Pttg1 (PTTG1 regulator of sister chromatid separation, securin) - Rat Genome Database

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Gene: Pttg1 (PTTG1 regulator of sister chromatid separation, securin) Rattus norvegicus
Analyze
Symbol: Pttg1
Name: PTTG1 regulator of sister chromatid separation, securin
RGD ID: 68359
Description: Enables heat shock protein binding activity and ribosome binding activity. Involved in negative regulation of cell population proliferation and regulation of cell growth. Predicted to be located in cytosol and nucleus. Orthologous to several human genes including PTTG1 (PTTG1 regulator of sister chromatid separation, securin) and PTTG3P (pituitary tumor-transforming 3, pseudogene); PARTICIPATES IN cell cycle pathway, mitotic; INTERACTS WITH 1,3-dinitrobenzene; 1-naphthyl isothiocyanate; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Pituitary tumor transforming; Pituitary tumor transforming gene; pituitary tumor-transforming 1; pituitary tumor-transforming gene 1 protein; Pttg; securin
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21027,893,466 - 27,904,965 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1027,893,689 - 27,904,837 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1032,659,668 - 32,665,276 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0101,198,056 - 1,203,663 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01027,630,195 - 27,635,798 (-)NCBIRnor_WKY
Rnor_6.01029,014,332 - 29,026,088 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1029,020,049 - 29,026,002 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01028,856,281 - 28,868,004 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41028,527,409 - 28,532,831 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11028,528,480 - 28,533,880 (-)NCBI
Celera1027,392,215 - 27,397,637 (-)NCBICelera
Cytogenetic Map10q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-dexrazoxane  (ISO)
1,3-dinitrobenzene  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,4-dinitrotoluene  (EXP)
2-acetamidofluorene  (EXP)
2-amino-2-deoxy-D-galactopyranose  (EXP)
2-amino-2-deoxy-D-glucopyranose  (EXP)
2-methylcholine  (ISO)
2-nitrofluorene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,7-dihydropurine-6-thione  (EXP)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-amino-2,6-dinitrotoluene  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucosamine  (EXP)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antimony(0)  (ISO)
antimycin A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
beta-D-glucosamine  (EXP)
beta-naphthoflavone  (EXP,ISO)
bisphenol A  (EXP,ISO)
buspirone  (EXP)
butein  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
chromium atom  (ISO)
cisplatin  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
corticosterone  (EXP)
coumestrol  (ISO)
CU-O LINKAGE  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dibutyl phthalate  (EXP)
dieldrin  (EXP)
diethylstilbestrol  (EXP)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
Echimidine  (ISO)
Enterolactone  (ISO)
ethanol  (EXP)
fenamidone  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
furan  (EXP)
gefitinib  (ISO)
geraniol  (ISO)
heptachlor  (EXP)
idarubicin  (ISO)
indole-3-methanol  (EXP)
irinotecan  (EXP)
isobutanol  (ISO)
Lasiocarpine  (ISO)
leflunomide  (EXP,ISO)
leptomycin B  (ISO)
levofloxacin  (EXP)
lidocaine  (EXP)
mercaptopurine  (EXP)
mercury atom  (ISO)
mercury(0)  (ISO)
methapyrilene  (EXP)
methcathinone  (ISO)
methyl methanesulfonate  (ISO)
mirex  (EXP)
monocrotaline  (ISO)
N-ethyl-N-nitrosourea  (EXP)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP,ISO)
N-Nitrosopyrrolidine  (ISO)
nickel atom  (ISO)
nickel dichloride  (EXP,ISO)
nimesulide  (EXP)
nitric oxide  (ISO)
ochratoxin A  (EXP)
okadaic acid  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paclitaxel  (ISO)
palbociclib  (ISO)
paracetamol  (EXP,ISO)
PCB138  (ISO)
pentachlorophenol  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
picoxystrobin  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (EXP)
propanal  (ISO)
purine-6-thiol  (EXP)
pyrimidifen  (ISO)
quercetin  (ISO)
resveratrol  (EXP,ISO)
riddelliine  (ISO)
rotenone  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
SB 431542  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
silver(1+) nitrate  (ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
titanium dioxide  (EXP,ISO)
toluene 2,4-diisocyanate  (ISO)
topotecan  (EXP)
trichloroethene  (EXP)
trimellitic anhydride  (ISO)
Triptolide  (EXP)
triptonide  (ISO)
troglitazone  (ISO)
trovafloxacin  (EXP,ISO)
tunicamycin  (ISO)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vancomycin  (ISO)
vincaleukoblastine  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA,ISO)
cytosol  (ISO)
nucleus  (IBA,IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Functional role of estrogen in pituitary tumor pathogenesis. Heaney AP, etal., J Clin Invest 2002 Jan;109(2):277-83.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. Isolation and characterization of a pituitary tumor-transforming gene (PTTG). Pei L and Melmed S, Mol Endocrinol 1997 Apr;11(4):433-41.
7. Pituitary tumor-transforming gene protein associates with ribosomal protein S10 and a novel human homologue of DnaJ in testicular cells. Pei L J Biol Chem. 1999 Jan 29;274(5):3151-8.
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. GOA pipeline RGD automated data pipeline
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:9478977   PMID:9811450   PMID:12477932   PMID:12970167   PMID:14561405   PMID:15845362   PMID:16533945   PMID:17325031   PMID:19800905   PMID:25023895   PMID:27250217   PMID:35050550  


