hypertrophy in SHR was indicated by higher heart/weigh ratio, left ventricular systolic pressure and +/-dp/dtmax (P<.001, P<.05, and P<.01, respectively). Enzyme activities of mitochondrial complex I and II were significantly reduced (P<.05 and P<.01) in SHR in concert with decreased expression of complex subunits (P<.01 for NDUFS3, P=.068 for SDHB, and P<.05 for ATP5A1). Mitochondrial fission protein Drp1 was decreased (P<.05), while fusion protein OPA1 was increased (P<.01). Parkin and SirT1/AMPK-PGC-1alpha signaling, responsible for mitochondrial elimination and biogenesis respectively, were decreased in SHR (P<.01 for Parkin, P<.001 for SirT1 and p-AMPK). CONCLUSION: Our results implicated that mitochondrial function and remodeling, indicated by mitochondrial enzyme activities and remodeling-related molecules, were compromised in compensatory hypertrophied myocardium of the SHR hypertensive model. SUMMARY: Mitochondrial function in compensatory hypertrophied myocardium is controversial. Our present study found mitochondrial dysfunction in the left ventricle of spontaneously hypertensive rats, which was possibly a result of compromised mitochondrial remodeling including mitochondrial dynamics, elimination, and biogenesis.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
NDUFS3HumanCardiomegaly  ISORGD:1309406 RGD 
Ndufs3RatCardiomegaly  IEP  RGD 
Ndufs3MouseCardiomegaly  ISORGD:1309406 RGD 
OPA1HumanCardiomegaly  ISORGD:708423associated with HypertensionRGD 
Opa1RatCardiomegaly  IEP associated with HypertensionRGD 
Opa1MouseCardiomegaly  ISORGD:708423associated with HypertensionRGD 
ATP5F1AHumanhypertension  ISORGD:619993protein:decreased expression:heart left ventricle (rat)RGD 
Atp5f1aRathypertension  IEP protein:decreased expression:heart left ventricle (rat)RGD 
Atp5f1aMousehypertension  ISORGD:619993protein:decreased expression:heart left ventricle (rat)RGD 
OPA1Humanhypertension  ISORGD:708423protein:increased expression:heart left ventricle (rat)RGD 
Opa1Rathypertension  IEP protein:increased expression:heart left ventricle (rat)RGD 
Opa1Mousehypertension  ISORGD:708423protein:increased expression:heart left ventricle (rat)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Atp5f1a  (ATP synthase F1 subunit alpha)
Ndufs3  (NADH:ubiquinone oxidoreductase core subunit S3)
Opa1  (OPA1, mitochondrial dynamin like GTPase)

Genes (Mus musculus)
Atp5f1a  (ATP synthase F1 subunit alpha)
Ndufs3  (NADH:ubiquinone oxidoreductase core subunit S3)
Opa1  (OPA1, mitochondrial dynamin like GTPase)

Genes (Homo sapiens)
ATP5F1A  (ATP synthase F1 subunit alpha)
NDUFS3  (NADH:ubiquinone oxidoreductase core subunit S3)
OPA1  (OPA1 mitochondrial dynamin like GTPase)


Additional Information