Htr1b (5-hydroxytryptamine receptor 1B) - Rat Genome Database

Send us a Message

Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Htr1b (5-hydroxytryptamine receptor 1B) Rattus norvegicus
Symbol: Htr1b
Name: 5-hydroxytryptamine receptor 1B
RGD ID: 2846
Description: Enables G protein-coupled serotonin receptor activity; heterocyclic compound binding activity; and voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels. Involved in several processes, including drinking behavior; modulation of chemical synaptic transmission; and regulation of amine transport. Is active in calyx of Held. Used to study anxiety disorder. Biomarker of hypertension; ischemia; and obesity. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder and conduct disorder. Orthologous to human HTR1B (5-hydroxytryptamine receptor 1B); INTERACTS WITH (+)-pilocarpine; (6aR,9R)-N-[(2S)-1-hydroxybutan-2-yl]-4,7-dimethyl-6,6a,8,9-tetrahydroindolo[4,3-fg]quinoline-9-carboxamide; (S)-nicotine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 5-HT-1B; 5-HT1B serotonin receptor; 5-hydroxytryptamine (serotonin ) receptor 1B; 5-hydroxytryptamine (serotonin) receptor 1B; 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled; Serotonin (5-hydroxytryptamine (5HT)) receptor type 1B; serotonin receptor 1B
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Is Marker For: Strains:   SD  
Candidate Gene For: Alc20
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2882,513,572 - 82,534,670 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl882,517,360 - 82,534,549 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx888,140,648 - 88,141,808 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0886,356,378 - 86,357,538 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0884,232,825 - 84,233,985 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0889,113,984 - 89,130,830 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl889,129,453 - 89,130,991 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0888,651,220 - 88,667,993 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4886,700,088 - 86,701,248 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1886,719,542 - 86,720,703 (-)NCBI
Celera882,222,051 - 82,223,211 (-)NCBICelera
Cytogenetic Map8q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(6aR,9R)-N-[(2S)-1-hydroxybutan-2-yl]-4,7-dimethyl-6,6a,8,9-tetrahydroindolo[4,3-fg]quinoline-9-carboxamide  (EXP)
(S)-nicotine  (EXP)
1,2-dimethylhydrazine  (EXP)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (EXP)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3',5'-cyclic AMP  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-(4-methylpiperazin-1-yl)-7-(trifluoromethyl)pyrrolo[1,2-a]quinoxaline dimaleate  (EXP)
4-nitrophenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-carboxamidotryptamine  (EXP)
6-propyl-2-thiouracil  (EXP)
almotriptan  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP)
capsaicin  (ISO)
chlorpyrifos  (EXP)
choline  (ISO)
citalopram  (EXP)
cocaine  (EXP,ISO)
colforsin daropate hydrochloride  (ISO)
Cuprizon  (EXP)
dextran sulfate  (ISO)
diazinon  (EXP)
Dicyclohexyl phthalate  (EXP)
eletriptan  (EXP)
endosulfan  (EXP)
ethanol  (ISO)
fluoxetine  (EXP)
folic acid  (ISO)
gamma-aminobutyric acid  (EXP)
genistein  (EXP)
gentamycin  (EXP)
GR 127935  (EXP)
hydroquinone  (ISO)
iodocyanopindolol  (EXP)
isotretinoin  (ISO)
L-methionine  (ISO)
lead diacetate  (EXP)
lipopolysaccharide  (ISO)
metergoline  (EXP)
methiothepin  (EXP)
methysergide  (EXP)
N-nitrosodiethylamine  (EXP)
naratriptan  (ISO)
nicotine  (EXP)
nitrofen  (EXP)
paracetamol  (ISO)
paraquat  (EXP)
paroxetine  (EXP)
PCB138  (ISO)
pindolol  (EXP)
propranolol  (EXP)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
sarpogrelate  (EXP)
serotonin  (EXP,ISO)
sodium arsenite  (ISO)
sumatriptan  (EXP)
sunitinib  (ISO)
tacrolimus hydrate  (ISO)
tertatolol  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
triclosan  (ISO)
valproic acid  (ISO)
vortioxetine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

References - curated
# Reference Title Reference Citation
1. Analysis of the role of the 5-HT1B receptor in spatial and aversive learning in the rat. Ahlander-Luttgen M, etal., Neuropsychopharmacology 2003 Sep;28(9):1642-55.
