Itpkb (inositol-trisphosphate 3-kinase B) - Rat Genome Database

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Gene: Itpkb (inositol-trisphosphate 3-kinase B) Rattus norvegicus
Analyze
Symbol: Itpkb
Name: inositol-trisphosphate 3-kinase B
RGD ID: 2932
Description: Predicted to have inositol hexakisphosphate kinase activity and inositol-1,4,5-trisphosphate 3-kinase activity. Predicted to be involved in several processes, including common myeloid progenitor cell proliferation; inositol phosphate metabolic process; and regulation of hemopoiesis. Predicted to localize to cytosol; membrane; and nucleus. Orthologous to human ITPKB (inositol-trisphosphate 3-kinase B); PARTICIPATES IN calcium/calcium-mediated signaling pathway; inositol phosphate metabolic pathway; phosphatidylinositol 3-kinase signaling pathway; INTERACTS WITH (S)-nicotine; acetamide; acrylamide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: inositol 1,4,5-trisphosphate 3-kinase B; insP 3-kinase B; IP3 3-kinase B; IP3K B; IP3K-B
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21392,069,160 - 92,164,281 (+)NCBI
Rnor_6.0 Ensembl1398,615,287 - 98,708,149 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01398,615,287 - 98,710,426 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.013103,624,308 - 103,716,372 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41396,044,260 - 96,138,456 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11396,235,230 - 96,327,084 (+)NCBI
Celera1391,617,603 - 91,709,915 (+)NCBICelera
RH 3.4 Map13629.9RGD
Cytogenetic Map13q26NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:1654894   PMID:8889548   PMID:14517551   PMID:15064401   PMID:15381088   PMID:16173920   PMID:18339802  


Genomics

Comparative Map Data
Itpkb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21392,069,160 - 92,164,281 (+)NCBI
Rnor_6.0 Ensembl1398,615,287 - 98,708,149 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01398,615,287 - 98,710,426 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.013103,624,308 - 103,716,372 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41396,044,260 - 96,138,456 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11396,235,230 - 96,327,084 (+)NCBI
Celera1391,617,603 - 91,709,915 (+)NCBICelera
RH 3.4 Map13629.9RGD
Cytogenetic Map13q26NCBI
ITPKB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1226,631,690 - 226,739,323 (-)EnsemblGRCh38hg38GRCh38
GRCh381226,631,690 - 226,739,296 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371226,819,391 - 226,926,983 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361224,886,014 - 224,991,818 (-)NCBINCBI36hg18NCBI36
Build 341223,126,126 - 223,231,930NCBI
Celera1200,010,306 - 200,117,787 (-)NCBI
Cytogenetic Map1q42.12NCBI
HuRef1197,336,497 - 197,443,479 (-)NCBIHuRef
CHM1_11228,092,188 - 228,199,660 (-)NCBICHM1_1
Itpkb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391180,156,655 - 180,252,367 (+)NCBIGRCm39mm39
GRCm39 Ensembl1180,158,050 - 180,252,367 (+)Ensembl
GRCm381180,330,390 - 180,424,802 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1180,330,485 - 180,424,802 (+)EnsemblGRCm38mm10GRCm38
MGSCv371182,260,607 - 182,353,790 (+)NCBIGRCm37mm9NCBIm37
MGSCv361182,167,151 - 182,260,334 (+)NCBImm8
Celera1187,393,960 - 187,488,842 (+)NCBICelera
Cytogenetic Map1H4NCBI
cM Map184.27NCBI
Itpkb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955489725,759 - 814,180 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955489726,641 - 814,180 (-)NCBIChiLan1.0ChiLan1.0
ITPKB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11207,084,883 - 207,191,692 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1207,084,883 - 207,191,678 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01202,091,263 - 202,198,880 (-)NCBIMhudiblu_PPA_v0panPan3
ITPKB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1738,253,257 - 38,346,400 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl738,253,407 - 38,343,345 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha737,736,914 - 37,828,383 (+)NCBI
ROS_Cfam_1.0738,089,021 - 38,180,423 (+)NCBI
UMICH_Zoey_3.1737,928,053 - 38,019,442 (+)NCBI
UNSW_CanFamBas_1.0737,935,010 - 38,026,325 (+)NCBI
UU_Cfam_GSD_1.0738,205,654 - 38,297,131 (+)NCBI
Itpkb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934451,270,129 - 51,387,160 (+)NCBI
SpeTri2.0NW_0049365263,378,046 - 3,477,177 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ITPKB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11014,362,883 - 14,469,586 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21016,758,349 - 16,763,114 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ITPKB
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1253,009,464 - 3,117,729 (+)NCBI
ChlSab1.1 Ensembl253,009,353 - 3,118,235 (+)Ensembl
Itpkb
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624807658,334 - 741,018 (-)NCBI

