Dnaja1 (DnaJ heat shock protein family (Hsp40) member A1) - Rat Genome Database

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Gene: Dnaja1 (DnaJ heat shock protein family (Hsp40) member A1) Rattus norvegicus
Analyze
Symbol: Dnaja1
Name: DnaJ heat shock protein family (Hsp40) member A1
RGD ID: 620942
Description: Enables ATPase activator activity. Predicted to be involved in several processes, including protein refolding; regulation of apoptotic process; and regulation of establishment of protein localization. Predicted to act upstream of or within androgen receptor signaling pathway; flagellated sperm motility; and spermatogenesis. Predicted to be located in membrane and microtubule cytoskeleton. Predicted to be active in cytosol. Orthologous to human DNAJA1 (DnaJ heat shock protein family (Hsp40) member A1); PARTICIPATES IN Endoplasmic Reticulum-associated degradation pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: DnaJ (Hsp40) homolog, subfamily A, member 1; dnaJ homolog subfamily A member 1; DnaJ-like protein; dnaJ-like protein 1; DnaJ-like protein 2; heat shock protein J2; HSJ-2; Hsj2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8560,638,404 - 60,649,315 (+)NCBIGRCr8
mRatBN7.2555,842,414 - 55,853,326 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl555,842,426 - 55,853,967 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx557,808,082 - 57,819,013 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0559,627,243 - 59,638,175 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0559,621,333 - 59,632,246 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0557,028,467 - 57,039,378 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl557,028,467 - 57,039,378 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0561,562,288 - 61,573,851 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4558,100,794 - 58,111,705 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1558,100,972 - 58,111,884 (+)NCBI
Celera554,454,606 - 54,465,517 (+)NCBICelera
Cytogenetic Map5q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(S)-nicotine  (ISO)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (ISO)
1H-pyrazole  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,6-dinitrotoluene  (EXP)
2-butoxyethanol  (ISO)
2-methylcholine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
9-cis-retinoic acid  (EXP)
acetamide  (EXP)
aconitine  (EXP)
acrylamide  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
amphibole asbestos  (ISO)
arecoline  (ISO)
arsenous acid  (ISO)
Aurin  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (ISO)
Benzo[ghi]perylene  (ISO)
Benzo[k]fluoranthene  (ISO)
bexarotene  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (ISO)
celastrol  (ISO)
chloropicrin  (ISO)
chrysene  (ISO)
cisplatin  (ISO)
clofibrate  (EXP,ISO)
clofibric acid  (EXP)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
CU-O LINKAGE  (ISO)
cyclosporin A  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (EXP)
diclofenac  (ISO)
dicrotophos  (ISO)
dioxygen  (ISO)
disulfiram  (ISO)
diuron  (EXP)
doxorubicin  (EXP,ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
flutamide  (EXP)
FR900359  (ISO)
fulvestrant  (ISO)
furan  (ISO)
gallium nitrate  (ISO)
gedunin  (ISO)
gentamycin  (EXP)
hyaluronic acid  (EXP)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
indometacin  (ISO)
isobutanol  (ISO)
ivermectin  (ISO)
kojic acid  (EXP)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
methamphetamine  (EXP)
methapyrilene  (ISO)
methotrexate  (ISO)
methylparaben  (ISO)
monocrotaline  (ISO)
monosodium L-glutamate  (ISO)
N-methylformamide  (ISO)
N-nitrosodiethylamine  (EXP)
nefazodone  (EXP)
niclosamide  (ISO)
nicotine  (ISO)
organoselenium compound  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
pentachlorophenol  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (EXP,ISO)
phenytoin  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
potassium dichromate  (ISO)
pravastatin  (ISO)
procymidone  (EXP)
propiconazole  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
rifampicin  (ISO)
rotenone  (EXP)
sarin  (ISO)
SCH 23390  (EXP)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
silver(1+) nitrate  (ISO)
sodium arsenite  (ISO)
succimer  (ISO)
tetrachloromethane  (ISO)
tetraphene  (ISO)
thapsigargin  (ISO)
thiostrepton  (ISO)
thiram  (ISO)
titanium dioxide  (EXP,ISO)
trichloroethene  (EXP,ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
zinc atom  (ISO)
zinc pyrithione  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Induction of molecular chaperones in carbon tetrachloride-treated rat liver: implications in protection against liver damage. Lee KJ, etal., Cell Stress Chaperones. 2004 Mar;9(1):58-68.
4. Isolation and characterization of a DnaJ-like protein in rats: the C-terminal 10-kDa domain of hsc70 is not essential for stimulating the ATP-hydrolytic activity of hsc70 by a DnaJ-like protein. Leng CH, etal., Protein Sci 1998 May;7(5):1186-94.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. Pituitary tumor-transforming gene protein associates with ribosomal protein S10 and a novel human homologue of DnaJ in testicular cells. Pei L J Biol Chem. 1999 Jan 29;274(5):3151-8.
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. GOA pipeline RGD automated data pipeline
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:12150907   PMID:14752510   PMID:15082773   PMID:15489334   PMID:15660130   PMID:16854843   PMID:17110338   PMID:19056867   PMID:19946888   PMID:20458337   PMID:21231916   PMID:23716698  
PMID:24318877   PMID:24512202   PMID:24625528   PMID:25002582   PMID:25281747   PMID:26959111   PMID:30053369  


