PLAU (plasminogen activator, urokinase) - Rat Genome Database

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Gene: PLAU (plasminogen activator, urokinase) Homo sapiens
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Symbol: PLAU
Name: plasminogen activator, urokinase
RGD ID: 735727
HGNC Page HGNC:9052
Description: Predicted to enable serine-type endopeptidase activity. Involved in several processes, including plasminogen activation; regulation of cell adhesion mediated by integrin; and regulation of smooth muscle cell-matrix adhesion. Acts upstream of or within positive regulation of cell migration. Located in several cellular components, including protein complex involved in cell-matrix adhesion; serine protease inhibitor complex; and serine-type endopeptidase complex. Implicated in several diseases, including Alzheimer's disease (multiple); Quebec platelet disorder; end stage renal disease; lung disease (multiple); and mitral valve prolapse. Biomarker of several diseases, including appendicitis; carcinoma (multiple); chronic obstructive pulmonary disease; end stage renal disease; and hepatitis B.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: ATF; BDPLT5; plasminogen activator, urinary; QPD; u-PA; U-plasminogen activator; UPA; URK; urokinase-type plasminogen activator
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381073,909,164 - 73,917,494 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1073,909,177 - 73,917,496 (+)EnsemblGRCh38hg38GRCh38
GRCh371075,670,890 - 75,677,252 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361075,340,896 - 75,347,261 (+)NCBINCBI36Build 36hg18NCBI36
Build 341075,340,895 - 75,347,260NCBI
Celera1068,954,178 - 68,960,575 (+)NCBICelera
Cytogenetic Map10q22.2NCBI
HuRef1069,665,797 - 69,672,195 (+)NCBIHuRef
CHM1_11075,952,624 - 75,959,021 (+)NCBICHM1_1
T2T-CHM13v2.01074,782,523 - 74,788,885 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Lung Injury  (ISO)
adenocarcinoma  (EXP)
adult respiratory distress syndrome  (IAGP)
alcoholic liver cirrhosis  (ISO)
Alzheimer's disease  (EXP,IAGP,IEP,ISO)
Alzheimer's disease 1  (IAGP)
Angina Pectoris  (EXP)
anuria  (EXP)
appendicitis  (IEP)
Arterial Occlusive Diseases  (EXP)
Asthenozoospermia  (EXP,ISO)
asthma  (EXP,IEP)
atherosclerosis  (IEP,ISO)
Bone Neoplasms  (EXP)
brain edema  (EXP,ISO)
brain ischemia  (EXP)
breast cancer  (IEP,ISO)
Cardiomegaly  (ISO)
carotid artery disease  (EXP)
Cerebral Hemorrhage  (EXP)
cerebral infarction  (EXP)
cerebrovascular disease  (EXP)
cholesterol embolism  (EXP)
Chronic Allograft Nephropathy  (IEP)
Chronic Hepatitis C  (IDA)
chronic obstructive pulmonary disease  (IEP,ISO)
Colonic Neoplasms  (IDA,IEP)
Coronary Disease  (EXP)
Diabetic Nephropathies  (ISO)
Eczema  (IDA)
end stage renal disease  (IDA,IEP,ISO)
Experimental Arthritis  (ISO)
Experimental Liver Cirrhosis  (EXP,IMP,ISO)
Experimental Mammary Neoplasms  (ISO)
familial hyperlipidemia  (ISO)
fatty liver disease  (ISS)
gliosarcoma  (ISO)
Graft Occlusion, Vascular  (EXP)
Heart Rupture, Post-Infarction  (EXP)
Hematuria  (EXP)
Hemorrhage  (EXP)
Henoch-Schoenlein purpura  (EXP)
hepatitis B  (IEP)
hepatocellular carcinoma  (ISS)
high grade glioma  (IEP)
Hirschsprung's disease  (IAGP)
Hyperoxia  (ISO)
Hypotension  (EXP)
Hypoxia-Ischemia, Brain  (ISO)
idiopathic pulmonary fibrosis  (EXP)
IgA glomerulonephritis  (EXP)
Inflammation  (IEP,ISO)
intermediate coronary syndrome  (EXP)
