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Gene: Txnip (thioredoxin interacting protein) Rattus norvegicus
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Symbol: Txnip
Name: thioredoxin interacting protein
Description: Predicted to have enzyme inhibitor activity and ubiquitin protein ligase binding activity. Involved in several processes, including response to estradiol; response to glucose; and response to progesterone. Localizes to the mitochondrial intermembrane space and nucleus. Used to study renal cell carcinoma. Biomarker of colorectal cancer; glaucoma; and stomach cancer. Orthologous to human TXNIP (thioredoxin interacting protein); INTERACTS WITH 1,2,4-trimethylbenzene; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: MGC94673; thioredoxin-interacting protein; upregulated by 1,25-dihydroxyvitamin D-3; Vdup1; vitamin D3 up-regulated protein 1
Orthologs:
Homo sapiens (human) : TXNIP (thioredoxin interacting protein)  HGNC  Alliance
Mus musculus (house mouse) : Txnip (thioredoxin interacting protein)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Txnip (thioredoxin interacting protein)
Pan paniscus (bonobo/pygmy chimpanzee) : TXNIP (thioredoxin interacting protein)
Canis lupus familiaris (dog) : TXNIP (thioredoxin interacting protein)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Txnip (thioredoxin interacting protein)
Sus scrofa (pig) : TXNIP (thioredoxin interacting protein)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.02198,683,168 - 198,686,971 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02218,170,102 - 218,173,905 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42191,356,954 - 191,360,757 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12191,319,631 - 191,323,506 (+)NCBI
Celera2176,618,301 - 176,622,104 (+)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Txnip
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 620886
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.