Genomics

Comparative Map Data
Dnaja1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8560,638,404 - 60,649,315 (+)NCBIGRCr8
mRatBN7.2555,842,414 - 55,853,326 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl555,842,426 - 55,853,967 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx557,808,082 - 57,819,013 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0559,627,243 - 59,638,175 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0559,621,333 - 59,632,246 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0557,028,467 - 57,039,378 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl557,028,467 - 57,039,378 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0561,562,288 - 61,573,851 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4558,100,794 - 58,111,705 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1558,100,972 - 58,111,884 (+)NCBI
Celera554,454,606 - 54,465,517 (+)NCBICelera
Cytogenetic Map5q22NCBI
DNAJA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38933,025,273 - 33,039,907 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl933,025,273 - 33,039,907 (+)EnsemblGRCh38hg38GRCh38
GRCh37933,025,271 - 33,039,905 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36933,015,209 - 33,029,062 (+)NCBINCBI36Build 36hg18NCBI36
Build 34933,015,208 - 33,029,062NCBI
Celera932,956,506 - 32,970,354 (+)NCBICelera
Cytogenetic Map9p21.1NCBI
HuRef932,983,591 - 32,997,444 (+)NCBIHuRef
CHM1_1933,024,975 - 33,038,828 (+)NCBICHM1_1
T2T-CHM13v2.0933,041,834 - 33,056,468 (+)NCBIT2T-CHM13v2.0
Dnaja1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39440,722,468 - 40,734,965 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl440,722,150 - 40,737,149 (+)EnsemblGRCm39 Ensembl
GRCm38440,722,468 - 40,734,965 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl440,722,150 - 40,737,149 (+)EnsemblGRCm38mm10GRCm38
MGSCv37440,669,501 - 40,684,186 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36440,911,204 - 40,923,635 (+)NCBIMGSCv36mm8
Celera440,382,728 - 40,397,413 (+)NCBICelera
Cytogenetic Map4A5NCBI
cM Map420.46NCBI
Dnaja1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554722,604,002 - 2,618,033 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554722,604,002 - 2,618,033 (-)NCBIChiLan1.0ChiLan1.0
DNAJA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21191,567,747 - 91,582,267 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1991,573,939 - 91,588,209 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0932,800,077 - 32,814,745 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1933,608,502 - 33,622,275 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl933,608,502 - 33,622,275 (+)Ensemblpanpan1.1panPan2
DNAJA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11150,156,089 - 50,168,379 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1150,156,089 - 50,167,536 (+)EnsemblCanFam3.1canFam3CanFam3.1
ROS_Cfam_1.01721,302,373 - 21,303,842 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1768,911,054 - 68,912,003 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02025,645,023 - 25,646,492 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02629,882,770 - 29,884,243 (-)NCBIUU_Cfam_GSD_1.0
Dnaja1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947165,052,278 - 165,063,722 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365241,599,913 - 1,610,682 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365241,599,883 - 1,611,302 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DNAJA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1033,432,844 - 33,445,532 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11033,432,529 - 33,445,556 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21037,687,721 - 37,699,598 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DNAJA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11247,220,976 - 47,235,684 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603844,122,907 - 44,137,626 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dnaja1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473637,780,867 - 37,793,594 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473637,780,852 - 37,793,594 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dnaja1