2. Prior exposure to chronic stress and MDMA potentiates mesoaccumbens dopamine release mediated by the 5-HT(1B) receptor. Amato JL, etal., Neuropsychopharmacology. 2007 Apr;32(4):946-54. Epub 2006 Aug 2.
3. Neurokinin-1 receptor antagonism in a rat model of subarachnoid hemorrhage: prevention of upregulation of contractile ETB and 5-HT1B receptors and cerebral blood flow reduction. Ansar S, etal., J Neurosurg. 2007 May;106(5):881-6.
4. Upregulation of arterial serotonin 1B and 2B receptors in deoxycorticosterone acetate-salt hypertension. Banes AK and Watts SW, Hypertension. 2002 Feb;39(2 Pt 2):394-8.
5. 5-HT(1B) receptors in nucleus accumbens efferents enhance both rewarding and aversive effects of cocaine. Barot SK, etal., Eur J Neurosci. 2007 May;25(10):3125-31. Epub 2007 May 17.
6. Contribution of 5-hydroxytryptamine1B receptors and 20-hydroxyeiscosatetraenoic acid to fall in cerebral blood flow after subarachnoid hemorrhage. Cambj-Sapunar L, etal., Stroke 2003 May;34(5):1269-75. Epub 2003 Apr 3.
7. Dopamine released from 5-HT terminals is the cause of L-DOPA-induced dyskinesia in parkinsonian rats. Carta M, etal., Brain. 2007 Jul;130(Pt 7):1819-33. Epub 2007 Apr 23.
8. The effects of long-term adrenalectomy on 5-HT1B receptors mRNA expression in cerebellum, striatum, frontal cortex and hippocampus of rats. Chennaoui M, etal., Neurosci Lett 2003 Apr 10;340(2):131-4.
9. Overexpression of 5-HT1B receptor in dorsal raphe nucleus using Herpes Simplex Virus gene transfer increases anxiety behavior after inescapable stress. Clark MS, etal., J Neurosci 2002 Jun 1;22(11):4550-62.
10. CB1 receptors in the paraventricular nucleus of the hypothalamus modulate the release of 5-HT and GABA to stimulate food intake in rats. Cruz-Martínez AM, etal., Eur Neuropsychopharmacol. 2018 Nov;28(11):1247-1259. doi: 10.1016/j.euroneuro.2018.08.002. Epub 2018 Sep 11.
11. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
12. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
13. Stimulation of the lateral hypothalamus produces antinociception mediated by 5-HT1A, 5-HT1B and 5-HT3 receptors in the rat spinal cord dorsal horn. Holden JE, etal., Neuroscience. 2005;135(4):1255-68. Epub 2005 Sep 13.
14. Serotonin Signaling Through the 5-HT1B Receptor and NADPH Oxidase 1 in Pulmonary Arterial Hypertension. Hood KY, etal., Arterioscler Thromb Vasc Biol. 2017 Jul;37(7):1361-1370. doi: 10.1161/ATVBAHA.116.308929. Epub 2017 May 4.
15. Increased expression of 5-HT1B receptors in rat nucleus accumbens via virally mediated gene transfer increases voluntary alcohol consumption. Hoplight BJ, etal., Alcohol. 2006 Feb;38(2):73-9.
16. Serotonin receptor blockade improves distal perfusion after lower limb ischemia in the fatty Zucker rat. Janiak P, etal., Cardiovasc Res. 2002 Nov;56(2):293-302.
17. Contribution of the 5-HT(1B) receptor to hypoxia-induced pulmonary hypertension: converging evidence using 5-HT(1B)-receptor knockout mice and the 5-HT(1B/1D)-receptor antagonist GR127935. Keegan A, etal., Circ Res. 2001 Dec 7;89(12):1231-9.
18. Serotonergic Modulation of GABAergic and Glutamatergic Synaptic Transmission in Mechanically Isolated Rat Medial Preoptic Area Neurons. Lee JJ, etal., Neuropsychopharmacology. 2007 Mar 28;.
19. 5-HT1B receptors modulate components of satiety in the rat: behavioural and pharmacological analyses of the selective serotonin1B agonist CP-94,253. Lee MD, etal., Psychopharmacology (Berl). 2002 Oct;164(1):49-60. Epub 2002 Jul 19.
20. Selective 5-HT receptor inhibition of glutamatergic and GABAergic synaptic activity in the rat dorsal and median raphe. Lemos JC, etal., Eur J Neurosci. 2006 Dec;24(12):3415-30.
