Imported Disease Annotations - ClinVarTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Alzheimer's disease | | ISO | RGD:735727 | 8554872 | ClinVar Annotator: match by term: Alzheimer disease more ... | ClinVar | PMID:12898287 more ... | Hirschsprung's disease | | ISO | RGD:735727 | 8554872 | ClinVar Annotator: match by term: Hirschsprung disease more ... | ClinVar | PMID:28492532 | Quebec platelet disorder | | ISO | RGD:735727 | 8554872 | ClinVar Annotator: match by term: Quebec platelet disorder | ClinVar | PMID:18988861 more ... | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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References
References - curated
| # | Reference Title | Reference Citation |
| 1. | Antineoplastic effect of iodine in mammary cancer: participation of 6-iodolactone (6-IL) and peroxisome proliferator-activated receptors (PPAR). | Aceves C, etal., Mol Cancer. 2009 Jun 6;8:33. doi: 10.1186/1476-4598-8-33. |
| 2. | Deleterious effects of plasminogen activators in neonatal cerebral hypoxia-ischemia. | Adhami F, etal., Am J Pathol. 2008 Jun;172(6):1704-16. Epub 2008 May 8. |
| 3. | Differences in the implantation rates of rat embryos developed in vivo and in vitro: possible role for plasminogen activators. | Aflalo ED, etal., Fertil Steril. 2004 Mar;81 Suppl 1:780-5. |
| 4. | Therapeutic potential and anti-amyloidosis mechanisms of tert-butylhydroquinone for Alzheimer's disease. | Akhter H, etal., J Alzheimers Dis. 2011;26(4):767-78. |
| 5. | Association between urokinase haplotypes and outcome from infection-associated acute lung injury. | Arcaroli J, etal., Intensive Care Med. 2008 Feb;34(2):300-7. Epub 2007 Nov 10. |
| 6. | Activators and inhibitors of the plasminogen system in Alzheimer's disease. | Barker R, etal., J Cell Mol Med. 2012 Apr;16(4):865-76. doi: 10.1111/j.1582-4934.2011.01394.x. |
| 7. | Transcriptional activation of endothelial cells by TGFbeta coincides with acute microvascular plasticity following focal spinal cord ischaemia/reperfusion injury. | Benton RL, etal., ASN Neuro. 2009 Aug 26;1(3). pii: e00015. doi: 10.1042/AN20090008. |
| 8. | Urokinase-type plasminogen activator gene therapy in liver cirrhosis is mediated by collagens gene expression down-regulation and up-regulation of MMPs, HGF and VEGF. | Bueno M, etal., J Gene Med. 2006 Nov;8(11):1291-9. |
| 9. | Protection of cerebral microvasculature after moderate hypothermia following experimental focal cerebral ischemia in mice. | Burk J, etal., Brain Res. 2008 Aug 21;1226:248-55. Epub 2008 Jun 16. |
| 10. | Both tissue-type plasminogen activator and urokinase prevent intraabdominal abscess formation after surgical treatment of peritonitis in the rat. | Buyne OR, etal., Surgery. 2008 Jul;144(1):66-73. Epub 2008 May 21. |
| 11. | Whole genome microarray of the major pelvic ganglion after cavernous nerve injury: new insights into molecular profile changes after nerve injury. | Calenda G, etal., BJU Int. 2012 May;109(10):1552-64. doi: 10.1111/j.1464-410X.2011.10705.x. Epub 2012 Feb 2. |
| 12. | Hepatocyte growth factor (HGF) modulates Leydig cell extracellular matrix components. | Catizone A, etal., J Androl. 2010 May-Jun;31(3):306-13. doi: 10.2164/jandrol.109.007658. Epub 2009 Oct 15. |
| 13. | Hepatocyte growth factor (HGF) regulates blood-testis barrier (BTB) in adult rats. | Catizone A, etal., Mol Cell Endocrinol. 2012 Jan 2;348(1):135-46. doi: 10.1016/j.mce.2011.07.050. Epub 2011 Aug 5. |