69 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:181
Count of miRNA genes:115
Interacting mature miRNAs:131
Transcripts:ENSRNOT00000010061
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578776Stresp18Stress response QTL 182.9thymus mass (VT:0004954)thymus wet weight (CMO:0000855)52795544072955440Rat
1298067Scl15Serum cholesterol level QTL 154.80.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53321566578215665Rat
1300115Hrtrt7Heart rate QTL 72.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)54786906290099692Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1358353Srcrtb2Stress Responsive Cort Basal QTL 23.480.003blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)51887394774251464Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)512789751113558310Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)543726656129132602Rat
1598807Glom12Glomerulus QTL 122.7kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)53321566578215665Rat
1302786Kidm8Kidney mass QTL 828.15kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)53321566578215665Rat
6903292Stl28Serum triglyceride level QTL 282.60.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)52851548973515489Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
1578767Stresp17Stress response QTL 174.30.01blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)52795544072955440Rat
7411561Bw134Body weight QTL 134240.001body mass (VT:0001259)body weight gain (CMO:0000420)54946360094463600Rat
1641922Alcrsp8Alcohol response QTL 8alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)53518915368564008Rat
2303615Vencon7Ventilatory control QTL 70.001respiration trait (VT:0001943)respiration rate (CMO:0000289)55098389595983895Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)550328551141643988Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)535189153141643988Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
6903306Scl35Serum cholesterol QTL 352.60.0073blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)52851548973515489Rat
1576317Eutr2Estrogen induced uterine response QTL 20.01uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)534730116104251008Rat
7394712Emca13Estrogen-induced mammary cancer QTL 13mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)5982326699753708Rat
1331773Scl26Serum cholesterol level QTL 263.065blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)54372665686724018Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555805606132207589Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)572947086724018Rat
61359EaexExperimental allergic encephalomyelitis QTL x3nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)555715622100715622Rat
8662454Vetf3Vascular elastic tissue fragility QTL 327.4artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)5228222669540447Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)531663789131345958Rat
9589025Epfw7Epididymal fat weight QTL 720.660.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)54946360094463600Rat
2303574Gluco42Glucose level QTL 422blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)55349671998496719Rat
1641903Alcrsp3Alcohol response QTL 3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)51268928557689285Rat
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)5190450412Rat
8552954Pigfal14Plasma insulin-like growth factor 1 level QTL 149blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)52122674466226744Rat
2316959Gluco59Glucose level QTL 594.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)534944474113558310Rat
1600358Mamtr5Mammary tumor resistance QTL 5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)51887394763873947Rat

Markers in Region
PMC153017P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5q22UniSTS
RH135166  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2555,852,909 - 55,853,117 (+)MAPPERmRatBN7.2
Rnor_6.0557,038,962 - 57,039,169NCBIRnor6.0
Rnor_5.0561,572,783 - 61,572,990UniSTSRnor5.0
RGSC_v3.4558,111,289 - 58,111,496UniSTSRGSC3.4
Celera554,465,101 - 54,465,308UniSTS
RH 3.4 Map5288.3UniSTS
Cytogenetic Map5q22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 10 74 35 41 11 8
Low 1
Below cutoff

