Itpkb (inositol-trisphosphate 3-kinase B) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Itpkb (inositol-trisphosphate 3-kinase B) Rattus norvegicus
Analyze
Symbol: Itpkb
Name: inositol-trisphosphate 3-kinase B
RGD ID: 2932
Description: Predicted to enable inositol hexakisphosphate kinase activity and inositol-1,4,5-trisphosphate 3-kinase activity. Predicted to be involved in cellular response to calcium ion; inositol phosphate metabolic process; and phosphatidylinositol phosphate biosynthetic process. Predicted to act upstream of or within several processes, including common myeloid progenitor cell proliferation; negative regulation of neutrophil apoptotic process; and regulation of hemopoiesis. Predicted to be located in several cellular components, including cytoskeleton; cytosol; and endoplasmic reticulum. Predicted to be active in cytoplasm and nucleus. Orthologous to human ITPKB (inositol-trisphosphate 3-kinase B); PARTICIPATES IN calcium/calcium-mediated signaling pathway; inositol phosphate metabolic pathway; phosphatidylinositol 3-kinase signaling pathway; INTERACTS WITH (S)-nicotine; 2,3,7,8-tetrachlorodibenzodioxine; acetamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: inositol 1,4,5-trisphosphate 3-kinase B; insP 3-kinase B; IP3 3-kinase B; IP3K B; IP3K-B
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21392,069,160 - 92,164,281 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1392,069,216 - 92,162,004 (+)Ensembl
Rnor_6.01398,615,287 - 98,710,426 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1398,615,287 - 98,708,149 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013103,624,308 - 103,716,372 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41396,044,260 - 96,138,456 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11396,235,230 - 96,327,084 (+)NCBI
Celera1391,617,603 - 91,709,915 (+)NCBICelera
RH 3.4 Map13629.9RGD
Cytogenetic Map13q26NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Isolation and sequence of a full length cDNA encoding a novel rat inositol 1,4,5-trisphosphate 3-kinase. Thomas S, etal., Biochim Biophys Acta 1994 Jan 13;1220(2):219-22.
9. KRP3A and KRP3B: candidate motors in spermatid maturation in the seminiferous epithelium. Zou Y, etal., Biol Reprod 2002 Mar;66(3):843-55.
Additional References at PubMed
PMID:1654894   PMID:8889548   PMID:14517551   PMID:15064401   PMID:15381088   PMID:16173920   PMID:18339802  


