Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Htr1b (5-hydroxytryptamine receptor 1B) Rattus norvegicus
Symbol: Htr1b
Name: 5-hydroxytryptamine receptor 1B
Description: Exhibits several functions, including G protein-coupled serotonin receptor activity; serotonin binding activity; and voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels. Involved in several processes, including modulation of chemical synaptic transmission; regulation of amine transport; and response to cocaine. Localizes to calyx of Held and plasma membrane. Used to study anxiety disorder. Biomarker of hypertension; ischemia; and obesity. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder and conduct disorder. Orthologous to human HTR1B (5-hydroxytryptamine receptor 1B); INTERACTS WITH (+)-pilocarpine; (6aR,9R)-N-[(2S)-1-hydroxybutan-2-yl]-4,7-dimethyl-6,6a,8,9-tetrahydroindolo[4,3-fg]quinoline-9-carboxamide; (S)-nicotine.
Type: protein-coding
Also known as: 5-HT-1B; 5-HT1B serotonin receptor; 5-hydroxytryptamine (serotonin ) receptor 1B; 5-hydroxytryptamine (serotonin) receptor 1B; 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled; Serotonin (5-hydroxytryptamine (5HT)) receptor type 1B; serotonin receptor 1B
Homo sapiens (human) : HTR1B (5-hydroxytryptamine receptor 1B)  HGNC  Alliance
Mus musculus (house mouse) : Htr1b (5-hydroxytryptamine (serotonin) receptor 1B)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Htr1b (5-hydroxytryptamine receptor 1B)
Pan paniscus (bonobo/pygmy chimpanzee) : HTR1B (5-hydroxytryptamine receptor 1B)
Canis lupus familiaris (dog) : HTR1B (5-hydroxytryptamine receptor 1B)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Htr1b (5-hydroxytryptamine receptor 1B)
Sus scrofa (pig) : HTR1B (5-hydroxytryptamine receptor 1B)
Chlorocebus sabaeus (African green monkey) : HTR1B (5-hydroxytryptamine receptor 1B)
Heterocephalus glaber (naked mole-rat) : Htr1b (5-hydroxytryptamine receptor 1B)
more info ...
Is Marker For: Strains:   SD  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0889,113,984 - 89,130,830 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl889,129,453 - 89,130,991 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0888,651,220 - 88,667,993 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4886,700,088 - 86,701,248 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1886,719,542 - 86,720,703 (-)NCBI
Celera882,222,051 - 82,223,211 (-)NCBICelera
Cytogenetic Map8q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Htr1b
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2846
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.