ITPKB (inositol-trisphosphate 3-kinase B) - Rat Genome Database

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Gene: ITPKB (inositol-trisphosphate 3-kinase B) Canis lupus familiaris
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Symbol: ITPKB
Name: inositol-trisphosphate 3-kinase B
RGD ID: 12062054
Description: ENCODES a protein that exhibits inositol-1,4,5-trisphosphate 3-kinase activity (ortholog); INVOLVED IN cell surface receptor signaling pathway (ortholog); cellular response to calcium ion (ortholog); common myeloid progenitor cell proliferation (ortholog); ASSOCIATED WITH gastrointestinal stromal tumor (ortholog); parathyroid carcinoma (ortholog); FOUND IN cytoplasm (ortholog); cytoskeleton (ortholog); cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: inositol 1,4,5-trisphosphate 3-kinase B
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1738,253,257 - 38,346,400 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl738,253,407 - 38,343,345 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha737,736,914 - 37,828,383 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0738,089,021 - 38,180,423 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl738,087,507 - 38,185,299 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1737,928,053 - 38,019,442 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0737,935,010 - 38,026,325 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0738,205,654 - 38,297,131 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

References

Genomics

Comparative Map Data
ITPKB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1738,253,257 - 38,346,400 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl738,253,407 - 38,343,345 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha737,736,914 - 37,828,383 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0738,089,021 - 38,180,423 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl738,087,507 - 38,185,299 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1737,928,053 - 38,019,442 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0737,935,010 - 38,026,325 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0738,205,654 - 38,297,131 (+)NCBIUU_Cfam_GSD_1.0
ITPKB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381226,631,690 - 226,739,282 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1226,631,690 - 226,739,323 (-)EnsemblGRCh38hg38GRCh38
GRCh371226,819,391 - 226,926,983 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361224,886,014 - 224,991,818 (-)NCBINCBI36Build 36hg18NCBI36
Build 341223,126,126 - 223,231,930NCBI
Celera1200,010,306 - 200,117,787 (-)NCBICelera
Cytogenetic Map1q42.12NCBI
HuRef1197,336,497 - 197,443,479 (-)NCBIHuRef
CHM1_11228,092,188 - 228,199,660 (-)NCBICHM1_1
T2T-CHM13v2.01225,819,873 - 225,927,469 (-)NCBIT2T-CHM13v2.0
Itpkb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391180,156,655 - 180,252,367 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1180,158,050 - 180,252,367 (+)EnsemblGRCm39 Ensembl
GRCm381180,330,390 - 180,424,802 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1180,330,485 - 180,424,802 (+)EnsemblGRCm38mm10GRCm38
MGSCv371182,260,607 - 182,353,790 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361182,167,151 - 182,260,334 (+)NCBIMGSCv36mm8
Celera1187,393,960 - 187,488,842 (+)NCBICelera
Cytogenetic Map1H4NCBI
cM Map184.27NCBI
Itpkb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21392,069,160 - 92,164,281 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1392,069,216 - 92,162,004 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1394,574,383 - 94,667,140 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01395,974,568 - 96,067,342 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01393,149,283 - 93,242,066 (+)NCBIRnor_WKY
Rnor_6.01398,615,287 - 98,710,426 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1398,615,287 - 98,708,149 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013103,624,308 - 103,716,372 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41396,044,260 - 96,138,456 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11396,235,230 - 96,327,084 (+)NCBI
Celera1391,617,603 - 91,709,915 (+)NCBICelera
RH 3.4 Map13629.9RGD
Cytogenetic Map13q26NCBI
Itpkb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955489725,759 - 814,180 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955489726,641 - 814,180 (-)NCBIChiLan1.0ChiLan1.0
ITPKB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11207,084,883 - 207,191,692 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1207,084,883 - 207,191,678 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01202,091,263 - 202,198,880 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
Itpkb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934451,270,129 - 51,387,160 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365263,376,786 - 3,477,554 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365263,378,046 - 3,477,177 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ITPKB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11014,362,883 - 14,469,586 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21016,758,349 - 16,763,114 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ITPKB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1253,009,464 - 3,117,729 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl253,009,353 - 3,118,235 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660553,015,041 - 3,123,072 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Itpkb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624807658,231 - 741,195 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624807658,334 - 741,018 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ITPKB
830 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 4 4 15 6 6 6 10 6
Low 1 1 7 6 6 6 6 8