| 14. | [Effects of Qinggan Huoxue Recipe and its separated recipes on urokinase-type plasminogen activator and plasminogen activator inhibitor-1 fibrinolytic system in rats with alcoholic liver fibrosis]. | Chen JM, etal., Zhong Xi Yi Jie He Xue Bao. 2009 Jul;7(7):642-50. doi: 10.3736/jcim20090708. |
| 15. | Intravesical administration of plasminogen activator inhibitor type-1 inhibits in vivo bladder tumor invasion and progression. | Chen SC, etal., J Urol. 2009 Jan;181(1):336-42. Epub 2008 Nov 17. |
| 16. | Lipopolysaccharide upregulates uPA, MMP-2 and MMP-9 via ERK1/2 signaling in H9c2 cardiomyoblast cells. | Cheng YC, etal., Mol Cell Biochem. 2009 May;325(1-2):15-23. doi: 10.1007/s11010-008-0016-y. Epub 2009 Jan 28. |
| 17. | Neuroprotection by urokinase plasminogen activator in the hippocampus. | Cho E, etal., Neurobiol Dis. 2012 Apr;46(1):215-24. Epub 2012 Jan 24. |
| 18. | Association between urokinase-plasminogen activator gene T4065C polymorphism and risk of mitral valve prolapse. | Chou HT, etal., Int J Cardiol. 2004 Aug;96(2):165-70. |
| 19. | Effects of losartan on hepatic expression of nonphagocytic NADPH oxidase and fibrogenic genes in patients with chronic hepatitis C. | Colmenero J, etal., Am J Physiol Gastrointest Liver Physiol. 2009 Oct;297(4):G726-34. Epub 2009 Jul 23. |
| 20. | Selective abrogation of the uPA-uPAR interaction in vivo reveals a novel role in suppression of fibrin-associated inflammation. | Connolly BM, etal., Blood. 2010 Sep 2;116(9):1593-603. Epub 2010 May 13. |
| 21. | No replication of genetic association between candidate polymorphisms and Alzheimer's disease. | Cousin E, etal., Neurobiol Aging. 2011 Aug;32(8):1443-51. Epub 2009 Nov 3. |
| 22. | Thrombus versus Wall Biological Activities in Experimental Aortic Aneurysms. | Coutard M, etal., J Vasc Res. 2009 Dec 16;47(4):355-366. |
| 23. | Macrophage-targeted overexpression of urokinase causes accelerated atherosclerosis, coronary artery occlusions, and premature death. | Cozen AE, etal., Circulation. 2004 May 4;109(17):2129-35. Epub 2004 Apr 19. |
| 24. | Microglia and the urokinase plasminogen activator receptor/uPA system in innate brain inflammation. | Cunningham O, etal., Glia. 2009 Dec;57(16):1802-14. |
| 25. | Urokinase-type plasminogen activator and arthritis progression: contrasting roles in systemic and monoarticular arthritis models. | De Nardo CM, etal., Arthritis Res Ther. 2010;12(5):R199. Epub 2010 Oct 25. |
| 26. | Impaired fibrinolytic system in ApoE gene-deleted mice with hyperlipidemia augments deep vein thrombosis. | Diaz JA, etal., J Vasc Surg. 2012 Mar;55(3):815-22. Epub 2011 Nov 25. |
| 27. | Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. | Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27. |
| 28. | Rat ISS GO annotations from GOA human gene data--August 2006 | GOA data from the GO Consortium |
| 29. | Effect of dietary beta carotene on cerebral aneurysm and subarachnoid haemorrhage in the brain apo E-/- mice. | Gopal K, etal., J Thromb Thrombolysis. 2011 Oct;32(3):343-55. |
| 30. | An Antiangiogenic Urokinase-derived Peptide Combined with Tamoxifen Decreases Tumor Growth and Metastasis in a Syngeneic Model of Breast Cancer. | Guo Y, etal., Cancer Res 2002 Aug 15;62(16):4678-84. |
| 31. | [Effect of amiloride on the pathology of a rat model of chronic obstructive pulmonary disease]. | Han XD, etal., Zhonghua Jie He He Hu Xi Za Zhi. 2007 May;30(5):363-7. |
| 32. | Partial reversal of established bleomycin-induced pulmonary fibrosis by rh-urokinase in a rat model. | Hart DA, etal., Clin Invest Med. 1994 Apr;17(2):69-76. |