intracranial aneurysm  (ISO)
Intracranial Embolism and Thrombosis  (EXP)
Intracranial Hemorrhages  (EXP,ISO)
ischemia  (EXP,ISO)
Jaw Cysts  (IEP)
Kidney Neoplasms  (IEP)
Left Ventricular Hypertrophy  (ISO)
liver cirrhosis  (EXP)
Lung Injury  (ISO)
Lung Neoplasms  (IEP)
lung non-small cell carcinoma  (IAGP)
meningitis  (IEP)
middle cerebral artery infarction  (EXP)
mitral valve prolapse  (IAGP)
Mouth Neoplasms  (IAGP)
myocardial infarction  (EXP,IAGP,IMP,ISO)
Neoplasm Invasiveness  (EXP)
Neoplasm Metastasis  (EXP)
Neoplasm Recurrence, Local  (EXP)
nephritis  (EXP)
Optic Nerve Injuries  (ISO)
oral squamous cell carcinoma  (IEP)
otitis media  (ISO)
pancreatic cancer  (EXP)
Peripheral Nerve Injuries  (ISO)
peritonitis  (IDA)
pleural empyema  (IDA)
prion disease  (ISO)
prostate cancer  (IEP)
Prostatic Neoplasms  (EXP)
pulmonary embolism  (EXP)
pulmonary fibrosis  (IDA,ISO)
Quebec platelet disorder  (IAGP)
renal cell carcinoma  (IEP)
renal fibrosis  (ISO)
Reperfusion Injury  (EXP,ISO)
rhinitis  (ISO)
sagittal sinus thrombosis  (EXP)
sciatic neuropathy  (ISO)
Sepsis  (IEP)
sinusitis  (IEP)
Spinal Cord Injuries  (ISO)
squamous cell carcinoma  (IEP)
status epilepticus  (ISO)
Stomach Neoplasms  (EXP)
Stroke  (EXP)
Strongylida Infections  (ISO)
Thromboembolism  (EXP)
thrombosis  (EXP,ISO)
thyroid gland papillary carcinoma  (IEP)
transient cerebral ischemia  (ISO)
transitional cell carcinoma  (EXP,IEP)
Transplant Rejection  (IEP)
urinary bladder cancer  (IAGP,IEP,ISO)
urolithiasis  (IAGP)
Venous Thrombosis  (EXP)
Ventricular Fibrillation  (EXP)
Viral Myocarditis  (ISO)
visual epilepsy  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (EXP,ISO)
(-)-epigallocatechin 3-gallate  (EXP)
(S)-nicotine  (EXP,ISO)
1,1-dichloroethene  (ISO)
1,10-phenanthroline  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (ISO)
1-octadec-9-enoylglycero-3-phosphate  (EXP)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (EXP)
3,3'-diindolylmethane  (EXP)
3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
3-methylcholanthrene  (EXP)
3-phenylprop-2-enal  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
5-aza-2'-deoxycytidine  (EXP)
5-fluorouracil  (EXP)
7,12-dimethyltetraphene  (EXP)
acetaldehyde  (ISO)
acetamide  (ISO)
actinomycin D  (EXP)
aflatoxin B1  (EXP)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (EXP,ISO)
alpha-D-galactose  (ISO)
amiloride  (EXP)
ammonium chloride  (ISO)
anethole  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
antirheumatic drug  (EXP)
aripiprazole  (EXP)
aristolochic acid  (EXP)
arsane  (EXP)
arsenic atom  (EXP)
arsenous acid  (EXP)
atorvastatin calcium  (EXP)
ATP  (ISO)
avobenzone  (EXP)
baicalein  (EXP)
belinostat  (EXP)
benazepril  (ISO)
benomyl  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
beta-naphthoflavone  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisdemethoxycurcumin  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
bleomycin A2  (ISO)
butan-1-ol  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
capsaicin  (EXP)
captan  (ISO)
carbamazepine  (EXP)
carbendazim  (EXP)
carbofuran  (ISO)
carbon nanotube  (EXP,ISO)
casticin  (ISO)
chlordecone  (ISO)
chloropicrin  (EXP)
choline  (ISO)
chrysin  (EXP)
cisplatin  (EXP,ISO)
clofibric acid  (ISO)
cobalt dichloride  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (EXP)
crocidolite asbestos  (EXP)
curcumin  (EXP)
cyclophosphamide  (EXP)