Genomics

Comparative Map Data
Itpkb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21392,069,160 - 92,164,281 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1392,069,216 - 92,162,004 (+)Ensembl
Rnor_6.01398,615,287 - 98,710,426 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1398,615,287 - 98,708,149 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013103,624,308 - 103,716,372 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41396,044,260 - 96,138,456 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11396,235,230 - 96,327,084 (+)NCBI
Celera1391,617,603 - 91,709,915 (+)NCBICelera
RH 3.4 Map13629.9RGD
Cytogenetic Map13q26NCBI
ITPKB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381226,631,690 - 226,739,282 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1226,631,690 - 226,739,323 (-)EnsemblGRCh38hg38GRCh38
GRCh371226,819,391 - 226,926,983 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361224,886,014 - 224,991,818 (-)NCBINCBI36hg18NCBI36
Build 341223,126,126 - 223,231,930NCBI
Celera1200,010,306 - 200,117,787 (-)NCBI
Cytogenetic Map1q42.12NCBI
HuRef1197,336,497 - 197,443,479 (-)NCBIHuRef
CHM1_11228,092,188 - 228,199,660 (-)NCBICHM1_1
T2T-CHM13v2.01225,819,873 - 225,927,469 (-)NCBI
Itpkb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391180,156,655 - 180,252,367 (+)NCBIGRCm39mm39
GRCm39 Ensembl1180,158,050 - 180,252,367 (+)Ensembl
GRCm381180,330,390 - 180,424,802 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1180,330,485 - 180,424,802 (+)EnsemblGRCm38mm10GRCm38
MGSCv371182,260,607 - 182,353,790 (+)NCBIGRCm37mm9NCBIm37
MGSCv361182,167,151 - 182,260,334 (+)NCBImm8
Celera1187,393,960 - 187,488,842 (+)NCBICelera
Cytogenetic Map1H4NCBI
cM Map184.27NCBI
Itpkb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955489725,759 - 814,180 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955489726,641 - 814,180 (-)NCBIChiLan1.0ChiLan1.0
ITPKB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11207,084,883 - 207,191,692 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1207,084,883 - 207,191,678 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01202,091,263 - 202,198,880 (-)NCBIMhudiblu_PPA_v0panPan3
ITPKB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1738,253,257 - 38,346,400 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl738,253,407 - 38,343,345 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha737,736,914 - 37,828,383 (+)NCBI
ROS_Cfam_1.0738,089,021 - 38,180,423 (+)NCBI
ROS_Cfam_1.0 Ensembl738,087,507 - 38,185,299 (+)Ensembl
UMICH_Zoey_3.1737,928,053 - 38,019,442 (+)NCBI
UNSW_CanFamBas_1.0737,935,010 - 38,026,325 (+)NCBI
UU_Cfam_GSD_1.0738,205,654 - 38,297,131 (+)NCBI
Itpkb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934451,270,129 - 51,387,160 (+)NCBI
SpeTri2.0NW_0049365263,378,046 - 3,477,177 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ITPKB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11014,362,883 - 14,469,586 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21016,758,349 - 16,763,114 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ITPKB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1253,009,464 - 3,117,729 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl253,009,353 - 3,118,235 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660553,015,041 - 3,123,072 (+)NCBIVero_WHO_p1.0
Itpkb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624807658,231 - 741,195 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_004624807658,334 - 741,018 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
RH94654  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21392,161,481 - 92,161,643 (+)MAPPERmRatBN7.2
Rnor_6.01398,707,627 - 98,707,788NCBIRnor6.0
Rnor_5.013103,715,849 - 103,716,010UniSTSRnor5.0
RGSC_v3.41396,137,933 - 96,138,094UniSTSRGSC3.4
Celera1391,709,392 - 91,709,553UniSTS
RH 3.4 Map13629.9UniSTS
Cytogenetic Map13q26UniSTS
RH94655  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21392,071,488 - 92,071,686 (+)MAPPERmRatBN7.2
Rnor_6.01398,617,558 - 98,617,755NCBIRnor6.0
Rnor_5.013103,626,580 - 103,626,777UniSTSRnor5.0
RGSC_v3.41396,046,532 - 96,046,729UniSTSRGSC3.4
Celera1391,619,874 - 91,620,071UniSTS
Cytogenetic Map13q26UniSTS
BE113255  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21392,161,840 - 92,162,001 (+)MAPPERmRatBN7.2
Rnor_6.01398,707,986 - 98,708,146NCBIRnor6.0
Rnor_5.013103,716,208 - 103,716,368UniSTSRnor5.0
RGSC_v3.41396,138,292 - 96,138,452UniSTSRGSC3.4
Celera1391,709,751 - 91,709,911UniSTS
RH 3.4 Map13628.6UniSTS
Cytogenetic Map13q26UniSTS
BE120603  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21392,141,586 - 92,141,750 (+)MAPPERmRatBN7.2
Rnor_6.01398,687,732 - 98,687,895NCBIRnor6.0
Rnor_5.013103,696,667 - 103,696,830UniSTSRnor5.0
RGSC_v3.41396,118,376 - 96,118,539UniSTSRGSC3.4
Celera1391,689,905 - 91,690,068UniSTS
RH 3.4 Map13620.0UniSTS
Cytogenetic Map13q26UniSTS
AU047843  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21392,070,008 - 92,070,156 (+)MAPPERmRatBN7.2
Rnor_6.01398,616,080 - 98,616,225NCBIRnor6.0
Rnor_5.013103,625,100 - 103,625,247NCBIRnor5.0
RGSC_v3.41396,045,053 - 96,045,198UniSTSRGSC3.4
Celera1391,618,396 - 91,618,541UniSTS
Cytogenetic Map13q26UniSTS
RH140655  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21392,069,271 - 92,069,451 (+)MAPPERmRatBN7.2
Rnor_6.01398,615,343 - 98,615,522NCBIRnor6.0
Rnor_5.013103,624,364 - 103,624,543UniSTSRnor5.0
RGSC_v3.41396,044,316 - 96,044,495UniSTSRGSC3.4
Celera1391,617,659 - 91,617,838UniSTS
RH 3.4 Map13630.3UniSTS
Cytogenetic Map13q26UniSTS
AW529865  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21392,147,165 - 92,147,336 (+)MAPPERmRatBN7.2
Rnor_6.01398,693,311 - 98,693,481NCBIRnor6.0
Rnor_5.013103,702,246 - 103,702,416UniSTSRnor5.0
RGSC_v3.41396,123,955 - 96,124,125UniSTSRGSC3.4
Celera1391,695,484 - 91,695,654UniSTS
RH 3.4 Map13618.2UniSTS
Cytogenetic Map13q26UniSTS
UniSTS:234290  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21392,069,242 - 92,069,463 (+)MAPPERmRatBN7.2
Rnor_6.01398,615,314 - 98,615,534NCBIRnor6.0
Rnor_5.013103,624,335 - 103,624,555UniSTSRnor5.0
RGSC_v3.41396,044,287 - 96,044,507UniSTSRGSC3.4
Celera1391,617,630 - 91,617,850UniSTS
Cytogenetic Map13q26UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
1641901Alcrsp6Alcohol response QTL 6response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)135236217197362171Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1356056920101056920Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1361825626106807694Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1365103704106807694Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1365103704106807694Rat
8655959Pur32Proteinuria QTL 328.4total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)137402391897213863Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1374862117101339893Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1380753256106807694Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:95
Count of miRNA genes:67
Interacting mature miRNAs:75
Transcripts:ENSRNOT00000004032
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 27 14 6 19 6 1 64 30 30 11
Low 1 16 43 35 35 8 10 10 5 11 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000004032   ⟹   ENSRNOP00000004032
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1392,069,216 - 92,162,004 (+)Ensembl
Rnor_6.0 Ensembl1398,615,287 - 98,708,149 (+)Ensembl
RefSeq Acc Id: NM_019312   ⟹   NP_062185
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21392,069,216 - 92,162,005 (+)NCBI
Rnor_6.01398,615,287 - 98,708,150 (+)NCBI
Rnor_5.013103,624,308 - 103,716,372 (+)NCBI
RGSC_v3.41396,044,260 - 96,138,456 (+)RGD
Celera1391,617,603 - 91,709,915 (+)RGD
Sequence:
RefSeq Acc Id: XM_039091025   ⟹   XP_038946953
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21392,069,160 - 92,148,680 (+)NCBI
RefSeq Acc Id: XM_039091026   ⟹   XP_038946954
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21392,117,707 - 92,164,281 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_062185   ⟸   NM_019312
- UniProtKB: Q91XW1 (UniProtKB/Swiss-Prot),   P42335 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000004032   ⟸   ENSRNOT00000004032
RefSeq Acc Id: XP_038946953   ⟸   XM_039091025
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038946954   ⟸   XM_039091026
- Peptide Label: isoform X2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P42335-F1-model_v2 AlphaFold P42335 1-934 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699058
Promoter ID:EPDNEW_R9583
Type:initiation region
Name:Itpkb_1
Description:inositol-trisphosphate 3-kinase B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01398,615,342 - 98,615,402EPDNEW

