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Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Itpkb | Rat | (S)-nicotine | increases expression | EXP | | 6480464 | Nicotine results in increased expression of ITPKB mRNA | CTD | PMID:11478936 | Itpkb | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | Itpkb (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of ITPKB mRNA | CTD | PMID:33956508 | Itpkb | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of ITPKB mRNA | CTD | PMID:33387578 | Itpkb | Rat | 3,4-methylenedioxymethamphetamine | increases expression | ISO | Itpkb (Mus musculus) | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in increased expression of ITPKB mRNA | CTD | PMID:20188158 | Itpkb | Rat | 4,4'-sulfonyldiphenol | increases methylation | ISO | Itpkb (Mus musculus) | 6480464 | bisphenol S results in increased methylation of ITPKB exon | CTD | PMID:33297965 | Itpkb | Rat | 8-Br-cAMP | increases expression | ISO | ITPKB (Homo sapiens) | 6480464 | 8-Bromo Cyclic Adenosine Monophosphate results in increased expression of ITPKB mRNA | CTD | PMID:22079614 | Itpkb | Rat | acetamide | increases expression | EXP | | 6480464 | acetamide results in increased expression of ITPKB mRNA | CTD | PMID:31881176 | Itpkb | Rat | acrolein | multiple interactions | ISO | ITPKB (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of ITPKB mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in decreased expression of ITPKB mRNA | CTD | PMID:32699268 | Itpkb | Rat | acrylamide | decreases expression | EXP | | 6480464 | Acrylamide results in decreased expression of ITPKB mRNA | CTD | PMID:28959563 | Itpkb | Rat | aflatoxin B1 | decreases methylation | ISO | ITPKB (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased methylation of ITPKB intron | CTD | PMID:30157460 | Itpkb | Rat | Aflatoxin B2 alpha | increases methylation | ISO | ITPKB (Homo sapiens) | 6480464 | aflatoxin B2 results in increased methylation of ITPKB intron | CTD | PMID:30157460 | Itpkb | Rat | all-trans-retinoic acid | multiple interactions | ISO | Itpkb (Mus musculus) | 6480464 | [mono-(2-ethylhexyl)phthalate co-treated with Tretinoin] results in increased expression of ITPKB mRNA | CTD | PMID:36189433 | Itpkb | Rat | alpha-pinene | multiple interactions | ISO | ITPKB (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of ITPKB mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in decreased expression of ITPKB mRNA | CTD | PMID:32699268 | Itpkb | Rat | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of ITPKB mRNA | CTD | PMID:16483693 | Itpkb | Rat | antirheumatic drug | increases expression | ISO | ITPKB (Homo sapiens) | 6480464 | Antirheumatic Agents results in increased expression of ITPKB mRNA | CTD | PMID:24449571 | Itpkb | Rat | avobenzone | increases expression | ISO | ITPKB (Homo sapiens) | 6480464 | avobenzone results in increased expression of ITPKB mRNA | CTD | PMID:31016361 | Itpkb | Rat | benzo[a]pyrene | decreases methylation | ISO | ITPKB (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased methylation of ITPKB exon and Benzo(a)pyrene results in decreased methylation of ITPKB promoter | CTD | PMID:27901495 | Itpkb | Rat | benzo[a]pyrene | increases methylation | ISO | Itpkb (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased methylation of ITPKB exon and Benzo(a)pyrene results in increased methylation of ITPKB intron | CTD | PMID:27901495 | Itpkb | Rat | benzo[a]pyrene | increases methylation | ISO | ITPKB (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of ITPKB 5' UTR | CTD | PMID:27901495 | Itpkb | Rat | benzo[e]pyrene | increases methylation | ISO | ITPKB (Homo sapiens) | 6480464 | benzo(e)pyrene results in increased methylation of ITPKB exon | CTD | PMID:30157460 | Itpkb | Rat | beta-naphthoflavone | multiple interactions | EXP | | 6480464 | [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of ITPKB mRNA and [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of ITPKB mRNA | CTD | PMID:18164116 | Itpkb | Rat | bisphenol A | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Testosterone] results in decreased expression of ITPKB mRNA | CTD | PMID:26496021 | Itpkb | Rat | bisphenol A | decreases methylation | ISO | ITPKB (Homo sapiens) | 6480464 | bisphenol A results in decreased methylation of ITPKB gene | CTD | PMID:31601247 | Itpkb | Rat | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of ITPKB mRNA | CTD | PMID:29097150 more ... | Itpkb | Rat | bisphenol A | increases expression | ISO | ITPKB (Homo sapiens) | 6480464 | bisphenol A results in increased expression of ITPKB mRNA | CTD | PMID:27685785 | Itpkb | Rat | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of