ITPKB (inositol-trisphosphate 3-kinase B) - Rat Genome Database

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Gene: ITPKB (inositol-trisphosphate 3-kinase B) Pan paniscus
Analyze
Symbol: ITPKB
Name: inositol-trisphosphate 3-kinase B
RGD ID: 11971819
Description: ENCODES a protein that exhibits inositol hexakisphosphate kinase activity (inferred); inositol phosphate kinase activity (inferred); inositol-1,4,5-trisphosphate 3-kinase activity (inferred); INVOLVED IN regulation of protein phosphorylation (ortholog); ASSOCIATED WITH gastrointestinal stromal tumor (ortholog); myeloproliferative neoplasm (ortholog); parathyroid carcinoma (ortholog); FOUND IN cytoplasm (inferred); cytoskeleton (inferred); cytosol (inferred)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2122,799,337 - 22,907,636 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1122,747,787 - 22,856,066 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01202,091,263 - 202,198,880 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11207,084,883 - 207,191,692 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1207,084,883 - 207,191,678 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
ITPKBBonobogastrointestinal stromal tumor  ISOITPKB (Homo sapiens)8554872ClinVar Annotator: match by term: Gastrointestinal stromal tumorClinVarPMID:28492532
ITPKBBonobomyeloproliferative neoplasm  ISOITPKB (Homo sapiens)8554872ClinVar Annotator: match by term: Myeloproliferative neoplasm and unclassifiableClinVarPMID:25741868 and PMID:35101336
ITPKBBonoboparathyroid carcinoma  ISOITPKB (Homo sapiens)8554872ClinVar Annotator: match by term: Parathyroid carcinomaClinVarPMID:28492532


Biological Process
1 to 18 of 18 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
ITPKBBonobocell surface receptor signaling pathway acts_upstream_of_or_withinIEAUniProtKB:B2RXC2 and ensembl:ENSMUSP00000069851150520179 EnsemblGO_REF:0000107
ITPKBBonobocellular response to calcium ion involved_inIEAUniProtKB:P27987 and ensembl:ENSP00000411152150520179 EnsemblGO_REF:0000107
ITPKBBonobocommon myeloid progenitor cell proliferation acts_upstream_of_or_withinIEAUniProtKB:B2RXC2 and ensembl:ENSMUSP00000069851150520179 EnsemblGO_REF:0000107
ITPKBBonoboinositol phosphate biosynthetic process involved_inIEAPANTHER:PTN007572788150520179 TreeGrafterGO_REF:0000118
ITPKBBonoboinositol phosphate biosynthetic process involved_inIEAInterPro:IPR005522150520179 InterProGO_REF:0000002
ITPKBBonoboinositol trisphosphate metabolic process involved_inIEAUniProtKB:P27987 and ensembl:ENSP00000411152150520179 EnsemblGO_REF:0000107
ITPKBBonoboMAPK cascade acts_upstream_of_or_withinIEAUniProtKB:B2RXC2 and ensembl:ENSMUSP00000069851150520179 EnsemblGO_REF:0000107
ITPKBBonobomyeloid cell homeostasis acts_upstream_of_or_withinIEAUniProtKB:B2RXC2 and ensembl:ENSMUSP00000069851150520179 EnsemblGO_REF:0000107
ITPKBBonobonegative regulation of myeloid cell differentiation acts_upstream_of_or_withinIEAUniProtKB:B2RXC2 and ensembl:ENSMUSP00000069851150520179 EnsemblGO_REF:0000107
ITPKBBonobonegative regulation of neutrophil apoptotic process acts_upstream_of_or_withinIEAUniProtKB:B2RXC2 and ensembl:ENSMUSP00000069851150520179 EnsemblGO_REF:0000107
ITPKBBonobophosphatidylinositol phosphate biosynthetic process involved_inIEAUniProtKB:P27987 and ensembl:ENSP00000411152150520179 EnsemblGO_REF:0000107
ITPKBBonobophosphatidylinositol phosphate biosynthetic process involved_inIEAPANTHER:PTN007572788150520179 TreeGrafterGO_REF:0000118
ITPKBBonobopositive regulation of alpha-beta T cell differentiation acts_upstream_of_or_withinIEAUniProtKB:B2RXC2 and ensembl:ENSMUSP00000069851150520179 EnsemblGO_REF:0000107
ITPKBBonobopositive regulation of Ras protein signal transduction acts_upstream_of_or_withinIEAUniProtKB:B2RXC2 and ensembl:ENSMUSP00000069851150520179 EnsemblGO_REF:0000107
ITPKBBonobopositive thymic T cell selection acts_upstream_of_or_withinIEAUniProtKB:B2RXC2 and ensembl:ENSMUSP00000069851150520179 EnsemblGO_REF:0000107
ITPKBBonoboregulation of protein phosphorylation acts_upstream_of_or_withinISOMGI:26807209068941 PMID:18339802MGIPMID:18339802
ITPKBBonoboT cell differentiation acts_upstream_of_or_withinIEAUniProtKB:B2RXC2 and ensembl:ENSMUSP00000069851150520179 EnsemblGO_REF:0000107
ITPKBBonobothymic T cell selection acts_upstream_of_or_withinIEAUniProtKB:B2RXC2 and ensembl:ENSMUSP00000069851150520179 EnsemblGO_REF:0000107
1 to 18 of 18 rows

