Il9 (interleukin 9) - Rat Genome Database

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Gene: Il9 (interleukin 9) Rattus norvegicus
Symbol: Il9
Name: interleukin 9
RGD ID: 620049
Description: Enables cytokine activity and interleukin-9 receptor binding activity. Involved in positive regulation of cell growth. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in asthma and respiratory syncytial virus infectious disease. Orthologous to human IL9 (interleukin 9); PARTICIPATES IN asthma pathway; cytokine mediated signaling pathway; Jak-Stat signaling pathway; INTERACTS WITH bisphenol A; corn oil; cypermethrin.
Type: protein-coding
Previously known as: interleukin-9
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr8178,117,028 - 8,120,151 (+)NCBIGRCr8
mRatBN7.2178,111,772 - 8,114,895 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl178,111,772 - 8,114,895 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx178,129,967 - 8,133,062 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0179,661,578 - 9,664,708 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0178,126,366 - 8,129,461 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0178,558,827 - 8,561,950 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl178,558,827 - 8,561,950 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01710,733,181 - 10,736,304 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41714,068,757 - 14,071,880 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11714,068,756 - 14,071,880 (+)NCBI
Celera178,204,235 - 8,207,358 (+)NCBICelera
Cytogenetic Map17p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. IL-9 protects against bleomycin-induced lung injury: involvement of prostaglandins. Arras M, etal., Am J Pathol. 2005 Jan;166(1):107-15.
2. Interleukin-9 reduces lung fibrosis and type 2 immune polarization induced by silica particles in a murine model. Arras M, etal., Am J Respir Cell Mol Biol. 2001 Apr;24(4):368-75.
3. Anti-interleukin-9 antibody treatment inhibits airway inflammation and hyperreactivity in mouse asthma model. Cheng G, etal., Am J Respir Crit Care Med. 2002 Aug 1;166(3):409-16.
4. Decreased expression of uteroglobin-related protein 1 in inflamed mouse airways is mediated by IL-9. Chiba Y, etal., Am J Physiol Lung Cell Mol Physiol. 2004 Dec;287(6):L1193-8.
5. IL-9 regulates pathology during primary and memory responses to respiratory syncytial virus infection. Dodd JS, etal., J Immunol. 2009 Dec 1;183(11):7006-13. Epub 2009 Nov 13.
6. Characterization and functional expression of a rat genomic DNA clone encoding a lymphocyte potassium channel. Douglass J, etal., J Immunol 1990 Jun 15;144(12):4841-50.
7. Replacement of interleukin-2 (IL-2)-generated mitogenic signals by a mink cell focus-forming (MCF) or xenotropic virus-induced IL-9-dependent autocrine loop: implications for MCF virus-induced leukemogenesis. Flubacher MM, etal., J Virol 1994 Dec;68(12):7709-16.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. Clinical aspects and cytokine response in severe H1N1 influenza A virus infection. Hagau N, etal., Crit Care. 2010;14(6):R203. Epub 2010 Nov 9.
11. Up-Regulation of Interleukin-9 and the Interleukin-9-Associated Calcium-Activated Chloride Channel hCLCA1 in Nasal Mucosa Following In Vivo Allergen Challenge. Hauber HP, etal., Allergy Asthma Clin Immunol. 2007 Mar 15;3(1):19-23. Epub 2007 Mar 15.
12. Increased expression of interleukin-9, interleukin-9 receptor, and the calcium-activated chloride channel hCLCA1 in the upper airways of patients with cystic fibrosis. Hauber HP, etal., Laryngoscope. 2003 Jun;113(6):1037-42.
13. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Huang C, etal., Lancet. 2020 Feb 15;395(10223):497-506. doi: 10.1016/S0140-6736(20)30183-5. Epub 2020 Jan 24.
14. [Role of interleukin-9 in the pathogenesis of chronic obstructive pulmonary disease]. Liu Z, etal., Beijing Da Xue Xue Bao. 2004 Aug 18;36(4):403-6.
15. Interleukin 9 production in the lungs of infants with severe respiratory syncytial virus bronchiolitis. McNamara PS, etal., Lancet. 2004 Mar 27;363(9414):1031-7.
16. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
17. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
18. Marked up-regulation of T lymphocytes and expression of interleukin-9 in bronchial biopsies from patients With chronic bronchitis with obstruction. Panzner P, etal., Chest. 2003 Nov;124(5):1909-15.
