Htr1b (5-hydroxytryptamine receptor 1B) - Rat Genome Database

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Gene: Htr1b (5-hydroxytryptamine receptor 1B) Rattus norvegicus
Analyze
Symbol: Htr1b
Name: 5-hydroxytryptamine receptor 1B
RGD ID: 2846
Description: Exhibits G protein-coupled serotonin receptor activity and voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels. Involved in several processes, including modulation of chemical synaptic transmission; regulation of amine transport; and response to cocaine. Localizes to calyx of Held and plasma membrane. Used to study anxiety disorder. Biomarker of hypertension; ischemia; and obesity. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder and conduct disorder. Orthologous to human HTR1B (5-hydroxytryptamine receptor 1B); INTERACTS WITH (+)-pilocarpine; (6aR,9R)-N-[(2S)-1-hydroxybutan-2-yl]-4,7-dimethyl-6,6a,8,9-tetrahydroindolo[4,3-fg]quinoline-9-carboxamide; (S)-nicotine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 5-HT-1B; 5-HT1B serotonin receptor; 5-hydroxytryptamine (serotonin ) receptor 1B; 5-hydroxytryptamine (serotonin) receptor 1B; 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled; Serotonin (5-hydroxytryptamine (5HT)) receptor type 1B; serotonin receptor 1B
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Is Marker For: Strains:   SD  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2882,513,572 - 82,534,892 (-)NCBI
Rnor_6.0 Ensembl889,129,453 - 89,130,991 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0889,113,984 - 89,130,830 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0888,651,220 - 88,667,993 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4886,700,088 - 86,701,248 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1886,719,542 - 86,720,703 (-)NCBI
Celera882,222,051 - 82,223,211 (-)NCBICelera
Cytogenetic Map8q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(6aR,9R)-N-[(2S)-1-hydroxybutan-2-yl]-4,7-dimethyl-6,6a,8,9-tetrahydroindolo[4,3-fg]quinoline-9-carboxamide  (EXP)
(S)-nicotine  (EXP)
1,2-dimethylhydrazine  (EXP)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (EXP)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3',5'-cyclic AMP  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-(4-methylpiperazin-1-yl)-7-(trifluoromethyl)pyrrolo[1,2-a]quinoxaline dimaleate  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-carboxamidotryptamine  (EXP)
6-propyl-2-thiouracil  (EXP)
almotriptan  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP)
capsaicin  (ISO)
chlorpyrifos  (EXP)
choline  (ISO)
citalopram  (EXP)
cocaine  (EXP,ISO)
colforsin daropate hydrochloride  (ISO)
dextran sulfate  (ISO)
diazinon  (EXP)
Dicyclohexyl phthalate  (EXP)
eletriptan  (EXP)
endosulfan  (EXP)
ethanol  (ISO)
fluoxetine  (EXP)
folic acid  (ISO)
gamma-aminobutyric acid  (EXP)
genistein  (EXP)
GR 127935  (EXP)
iodocyanopindolol  (EXP)
L-methionine  (ISO)
lead diacetate  (EXP)
metergoline  (EXP)
methiothepin  (EXP)
methysergide  (EXP)
N-nitrosodiethylamine  (EXP)
naratriptan  (ISO)
nicotine  (EXP)
paracetamol  (ISO)
paraquat  (EXP)
paroxetine  (EXP)
PCB138  (ISO)
pindolol  (EXP)
propranolol  (EXP)