| 33. | Urokinase-targeted fusion by oncolytic Sendai virus eradicates orthotopic glioblastomas by pronounced synergy with interferon-beta gene. | Hasegawa Y, etal., Mol Ther. 2010 Oct;18(10):1778-86. doi: 10.1038/mt.2010.138. Epub 2010 Jul 6. |
| 34. | Transcriptional and posttranscriptional activation of urokinase plasminogen activator gene expression in metastatic tumor cells. | Henderson BR, etal., Cancer Res 1992 May 1;52(9):2489-96. |
| 35. | Loss or inhibition of uPA or MMP-9 attenuates LV remodeling and dysfunction after acute pressure overload in mice. | Heymans S, etal., Am J Pathol. 2005 Jan;166(1):15-25. |
| 36. | Fasudil, a Rho-kinase inhibitor, protects against excessive endurance exercise training-induced cardiac hypertrophy, apoptosis and fibrosis in rats. | Ho TJ, etal., Eur J Appl Physiol. 2012 Aug;112(8):2943-55. doi: 10.1007/s00421-011-2270-z. Epub 2011 Dec 9. |
| 37. | Prognostic role of urokinase-type plasminogen activator in human gliomas. | Hsu DW, etal., Am J Pathol. 1995 Jul;147(1):114-23. |
| 38. | Tissue-type plasminogen activator depletion affects the nasal mucosa matrix reconstruction in allergic rhinitis mice. | Hua H, etal., Allergol Immunopathol (Madr). 2011 Jul-Aug;39(4):206-11. doi: 10.1016/j.aller.2010.09.010. Epub 2011 Feb 19. |
| 39. | Gene expression changes of urokinase plasminogen activator and urokinase receptor in rat testes at postnatal stages. | Huang DH, etal., Asian J Androl. 2007 Sep;9(5):679-83. |
| 40. | Tumour-associated urokinase-type plasminogen activator (uPA) and its inhibitor PAI-1 in normal and neoplastic tissues of patients with squamous cell cancer of the oral cavity - clinical relevance and prognostic value. | Hundsdorfer B, etal., J Craniomaxillofac Surg. 2005 Jun;33(3):191-6. Epub 2005 Apr 22. |
| 41. | Urokinase-type plasminogen activator system and human cationic antimicrobial protein 18 in serum and induced sputum of patients with chronic obstructive pulmonary disease. | Jiang Y, etal., Respirology. 2010 Aug;15(6):939-46. Epub 2010 Jul 6. |
| 42. | Small, potent, and selective diaryl phosphonate inhibitors for urokinase-type plasminogen activator with in vivo antimetastatic properties. | Joossens J, etal., J Med Chem. 2007 Dec 27;50(26):6638-46. Epub 2007 Dec 1. |
| 43. | Renal synthesis of urokinase type-plasminogen activator, its receptor, and plasminogen activator inhibitor-1 in diabetic nephropathy in rats: modulation by angiotensin-converting-enzyme inhibitor. | Kenichi M, etal., J Lab Clin Med. 2004 Aug;144(2):69-77. |
| 44. | Localization of plasminogen activators in human colon cancer by immunoperoxidase staining. | Kohga S, etal., Cancer Res. 1985 Apr;45(4):1787-96. |
| 45. | [Effects of acupoint-embedment of medicated-thread and acupoint-injection on expression of cortical urokinase-type plasminogen activator and plasminogen activator inhibitor-1 in rats with cerebral ischemia-reperfusion injury]. | Kong LH, etal., Zhen Ci Yan Jiu. 2010 Dec;35(6):409-14. |
| 46. | Plasminogen activator inhibitor-1 (PAI-1) and urokinase plasminogen activator (uPA) in sputum of allergic asthma patients. | Kowal K, etal., Folia Histochem Cytobiol. 2008;46(2):193-8. |
| 47. | Increased expression and activity of urokinase-type plasminogen activator during epileptogenesis. | Lahtinen L, etal., Eur J Neurosci. 2006 Oct;24(7):1935-45. Epub 2006 Oct 16. |
