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Gene: Pttg1 (PTTG1 regulator of sister chromatid separation, securin) Rattus norvegicus
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Symbol: Pttg1
Name: PTTG1 regulator of sister chromatid separation, securin
Description: Exhibits heat shock protein binding activity and ribosome binding activity. Involved in negative regulation of cell population proliferation and regulation of cell growth. Predicted to localize to the cytosol and nucleus. Orthologous to several human genes including PTTG1 (PTTG1 regulator of sister chromatid separation, securin); PARTICIPATES IN cell cycle pathway, mitotic; INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 1,3-dinitrobenzene; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Pituitary tumor transforming; Pituitary tumor transforming gene; pituitary tumor-transforming 1; pituitary tumor-transforming gene 1 protein; Pttg; securin
Orthologs:
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01029,014,332 - 29,026,088 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01028,856,281 - 28,868,004 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41028,527,409 - 28,532,831 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11028,528,480 - 28,533,880 (-)NCBI
Celera1027,392,215 - 27,397,637 (-)NCBICelera
Cytogenetic Map10q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Pttg1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 68359
Created: 2001-07-11
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.