Strain Variation

Strain Sequence Variants (mRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
Damaging Variants


Assembly: RGSC_v3.4

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
13 96046657 96046658 C A snv LCR/1Mco (UMich)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2932 AgrOrtholog
BioCyc Gene G2FUF-17127 BioCyc
BioCyc Pathway PWY-6361 [1D-myo-inositol hexakisphosphate biosynthesis I (from Ins(1,4,5)P3)] BioCyc
  PWY-6362 [1D-myo-inositol hexakisphosphate biosynthesis II (mammalian)] BioCyc
  PWY-6364 [D-myo-inositol (1,3,4)-trisphosphate biosynthesis] BioCyc
Ensembl Genes ENSRNOG00000002969 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000004032 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000004032 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.470.160 UniProtKB/Swiss-Prot
InterPro IPK UniProtKB/Swiss-Prot
  IPK_sf UniProtKB/Swiss-Prot
KEGG Report rno:54260 UniProtKB/Swiss-Prot
NCBI Gene 54260 ENTREZGENE
PANTHER PTHR12400 UniProtKB/Swiss-Prot
Pfam IPK UniProtKB/Swiss-Prot
PhenoGen Itpkb PhenoGen
UniProt IP3KB_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q91XW1 ENTREZGENE
UniProt Secondary Q91XW1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-02 Itpkb  inositol-trisphosphate 3-kinase B  Itpkb  inositol 1,4,5-trisphosphate 3-kinase B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Itpkb  Inositol 1,4,5-trisphosphate 3-kinase B      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_homology 93% identical to the human gene 633051