| 48. | Urokinase-type plasminogen activator regulates neurodegeneration and neurogenesis but not vascular changes in the mouse hippocampus after status epilepticus. | Lahtinen L, etal., Neurobiol Dis. 2010 Mar;37(3):692-703. Epub 2009 Dec 21. |
| 49. | Expression of urokinase-type plasminogen activator receptor is increased during epileptogenesis in the rat hippocampus. | Lahtinen L, etal., Neuroscience. 2009 Sep 29;163(1):316-28. Epub 2009 Jun 12. |
| 50. | Angiostrongylus cantonensis: induction of urokinase-type PA and degradation of type IV collagen in rat lung granulomatous fibrosis. | Lan KP and Lai SC, Exp Parasitol. 2008 Apr;118(4):472-7. Epub 2007 Oct 22. |
| 51. | [Association of uPA and uPAR expression with invasive behaviors of urinary transitional cell carcinoma]. | Li YJ, etal., Ai Zheng. 2004 Jun;23(6):704-6. |
| 52. | Norrin attenuates protease-mediated death of transformed retinal ganglion cells. | Lin S, etal., Mol Vis. 2009;15:26-37. Epub 2009 Jan 12. |
| 53. | Combination therapy of 17beta-estradiol and recombinant tissue plasminogen activator for experimental ischemic stroke. | Liu R, etal., J Pharmacol Exp Ther. 2010 Mar;332(3):1006-12. doi: 10.1124/jpet.109.160937. Epub 2009 Dec 1. |
| 54. | [Changes of u-PA and PAI-1 expression in the lung tissue of neonatal rats after inhaling high concentration oxygen] | Liu XY and Xue XD, Zhonghua Er Ke Za Zhi. 2008 Jun;46(6):458-63. |
| 55. | [Correlation of the content and expression of urokinase plasminogen activator with asthenospermia in rat models]. | Liu Y, etal., Zhonghua Nan Ke Xue. 2008 Sep;14(9):786-91. |
| 56. | Basic mechanisms and regulation of fibrinolysis. | Longstaff C and Kolev K, J Thromb Haemost. 2015 Jun;13 Suppl 1:S98-105. doi: 10.1111/jth.12935. |
| 57. | Urokinase redistribution from the secreted to the cell-bound fraction in granulosa cells of rat preovulatory follicles. | Macchione E, etal., Biol Reprod. 2000 Apr;62(4):895-903. |
| 58. | Association of Urokinase Gene 3'-UTR T/C polymorphism with bladder cancer. | Manchanda PK, etal., Urol Int. 2006;77(1):81-4. |
| 59. | Multifunctionality of PAI-1 in fibrogenesis: evidence from obstructive nephropathy in PAI-1-overexpressing mice. | Matsuo S, etal., Kidney Int. 2005 Jun;67(6):2221-38. |
| 60. | Urokinase plasminogen activator stimulates vascular smooth muscle cell proliferation via redox-dependent pathways. | Menshikov M, etal., Arterioscler Thromb Vasc Biol. 2006 Apr;26(4):801-7. Epub 2006 Feb 2. |
| 61. | Rat ISS GO annotations from MGI mouse gene data--August 2006 | MGD data from the GO Consortium |
| 62. | Elevation of urokinase-type plasminogen activator and its receptor densities as new predictors of disease progression and prognosis in men with prostate cancer. | Miyake H, etal., Int J Oncol. 1999 Mar;14(3):535-41. |
| 63. | Downregulation of matrix metalloprotease-9 and urokinase plasminogen activator by TX-1877 results in decreased tumor growth and metastasis on xenograft model of rectal cancer. | Miyake K, etal., Cancer Chemother Pharmacol. 2009 Oct;64(5):885-92. doi: 10.1007/s00280-009-0937-5. Epub 2009 Feb 12. |
| 64. | Identification of potential biomarkers of lymph node metastasis in oral squamous cell carcinoma by cDNA microarray analysis. | Nagata M, etal., Int J Cancer. 2003 Sep 20;106(5):683-9. |
| 65. | Partial purification and characterization of epidermal plasminogen activator and their inhibitor. | Nakagawa M, etal., Chem Pharm Bull (Tokyo). 1989 Jul;37(7):1859-63. |