21. Hypothalamic 5-HT1B-receptor changes in anorectic tumor bearing rats. Makarenko IG, etal., Neurosci Lett. 2005 Mar 11;376(2):71-5. Epub 2004 Dec 8.
22. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
23. 5-HT1B receptor-mediated presynaptic inhibition at the calyx of Held of immature rats. Mizutani H, etal., Eur J Neurosci. 2006 Oct;24(7):1946-54. doi: 10.1111/j.1460-9568.2006.05063.x.
24. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
25. Increased binding at 5-HT(1A), 5-HT(1B), and 5-HT(2A) receptors and 5-HT transporters in diet-induced obese rats. Park S, etal., Brain Res. 1999 Nov 13;847(1):90-7.
26. The serotonin 5-HT1B receptor gene and attention deficit hyperactivity disorder. Quist JF, etal., Mol Psychiatry 2003 Jan;8(1):98-102.
27. GOA pipeline RGD automated data pipeline
28. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
29. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
30. SB-616234-A (1-[6-(cis-3,5-dimethylpiperazin-1-yl)-2,3-dihydro-5-methoxyindol-1-yl]-1- [2'methyl-4'-(5-methyl-1,2,3-oxadiazol-3-yl)biphenyl-4-yl]methanone hydrochloride): a novel, potent and selective 5-HT1B receptor antagonist. Scott C, etal., Neuropharmacology. 2006 Jun;50(8):984-90. Epub 2006 Mar 20.
31. Association of 5-HT1B receptor gene and antisocial behavior in alcoholism. Soyka M, etal., J Neural Transm 2004 Jan;111(1):101-9. Epub 2003 Dec 3.
32. Quantitative autoradiography of multiple 5-HT1 receptor subtypes in the brain of control or 5,7-dihydroxytryptamine-treated rats. Verge D, etal., J Neurosci. 1986 Dec;6(12):3474-82.
33. Involvement of 5-HT1B receptors within the ventral tegmental area in regulation of mesolimbic dopaminergic neuronal activity via GABA mechanisms: a study with dual-probe microdialysis. Yan QS, etal., Brain Res 2004 Sep 17;1021(1):82-91.
34. Involvement of 5-HT1B receptors within the ventral tegmental area in ethanol-induced increases in mesolimbic dopaminergic transmission. Yan QS, etal., Brain Res. 2005 Oct 26;1060(1-2):126-37. Epub 2005 Oct 5.
Additional References at PubMed
PMID:1315531   PMID:1836757   PMID:8882600   PMID:9349547   PMID:10234032   PMID:12957218   PMID:16310183   PMID:17074068   PMID:17325130   PMID:17873013   PMID:18207350   PMID:18502320  
PMID:18638459   PMID:18793415   PMID:19041748   PMID:19121358   PMID:19556691   PMID:19819310   PMID:19963045   PMID:20226766   PMID:20385119   PMID:20510890   PMID:20833155   PMID:20843634  
PMID:21047499   PMID:21107539   PMID:21653728   PMID:21681557   PMID:21718722   PMID:21801291   PMID:21982809   PMID:22585122   PMID:22659115   PMID:22848635   PMID:22883081   PMID:23155193  
PMID:23583574   PMID:23609771   PMID:23988741   PMID:24269608   PMID:25871906   PMID:26547948   PMID:28720013   PMID:31468338   PMID:32574671   PMID:34061415  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2882,513,572 - 82,534,670 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl882,517,360 - 82,534,549 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx888,140,648 - 88,141,808 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0886,356,378 - 86,357,538 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0884,232,825 - 84,233,985 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0889,113,984 - 89,130,830 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl889,129,453 - 89,130,991 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0888,651,220 - 88,667,993 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4886,700,088 - 86,701,248 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1886,719,542 - 86,720,703 (-)NCBI
Celera882,222,051 - 82,223,211 (-)NCBICelera
Cytogenetic Map8q31NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38677,460,924 - 77,463,491 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl677,460,924 - 77,463,491 (-)EnsemblGRCh38hg38GRCh38
GRCh37678,170,641 - 78,173,208 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36678,228,667 - 78,229,839 (-)NCBINCBI36Build 36hg18NCBI36
Build 34678,228,666 - 78,229,839NCBI
Celera678,559,593 - 78,560,765 (-)NCBICelera
Cytogenetic Map6q14.1NCBI
HuRef675,364,405 - 75,365,577 (-)NCBIHuRef
CHM1_1678,338,190 - 78,339,362 (-)NCBICHM1_1
T2T-CHM13v2.0678,638,386 - 78,640,951 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39981,510,344 - 81,515,885 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl981,510,344 - 81,515,881 (-)EnsemblGRCm39 Ensembl
GRCm38981,628,291 - 81,633,832 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl981,628,291 - 81,633,828 (-)EnsemblGRCm38mm10GRCm38
MGSCv37981,524,999 - 81,526,159 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36981,428,110 - 81,429,270 (-)NCBIMGSCv36mm8
Celera978,725,698 - 78,726,858 (-)NCBICelera
Cytogenetic Map9E1NCBI