sarpogrelate  (EXP)
serotonin  (EXP,ISO)
sumatriptan  (EXP)
sunitinib  (ISO)
tertatolol  (EXP)
titanium dioxide  (ISO)
triclosan  (ISO)
valproic acid  (ISO)
vortioxetine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
1. Ahlander-Luttgen M, etal., Neuropsychopharmacology 2003 Sep;28(9):1642-55.
2. Amato JL, etal., Neuropsychopharmacology. 2007 Apr;32(4):946-54. Epub 2006 Aug 2.
3. Ansar S, etal., J Neurosurg. 2007 May;106(5):881-6.
4. Banes AK and Watts SW, Hypertension. 2002 Feb;39(2 Pt 2):394-8.
5. Barot SK, etal., Eur J Neurosci. 2007 May;25(10):3125-31. Epub 2007 May 17.
6. Cambj-Sapunar L, etal., Stroke 2003 May;34(5):1269-75. Epub 2003 Apr 3.
7. Carta M, etal., Brain. 2007 Jul;130(Pt 7):1819-33. Epub 2007 Apr 23.
8. Chennaoui M, etal., Neurosci Lett 2003 Apr 10;340(2):131-4.
9. Clark MS, etal., J Neurosci 2002 Jun 1;22(11):4550-62.
10. Cruz-Martínez AM, etal., Eur Neuropsychopharmacol. 2018 Nov;28(11):1247-1259. doi: 10.1016/j.euroneuro.2018.08.002. Epub 2018 Sep 11.
11. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
12. GOA data from the GO Consortium
13. Holden JE, etal., Neuroscience. 2005;135(4):1255-68. Epub 2005 Sep 13.
14. Hoplight BJ, etal., Alcohol. 2006 Feb;38(2):73-9.
15. Janiak P, etal., Cardiovasc Res. 2002 Nov;56(2):293-302.
16. Keegan A, etal., Circ Res. 2001 Dec 7;89(12):1231-9.
17. Lee JJ, etal., Neuropsychopharmacology. 2007 Mar 28;.
18. Lee MD, etal., Psychopharmacology (Berl). 2002 Oct;164(1):49-60. Epub 2002 Jul 19.
19. Lemos JC, etal., Eur J Neurosci. 2006 Dec;24(12):3415-30.
20. Makarenko IG, etal., Neurosci Lett. 2005 Mar 11;376(2):71-5. Epub 2004 Dec 8.
21. MGD data from the GO Consortium
22. Mizutani H, etal., Eur J Neurosci. 2006 Oct;24(7):1946-54. doi: 10.1111/j.1460-9568.2006.05063.x.
23. NCBI rat LocusLink and RefSeq merged data July 26, 2002
24. Park S, etal., Brain Res. 1999 Nov 13;847(1):90-7.
25. Quist JF, etal., Mol Psychiatry 2003 Jan;8(1):98-102.
26. RGD automated data pipeline
27. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
28. RGD automated import pipeline for gene-chemical interactions
29. Scott C, etal., Neuropharmacology. 2006 Jun;50(8):984-90. Epub 2006 Mar 20.
30. Soyka M, etal., J Neural Transm 2004 Jan;111(1):101-9. Epub 2003 Dec 3.
31. Verge D, etal., J Neurosci. 1986 Dec;6(12):3474-82.
32. Yan QS, etal., Brain Res 2004 Sep 17;1021(1):82-91.
33. Yan QS, etal., Brain Res. 2005 Oct 26;1060(1-2):126-37. Epub 2005 Oct 5.
Additional References at PubMed
PMID:1315531   PMID:1836757   PMID:8882600   PMID:9349547   PMID:10234032   PMID:12957218   PMID:16310183   PMID:17074068   PMID:17325130   PMID:17873013   PMID:18207350   PMID:18502320  
PMID:18638459   PMID:18793415   PMID:19041748   PMID:19121358   PMID:19556691   PMID:19819310   PMID:19963045   PMID:20226766   PMID:20385119   PMID:20510890   PMID:20833155   PMID:20843634  
PMID:21047499   PMID:21107539   PMID:21653728   PMID:21681557   PMID:21718722   PMID:21801291   PMID:21982809   PMID:22585122   PMID:22659115   PMID:22848635   PMID:22883081   PMID:23155193  
PMID:23583574   PMID:23609771   PMID:23988741   PMID:24269608   PMID:25871906   PMID:26547948   PMID:28720013   PMID:31468338  


