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Gene: HTR1B (5-hydroxytryptamine receptor 1B) Homo sapiens
Symbol: HTR1B
Name: 5-hydroxytryptamine receptor 1B
Description: Exhibits G protein-coupled serotonin receptor activity. Involved in adenylate cyclase-inhibiting serotonin receptor signaling pathway; cellular response to alkaloid; and positive regulation of vascular smooth muscle cell proliferation. Localizes to integral component of plasma membrane. Implicated in attention deficit hyperactivity disorder and conduct disorder.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 5-HT-1B; 5-HT-1D-beta; 5-HT1B; 5-HT1DB; 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled; HTR1D2; HTR1DB; S12; serotonin 1D beta receptor; serotonin receptor 1B
Mus musculus (house mouse) : Htr1b (5-hydroxytryptamine (serotonin) receptor 1B)  MGI  Alliance
Rattus norvegicus (Norway rat) : Htr1b (5-hydroxytryptamine receptor 1B)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Htr1b (5-hydroxytryptamine receptor 1B)
Pan paniscus (bonobo/pygmy chimpanzee) : HTR1B (5-hydroxytryptamine receptor 1B)
Canis lupus familiaris (dog) : HTR1B (5-hydroxytryptamine receptor 1B)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Htr1b (5-hydroxytryptamine receptor 1B)
Sus scrofa (pig) : HTR1B (5-hydroxytryptamine receptor 1B)
Chlorocebus sabaeus (African green monkey) : HTR1B (5-hydroxytryptamine receptor 1B)
Heterocephalus glaber (naked mole-rat) : Htr1b (5-hydroxytryptamine receptor 1B)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl677,461,753 - 77,463,773 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl677,460,924 - 77,463,491 (-)EnsemblGRCh38hg38GRCh38
GRCh38677,460,924 - 77,463,491 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37678,171,948 - 78,173,120 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36678,228,667 - 78,229,839 (-)NCBINCBI36hg18NCBI36
Build 34678,228,666 - 78,229,839NCBI
Celera678,559,593 - 78,560,765 (-)NCBI
Cytogenetic Map6q14.1NCBI
HuRef675,364,405 - 75,365,577 (-)NCBIHuRef
CHM1_1678,336,807 - 78,339,981 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on HTR1B
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 731005
Created: 2003-12-10
Species: Homo sapiens
Last Modified: 2020-08-04
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.