cM Map944.61NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049555025,645,644 - 5,646,816 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555025,640,919 - 5,646,899 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1695,362,194 - 95,398,144 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0675,309,078 - 75,313,747 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1678,594,870 - 78,598,204 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl678,596,408 - 78,597,580 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.11238,659,088 - 38,659,546 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1238,541,798 - 38,542,967 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01239,430,205 - 39,431,374 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1239,430,205 - 39,431,374 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11238,755,029 - 38,756,198 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01238,739,892 - 38,741,061 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01238,869,413 - 38,870,583 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440494674,024,237 - 74,029,424 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936890155,233 - 156,408 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936890154,252 - 157,044 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl188,596,237 - 88,601,757 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1188,597,510 - 88,598,682 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2199,465,592 - 99,466,764 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1132,143,646 - 2,145,943 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl132,144,313 - 2,145,485 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040178,365,080 - 178,420,109 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046248194,427,827 - 4,428,999 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248194,425,271 - 4,429,165 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Htr1b
153 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:41
Count of miRNA genes:38
Interacting mature miRNAs:41
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
631271Lecl1Lens clarity QTL 10.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)81898416884531599Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)81933115293965294Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)82720571599103503Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)82720571599103503Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)82720571599103503Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)82824291299525068Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)83018886794457446Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)830848154101699754Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)830848154101699754Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)830848154101699754Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)830848259105647037Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83646953599083736Rat
737824Hcar10Hepatocarcinoma resistance QTL 102.9liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)84071306682925667Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84071306693965294Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)84186687686866876Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84269268490165460Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)84329616998968765Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)84329616998968765Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)84329616998968765Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)84329616998968765Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)84329616998968765Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)84329616998968765Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088626Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)84653172299083736Rat
2303570Gluco48Glucose level QTL 482blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)84980583194805831Rat
1358912Bw51Body weight QTL 512.95body mass (VT:0001259)body weight (CMO:0000012)851351728107062046Rat
10402857Bp380Blood pressure QTL 3800.95arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)85396876598968765Rat
2301402Bp316Blood pressure QTL 3160.005arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)85396876598968765Rat
2293697Bmd39Bone mineral density QTL 39femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)85404374498968765Rat
1582243Bw66Body weight QTL 663.40.0048body mass (VT:0001259)body weight (CMO:0000012)85423764485365202Rat
1582254Kidm31Kidney mass QTL 313kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)85423764485365202Rat
631664Hcar3Hepatocarcinoma resistance QTL 32.90.0005liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)85423764499103503Rat
1300177Cm2Cardiac mass QTL 23.65heart mass (VT:0007028)heart weight (CMO:0000017)854259986100382532Rat
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)861290298119084929Rat
631653Bp125Blood pressure QTL 1253.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)866142385111142385Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)869349194112783834Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)870513503118219066Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)871888757116888757Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)871888757116888757Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)871888757116888757Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)871888757116888757Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)873473045118473045Rat
10450865Bw175Body weight QTL 1754.1total fat pad mass (VT:0015008)adipose tissue molecular composition measurement (CMO:0000484)87531177784531599Rat