| 66. | Electronic Transfer of LocusLink and RefSeq Data | NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 67. | Immunohistochemical evidence of urokinase-type plasminogen activator in primary and metastatic tumors of pulmonary adenocarcinoma. | Oka T, etal., Cancer Res. 1991 Jul 1;51(13):3522-5. |
| 68. | Cell surface-bound plasminogen regulates hepatocyte proliferation through a uPA-dependent mechanism. | Okumura N, etal., Biosci Biotechnol Biochem. 2007 Jun;71(6):1542-9. |
| 69. | OMIM Disease Annotation Pipeline | OMIM Disease Annotation Pipeline |
| 70. | Association of urokinase gene 3'-UTR T/C polymorphism with calcium oxalate urolithiasis in children. | Ozturk M, etal., Int Urol Nephrol. 2008;40(3):563-8. doi: 10.1007/s11255-008-9335-x. Epub 2008 Feb 1. |
| 71. | Blood brain barrier (BBB) dysfunction associated with increased expression of tissue and urokinase plasminogen activators following peripheral thermal injury. | Patel TH, etal., Neurosci Lett. 2008 Oct 31;444(3):222-6. Epub 2008 Aug 13. |
| 72. | Identification of a novel biomarker signature associated with risk for bone metastasis in patients with renal cell carcinoma. | Paule B, etal., Int J Biol Markers. 2010 Apr-Jun;25(2):112-5. |
| 73. | Hyperfibrinolysis, uPA/suPAR system, kynurenines, and the prevalence of cardiovascular disease in patients with chronic renal failure on conservative treatment. | Pawlak K, etal., Am J Med Sci. 2010 Jan;339(1):5-9. |
| 74. | Urokinase-type plasminogen activator and metalloproteinase-2 are independently related to the carotid atherosclerosis in haemodialysis patients. | Pawlak K, etal., Thromb Res. 2008;121(4):543-8. Epub 2007 Aug 15. |
| 75. | Effects of long-term erythropoietin therapy on fibrinolytic system in haemodialyzed patients. | Pawlak K, etal., Thromb Res. 2008;121(6):787-91. Epub 2007 Sep 14. |
| 76. | Vascular endothelial growth factor and uPA/suPAR system in early and advanced chronic kidney disease patients: a new link between angiogenesis and hyperfibrinolysis? | Pawlak K, etal., Transl Res. 2012 Nov;160(5):346-54. doi: 10.1016/j.trsl.2012.04.004. Epub 2012 May 8. |
| 77. | Fraxinus rhynchophylla ethanol extract attenuates carbon tetrachloride-induced liver fibrosis in rats via down-regulating the expressions of uPA, MMP-2, MMP-9 and TIMP-1. | Peng WH, etal., J Ethnopharmacol. 2010 Feb 17;127(3):606-13. Epub 2009 Dec 24. |
| 78. | Involvement of urokinase-type plasminogen activator in sphingosylphosphorylcholine-induced angiogenesis. | Piao YJ, etal., Exp Dermatol. 2005 May;14(5):356-62. |
| 79. | KEGG Annotation Import Pipeline | Pipeline to import KEGG annotations from KEGG into RGD |
| 80. | PID Annotation Import Pipeline | Pipeline to import Pathway Interaction Database annotations from NCI into RGD |
| 81. | Momordica charantia leaf extract suppresses rat prostate cancer progression in vitro and in vivo. | Pitchakarn P, etal., Cancer Sci. 2010 Oct;101(10):2234-40. doi: 10.1111/j.1349-7006.2010.01669.x. Epub 2010 Aug 22. |
| 82. | Urokinase plasminogen activator in injured adventitia increases the number of myofibroblasts and augments early proliferation. | Plekhanova OS, etal., J Vasc Res. 2006;43(5):437-46. Epub 2006 Aug 7. |
| 83. | [Effects of shear stress on expression of plasminogen activator (tPA and uPA) in cultured kidney proximal tubular epithelial cells and its significance]. | Pu L, etal., Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2008 Dec;25(6):1319-21, 1343. |