D-glucose  (EXP)
demethoxycurcumin  (EXP)
desferrioxamine B  (EXP)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (EXP)
diclofenac  (ISO)
dieckol  (EXP)
dimethylarsinic acid  (EXP)
dinophysistoxin 1  (EXP)
dioxygen  (EXP,ISO)
diuron  (ISO)
dorsomorphin  (EXP)
doxorubicin  (EXP,ISO)
entinostat  (EXP)
ethanol  (EXP,ISO)
etoposide  (EXP)
fenamidone  (ISO)
flavonol  (EXP)
flutamide  (ISO)
folic acid  (EXP,ISO)
folpet  (ISO)
furan  (ISO)
galactose  (ISO)
gefitinib  (EXP)
geldanamycin  (EXP)
gemcitabine  (EXP)
Genipin  (EXP)
genistein  (EXP,ISO)
glucose  (EXP)
heparin  (EXP)
hyaluronic acid  (EXP)
ibuprofen  (EXP)
indole-3-methanol  (EXP)
indometacin  (EXP)
iron(III) nitrilotriacetate  (EXP)
isoprenaline  (ISO)
L-methionine  (ISO)
leflunomide  (EXP)
Licochalcone A  (EXP)
lidocaine  (ISO)
lipopolysaccharide  (EXP,ISO)
lithium chloride  (EXP)
lovastatin  (ISO)
LY294002  (EXP)
malathion  (EXP)
mangiferin  (ISO)
medroxyprogesterone acetate  (EXP)
methotrexate  (EXP)
methoxychlor  (ISO)
methylmercury chloride  (EXP)
mitomycin C  (EXP)
N-acetyl-L-cysteine  (EXP)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (ISO)
N-tosyl-L-phenylalanyl chloromethyl ketone  (EXP)
nickel atom  (EXP)
nickel sulfate  (EXP)
nicotine  (EXP,ISO)
nonanedioic acid  (EXP)
notoginsenoside R1  (EXP)
ornidazole  (ISO)
oxaliplatin  (ISO)
ozone  (EXP,ISO)
panobinostat  (EXP)
paraquat  (ISO)
PD 0325901  (EXP)
pentane-2,3-dione  (ISO)
phenylmercury acetate  (EXP)
phorbol 13-acetate 12-myristate  (EXP,ISO)
platycodin D  (ISO)
potassium chromate  (EXP)
progesterone  (EXP)
propanal  (EXP)
pyrrolidine dithiocarbamate  (EXP)
quercetin  (EXP,ISO)
rac-lactic acid  (EXP)
raloxifene  (EXP)
resveratrol  (EXP,ISO)
ryanodine  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (EXP)
SB 431542  (EXP)
serpentine asbestos  (EXP,ISO)
silibinin  (EXP)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP)
sodium hydroxide  (EXP)
sorafenib  (EXP)
streptozocin  (ISO)
succimer  (EXP,ISO)
sulindac sulfide  (EXP)
sunitinib  (EXP)
tamoxifen  (EXP)
tebuconazole  (EXP)
telmisartan  (ISO)
temozolomide  (EXP)
tetrachloromethane  (ISO)
thalidomide  (ISO)
thioacetamide  (ISO)
titanium dioxide  (ISO)
topotecan  (ISO)
trans-anethole  (EXP)
trichloroethene  (ISO)
trichostatin A  (EXP)
triclosan  (EXP)
troglitazone  (EXP)
tubocurarine  (ISO)
valproic acid  (EXP)
vanadium atom  (EXP)
vanadium(0)  (EXP)
vincaleukoblastine  (EXP)
vorinostat  (EXP)
zinc atom  (EXP)
zinc(0)  (EXP)
zoledronic acid  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (ISO)
blood coagulation  (IEA)
cellular response to fluid shear stress  (ISO)
cellular response to glucose stimulus  (ISO)
cellular response to hepatocyte growth factor stimulus  (ISO)
cellular response to hypoxia  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to organic substance  (ISO)
cellular response to staurosporine  (ISO)
chemotaxis  (TAS)
embryo implantation  (ISO)
fibrinolysis  (IBA,IEA,ISO,TAS)
hemostasis  (IEA)
negative regulation of fibrinolysis  (IC)
negative regulation of plasminogen activation  (IC)
neuron death  (ISO)
phosphorylation  (IEA)
plasminogen activation  (IBA,IDA,IEA)
positive regulation of cell migration  (IDA)
positive regulation of cell population proliferation  (ISO)
positive regulation of ovulation  (ISO)
positive regulation of reactive oxygen species metabolic process  (ISO)
positive regulation of smooth muscle cell migration  (ISO)