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_038481453 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038481454 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038481455 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038542808 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038542809 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038542810 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038569259 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038569263 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038606953 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038671651 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038671652 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038671653 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_547504 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005328420 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005362270 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005375837 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005429978 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000084 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000093 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000022 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000025466   ⟹   ENSCAFP00000023644
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl738,253,407 - 38,343,345 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845014441   ⟹   ENSCAFP00845011185
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl738,087,507 - 38,185,299 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845014482   ⟹   ENSCAFP00845011221
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl738,087,507 - 38,180,406 (+)Ensembl
RefSeq Acc Id: XM_038481453   ⟹   XP_038337381
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1737,928,070 - 38,019,442 (+)NCBI
RefSeq Acc Id: XM_038481454   ⟹   XP_038337382
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1737,928,053 - 37,974,042 (+)NCBI
RefSeq Acc Id: XM_038481455   ⟹   XP_038337383
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1737,928,053 - 37,955,342 (+)NCBI
RefSeq Acc Id: XM_038542808   ⟹   XP_038398736
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0738,205,671 - 38,297,131 (+)NCBI
RefSeq Acc Id: XM_038542809   ⟹   XP_038398737
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0738,205,654 - 38,251,726 (+)NCBI
RefSeq Acc Id: XM_038542810   ⟹   XP_038398738
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0738,205,654 - 38,232,989 (+)NCBI
RefSeq Acc Id: XM_038569259   ⟹   XP_038425187
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha737,736,914 - 37,782,979 (+)NCBI
RefSeq Acc Id: XM_038569263   ⟹   XP_038425191
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha737,736,914 - 37,764,245 (+)NCBI
RefSeq Acc Id: XM_038606953   ⟹   XP_038462881
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0737,935,010 - 38,026,325 (+)NCBI
RefSeq Acc Id: XM_038671651   ⟹   XP_038527579
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0738,089,038 - 38,180,423 (+)NCBI
RefSeq Acc Id: XM_038671652   ⟹   XP_038527580
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0738,089,021 - 38,134,954 (+)NCBI
RefSeq Acc Id: XM_038671653   ⟹   XP_038527581
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0738,089,021 - 38,116,234 (+)NCBI
RefSeq Acc Id: XM_547504   ⟹   XP_547504
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1738,253,257 - 38,346,400 (+)NCBI
Dog10K_Boxer_Tasha737,736,931 - 37,828,383 (+)NCBI
Sequence:
RefSeq Acc Id: XR_005328420
RefSeq Status:
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1737,928,053 - 38,004,803 (+)NCBI
RefSeq Acc Id: XR_005362270
RefSeq Status:
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0738,205,654 - 38,282,490 (+)NCBI
RefSeq Acc Id: XR_005375837
RefSeq Status:
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha737,736,914 - 37,813,743 (+)NCBI
RefSeq Acc Id: XR_005429978
RefSeq Status:
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0738,089,021 - 38,165,775 (+)NCBI
Reference Sequences
RefSeq Acc Id: XP_547504   ⟸   XM_547504
- Peptide Label: isoform X1
- UniProtKB: F1PWW8 (UniProtKB/TrEMBL),   A0A8P0PQ55 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000023644   ⟸   ENSCAFT00000025466
RefSeq Acc Id: XP_038337382   ⟸   XM_038481454
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038337383   ⟸   XM_038481455
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038337381   ⟸   XM_038481453
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038462881   ⟸   XM_038606953
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038527580   ⟸   XM_038671652
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038527581   ⟸   XM_038671653
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038527579   ⟸   XM_038671651
- Peptide Label: isoform X1
- UniProtKB: A0A8I3N810 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038425187   ⟸   XM_038569259
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038425191   ⟸   XM_038569263
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038398737   ⟸   XM_038542809
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038398738   ⟸   XM_038542810
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038398736   ⟸   XM_038542808
- Peptide Label: isoform X1
RefSeq Acc Id: ENSCAFP00845011221   ⟸   ENSCAFT00845014482
RefSeq Acc Id: ENSCAFP00845011185   ⟸   ENSCAFT00845014441


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000016055 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00845008212 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00000023644.5 UniProtKB/TrEMBL
  ENSCAFP00000073908.1 UniProtKB/TrEMBL
  ENSCAFP00845011185.1 UniProtKB/TrEMBL
  ENSCAFP00845011221 ENTREZGENE
  ENSCAFP00845011221.1 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000025466.6 UniProtKB/TrEMBL
  ENSCAFT00000097574.1 UniProtKB/TrEMBL
  ENSCAFT00845014441.1 UniProtKB/TrEMBL
  ENSCAFT00845014482 ENTREZGENE
  ENSCAFT00845014482.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.470.160 UniProtKB/TrEMBL
InterPro IPK UniProtKB/TrEMBL
  IPK_sf UniProtKB/TrEMBL
NCBI Gene ITPKB ENTREZGENE
PANTHER PTHR12400 UniProtKB/TrEMBL
Pfam IPK UniProtKB/TrEMBL
UniProt A0A8I3MX79_CANLF UniProtKB/TrEMBL
  A0A8I3N810 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0PQ55 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0SKD1_CANLF UniProtKB/TrEMBL
  F1PWW8 ENTREZGENE
VGNC ID VGNC:42155 ENTREZGENE