| 84. | [Effects of losartan on expressions of plasminogen activator and plasminogen activator inhibitor-1 of rat proximal tubular epithelial cells cultured with high glucose]. | Pu LJ, etal., Sichuan Da Xue Xue Bao Yi Xue Ban. 2007 Sep;38(5):813-5. |
| 85. | Proteins and carbohydrates in nipple aspirate fluid predict the presence of atypia and cancer in women requiring diagnostic breast biopsy. | Qin W, etal., BMC Cancer. 2012 Feb 1;12:52. doi: 10.1186/1471-2407-12-52. |
| 86. | GOA pipeline | RGD automated data pipeline |
| 87. | ClinVar Automated Import and Annotation Pipeline | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
| 88. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
| 89. | Expression of urokinase plasminogen activator and its receptor during acute renal allograft rejection. | Roelofs JJ, etal., Kidney Int. 2003 Nov;64(5):1845-53. |
| 90. | Role of plasminogen activators during healing after uterine serosal lesioning in the rat. | Rout UK and Diamond MP, Fertil Steril 2003 Jan;79(1):138-45. |
| 91. | Cerebrospinal fluid u-plasminogen activator and matrix metalloproteinase-9 levels in human eosinophilic meningitis associated with angiostrongyliasis. | Sanpool O, etal., Cytokine. 2010 Sep;51(3):294-7. Epub 2010 Jun 26. |
| 92. | Plasminogen activator promotes recovery following spinal cord injury. | Seeds N, etal., Cell Mol Neurobiol. 2011 Aug;31(6):961-7. Epub 2011 May 14. |
| 93. | The expression of fibrinolytic components in chronic paranasal sinus disease. | Sejima T, etal., Am J Rhinol Allergy. 2011 Jan-Feb;25(1):1-6. |
| 94. | Urokinase and its receptor in follicular and inflammatory cysts of the jaws. | Serrati S, etal., Oral Dis. 2010 Nov;16(8):753-9. doi: 10.1111/j.1601-0825.2010.01679.x. |
| 95. | Neuron Regeneration and Proliferation Effects of Danshen and Tanshinone IIA. | Shen JL, etal., Evid Based Complement Alternat Med. 2011;2011:378907. doi: 10.1155/2011/378907. Epub 2010 Dec 1. |
| 96. | Association of polymorphisms in the genes of the urokinase plasminogen activation system with susceptibility to and severity of non-small cell lung cancer. | Shih CM, etal., Clin Chim Acta. 2011 Jan 14;412(1-2):194-8. Epub 2010 Oct 16. |
| 97. | Inducible lung-specific urokinase expression reduces fibrosis and mortality after lung injury in mice. | Sisson TH, etal., Am J Physiol Lung Cell Mol Physiol. 2002 Nov;283(5):L1023-32. |
| 98. | Differential regulation of urokinase-type plasminogen activator expression by fluid shear stress in human coronary artery endothelial cells. | Sokabe T, etal., Am J Physiol Heart Circ Physiol. 2004 Nov;287(5):H2027-34. Epub 2004 Jul 1. |
| 99. | Progress of tissue injury in appendicitis involves the serine proteases uPA and PAI-1. | Solberg A, etal., Scand J Gastroenterol. 2009;44(5):579-84. |
| 100. | Components of the plasminogen activator system and their complexes in renal cell and bladder cancer: comparison between normal and matched cancerous tissues. | Span PN, etal., BJU Int. 2008 Jul;102(2):177-82. doi: 10.1111/j.1464-410X.2008.07568.x. Epub 2008 Jul 1. |
| 101. | uPA, uPAR and TGFbeta(1) expression during early and late post myocardial infarction period in rat myocardium. | Stavropoulou A, etal., In Vivo. 2010 Sep-Oct;24(5):647-52. |
| 102. | Evaluation of a pediatric protocol of intrapleural urokinase for pleural empyema: a prospective study. | Stefanutti G, etal., Surgery. 2010 Sep;148(3):589-94. Epub 2010 Mar 20. |
| 103. | Urokinase plasminogen activator induces smooth muscle cell migration: key role of growth factor-like domain. | Stepanova V, etal., FEBS Lett. 1997 Sep 8;414(2):471-4. |