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
ITPKBBonobocytoplasm located_inIEAUniProtKB:P27987 and ensembl:ENSP00000411152150520179 EnsemblGO_REF:0000107
ITPKBBonobocytoplasm located_inIEAPANTHER:PTN007572788150520179 TreeGrafterGO_REF:0000118
ITPKBBonobocytoskeleton located_inIEAUniProtKB:P27987 and ensembl:ENSP00000411152150520179 EnsemblGO_REF:0000107
ITPKBBonobocytosol located_inIEAUniProtKB:B2RXC2 and ensembl:ENSMUSP00000069851150520179 EnsemblGO_REF:0000107
ITPKBBonoboendoplasmic reticulum located_inIEAUniProtKB:P27987 and ensembl:ENSP00000411152150520179 EnsemblGO_REF:0000107
ITPKBBonobomembrane located_inIEAUniProtKB:B2RXC2 and ensembl:ENSMUSP00000069851150520179 EnsemblGO_REF:0000107
ITPKBBonobonucleus located_inIEAUniProtKB:B2RXC2 and ensembl:ENSMUSP00000069851150520179 EnsemblGO_REF:0000107
ITPKBBonobonucleus located_inIEAPANTHER:PTN007572788150520179 TreeGrafterGO_REF:0000118

Molecular Function
1 to 10 of 10 rows

  
1 to 10 of 10 rows

PMID:22301074   PMID:30032202  



ITPKB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2122,799,337 - 22,907,636 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1122,747,787 - 22,856,066 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01202,091,263 - 202,198,880 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11207,084,883 - 207,191,692 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1207,084,883 - 207,191,678 (-)Ensemblpanpan1.1panPan2
ITPKB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381226,631,690 - 226,739,282 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1226,631,690 - 226,739,323 (-)EnsemblGRCh38hg38GRCh38
GRCh371226,819,391 - 226,926,983 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361224,886,014 - 224,991,818 (-)NCBINCBI36Build 36hg18NCBI36
Build 341223,126,126 - 223,231,930NCBI
Celera1200,010,306 - 200,117,787 (-)NCBICelera
Cytogenetic Map1q42.12NCBI
HuRef1197,336,497 - 197,443,479 (-)NCBIHuRef
CHM1_11228,092,188 - 228,199,660 (-)NCBICHM1_1
T2T-CHM13v2.01225,819,873 - 225,927,469 (-)NCBIT2T-CHM13v2.0
Itpkb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391180,156,655 - 180,252,367 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1180,158,050 - 180,252,367 (+)EnsemblGRCm39 Ensembl
GRCm381180,330,390 - 180,424,802 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1180,330,485 - 180,424,802 (+)EnsemblGRCm38mm10GRCm38
MGSCv371182,260,607 - 182,353,790 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361182,167,151 - 182,260,334 (+)NCBIMGSCv36mm8
Celera1187,393,960 - 187,488,842 (+)NCBICelera
Cytogenetic Map1H4NCBI
cM Map184.27NCBI
Itpkb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81394,601,072 - 94,696,180 (+)NCBIGRCr8
mRatBN7.21392,069,160 - 92,164,281 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1392,069,216 - 92,162,004 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1394,574,383 - 94,667,140 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01395,974,568 - 96,067,342 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01393,149,283 - 93,242,066 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01398,615,287 - 98,710,426 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1398,615,287 - 98,708,149 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013103,624,308 - 103,716,372 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41396,044,260 - 96,138,456 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11396,235,230 - 96,327,084 (+)NCBI
Celera1391,617,603 - 91,709,915 (+)NCBICelera
RH 3.4 Map13629.9RGD
Cytogenetic Map13q26NCBI
Itpkb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955489725,759 - 814,180 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955489726,641 - 814,180 (-)NCBIChiLan1.0ChiLan1.0
