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Gene: Plau (plasminogen activator, urokinase) Rattus norvegicus
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Symbol: Plau
Name: plasminogen activator, urokinase
Description: Exhibits peptidase activity. Involved in several processes, including cellular response to hepatocyte growth factor stimulus; cellular response to staurosporine; and positive regulation of ovulation. Localizes to the extracellular space and membrane. Used to study several diseases, including alcoholic liver cirrhosis; lung disease (multiple); sciatic neuropathy; status epilepticus; and transient cerebral ischemia. Biomarker of brain disease (multiple); end stage renal failure; myocardial infarction; sciatic neuropathy; and thrombosis. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease (multiple); Quebec platelet disorder; end stage renal failure; lung disease (multiple); and mitral valve prolapse. Orthologous to human PLAU (plasminogen activator, urokinase); PARTICIPATES IN fibrinolysis pathway; fibroblast growth factor signaling pathway; coagulation cascade pathway; INTERACTS WITH (+)-catechin; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: MGC124931; U-plasminogen activator; uPA; UPAM; Urinary plasminogen activator urokinase; Urinary plasminogen activator, urokinase; urokinase plasminogen activator; urokinase-type plasminogen activator
Orthologs:
Homo sapiens (human) : PLAU (plasminogen activator, urokinase)  HGNC  Alliance
Mus musculus (house mouse) : Plau (plasminogen activator, urokinase)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Plau (plasminogen activator, urokinase)
Pan paniscus (bonobo/pygmy chimpanzee) : PLAU (plasminogen activator, urokinase)
Canis lupus familiaris (dog) : PLAU (plasminogen activator, urokinase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Plau (plasminogen activator, urokinase)
Sus scrofa (pig) : PLAU (plasminogen activator, urokinase)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: suggests misassembly; Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0153,644,296 - 3,650,765 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl153,644,769 - 3,650,819 (-)Ensembl
Rnor_5.0153,621,057 - 3,627,467 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4153,680,072 - 3,686,232 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1153,680,073 - 3,686,275 (-)NCBI
Celera151,129,191 - 1,135,694 (+)NCBICelera
Cytogenetic Map15p16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Plau
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3343
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-11-27
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.