proteolysis  (IBA,IEA,TAS)
regulation of cell adhesion  (IDA)
regulation of cell adhesion mediated by integrin  (IBA,IDA)
regulation of cell population proliferation  (IEA,ISO)
regulation of fibrinolysis  (IC)
regulation of hepatocyte proliferation  (ISO)
regulation of plasminogen activation  (IC)
regulation of signaling receptor activity  (IDA)
regulation of smooth muscle cell migration  (IDA)
regulation of smooth muscle cell-matrix adhesion  (IDA)
regulation of wound healing  (IC)
response to activity  (ISO)
response to hepatocyte growth factor  (ISO)
response to hyperoxia  (ISO)
response to hypoxia  (IEA,ISO)
signal transduction  (TAS)
skeletal muscle tissue regeneration  (ISO)
smooth muscle cell migration  (IEA,ISO)
spermatogenesis  (ISO)
urokinase plasminogen activator signaling pathway  (IC)
wound healing  (ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Antineoplastic effect of iodine in mammary cancer: participation of 6-iodolactone (6-IL) and peroxisome proliferator-activated receptors (PPAR). Aceves C, etal., Mol Cancer. 2009 Jun 6;8:33. doi: 10.1186/1476-4598-8-33.
2. Deleterious effects of plasminogen activators in neonatal cerebral hypoxia-ischemia. Adhami F, etal., Am J Pathol. 2008 Jun;172(6):1704-16. Epub 2008 May 8.
3. Therapeutic potential and anti-amyloidosis mechanisms of tert-butylhydroquinone for Alzheimer's disease. Akhter H, etal., J Alzheimers Dis. 2011;26(4):767-78.
4. Association between urokinase haplotypes and outcome from infection-associated acute lung injury. Arcaroli J, etal., Intensive Care Med. 2008 Feb;34(2):300-7. Epub 2007 Nov 10.
5. Activators and inhibitors of the plasminogen system in Alzheimer's disease. Barker R, etal., J Cell Mol Med. 2012 Apr;16(4):865-76. doi: 10.1111/j.1582-4934.2011.01394.x.
6. Transcriptional activation of endothelial cells by TGFbeta coincides with acute microvascular plasticity following focal spinal cord ischaemia/reperfusion injury. Benton RL, etal., ASN Neuro. 2009 Aug 26;1(3). pii: e00015. doi: 10.1042/AN20090008.
7. Urokinase-type plasminogen activator gene therapy in liver cirrhosis is mediated by collagens gene expression down-regulation and up-regulation of MMPs, HGF and VEGF. Bueno M, etal., J Gene Med. 2006 Nov;8(11):1291-9.
8. Protection of cerebral microvasculature after moderate hypothermia following experimental focal cerebral ischemia in mice. Burk J, etal., Brain Res. 2008 Aug 21;1226:248-55. Epub 2008 Jun 16.
9. Both tissue-type plasminogen activator and urokinase prevent intraabdominal abscess formation after surgical treatment of peritonitis in the rat. Buyne OR, etal., Surgery. 2008 Jul;144(1):66-73. Epub 2008 May 21.
10. Whole genome microarray of the major pelvic ganglion after cavernous nerve injury: new insights into molecular profile changes after nerve injury. Calenda G, etal., BJU Int. 2012 May;109(10):1552-64. doi: 10.1111/j.1464-410X.2011.10705.x. Epub 2012 Feb 2.
11. [Effects of Qinggan Huoxue Recipe and its separated recipes on urokinase-type plasminogen activator and plasminogen activator inhibitor-1 fibrinolytic system in rats with alcoholic liver fibrosis]. Chen JM, etal., Zhong Xi Yi Jie He Xue Bao. 2009 Jul;7(7):642-50. doi: 10.3736/jcim20090708.
12. Intravesical administration of plasminogen activator inhibitor type-1 inhibits in vivo bladder tumor invasion and progression. Chen SC, etal., J Urol. 2009 Jan;181(1):336-42. Epub 2008 Nov 17.
