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Gene: NR1H2 (nuclear receptor subfamily 1 group H member 2) Homo sapiens
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Symbol: NR1H2
Name: nuclear receptor subfamily 1 group H member 2
Description: Exhibits several functions, including ATPase binding activity; DNA-binding transcription activator activity, RNA polymerase II-specific; and apolipoprotein A-I receptor binding activity. Involved in several processes, including negative regulation of lipid localization; positive regulation of cellular metabolic process; and positive regulation of cholesterol efflux. Localizes to cytoplasm and nucleus. Implicated in obesity and type 2 diabetes mellitus.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: FLJ17564; liver X nuclear receptor beta; liver X receptor beta; liver X receptor-beta; LX receptor beta; LXR-b; LXRB; NER; NER-I; nuclear orphan receptor LXR-beta; nuclear receptor NER; nuclear receptor subfamily 1, group H, member 2; oxysterols receptor LXR-beta; RIP15; steroid hormone-nuclear receptor NER; ubiquitously-expressed nuclear receptor; UNR
Orthologs:
Mus musculus (house mouse) : Nr1h2 (nuclear receptor subfamily 1, group H, member 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Nr1h2 (nuclear receptor subfamily 1, group H, member 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nr1h2 (nuclear receptor subfamily 1 group H member 2)
Pan paniscus (bonobo/pygmy chimpanzee) : NR1H2 (nuclear receptor subfamily 1 group H member 2)
Canis lupus familiaris (dog) : NR1H2 (nuclear receptor subfamily 1 group H member 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nr1h2 (nuclear receptor subfamily 1 group H member 2)
Sus scrofa (pig) : NR1H2 (nuclear receptor subfamily 1 group H member 2)
Chlorocebus sabaeus (African green monkey) : NR1H2 (nuclear receptor subfamily 1 group H member 2)
Heterocephalus glaber (naked mole-rat) : Nr1h2 (nuclear receptor subfamily 1 group H member 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1950,329,653 - 50,383,388 (+)EnsemblGRCh38hg38GRCh38
GRCh381950,376,457 - 50,383,388 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371950,879,680 - 50,886,285 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361955,571,497 - 55,578,079 (+)NCBINCBI36hg18NCBI36
Build 341955,571,514 - 55,578,048NCBI
Celera1947,929,924 - 47,936,510 (+)NCBI
Cytogenetic Map19q13.33NCBI
HuRef1947,217,814 - 47,224,423 (+)NCBIHuRef
CHM1_11950,881,453 - 50,888,062 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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References - uncurated

Genomics

Candidate Gene Status
Comparative Map Data
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miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
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Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on NR1H2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1352469
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-09-08
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.