634332Pia18Pristane induced arthritis QTL 184joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)87531193882925521Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)876468691121468691Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)882460758122812818Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2882,533,078 - 82,533,410 (+)MAPPERmRatBN7.2
Rnor_6.0889,130,477 - 89,130,808NCBIRnor6.0
Rnor_5.0888,667,644 - 88,667,975UniSTSRnor5.0
RGSC_v3.4886,700,913 - 86,701,244UniSTSRGSC3.4
Celera882,222,876 - 82,223,207UniSTS
Cytogenetic Map8q31UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2882,532,623 - 82,532,824 (+)MAPPERmRatBN7.2
Rnor_6.0889,130,022 - 89,130,222NCBIRnor6.0
Rnor_5.0888,667,189 - 88,667,389UniSTSRnor5.0
RGSC_v3.4886,700,458 - 86,700,658UniSTSRGSC3.4
Celera882,222,421 - 82,222,621UniSTS
Cytogenetic Map8q31UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2882,532,198 - 82,533,477 (+)MAPPERmRatBN7.2
Rnor_6.0889,129,597 - 89,130,875NCBIRnor6.0
Rnor_5.0888,666,764 - 88,668,042UniSTSRnor5.0
RGSC_v3.4886,700,033 - 86,701,311UniSTSRGSC3.4
Celera882,221,996 - 82,223,274UniSTS
Cytogenetic Map8q31UniSTS

Related Rat Strains
The following Strains have been annotated to Htr1b


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 31 6
Low 2 20 13 4 3 4 8 10 35 23 26 11 8
Below cutoff 1 20 16 9 13 9 1 8 11 9


RefSeq Acc Id: ENSRNOT00000017411   ⟹   ENSRNOP00000017411
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl882,517,360 - 82,534,549 (-)Ensembl
Rnor_6.0 Ensembl889,129,453 - 89,130,991 (-)Ensembl
RefSeq Acc Id: NM_022225   ⟹   NP_071561
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
mRatBN7.2882,529,144 - 82,534,670 (-)NCBI
Rnor_6.0889,129,652 - 89,130,812 (-)NCBI
Rnor_5.0888,651,220 - 88,667,993 (-)NCBI
RGSC_v3.4886,700,088 - 86,701,248 (-)RGD
Celera882,222,051 - 82,223,211 (-)RGD
RefSeq Acc Id: XR_356450
Rat AssemblyChrPosition (strand)Source
mRatBN7.2882,513,572 - 82,534,386 (-)NCBI
Rnor_6.0889,113,984 - 89,130,830 (-)NCBI
Rnor_5.0888,651,220 - 88,667,993 (-)NCBI
Protein Sequences
Protein RefSeqs NP_071561 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA40613 (Get FASTA)   NCBI Sequence Viewer  
  EDL77686 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000017411
GenBank Protein P28564 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_071561   ⟸   NM_022225
- UniProtKB: P28564 (UniProtKB/Swiss-Prot),   A6I1P1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000017411   ⟸   ENSRNOT00000017411
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P28564-F1-model_v2 AlphaFold P28564 1-386 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2846 AgrOrtholog
BioCyc Gene G2FUF-29731 BioCyc
Ensembl Genes ENSRNOG00000013042 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055004785 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000017411 ENTREZGENE
  ENSRNOT00000017411.4 UniProtKB/Swiss-Prot
  ENSRNOT00055007617 UniProtKB/Swiss-Prot
  ENSRNOT00055007619 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro 5HT1B_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  5HT_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25075 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Htr1b PhenoGen
  5HTRECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000013042 RatGTEx
  ENSRNOG00055004785 RatGTEx
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt 5HT1B_RAT UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Htr1b  5-hydroxytryptamine receptor 1B  Htr1b  5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-17 Htr1b  5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled  Htr1b  5-hydroxytryptamine (serotonin) receptor 1B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2001-07-23 Htr1b  5-hydroxytryptamine (serotonin) receptor 1B      Name updated to reflect Human and Mouse nomenclature 67952 APPROVED
2001-07-23 Htr1b  Serotonin (5-hydroxytryptamine (5HT)) receptor, type 1B      Name withdrawn 67952 WITHDRAWN
2001-07-23 Htr1b  5-hydroxytryptamine (serotonin ) receptor 1B      Name updated to reflect Human and Mouse nomenclature 67952 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease associated with stress, depression and anxiety behaviors 625756
gene_drugs antidepressants downregulate the receptor activity and normalize serotonergic neurotransmission; fluoxetine or paroxetine acts on a time-dependent and reversible manner resulting in decrease of receptor expression in striatum 625756
gene_expression expressed in the midbrain raphe nuclei and dorsal raphe nucleus (DRN) and serotonergic neurons of brain 625756
gene_mutations_overexpression receptor overexpression in dorsal raphe nucleus mediates pathological response to behavioural disorders such as anxiety and stress 625756
gene_mutations_overexpression overexpression in dorsal raphe nucleus causes an increase in anxiety behavior 625756
gene_process involved in the negative feedback system regulating extracellular serotonin [ 5-HT ] neurotransmission 625756
gene_regulation upregulated in animals during behavior related learning periods and downregulated by antidepressants 625756
gene_regulation activated by subarachnoid hemorrhage 737621