19. Safety profile and clinical activity of multiple subcutaneous doses of MEDI-528, a humanized anti-interleukin-9 monoclonal antibody, in two randomized phase 2a studies in subjects with asthma. Parker JM, etal., BMC Pulm Med. 2011 Feb 28;11(1):14.
20. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
21. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
22. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. Schuurhof A, etal., Pediatr Pulmonol. 2010 Jun;45(6):608-13.
23. Involvement of IL-9 in the bronchial phenotype of patients with nasal polyposis. Tsicopoulos A, etal., J Allergy Clin Immunol. 2004 Mar;113(3):462-9.
24. Profibrotic effect of IL-9 overexpression in a model of airway remodeling. van den Brule S, etal., Am J Respir Cell Mol Biol. 2007 Aug;37(2):202-9. Epub 2007 Apr 19.
Additional References at PubMed
PMID:16266865   PMID:18997793   PMID:29359591   PMID:29944018  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr8178,117,028 - 8,120,151 (+)NCBIGRCr8
mRatBN7.2178,111,772 - 8,114,895 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl178,111,772 - 8,114,895 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx178,129,967 - 8,133,062 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0179,661,578 - 9,664,708 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0178,126,366 - 8,129,461 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0178,558,827 - 8,561,950 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl178,558,827 - 8,561,950 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01710,733,181 - 10,736,304 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41714,068,757 - 14,071,880 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11714,068,756 - 14,071,880 (+)NCBI
Celera178,204,235 - 8,207,358 (+)NCBICelera
Cytogenetic Map17p14NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh385135,892,246 - 135,895,841 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5135,892,246 - 135,895,841 (-)EnsemblGRCh38hg38GRCh38
GRCh375135,227,935 - 135,231,530 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365135,255,834 - 135,259,415 (-)NCBINCBI36Build 36hg18NCBI36
Build 345135,255,833 - 135,259,415NCBI
Celera5131,352,664 - 131,356,247 (-)NCBICelera
Cytogenetic Map5q31.1NCBI
HuRef5130,416,404 - 130,419,991 (-)NCBIHuRef
CHM1_15134,660,566 - 134,664,147 (-)NCBICHM1_1
T2T-CHM13v2.05136,414,743 - 136,418,342 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391356,627,090 - 56,630,070 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1356,627,090 - 56,630,059 (-)EnsemblGRCm39 Ensembl
GRCm381356,479,277 - 56,482,257 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1356,479,277 - 56,482,246 (-)EnsemblGRCm38mm10GRCm38
MGSCv371356,580,638 - 56,583,607 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361356,488,899 - 56,491,868 (-)NCBIMGSCv36mm8
Celera1357,542,869 - 57,545,822 (-)NCBICelera
Cytogenetic Map13B1NCBI
cM Map1330.06NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495540830,950,816 - 30,953,571 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540830,950,816 - 30,953,571 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v24131,181,066 - 131,184,621 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15129,320,626 - 129,324,181 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05131,283,170 - 131,289,777 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15137,425,367 - 137,428,945 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5137,425,367 - 137,428,945 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.11123,808,919 - 23,814,085 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1123,811,117 - 23,814,079 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1122,559,274 - 22,562,311 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01124,627,628 - 24,630,667 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1124,627,473 - 24,630,592 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11123,315,114 - 23,318,150 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01123,180,949 - 23,183,990 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01123,831,104 - 23,834,141 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024407213123,959,046 - 123,962,068 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365972,983,953 - 2,986,975 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365972,983,953 - 2,986,975 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl2138,048,943 - 138,052,588 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12138,048,943 - 138,052,588 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22143,648,289 - 143,651,957 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.12338,641,228 - 38,645,810 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2338,641,741 - 38,645,276 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603439,263,786 - 39,267,322 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462473311,226,769 - 11,229,461 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473311,226,769 - 11,229,461 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Il9
15 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:66