Position Markers
RH94654  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01398,707,627 - 98,707,788NCBIRnor6.0
Rnor_5.013103,715,849 - 103,716,010UniSTSRnor5.0
RGSC_v3.41396,137,933 - 96,138,094UniSTSRGSC3.4
Celera1391,709,392 - 91,709,553UniSTS
RH 3.4 Map13629.9UniSTS
Cytogenetic Map13q26UniSTS
RH94655  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01398,617,558 - 98,617,755NCBIRnor6.0
Rnor_5.013103,626,580 - 103,626,777UniSTSRnor5.0
RGSC_v3.41396,046,532 - 96,046,729UniSTSRGSC3.4
Celera1391,619,874 - 91,620,071UniSTS
Cytogenetic Map13q26UniSTS
BE113255  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01398,707,986 - 98,708,146NCBIRnor6.0
Rnor_5.013103,716,208 - 103,716,368UniSTSRnor5.0
RGSC_v3.41396,138,292 - 96,138,452UniSTSRGSC3.4
Celera1391,709,751 - 91,709,911UniSTS
RH 3.4 Map13628.6UniSTS
Cytogenetic Map13q26UniSTS
BE120603  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01398,687,732 - 98,687,895NCBIRnor6.0
Rnor_5.013103,696,667 - 103,696,830UniSTSRnor5.0
RGSC_v3.41396,118,376 - 96,118,539UniSTSRGSC3.4
Celera1391,689,905 - 91,690,068UniSTS
RH 3.4 Map13620.0UniSTS
Cytogenetic Map13q26UniSTS
AU047843  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01398,616,080 - 98,616,225NCBIRnor6.0
Rnor_5.013103,625,100 - 103,625,247NCBIRnor5.0
RGSC_v3.41396,045,053 - 96,045,198UniSTSRGSC3.4
Celera1391,618,396 - 91,618,541UniSTS
Cytogenetic Map13q26UniSTS
RH140655  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01398,615,343 - 98,615,522NCBIRnor6.0
Rnor_5.013103,624,364 - 103,624,543UniSTSRnor5.0
RGSC_v3.41396,044,316 - 96,044,495UniSTSRGSC3.4
Celera1391,617,659 - 91,617,838UniSTS
RH 3.4 Map13630.3UniSTS
Cytogenetic Map13q26UniSTS
AW529865  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01398,693,311 - 98,693,481NCBIRnor6.0
Rnor_5.013103,702,246 - 103,702,416UniSTSRnor5.0
RGSC_v3.41396,123,955 - 96,124,125UniSTSRGSC3.4
Celera1391,695,484 - 91,695,654UniSTS
RH 3.4 Map13618.2UniSTS
Cytogenetic Map13q26UniSTS
UniSTS:234290  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01398,615,314 - 98,615,534NCBIRnor6.0
Rnor_5.013103,624,335 - 103,624,555UniSTSRnor5.0
RGSC_v3.41396,044,287 - 96,044,507UniSTSRGSC3.4
Celera1391,617,630 - 91,617,850UniSTS
Cytogenetic Map13q26UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131107975663Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131107975663Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131107975663Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)1312193394108478121Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1324502279108770533Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1335301263107975663Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133614753399968921Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133614753399968921Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133614753399968921Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133614753399968921Rat
1641901Alcrsp6Alcohol response QTL 6response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1357903612102903612Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1362975663107975663Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1366971778111971778Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1371230858114033958Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1371230858114033958Rat
7387280Uae43Urinary albumin excretion QTL 435.690.4174urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1372583716114033958Rat
10755455Coatc13Coat color QTL 130coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)777694986114033958Rat
8655959Pur32Proteinuria QTL 328.4total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1379567081103613733Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1380403559108770687Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1386833393114033958Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:95
Count of miRNA genes:67
Interacting mature miRNAs:75
Transcripts:ENSRNOT00000004032
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 27 14 6 19 6 1 64 30 30 11
Low 1 16 43 35 35 8 10 10 5 11 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000004032   ⟹   ENSRNOP00000004032
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1398,615,287 - 98,708,149 (+)Ensembl
RefSeq Acc Id: NM_019312   ⟹   NP_062185
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21392,069,216 - 92,162,005 (+)NCBI
Rnor_6.01398,615,287 - 98,708,150 (+)NCBI
Rnor_5.013103,624,308 - 103,716,372 (+)NCBI
RGSC_v3.41396,044,260 - 96,138,456 (+)RGD
Celera1391,617,603 - 91,709,915 (+)RGD
Sequence:
RefSeq Acc Id: XM_017598917   ⟹   XP_017454406
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01398,615,591 - 98,710,426 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017598918   ⟹   XP_017454407
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01398,615,591 - 98,710,426 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039091025   ⟹   XP_038946953
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21392,069,160 - 92,148,680 (+)NCBI
RefSeq Acc Id: XM_039091026   ⟹   XP_038946954
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21392,117,707 - 92,164,281 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_062185   ⟸   NM_019312
- UniProtKB: P42335 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017454406   ⟸   XM_017598917
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017454407   ⟸   XM_017598918
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000004032   ⟸   ENSRNOT00000004032
RefSeq Acc Id: XP_038946953   ⟸   XM_039091025
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038946954   ⟸   XM_039091026
- Peptide Label: isoform X2

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699058
Promoter ID:EPDNEW_R9583
Type:initiation region
Name:Itpkb_1
Description:inositol-trisphosphate 3-kinase B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01398,615,342 - 98,615,402EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Damaging Variants


Assembly: RGSC_v3.4

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
13 96046657 96046658 C A snv LCR/1Mco (UMich)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2932 AgrOrtholog
Ensembl Genes ENSRNOG00000002969 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000004032 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000004032 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.510.50 UniProtKB/Swiss-Prot
InterPro IPK UniProtKB/Swiss-Prot
  IPK_sf UniProtKB/Swiss-Prot
KEGG Report rno:54260 UniProtKB/Swiss-Prot
NCBI Gene 54260 ENTREZGENE
PANTHER PTHR12400 UniProtKB/Swiss-Prot
Pfam IPK UniProtKB/Swiss-Prot
PhenoGen Itpkb PhenoGen
UniProt IP3KB_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q91XW1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-02 Itpkb  inositol-trisphosphate 3-kinase B  Itpkb  inositol 1,4,5-trisphosphate 3-kinase B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Itpkb  Inositol 1,4,5-trisphosphate 3-kinase B      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_homology 93% identical to the human gene 633051