| 104. | Osteopontin: a fibrosis-related marker molecule in cardiac remodeling of enterovirus myocarditis in the susceptible host. | Szalay G, etal., Circ Res. 2009 Apr 10;104(7):851-9. doi: 10.1161/CIRCRESAHA.109.193805. Epub 2009 Feb 26. |
| 105. | Tentative Sequence Identification Numbers | Tentative Sequence Data IDs. TIGR Gene Index, Rat Data |
| 106. | Matrix metalloproteinase-9 and urokinase plasminogen activator mediate interleukin-1-induced neurotoxicity. | Thornton P, etal., Mol Cell Neurosci. 2008 Jan;37(1):135-42. Epub 2007 Sep 12. |
| 107. | Confronting complexity in late-onset Alzheimer disease: application of two-stage analysis approach addressing heterogeneity and epistasis. | Thornton-Wells TA, etal., Genet Epidemiol. 2008 Apr;32(3):187-203. |
| 108. | Mutant prourokinase with adjunctive C1-inhibitor is an effective and safer alternative to tPA in rat stroke. | Tomasi S, etal., PLoS One. 2011;6(7):e21999. Epub 2011 Jul 14. |
| 109. | Urokinase gene transfer augments angiogenesis in ischemic skeletal and myocardial muscle. | Traktuev DO, etal., Mol Ther. 2007 Nov;15(11):1939-46. Epub 2007 Jul 24. |
| 110. | Urokinase gene 3'-UTR T/C polymorphism is associated with oral cancer. | Tsai MH, etal., J Clin Lab Anal. 2004;18(5):276-9. |
| 111. | In papillary thyroid carcinoma BRAFV600E is associated with increased expression of the urokinase plasminogen activator and its cognate receptor, but not with disease-free interval. | Ulisse S, etal., Clin Endocrinol (Oxf). 2012 Nov;77(5):780-6. doi: 10.1111/j.1365-2265.2012.04465.x. |
| 112. | Increased stratum corneum serine protease activity in acute eczematous atopic skin. | Voegeli R, etal., Br J Dermatol. 2009 Jul;161(1):70-7. Epub 2009 Mar 30. |
| 113. | Coexpression of Smad7 and UPA attenuates carbon tetrachloride-induced rat liver fibrosis. | Wang B, etal., Med Sci Monit. 2012 Oct;18(10):BR394-401. |
| 114. | Inhaled unfractionated heparin improves abnormalities of alveolar coagulation, fibrinolysis and inflammation in endotoxemia-induced lung injury rats. | Wang ZY, etal., Chin Med J (Engl). 2013 Jan;126(2):318-24. |
| 115. | [Effect of inhalation of aerosolized unfractioned heparin on peri alveolar coagulability and inflammatory response in endotoxin induced acute lung injury rat model]. | Wang ZY, etal., Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2011 Apr;23(4):239-42. |
| 116. | [Curative machanism of Shenle capsule on 5/6 nephrectomy rats]. | Wei RB, etal., Zhongguo Zhong Yao Za Zhi. 2004 Aug;29(8):770-3. |
| 117. | Urokinase receptor is necessary for bacterial defense against pneumonia-derived septic melioidosis by facilitating phagocytosis. | Wiersinga WJ, etal., J Immunol. 2010 Mar 15;184(6):3079-86. Epub 2010 Feb 8. |
| 118. | Expression of urokinase-type plasminogen activator and its receptor is up-regulated during tendon healing. | Xia W, etal., J Orthop Res. 2003 Sep;21(5):819-25. |
| 119. | Effects of overtraining on skeletal muscle growth and gene expression. | Xiao W, etal., Int J Sports Med. 2012 Oct;33(10):846-53. Epub 2012 May 16. |
| 120. | Association of putative functional variants in the PLAU gene and the PLAUR gene with myocardial infarction. | Xu J, etal., Clin Sci (Lond). 2010 Jul 9;119(8):353-9. |
| 121. | [Effects of aerosolized earthworm fibrinolytic enzyme on bleomycin induced pulmonary fibrosis in rats]. | Xue Y, etal., Zhonghua Yi Xue Za Zhi. 2012 Dec 25;92(48):3429-33. |