Count of miRNA genes:50
Interacting mature miRNAs:54
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590316Scort21Serum corticosterone level QTL 214.750.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17122871563Rat
10401807Kidm52Kidney mass QTL 52kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17131701463Rat
70184BpQTLcluster14Blood pressure QTL cluster 143.38arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)17131990913Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17137830672Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17160781592Rat
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17169599340Rat
1641902Colcr7Colorectal carcinoma resistance QTL 73.350.0044intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)17211514921881669Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17211514934551001Rat
631499Stl1Serum triglyceride level QTL 13.6blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)17327139827389946Rat
2324619Coatc4Coat color QTL 40.001coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)17429913021293263Rat
2324619Coatc4Coat color QTL 40.001coat/hair pigmentation trait (VT:0010463)pigmented dorsal coat/hair area to total dorsal coat/hair area ratio (CMO:0001811)17429913021293263Rat
1354613Kidm14Kidney mass QTL 146.2kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)17429913035837242Rat
1354596Bw32Body weight QTL 324.5body mass (VT:0001259)body weight (CMO:0000012)17429913060781592Rat
1354630Cm34Cardiac mass QTL 348.7heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)17429913069599340Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)17429913069599340Rat
1354651Lmblg2Limb length QTL 26tibia length (VT:0004357)tibia length (CMO:0000450)17429913069599340Rat
2293648Bmd31Bone mineral density QTL 314.50.0001femur size trait (VT:1000369)femoral neck cortical cross-sectional area (CMO:0001702)17435448727028127Rat
2293664Bmd28Bone mineral density QTL 285.10.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)17435448727028127Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17452803849528038Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17452803849528038Rat
1581553Pur14Proteinuria QTL 145.30.0001urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)17797996816317111Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2178,112,457 - 8,112,650 (+)MAPPERmRatBN7.2
Rnor_6.0178,559,513 - 8,559,705NCBIRnor6.0
Rnor_5.01710,733,867 - 10,734,059UniSTSRnor5.0
RGSC_v3.41714,069,443 - 14,069,635UniSTSRGSC3.4
RGSC_v3.113106,281,961 - 106,282,066RGD
Celera178,204,921 - 8,205,113UniSTS
RH 3.4 Map13703.0RGD
RH 2.0 Map13744.0RGD
Cytogenetic Map17p14UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.213101,356,778 - 101,356,884 (-)MAPPERmRatBN7.2
Rnor_6.013108,753,536 - 108,753,641NCBIRnor6.0
Rnor_5.013113,370,014 - 113,370,119UniSTSRnor5.0
RGSC_v3.413106,092,857 - 106,092,962UniSTSRGSC3.4
Celera13100,842,388 - 100,842,493UniSTS
RH 3.4 Map13703.0UniSTS
Cytogenetic Map13q27UniSTS
Cytogenetic Map17p14UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 2
Low 3 3 5
Below cutoff 3 4 1 1 6 11 4 2 1


RefSeq Acc Id: ENSRNOT00000016187   ⟹   ENSRNOP00000016187
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl178,111,772 - 8,114,895 (+)Ensembl
Rnor_6.0 Ensembl178,558,827 - 8,561,950 (+)Ensembl
RefSeq Acc Id: NM_001105747   ⟹   NP_001099217
Rat AssemblyChrPosition (strand)Source
GRCr8178,117,028 - 8,120,151 (+)NCBI
mRatBN7.2178,111,772 - 8,114,895 (+)NCBI
Rnor_6.0178,558,827 - 8,561,950 (+)NCBI
Rnor_5.01710,733,181 - 10,736,304 (+)NCBI
RGSC_v3.41714,068,757 - 14,071,880 (+)RGD
Celera178,204,235 - 8,207,358 (+)RGD
Protein Sequences
Protein RefSeqs NP_001099217 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL93938 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000016187
RefSeq Acc Id: NP_001099217   ⟸   NM_001105747
- Peptide Label: precursor
- UniProtKB: D4A8I9 (UniProtKB/TrEMBL),   A6KAN0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000016187   ⟸   ENSRNOT00000016187

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A8I9-F1-model_v2 AlphaFold D4A8I9 1-144 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620049 AgrOrtholog
BioCyc Gene G2FUF-10264 BioCyc
Ensembl Genes ENSRNOG00000012131 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000016187 ENTREZGENE
  ENSRNOT00000016187.3 UniProtKB/TrEMBL
InterPro Interleukin-9 UniProtKB/TrEMBL
KEGG Report rno:116558 UniProtKB/TrEMBL
  PTHR16926 UniProtKB/TrEMBL
PhenoGen Il9 PhenoGen
RatGTEx ENSRNOG00000012131 RatGTEx

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-01-20 Il9  interleukin 9      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Il9  interleukin 9      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed only when the T-cell lymphoma line (4437A) were transfected by Gfi-2/IL-9R construct 633086
gene_process helps in the formation of the dependent autocrine loop 633086
gene_regulation expression induced by polytropic or xenotropic viruses 633085
gene_regulation expression induced by infection of 4437A cells by mink cell focus-forming or xenotropic viruses 633086