ITPKB mRNA | CTD | PMID:25181051 and PMID:32145629 | Itpkb | Rat | bisphenol F | increases expression | ISO | Itpkb (Mus musculus) | 6480464 | bisphenol F results in increased expression of ITPKB mRNA | CTD | PMID:38685157 | Itpkb | Rat | Brodifacoum | decreases expression | EXP | | 6480464 | bromfenacoum results in decreased expression of ITPKB protein | CTD | PMID:28903499 | Itpkb | Rat | cadmium dichloride | increases expression | ISO | ITPKB (Homo sapiens) | 6480464 | Cadmium Chloride results in increased expression of ITPKB mRNA | CTD | PMID:38382870 | Itpkb | Rat | cefaloridine | increases expression | EXP | | 6480464 | Cephaloridine results in increased expression of ITPKB mRNA | CTD | PMID:18500788 | Itpkb | Rat | chlordecone | increases expression | ISO | Itpkb (Mus musculus) | 6480464 | Chlordecone results in increased expression of ITPKB mRNA | CTD | PMID:33711761 | Itpkb | Rat | chlorpyrifos | increases expression | ISO | Itpkb (Mus musculus) | 6480464 | Chlorpyrifos results in increased expression of ITPKB mRNA | CTD | PMID:37019170 | Itpkb | Rat | choline | multiple interactions | ISO | Itpkb (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of ITPKB gene | CTD | PMID:20938992 | Itpkb | Rat | cocaine | increases expression | EXP | | 6480464 | Cocaine results in increased expression of ITPKB mRNA | CTD | PMID:16076954 | Itpkb | Rat | copper atom | increases expression | EXP | | 6480464 | Copper deficiency results in increased expression of ITPKB mRNA | CTD | PMID:26033743 | Itpkb | Rat | copper(0) | increases expression | EXP | | 6480464 | Copper deficiency results in increased expression of ITPKB mRNA | CTD | PMID:26033743 | Itpkb | Rat | Dibutyl phosphate | affects expression | ISO | ITPKB (Homo sapiens) | 6480464 | di-n-butylphosphoric acid affects the expression of ITPKB mRNA | CTD | PMID:37042841 | Itpkb | Rat | dorsomorphin | multiple interactions | ISO | ITPKB (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | Itpkb | Rat | doxorubicin | decreases expression | ISO | ITPKB (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of ITPKB mRNA | CTD | PMID:29803840 | Itpkb | Rat | endosulfan | decreases expression | EXP | | 6480464 | Endosulfan results in decreased expression of ITPKB mRNA | CTD | PMID:31464424 | Itpkb | Rat | ethanol | increases expression | ISO | Itpkb (Mus musculus) | 6480464 | Ethanol results in increased expression of ITPKB mRNA | CTD | PMID:30319688 | Itpkb | Rat | ethanol | affects expression | ISO | Itpkb (Mus musculus) | 6480464 | Ethanol affects the expression of ITPKB mRNA | CTD | PMID:30319688 | Itpkb | Rat | folic acid | multiple interactions | ISO | Itpkb (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of ITPKB gene | CTD | PMID:20938992 | Itpkb | Rat | FR900359 | decreases phosphorylation | ISO | ITPKB (Homo sapiens) | 6480464 | FR900359 results in decreased phosphorylation of ITPKB protein | CTD | PMID:37730182 | Itpkb | Rat | gentamycin | decreases expression | EXP | | 6480464 | Gentamicins results in decreased expression of ITPKB mRNA | CTD | PMID:33387578 | Itpkb | Rat | isoprenaline | decreases expression | ISO | Itpkb (Mus musculus) | 6480464 | Isoproterenol results in decreased expression of ITPKB mRNA | CTD | PMID:20003209 | Itpkb | Rat | L-methionine | multiple interactions | ISO | Itpkb (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of ITPKB gene | CTD | PMID:20938992 | Itpkb | Rat | lead(0) | affects expression | ISO | ITPKB (Homo sapiens) | 6480464 | Lead affects the expression of ITPKB mRNA | CTD | PMID:28903495 | Itpkb | Rat | lipopolysaccharide | decreases expression | ISO | ITPKB (Homo sapiens) | 6480464 | Lipopolysaccharides results in decreased expression of ITPKB mRNA | CTD | PMID:35811015 | Itpkb | Rat | lipopolysaccharide | multiple interactions | ISO | ITPKB (Homo sapiens) | 6480464 | [S-(1 more ... | CTD | PMID:35811015 | Itpkb | Rat | methapyrilene | increases methylation | ISO | ITPKB (Homo sapiens) | 6480464 | Methapyrilene results in increased methylation of ITPKB exon | CTD | PMID:30157460 | Itpkb | Rat | methylmercury chloride | increases expression | ISO | ITPKB (Homo sapiens) | 6480464 | methylmercuric chloride results in increased expression of ITPKB mRNA | CTD | PMID:28001369 | Itpkb | Rat | mono(2-ethylhexyl) phthalate | multiple interactions | ISO | Itpkb (Mus musculus) | 6480464 | [mono-(2-ethylhexyl)phthalate co-treated with Tretinoin] results in increased expression of ITPKB mRNA | CTD | PMID:36189433 | Itpkb | Rat | N-ethyl-N-nitrosourea | increases mutagenesis | ISO | Itpkb (Mus musculus) | 6480464 | Ethylnitrosourea results in increased mutagenesis of ITPKB gene | CTD | PMID:16724327 | Itpkb | Rat | N-nitrosodiethylamine | decreases expression | ISO | Itpkb (Mus musculus) | 6480464 | Diethylnitrosamine results in decreased expression of ITPKB mRNA | CTD | PMID:17942915 | Itpkb | Rat | N-nitrosodiethylamine | multiple interactions | ISO | Itpkb (Mus musculus) | 6480464 | MET protein inhibits the reaction [Diethylnitrosamine results in decreased expression of ITPKB mRNA] | CTD | PMID:17942915 | Itpkb | Rat | N-nitrosodiethylamine | multiple interactions | EXP | | 6480464 | [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of ITPKB mRNA and [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of ITPKB mRNA | CTD | PMID:18164116 | Itpkb | Rat | nicotine | increases expression | EXP | | 6480464 | Nicotine results in increased expression of ITPKB mRNA | CTD | PMID:11478936 | Itpkb | Rat | nitrofen | decreases expression | EXP | | 6480464 | nitrofen results in decreased expression of ITPKB mRNA | CTD | PMID:26720608 | Itpkb | Rat | ochratoxin A | increases expression | ISO | ITPKB (Homo sapiens) | 6480464 | ochratoxin A results in increased expression of ITPKB mRNA | CTD | PMID:30559759 | Itpkb | Rat | ozone | multiple interactions | ISO | ITPKB (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of ITPKB mRNA more ... | CTD | PMID:32699268 | Itpkb | Rat | ozone | multiple interactions | ISO | Itpkb (Mus musculus) | 6480464 | [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in decreased expression of ITPKB mRNA | CTD | PMID:34911549 | Itpkb | Rat | paracetamol | affects expression | ISO | Itpkb (Mus musculus) | 6480464 | Acetaminophen affects the expression of ITPKB mRNA | CTD | PMID:17562736 | Itpkb | Rat | paracetamol | decreases expression | EXP | | 6480464 | Acetaminophen results in decreased expression of ITPKB mRNA | CTD | PMID:33387578 | Itpkb | Rat | paracetamol | increases expression | ISO | ITPKB (Homo sapiens) | 6480464 | Acetaminophen results in increased expression of ITPKB mRNA | CTD | PMID:26690555 | Itpkb | Rat | phenylmercury acetate | increases expression | ISO | ITPKB (Homo sapiens) | 6480464 | Phenylmercuric Acetate results in increased expression of ITPKB mRNA | CTD | PMID:26272509 | Itpkb | Rat | phenylmercury acetate | multiple interactions | ISO | ITPKB (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITPKB mRNA | CTD | PMID:27188386 | Itpkb | Rat | S-(1,2-dichlorovinyl)-L-cysteine | multiple interactions | ISO | ITPKB (Homo sapiens) | 6480464 | [S-(1 more ... | CTD | PMID:35811015 | Itpkb | Rat | SB 431542 | multiple interactions | ISO | ITPKB (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | Itpkb | Rat | silicon dioxide | increases expression | ISO | ITPKB (Homo sapiens) | 6480464 | Silicon Dioxide results in increased expression of ITPKB mRNA | CTD | PMID:25351596 | Itpkb | Rat | sodium arsenate | increases expression | ISO | Itpkb (Mus musculus) | 6480464 | sodium arsenate results in increased expression of ITPKB mRNA | CTD | PMID:21795629 | Itpkb | Rat | sunitinib | decreases expression | ISO | ITPKB (Homo sapiens) | 6480464 | Sunitinib results in decreased expression of ITPKB mRNA | CTD | PMID:31533062 | Itpkb | Rat | testosterone | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Testosterone] results in decreased expression of ITPKB mRNA | CTD | PMID:26496021 | Itpkb | Rat | tetrachloromethane | decreases expression | EXP | | 6480464 | Carbon Tetrachloride results in decreased expression of ITPKB mRNA | CTD | PMID:31150632 | Itpkb | Rat | titanium dioxide | increases expression | ISO | Itpkb (Mus musculus) | 6480464 | titanium dioxide results in increased expression of ITPKB mRNA | CTD | PMID:29264374 and PMID:35295148 | Itpkb | Rat | trichostatin A | multiple interactions | ISO | ITPKB (Homo sapiens) | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITPKB mRNA | CTD | PMID:27188386 | Itpkb | Rat | tungsten | decreases expression | ISO | Itpkb (Mus musculus) | 6480464 | Tungsten results in decreased expression of ITPKB mRNA | CTD | PMID:30912803 | Itpkb | Rat | valproic acid | decreases expression | ISO | ITPKB (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of ITPKB mRNA | CTD | PMID:23179753 and PMID:28001369 | Itpkb | Rat | valproic acid | affects expression | ISO | ITPKB (Homo sapiens) | 6480464 | Valproic Acid affects the expression of ITPKB mRNA | CTD | PMID:25979313 | Itpkb | Rat | vincristine | decreases expression | ISO | ITPKB (Homo sapiens) | 6480464 | Vincristine results in decreased expression of ITPKB mRNA | CTD | PMID:23649840 | Itpkb | Rat | vitamin E | increases expression | ISO | ITPKB (Homo sapiens) | 6480464 | Vitamin E results in increased expression of ITPKB mRNA | CTD | PMID:19244175 | |