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Gene: Col1a2 (collagen type I alpha 2 chain) Rattus norvegicus
Symbol: Col1a2
Name: collagen type I alpha 2 chain
Description: Predicted to have several functions, including identical protein binding activity; platelet-derived growth factor binding activity; and protease binding activity. Involved in cellular response to retinoic acid; cellular response to thyroid hormone stimulus; and response to norepinephrine. Predicted to localize to collagen type I trimer; endoplasmic reticulum; and extracellular space. Biomarker of hypothyroidism; muscular atrophy; pulmonary fibrosis; and ureteral obstruction. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome; heart valve disease; intracranial aneurysm; osteogenesis imperfecta (multiple); and osteoporosis. Orthologous to human COL1A2 (collagen type I alpha 2 chain); PARTICIPATES IN endothelin signaling pathway; interleukin-4 signaling pathway; syndecan signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
Also known as: alpha-2 type I collagen; collagen alpha-2(I) chain; collagen, type I, alpha 2; procollagen, type I, alpha 2
Homo sapiens (human) : COL1A2 (collagen type I alpha 2 chain)  HGNC  Alliance
Mus musculus (house mouse) : Col1a2 (collagen, type I, alpha 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Col1a2 (collagen type I alpha 2 chain)
Pan paniscus (bonobo/pygmy chimpanzee) : COL1A2 (collagen type I alpha 2 chain)
Canis lupus familiaris (dog) : COL1A2 (collagen type I alpha 2 chain)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Col1a2 (collagen type I alpha 2 chain)
Sus scrofa (pig) : COL1A2 (collagen type I alpha 2 chain)
Chlorocebus sabaeus (African green monkey) : COL1A2 (collagen type I alpha 2 chain)
Heterocephalus glaber (naked mole-rat) : Col1a2 (collagen type I alpha 2 chain)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0431,534,225 - 31,569,152 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl431,534,225 - 31,569,151 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0431,405,253 - 31,440,180 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0429,442,828 - 29,478,616 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4429,393,645 - 29,428,572 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1429,431,383 - 29,467,014 (+)NCBI
Celera427,947,892 - 27,982,658 (+)NCBICelera
Cytogenetic Map4q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Col1a2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 621351
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-11-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.