Genomics

Candidate Gene Status
Htr1b is a candidate Gene for QTL Alc20
Comparative Map Data
Htr1b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2882,513,572 - 82,534,892 (-)NCBI
Rnor_6.0 Ensembl889,129,453 - 89,130,991 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0889,113,984 - 89,130,830 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0888,651,220 - 88,667,993 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4886,700,088 - 86,701,248 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1886,719,542 - 86,720,703 (-)NCBI
Celera882,222,051 - 82,223,211 (-)NCBICelera
Cytogenetic Map8q31NCBI
HTR1B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl677,460,924 - 77,463,491 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl677,461,753 - 77,463,773 (-)EnsemblGRCh38hg38GRCh38
GRCh38677,460,924 - 77,463,491 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37678,170,641 - 78,173,208 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36678,228,667 - 78,229,839 (-)NCBINCBI36hg18NCBI36
Build 34678,228,666 - 78,229,839NCBI
Celera678,559,593 - 78,560,765 (-)NCBI
Cytogenetic Map6q14.1NCBI
HuRef675,364,405 - 75,365,577 (-)NCBIHuRef
CHM1_1678,336,807 - 78,339,981 (-)NCBICHM1_1
Htr1b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39981,510,344 - 81,515,885 (-)NCBIGRCm39mm39
GRCm39 Ensembl981,510,344 - 81,515,881 (-)Ensembl
GRCm38981,628,291 - 81,633,832 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl981,628,291 - 81,633,828 (-)EnsemblGRCm38mm10GRCm38
MGSCv37981,524,999 - 81,526,159 (-)NCBIGRCm37mm9NCBIm37
MGSCv36981,428,110 - 81,429,270 (-)NCBImm8
Celera978,725,698 - 78,726,858 (-)NCBICelera
Cytogenetic Map9E1NCBI
cM Map944.61NCBI
Htr1b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555025,645,644 - 5,646,816 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555025,640,919 - 5,646,899 (-)NCBIChiLan1.0ChiLan1.0
HTR1B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1678,594,870 - 78,598,204 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl678,596,408 - 78,597,580 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0675,309,078 - 75,313,747 (-)NCBIMhudiblu_PPA_v0panPan3
HTR1B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11238,659,088 - 38,659,546 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1238,541,798 - 38,542,967 (-)NCBI
ROS_Cfam_1.01239,430,205 - 39,431,374 (-)NCBI
UMICH_Zoey_3.11238,755,029 - 38,756,198 (-)NCBI
UNSW_CanFamBas_1.01238,739,892 - 38,741,061 (-)NCBI
UU_Cfam_GSD_1.01238,869,413 - 38,870,583 (-)NCBI
Htr1b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494674,024,237 - 74,029,424 (-)NCBI
SpeTri2.0NW_004936890154,252 - 157,044 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HTR1B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl188,596,215 - 88,601,047 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1188,597,510 - 88,598,682 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2199,465,592 - 99,466,764 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HTR1B
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1132,143,646 - 2,145,943 (-)NCBI
ChlSab1.1 Ensembl132,144,313 - 2,145,485 (-)Ensembl
Htr1b
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248194,425,271 - 4,429,165 (-)NCBI

Position Markers
PMC166422P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0889,130,477 - 89,130,808NCBIRnor6.0
Rnor_5.0888,667,644 - 88,667,975UniSTSRnor5.0
RGSC_v3.4886,700,913 - 86,701,244UniSTSRGSC3.4
Celera882,222,876 - 82,223,207UniSTS
Cytogenetic Map8q31UniSTS
GDB:580614  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0889,130,022 - 89,130,222NCBIRnor6.0
Rnor_5.0888,667,189 - 88,667,389UniSTSRnor5.0
RGSC_v3.4886,700,458 - 86,700,658UniSTSRGSC3.4
Celera882,222,421 - 82,222,621UniSTS
Cytogenetic Map8q31UniSTS
UniSTS:491331  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0889,129,597 - 89,130,875NCBIRnor6.0
Rnor_5.0888,666,764 - 88,668,042UniSTSRnor5.0
RGSC_v3.4886,700,033 - 86,701,311UniSTSRGSC3.4
Celera882,221,996 - 82,223,274UniSTS
Cytogenetic Map8q31UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)89531047119211942Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810938911120496129Rat
631271Lecl1Lens clarity QTL 10.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)82146491991140553Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)821813070100873963Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)829867983106526740Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)829867983106526740Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)829867983106526740Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)830918112107206309Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)832888352101374135Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)833558660109028082Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)833558660109028082Rat
1578755Pur5Proteinuria QTL 53.30.0001total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)833558660109028082Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)833558764113580387Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)839230130106506973Rat
737824Hcar10Hepatocarcinoma resistance QTL 102.9liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)84421919789542960Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)844219197100873963Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)844458129118087517Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)84571234490712344Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84658843796998640Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)847200750106394378Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)847200750106394378Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)847200750106394378Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)847200750106394378Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)847200750106394378Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)847200750106394378Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)850529480128036471Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)850529480128036471Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)850529480128036471Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)850529480128036471Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)850529563106506973Rat
1358912Bw51Body weight QTL 512.95body mass (VT:0001259)body weight (CMO:0000012)855435004115812386Rat
2303570Gluco48Glucose level QTL 482blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)855659105100659105Rat
2293697Bmd39Bone mineral density QTL 39femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)858230766106394378Rat
1582243Bw66Body weight QTL 663.40.0048body mass (VT:0001259)body weight (CMO:0000012)85842551091990535Rat
1582254Kidm31Kidney mass QTL 313kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)85842551091990535Rat
631664Hcar3Hepatocarcinoma resistance QTL 32.90.0005liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)858425510106526740Rat
1300177Cm2Cardiac mass QTL 23.65heart mass (VT:0007028)heart weight (CMO:0000017)859234112108068306Rat
2301402Bp316Blood pressure QTL 3160.005arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)861394378106394378Rat
10402857Bp380Blood pressure QTL 3800.95arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)861394378106394378Rat
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)865717449128033050Rat
631653Bp125Blood pressure QTL 1253.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)872849686117849686Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight as a percentage of body weight (CMO:0000654)874917593121080545Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)876103982127182642Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)878805083123805083Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)878805083123805083Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)878805083123805083Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)878805083123805083Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)880697934125697934Rat
10450865Bw175Body weight QTL 1754.1total fat pad mass (VT:0015008)adipose tissue molecular composition measurement (CMO:0000484)88141389891140553Rat
634332Pia18Pristane induced arthritis QTL 184joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)88141405889542815Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)883894304128894304Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)889058229132243842Rat


