Enables G protein-coupled serotonin receptor activity; heterocyclic compound binding activity; and voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels. Involved in several processes, including drinking behavior; modulation of chemical synaptic transmission; and regulation of amine transport. Is active in calyx of Held. Used to study anxiety disorder. Biomarker of hypertension; ischemia; and obesity. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; antisocial personality disorder; attention deficit hyperactivity disorder; conduct disorder; and substance abuse (multiple). Orthologous to human HTR1B (5-hydroxytryptamine receptor 1B); INTERACTS WITH (+)-pilocarpine; (6aR,9R)-N-[(2S)-1-hydroxybutan-2-yl]-4,7-dimethyl-6,6a,8,9-tetrahydroindolo[4,3-fg]quinoline-9-carboxamide; (S)-nicotine.
sarpogrelate inhibits the reaction [Iodocyanopindolol binds to HTR1B protein] and sarpogrelate metabolite inhibits the reaction [Iodocyanopindolol binds to HTR1B protein]
sarpogrelate inhibits the reaction [Iodocyanopindolol binds to HTR1B protein] and sarpogrelate metabolite inhibits the reaction [Iodocyanopindolol binds to HTR1B protein]
Endocannabinoids inhibits the reaction [Serotonin binds to and results in increased activity of HTR1B protein] and Serotonin binds to and results in increased activity of HTR1B protein
Neurokinin-1 receptor antagonism in a rat model of subarachnoid hemorrhage: prevention of upregulation of contractile ETB and 5-HT1B receptors and cerebral blood flow reduction.
Novel and previously reported single-nucleotide polymorphisms in the human 5-HT(1B) receptor gene: no association with cocaine or alcohol abuse or dependence.
Overexpression of 5-HT1B receptor in dorsal raphe nucleus using Herpes Simplex Virus gene transfer increases anxiety behavior after inescapable stress.
Contribution of the 5-HT(1B) receptor to hypoxia-induced pulmonary hypertension: converging evidence using 5-HT(1B)-receptor knockout mice and the 5-HT(1B/1D)-receptor antagonist GR127935.
Involvement of 5-HT1B receptors within the ventral tegmental area in regulation of mesolimbic dopaminergic neuronal activity via GABA mechanisms: a study with dual-probe microdialysis.
antidepressants downregulate the receptor activity and normalize serotonergic neurotransmission; fluoxetine or paroxetine acts on a time-dependent and reversible manner resulting in decrease of receptor expression in striatum