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Gene: Prg4 (proteoglycan 4) Rattus norvegicus
Symbol: Prg4
Name: proteoglycan 4
RGD ID: 1308976
Description: Predicted to have polysaccharide binding activity and scavenger receptor activity. Predicted to be involved in hematopoietic stem cell proliferation; negative regulation of interleukin-6 production; and regulation of cell population proliferation. Predicted to localize to extracellular space. Human ortholog(s) of this gene implicated in camptodactyly-arthropathy-coxa vara-pericarditis syndrome and pericarditis. Orthologous to human PRG4 (proteoglycan 4); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acetamide; acrylamide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: LOC289104; lubricin; proteoglycan 4, (megakaryocyte stimulating factor, articular superficial zone protein, camptodactyly, arthropathy, coxa vara, pericarditis syndrome)
Homo sapiens (human) : PRG4 (proteoglycan 4)  HGNC  Alliance
Mus musculus (house mouse) : Prg4 (proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein))  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Prg4 (proteoglycan 4)
Pan paniscus (bonobo/pygmy chimpanzee) : PRG4 (proteoglycan 4)
Canis lupus familiaris (dog) : PRG4 (proteoglycan 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Prg4 (proteoglycan 4)
Sus scrofa (pig) : PRG4 (proteoglycan 4)
Chlorocebus sabaeus (African green monkey) : PRG4 (proteoglycan 4)
Heterocephalus glaber (naked mole-rat) : Prg4 (proteoglycan 4)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01367,672,588 - 67,688,902 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1367,672,878 - 67,688,477 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01372,637,409 - 72,653,723 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41364,753,316 - 64,769,533 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11364,767,685 - 64,783,195 (-)NCBI
Celera1362,446,883 - 62,463,361 (-)NCBICelera
Cytogenetic Map13q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Prg4
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1308976
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.