Related Rat Strains
The following Strains have been annotated to Htr1b
SD

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:41
Count of miRNA genes:38
Interacting mature miRNAs:41
Transcripts:ENSRNOT00000017411
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 31 6
Low 2 20 13 4 3 4 8 10 35 23 26 11 8
Below cutoff 1 20 16 9 13 9 1 8 11 9

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000017411   ⟹   ENSRNOP00000017411
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl889,129,453 - 89,130,991 (-)Ensembl
RefSeq Acc Id: NM_022225   ⟹   NP_071561
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2882,532,254 - 82,533,414 (-)NCBI
Rnor_6.0889,129,652 - 89,130,812 (-)NCBI
Rnor_5.0888,651,220 - 88,667,993 (-)NCBI
RGSC_v3.4886,700,088 - 86,701,248 (-)RGD
Celera882,222,051 - 82,223,211 (-)RGD
Sequence:
RefSeq Acc Id: XM_039080866   ⟹   XP_038936794
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2882,529,141 - 82,534,892 (-)NCBI
RefSeq Acc Id: XR_356450
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2882,513,572 - 82,534,386 (-)NCBI
Rnor_6.0889,113,984 - 89,130,830 (-)NCBI
Rnor_5.0888,651,220 - 88,667,993 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_071561 (Get FASTA)   NCBI Sequence Viewer  
  XP_038936794 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA40613 (Get FASTA)   NCBI Sequence Viewer  
  EDL77686 (Get FASTA)   NCBI Sequence Viewer  
  P28564 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_071561   ⟸   NM_022225
- UniProtKB: P28564 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000017411   ⟸   ENSRNOT00000017411
RefSeq Acc Id: XP_038936794   ⟸   XM_039080866
- Peptide Label: isoform X1

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2846 AgrOrtholog
Ensembl Genes ENSRNOG00000013042 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000017411 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000017411 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro 5HT1B_rcpt UniProtKB/Swiss-Prot
  5HT_rcpt UniProtKB/Swiss-Prot
  GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
KEGG Report rno:25075 UniProtKB/Swiss-Prot
NCBI Gene 25075 ENTREZGENE
PANTHER PTHR24247:SF16 UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PharmGKB HTR1B RGD
PhenoGen Htr1b PhenoGen
PRINTS 5HT1BRECEPTR UniProtKB/Swiss-Prot
  5HTRECEPTOR UniProtKB/Swiss-Prot
  GPCRRHODOPSN UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot
UniProt 5HT1B_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Htr1b  5-hydroxytryptamine receptor 1B  Htr1b  5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-17 Htr1b  5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled  Htr1b  5-hydroxytryptamine (serotonin) receptor 1B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2001-07-23 Htr1b  5-hydroxytryptamine (serotonin) receptor 1B      Name updated to reflect Human and Mouse nomenclature 67952 APPROVED
2001-07-23 Htr1b  5-hydroxytryptamine (serotonin ) receptor 1B      Name updated to reflect Human and Mouse nomenclature 67952 APPROVED
2001-07-23 Htr1b  Serotonin (5-hydroxytryptamine (5HT)) receptor, type 1B      Name withdrawn 67952 WITHDRAWN

RGD Curation Notes
Note Type Note Reference
gene_disease associated with stress, depression and anxiety behaviors 625756
gene_drugs antidepressants downregulate the receptor activity and normalize serotonergic neurotransmission; fluoxetine or paroxetine acts on a time-dependent and reversible manner resulting in decrease of receptor expression in striatum 625756
gene_expression expressed in the midbrain raphe nuclei and dorsal raphe nucleus (DRN) and serotonergic neurons of brain 625756
gene_mutations_overexpression receptor overexpression in dorsal raphe nucleus mediates pathological response to behavioural disorders such as anxiety and stress 625756
gene_mutations_overexpression overexpression in dorsal raphe nucleus causes an increase in anxiety behavior 625756
gene_process involved in the negative feedback system regulating extracellular serotonin [ 5-HT ] neurotransmission 625756
gene_regulation upregulated in animals during behavior related learning periods and downregulated by antidepressants 625756
gene_regulation activated by subarachnoid hemorrhage 737621