HTR1B (5-hydroxytryptamine receptor 1B) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: HTR1B (5-hydroxytryptamine receptor 1B) Canis lupus familiaris
Analyze
Symbol: HTR1B
Name: 5-hydroxytryptamine receptor 1B
RGD ID: 12408957
Description: ENCODES a protein that exhibits G protein-coupled serotonin receptor activity (ortholog); heterocyclic compound binding (ortholog); voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels (ortholog); INVOLVED IN adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway (ortholog); adenylate cyclase-inhibiting serotonin receptor signaling pathway (ortholog); bone remodeling (ortholog); ASSOCIATED WITH alcohol dependence (ortholog); amphetamine abuse (ortholog); Anorexia (ortholog); FOUND IN calyx of Held (ortholog); plasma membrane (ortholog); presynaptic membrane (ortholog); INTERACTS WITH capsaicin
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 5-HT-1B; 5-HT1B; 5-HT1D beta; 5-HT1D subtype beta; 5-HTR1B; 5-Hydroxytryptamine 1D receptor subtype beta; serotonin receptor 1B
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11238,659,088 - 38,659,546 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1238,541,798 - 38,542,967 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01239,430,205 - 39,431,374 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1239,430,205 - 39,431,374 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11238,755,029 - 38,756,198 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01238,739,892 - 38,741,061 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01238,869,413 - 38,870,583 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
capsaicin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References
Additional References at PubMed
PMID:8763409   PMID:14729271   PMID:15220384   PMID:15353848   PMID:18066658   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
HTR1B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11238,659,088 - 38,659,546 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1238,541,798 - 38,542,967 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01239,430,205 - 39,431,374 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1239,430,205 - 39,431,374 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11238,755,029 - 38,756,198 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01238,739,892 - 38,741,061 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01238,869,413 - 38,870,583 (-)NCBIUU_Cfam_GSD_1.0
HTR1B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38677,460,924 - 77,463,491 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl677,460,924 - 77,463,491 (-)EnsemblGRCh38hg38GRCh38
GRCh37678,170,641 - 78,173,208 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36678,228,667 - 78,229,839 (-)NCBINCBI36Build 36hg18NCBI36
Build 34678,228,666 - 78,229,839NCBI
Celera678,559,593 - 78,560,765 (-)NCBICelera
Cytogenetic Map6q14.1NCBI
HuRef675,364,405 - 75,365,577 (-)NCBIHuRef
CHM1_1678,338,190 - 78,339,362 (-)NCBICHM1_1
T2T-CHM13v2.0678,638,386 - 78,640,951 (-)NCBIT2T-CHM13v2.0
Htr1b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39981,510,344 - 81,515,885 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl981,510,344 - 81,515,881 (-)EnsemblGRCm39 Ensembl
GRCm38981,628,291 - 81,633,832 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl981,628,291 - 81,633,828 (-)EnsemblGRCm38mm10GRCm38
MGSCv37981,524,999 - 81,526,159 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36981,428,110 - 81,429,270 (-)NCBIMGSCv36mm8
Celera978,725,698 - 78,726,858 (-)NCBICelera
Cytogenetic Map9E1NCBI
cM Map944.61NCBI
Htr1b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8891,395,405 - 91,414,815 (-)NCBIGRCr8
mRatBN7.2882,513,572 - 82,534,670 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl882,517,360 - 82,534,549 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx888,140,648 - 88,141,808 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0886,356,378 - 86,357,538 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0884,232,825 - 84,233,985 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0889,113,984 - 89,130,830 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl889,129,453 - 89,130,991 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0888,651,220 - 88,667,993 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4886,700,088 - 86,701,248 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1886,719,542 - 86,720,703 (-)NCBI
Celera882,222,051 - 82,223,211 (-)NCBICelera
Cytogenetic Map8q31NCBI
Htr1b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555025,645,644 - 5,646,816 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555025,640,919 - 5,646,899 (-)NCBIChiLan1.0ChiLan1.0
HTR1B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2597,481,591 - 97,517,530 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1695,362,194 - 95,398,144 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0675,309,078 - 75,313,747 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1678,594,870 - 78,598,204 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl678,596,408 - 78,597,580 (-)Ensemblpanpan1.1panPan2
Htr1b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494674,024,237 - 74,029,424 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936890155,233 - 156,408 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936890154,252 - 157,044 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HTR1B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl188,596,237 - 88,601,757 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1188,597,510 - 88,598,682 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2199,465,592 - 99,466,764 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HTR1B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1132,143,646 - 2,145,943 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl132,144,313 - 2,145,485 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040178,365,080 - 178,420,109 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Htr1b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248194,427,827 - 4,428,999 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248194,425,271 - 4,429,165 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in HTR1B
26 total Variants

Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSCAFT00845015216   ⟹   ENSCAFP00845011816
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1239,430,205 - 39,431,374 (-)Ensembl
RefSeq Acc Id: NM_001006948   ⟹   NP_001006949
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11238,659,088 - 38,659,546 (-)NCBI
Dog10K_Boxer_Tasha1238,541,798 - 38,542,967 (-)NCBI
ROS_Cfam_1.01239,430,205 - 39,431,374 (-)NCBI
UMICH_Zoey_3.11238,755,029 - 38,756,198 (-)NCBI
UNSW_CanFamBas_1.01238,739,892 - 38,741,061 (-)NCBI
UU_Cfam_GSD_1.01238,869,413 - 38,870,583 (-)NCBI
Sequence:
RefSeq Acc Id: NP_001006949   ⟸   NM_001006948
- UniProtKB: Q6VVV0 (UniProtKB/Swiss-Prot),   P79250 (UniProtKB/Swiss-Prot),   A0A8C0KGB7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00845011816   ⟸   ENSCAFT00845015216


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000055063 UniProtKB/Swiss-Prot
  ENSCAFG00030007970 UniProtKB/Swiss-Prot
  ENSCAFG00040022012 UniProtKB/Swiss-Prot
  ENSCAFG00845008653 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSCAFT00000107710.1 UniProtKB/Swiss-Prot
  ENSCAFT00030014608.1 UniProtKB/Swiss-Prot
  ENSCAFT00040040864.1 UniProtKB/Swiss-Prot
  ENSCAFT00845015216 ENTREZGENE
  ENSCAFT00845015216.1 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
InterPro 5HT1B_rcpt UniProtKB/Swiss-Prot
  5HT_rcpt UniProtKB/Swiss-Prot
  GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
KEGG Report cfa:403741 UniProtKB/Swiss-Prot
NCBI Gene HTR1B ENTREZGENE
PANTHER ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR UniProtKB/Swiss-Prot
  G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PRINTS 5HT1BRECEPTR UniProtKB/Swiss-Prot
  5HTRECEPTOR UniProtKB/Swiss-Prot
  GPCRRHODOPSN UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
UniProt 5HT1B_CANLF UniProtKB/Swiss-Prot
  A0A8C0KGB7 ENTREZGENE
  P79250 ENTREZGENE
  Q6VVV0 ENTREZGENE
UniProt Secondary Q6VVV0 UniProtKB/Swiss-Prot
VGNC ID VGNC:110597 ENTREZGENE