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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68359
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pttg1
Name: PTTG1 regulator of sister chromatid separation, securin
Acc ID: CHEBI:63924
Term: riddelliine
Definition: A macrodiolide that is 13,19-didehydrosenecionan bearing two additional hydroxy substituents at positions 12 and 18 as well as two additional oxo groups at positions 11 and 16.
Chemical ID: MESH:C013672
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pttg1multiple interactionsISOPTTG1 (Homo sapiens)6480464CTD[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of PTTG1 mRNAPMID:33884520
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