ITPKB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1738,253,257 - 38,346,400 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl738,253,407 - 38,343,345 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha737,736,914 - 37,828,383 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0738,089,021 - 38,180,423 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl738,087,507 - 38,185,299 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1737,928,053 - 38,019,442 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0737,935,010 - 38,026,325 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0738,205,654 - 38,297,131 (+)NCBIUU_Cfam_GSD_1.0
Itpkb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934451,270,129 - 51,387,160 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365263,376,786 - 3,477,554 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365263,378,046 - 3,477,177 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ITPKB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11014,362,883 - 14,469,586 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21016,758,349 - 16,763,114 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ITPKB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1253,009,464 - 3,117,729 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl253,009,353 - 3,118,235 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660553,015,041 - 3,123,072 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Itpkb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624807658,231 - 741,195 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624807658,334 - 741,018 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.






Ensembl Acc Id: ENSPPAT00000044757   ⟹   ENSPPAP00000021953
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1207,084,883 - 207,191,678 (-)Ensembl
RefSeq Acc Id: XM_003814929   ⟹   XP_003814977
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2122,799,356 - 22,907,636 (+)NCBI
NHGRI_mPanPan1122,747,806 - 22,856,066 (+)NCBI
Mhudiblu_PPA_v01202,091,263 - 202,198,880 (-)NCBI
PanPan1.11207,084,883 - 207,191,692 (-)NCBI
Sequence:
RefSeq Acc Id: XM_055107396   ⟹   XP_054963371
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2122,799,337 - 22,867,511 (+)NCBI
NHGRI_mPanPan1122,747,787 - 22,815,952 (+)NCBI
RefSeq Acc Id: XM_055107402   ⟹   XP_054963377
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2122,799,339 - 22,849,564 (+)NCBI
NHGRI_mPanPan1122,747,789 - 22,782,611 (+)NCBI
Protein RefSeqs XP_003814977 (Get FASTA)   NCBI Sequence Viewer  
  XP_054963371 (Get FASTA)   NCBI Sequence Viewer  
  XP_054963377 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000021953.1
RefSeq Acc Id: XP_003814977   ⟸   XM_003814929
- Peptide Label: isoform X1
- UniProtKB: A0A2R9AXD5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSPPAP00000021953   ⟸   ENSPPAT00000044757
RefSeq Acc Id: XP_054963371   ⟸   XM_055107396
- Peptide Label: isoform X2
RefSeq Acc Id: XP_054963377   ⟸   XM_055107402
- Peptide Label: isoform X3



1 to 12 of 12 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSPPAG00000034181 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000044757.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.470.160 UniProtKB/TrEMBL
InterPro IPK UniProtKB/TrEMBL
  IPK_sf UniProtKB/TrEMBL
KEGG Report pps:100974308 UniProtKB/TrEMBL
NCBI Gene ITPKB ENTREZGENE
PANTHER INOSITOL-TRISPHOSPHATE 3-KINASE B UniProtKB/TrEMBL
  PTHR12400 UniProtKB/TrEMBL
Pfam IPK UniProtKB/TrEMBL
Superfamily-SCOP SAICAR synthase-like UniProtKB/TrEMBL
UniProt A0A2R9AXD5 ENTREZGENE, UniProtKB/TrEMBL
1 to 12 of 12 rows