Genomics

Comparative Map Data
Pttg1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21027,893,466 - 27,904,965 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1027,893,689 - 27,904,837 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1032,659,668 - 32,665,276 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0101,198,056 - 1,203,663 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01027,630,195 - 27,635,798 (-)NCBIRnor_WKY
Rnor_6.01029,014,332 - 29,026,088 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1029,020,049 - 29,026,002 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01028,856,281 - 28,868,004 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41028,527,409 - 28,532,831 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11028,528,480 - 28,533,880 (-)NCBI
Celera1027,392,215 - 27,397,637 (-)NCBICelera
Cytogenetic Map10q21NCBI
PTTG1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385160,421,855 - 160,428,744 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl5160,421,855 - 160,428,739 (+)EnsemblGRCh38hg38GRCh38
GRCh375159,848,862 - 159,855,751 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365159,781,443 - 159,788,324 (+)NCBINCBI36Build 36hg18NCBI36
Build 345159,781,442 - 159,788,323NCBI
Celera5155,881,349 - 155,888,231 (+)NCBICelera
Cytogenetic Map5q33.3NCBI
HuRef5154,942,291 - 154,949,173 (+)NCBIHuRef
CHM1_15159,281,784 - 159,288,665 (+)NCBICHM1_1
T2T-CHM13v2.05160,950,365 - 160,957,262 (+)NCBIT2T-CHM13v2.0
Pttg1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391143,311,071 - 43,318,290 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1143,311,077 - 43,317,078 (-)EnsemblGRCm39 Ensembl
GRCm381143,420,244 - 43,427,463 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1143,420,250 - 43,426,251 (-)EnsemblGRCm38mm10GRCm38
MGSCv371143,233,750 - 43,239,750 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361143,263,687 - 43,269,404 (-)NCBIMGSCv36mm8
Celera1148,048,753 - 48,054,761 (-)NCBICelera
Cytogenetic Map11B1.1NCBI
Pttg1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495540814,293,704 - 14,301,357 (+)NCBIChiLan1.0ChiLan1.0
PTTG1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.15162,506,954 - 162,513,869 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5162,506,832 - 162,513,869 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v05155,812,745 - 155,819,684 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PTTG1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1450,301,868 - 50,309,636 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha450,197,498 - 50,205,256 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0450,737,382 - 50,745,152 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl450,737,391 - 50,744,665 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1450,545,760 - 50,553,525 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0450,669,501 - 50,677,252 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0451,189,832 - 51,197,602 (-)NCBIUU_Cfam_GSD_1.0
LOC101977070
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494754,812,154 - 54,812,816 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936841274,458 - 275,148 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTTG1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11663,104,698 - 63,112,382 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21668,455,362 - 68,463,042 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PTTG1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12362,781,184 - 62,787,832 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603414,816,659 - 14,823,249 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pttg1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473329,134,720 - 29,147,261 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pttg1
72 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:20
Count of miRNA genes:19
Interacting mature miRNAs:20
Transcripts:ENSRNOT00000005070
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135225947Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138328221Rat
7411611Foco17Food consumption QTL 1718.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)10142315980Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1041834445418344Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)cortical volumetric bone mineral density (CMO:0001730)10538701450387014Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10538701450387014Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10538701450387014Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101502851360430477Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101527595560275955Rat
6893350Bw99Body weight QTL 990.870.16body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
6893352Bw100Body weight QTL 1000.330.6body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101790711351786432Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101816784163167841Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)101960648364606483Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)101960648364606483Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102132980561345413Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
631531Iresp2Immunoglobin response QTL26.3blood immunoglobulin E amount (VT:0002492)serum total immunoglobulin E level (CMO:0001542)102291826836400810Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102652195761345413Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102694462871944628Rat
10402859Bp381Blood pressure QTL 3810.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2292441Bp308Blood pressure QTL 308arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat

Markers in Region
D10Wox45  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21027,905,955 - 27,906,187 (+)MAPPERmRatBN7.2
Rnor_6.01029,027,121 - 29,027,348NCBIRnor6.0
Rnor_5.01028,869,037 - 28,869,264UniSTSRnor5.0
RGSC_v3.41028,534,193 - 28,534,422UniSTSRGSC3.4
Celera1027,398,999 - 27,399,226UniSTS
Cytogenetic Map10q21UniSTS
RH133996  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21027,899,170 - 27,900,043 (+)MAPPERmRatBN7.2
Rnor_6.01029,020,027 - 29,020,899NCBIRnor6.0
Rnor_5.01028,861,943 - 28,862,815UniSTSRnor5.0
RGSC_v3.41028,527,410 - 28,528,282UniSTSRGSC3.4
Celera1027,392,216 - 27,393,088UniSTS
RH 3.4 Map10292.9UniSTS
Cytogenetic Map10q21UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 26 32 26 16 26 49 20 37 1
Low 15 23 14 3 14 4 7 22 14 4 10 4
Below cutoff 2 2 1 1 4 4 3 1 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000005070   ⟹   ENSRNOP00000005070
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1027,899,193 - 27,904,837 (-)Ensembl
Rnor_6.0 Ensembl1029,020,049 - 29,026,002 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000093944   ⟹   ENSRNOP00000086678
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1027,893,689 - 27,904,837 (-)Ensembl
RefSeq Acc Id: NM_022391   ⟹   NP_071786
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21027,899,170 - 27,904,854 (-)NCBI
Rnor_6.01029,020,026 - 29,025,759 (-)NCBI
Rnor_5.01028,856,281 - 28,868,004 (-)NCBI
RGSC_v3.41028,527,409 - 28,532,831 (-)RGD
Celera1027,392,215 - 27,397,637 (-)RGD
Sequence:
RefSeq Acc Id: XM_006246142   ⟹   XP_006246204
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21027,899,170 - 27,904,965 (-)NCBI
Rnor_6.01029,020,026 - 29,026,088 (-)NCBI
Rnor_5.01028,856,281 - 28,868,004 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006246143   ⟹   XP_006246205
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21027,899,170 - 27,904,835 (-)NCBI
Rnor_6.01029,020,026 - 29,025,989 (-)NCBI
Rnor_5.01028,856,281 - 28,868,004 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006246144   ⟹   XP_006246206
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21027,899,170 - 27,904,835 (-)NCBI
Rnor_6.01029,020,026 - 29,025,997 (-)NCBI
Rnor_5.01028,856,281 - 28,868,004 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006246145   ⟹   XP_006246207
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21027,893,466 - 27,904,965 (-)NCBI
Rnor_6.01029,014,332 - 29,026,088 (-)NCBI
Rnor_5.01028,856,281 - 28,868,004 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039086789   ⟹   XP_038942717
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21027,893,466 - 27,904,965 (-)NCBI
RefSeq Acc Id: XR_005489940
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21027,893,466 - 27,904,965 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_071786   ⟸   NM_022391
- UniProtKB: P97613 (UniProtKB/Swiss-Prot),   B0BMT1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006246207   ⟸   XM_006246145
- Peptide Label: isoform X1
- UniProtKB: P97613 (UniProtKB/Swiss-Prot),   B0BMT1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006246204   ⟸   XM_006246142
- Peptide Label: isoform X1
- UniProtKB: P97613 (UniProtKB/Swiss-Prot),   B0BMT1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006246206   ⟸   XM_006246144
- Peptide Label: isoform X1
- UniProtKB: P97613 (UniProtKB/Swiss-Prot),   B0BMT1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006246205   ⟸   XM_006246143
- Peptide Label: isoform X1
- UniProtKB: P97613 (UniProtKB/Swiss-Prot),   B0BMT1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000005070   ⟸   ENSRNOT00000005070
RefSeq Acc Id: XP_038942717   ⟸   XM_039086789
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A1P6 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000086678   ⟸   ENSRNOT00000093944

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P97613-F1-model_v2 AlphaFold P97613 1-199 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697111
Promoter ID:EPDNEW_R7636
Type:initiation region
Name:Pttg1_1
Description:pituitary tumor-transforming 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01029,026,045 - 29,026,105EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:68359 AgrOrtholog
BioCyc Gene G2FUF-25455 BioCyc
Ensembl Genes ENSRNOG00000003802 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000005070 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000086678 ENTREZGENE
  ENSRNOP00000086678.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000005070 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000093944 ENTREZGENE
  ENSRNOT00000093944.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:9032805 IMAGE-MGC_LOAD
InterPro Securin_separation_inhibitor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:64193 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:187213 IMAGE-MGC_LOAD
NCBI Gene 64193 ENTREZGENE
PANTHER PTHR10418 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Securin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pttg1 PhenoGen
TIGR TC217859
UniProt A0A8I6A1P6 ENTREZGENE, UniProtKB/TrEMBL
  B0BMT1 ENTREZGENE, UniProtKB/TrEMBL
  P97613 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-03 Pttg1  PTTG1 regulator of sister chromatid separation, securin  Pttg1  pituitary tumor-transforming 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Pttg1  pituitary tumor-transforming 1      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in the pituitary adenoma during the rat estrus cycle 70521
gene_expression displays highest mRNA expression in pituitary tumor cells 68295
gene_process induced by estrogen 70521
gene_regulation progesterone down inhibits mRNA induction 70521