Sequence


Ensembl Acc Id: ENSRNOT00000010061   ⟹   ENSRNOP00000010061
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl555,842,426 - 55,853,967 (+)Ensembl
Rnor_6.0 Ensembl557,028,467 - 57,039,378 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000095533   ⟹   ENSRNOP00000079023
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl555,842,809 - 55,853,967 (+)Ensembl
RefSeq Acc Id: NM_022934   ⟹   NP_075223
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8560,638,404 - 60,649,315 (+)NCBI
mRatBN7.2555,842,414 - 55,853,326 (+)NCBI
Rnor_6.0557,028,467 - 57,039,378 (+)NCBI
Rnor_5.0561,562,288 - 61,573,851 (+)NCBI
RGSC_v3.4558,100,794 - 58,111,705 (+)RGD
Celera554,454,606 - 54,465,517 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_075223 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA98855 (Get FASTA)   NCBI Sequence Viewer  
  AAH62009 (Get FASTA)   NCBI Sequence Viewer  
  EDL98641 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000010061.2
  ENSRNOP00000079023.1
  ENSRNOP00055022299
  ENSRNOP00060004449
  ENSRNOP00065004642
GenBank Protein P63036 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_075223   ⟸   NM_022934
- UniProtKB: P63036 (UniProtKB/Swiss-Prot),   A6IIS1 (UniProtKB/TrEMBL),   A0A8I5ZPY5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000010061   ⟸   ENSRNOT00000010061
Ensembl Acc Id: ENSRNOP00000079023   ⟸   ENSRNOT00000095533
Protein Domains
CR-type   J

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P63036-F1-model_v2 AlphaFold P63036 1-397 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693635
Promoter ID:EPDNEW_R4159
Type:multiple initiation site
Name:Dnaja1_1
Description:DnaJ heat shock protein family member A1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0557,028,475 - 57,028,535EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620942 AgrOrtholog
BioCyc Gene G2FUF-41590 BioCyc
Ensembl Genes ENSRNOG00000007029 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055016378 UniProtKB/Swiss-Prot
  ENSRNOG00060003657 UniProtKB/Swiss-Prot
  ENSRNOG00065004655 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000010061.4 UniProtKB/Swiss-Prot
  ENSRNOT00000095533.1 UniProtKB/TrEMBL
  ENSRNOT00055027767 UniProtKB/Swiss-Prot
  ENSRNOT00060006030 UniProtKB/Swiss-Prot
  ENSRNOT00065006743 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.287.110 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Heat shock protein DnaJ, cysteine-rich domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Urease metallochaperone UreE, N-terminal domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5621557 IMAGE-MGC_LOAD
InterPro DnaJ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DnaJ_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DnaJ_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DnaJ_domain_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNJA1/2-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSP40/DnaJ_pept-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSP_DnaJ_Cys-rich_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSP_DnaJ_Cys-rich_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  J_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:65028 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:72435 IMAGE-MGC_LOAD
NCBI Gene 65028 ENTREZGENE
PANTHER DNAJ HOMOLOG SUBFAMILY A MEMBER 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR43888 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DnaJ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DnaJ_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DnaJ_CXXCXGXG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Dnaja1 PhenoGen
PRINTS JDOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE DNAJ_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNAJ_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_CR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000007029 RatGTEx
  ENSRNOG00055016378 RatGTEx
  ENSRNOG00060003657 RatGTEx
  ENSRNOG00065004655 RatGTEx
SMART DnaJ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF46565 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49493 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57938 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZPY5 ENTREZGENE, UniProtKB/TrEMBL
  A6IIS1 ENTREZGENE, UniProtKB/TrEMBL
  DNJA1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary P54102 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-25 Dnaja1  DnaJ heat shock protein family (Hsp40) member A1  Dnaja1  DnaJ (Hsp40) homolog, subfamily A, member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Dnaja1  DnaJ (Hsp40) homolog, subfamily A, member 1    DnaJ-like protein  Name updated 1299863 APPROVED
2004-09-10 Dnaja1  DnaJ-like protein  Hsj2    Symbol and Name updated 1299863 APPROVED
2002-08-07 Hsj2  DnaJ-like protein      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_homology 99% identity to human HDJ2 633115
gene_protein 397 amino acid residues 633115