| 122. | Possible involvement of urokinase-type plasminogen activator release from human peripheral blood lymphocytes in the pathophysiology of chronic allograft nephropathy. | Yamaguchi Y, etal., Transplant Proc. 2005 Dec;37(10):4276-81. |
| 123. | Tissue plasminogen activator in primary afferents induces dorsal horn excitability and pain response after peripheral nerve injury. | Yamanaka H, etal., Eur J Neurosci. 2004 Jan;19(1):93-102. |
| 124. | Therapeutic administration of plasminogen activator inhibitor-1 prevents hypoxic-ischemic brain injury in newborns. | Yang D, etal., J Neurosci. 2009 Jul 8;29(27):8669-74. |
| 125. | Plasma soluble vascular endothelial growth factor receptor-1 levels predict outcomes of pneumonia-related septic shock patients: a prospective observational study. | Yang KY, etal., Crit Care. 2011 Jan 10;15(1):R11. |
| 126. | The role and mechanism of the up-regulation of fibrinolytic activity in painful peripheral nerve injury. | Yong N and Guoping C, Neurochem Res. 2009 Mar;34(3):587-92. Epub 2008 Aug 21. |
| 127. | A novel signaling pathway: fibroblast nicotinic receptor alpha1 binds urokinase and promotes renal fibrosis. | Zhang G, etal., J Biol Chem. 2009 Oct 16;284(42):29050-64. doi: 10.1074/jbc.M109.010249. Epub 2009 Aug 18. |
| 128. | Evaluation of plasma urokinase-type plasminogen activator and urokinase-type plasminogen-activator receptor in patients with acute and chronic hepatitis B. | Zhou H, etal., Thromb Res. 2009;123(3):537-42. Epub 2008 Aug 8. |
| 129. | Role of hypoxia-inducible factor-1 alpha in the regulation of plasminogen activator activity in rat knee joint chondrocytes. | Zhu G, etal., Osteoarthritis Cartilage. 2009 Nov;17(11):1494-502. doi: 10.1016/j.joca.2009.05.005. Epub 2009 May 19. |
| 130. | Differential patterns of local gene regulation in crush lesions of the rat optic and sciatic nerve: relevance to posttraumatic regeneration. | Zickler P, etal., Cell Physiol Biochem. 2010;26(3):483-94. Epub 2010 Aug 24. |
Additional References at PubMed
| PMID:1321734 | PMID:8837777 | PMID:9733098 | PMID:12431485 | PMID:12477932 | PMID:17382917 | PMID:17655862 | PMID:17893885 | PMID:18481824 | PMID:18835034 | PMID:19885954 | PMID:21423176 |
| PMID:23376485 | PMID:23533145 | PMID:23812296 | PMID:25168896 | PMID:25978044 | PMID:26363453 | PMID:30671487 | PMID:34852179 |
Genomics
Comparative Map Data
| Plau (Rattus norvegicus - Norway rat) |
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| PLAU (Homo sapiens - human) |
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| Plau (Mus musculus - house mouse) |
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| Plau (Chinchilla lanigera - long-tailed chinchilla) |
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| PLAU (Pan paniscus - bonobo/pygmy chimpanzee) |
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| PLAU (Canis lupus familiaris - dog) |
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| Plau (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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| PLAU (Sus scrofa - pig) |
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| PLAU (Chlorocebus sabaeus - green monkey) |
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| Plau (Heterocephalus glaber - naked mole-rat) |
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Variants
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Variants in Plau
21 total Variants 
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