13. Neuroprotection by urokinase plasminogen activator in the hippocampus. Cho E, etal., Neurobiol Dis. 2012 Apr;46(1):215-24. Epub 2012 Jan 24.
14. Association between urokinase-plasminogen activator gene T4065C polymorphism and risk of mitral valve prolapse. Chou HT, etal., Int J Cardiol. 2004 Aug;96(2):165-70.
15. Effects of losartan on hepatic expression of nonphagocytic NADPH oxidase and fibrogenic genes in patients with chronic hepatitis C. Colmenero J, etal., Am J Physiol Gastrointest Liver Physiol. 2009 Oct;297(4):G726-34. Epub 2009 Jul 23.
16. Selective abrogation of the uPA-uPAR interaction in vivo reveals a novel role in suppression of fibrin-associated inflammation. Connolly BM, etal., Blood. 2010 Sep 2;116(9):1593-603. Epub 2010 May 13.
17. No replication of genetic association between candidate polymorphisms and Alzheimer's disease. Cousin E, etal., Neurobiol Aging. 2011 Aug;32(8):1443-51. Epub 2009 Nov 3.
18. Thrombus versus Wall Biological Activities in Experimental Aortic Aneurysms. Coutard M, etal., J Vasc Res. 2009 Dec 16;47(4):355-366.
19. Macrophage-targeted overexpression of urokinase causes accelerated atherosclerosis, coronary artery occlusions, and premature death. Cozen AE, etal., Circulation. 2004 May 4;109(17):2129-35. Epub 2004 Apr 19.
20. Microglia and the urokinase plasminogen activator receptor/uPA system in innate brain inflammation. Cunningham O, etal., Glia. 2009 Dec;57(16):1802-14.
21. Urokinase-type plasminogen activator and arthritis progression: contrasting roles in systemic and monoarticular arthritis models. De Nardo CM, etal., Arthritis Res Ther. 2010;12(5):R199. Epub 2010 Oct 25.
22. Impaired fibrinolytic system in ApoE gene-deleted mice with hyperlipidemia augments deep vein thrombosis. Diaz JA, etal., J Vasc Surg. 2012 Mar;55(3):815-22. Epub 2011 Nov 25.
23. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
24. Effect of dietary beta carotene on cerebral aneurysm and subarachnoid haemorrhage in the brain apo E-/- mice. Gopal K, etal., J Thromb Thrombolysis. 2011 Oct;32(3):343-55.
25. Proteases and protease inhibitors in immune complex otitis media in chinchillas. Hamaguchi Y, etal., Ann Otol Rhinol Laryngol. 1989 Jul;98(7 Pt 1):563-8.
26. [Effect of amiloride on the pathology of a rat model of chronic obstructive pulmonary disease]. Han XD, etal., Zhonghua Jie He He Hu Xi Za Zhi. 2007 May;30(5):363-7.
27. Partial reversal of established bleomycin-induced pulmonary fibrosis by rh-urokinase in a rat model. Hart DA, etal., Clin Invest Med. 1994 Apr;17(2):69-76.
28. Urokinase-targeted fusion by oncolytic Sendai virus eradicates orthotopic glioblastomas by pronounced synergy with interferon-beta gene. Hasegawa Y, etal., Mol Ther. 2010 Oct;18(10):1778-86. doi: 10.1038/mt.2010.138. Epub 2010 Jul 6.
29. Loss or inhibition of uPA or MMP-9 attenuates LV remodeling and dysfunction after acute pressure overload in mice. Heymans S, etal., Am J Pathol. 2005 Jan;166(1):15-25.
30. Fasudil, a Rho-kinase inhibitor, protects against excessive endurance exercise training-induced cardiac hypertrophy, apoptosis and fibrosis in rats. Ho TJ, etal., Eur J Appl Physiol. 2012 Aug;112(8):2943-55. doi: 10.1007/s00421-011-2270-z. Epub 2011 Dec 9.
31. Prognostic role of urokinase-type plasminogen activator in human gliomas. Hsu DW, etal., Am J Pathol. 1995 Jul;147(1):114-23.
32. Tissue-type plasminogen activator depletion affects the nasal mucosa matrix reconstruction in allergic rhinitis mice. Hua H, etal., Allergol Immunopathol (Madr). 2011 Jul-Aug;39(4):206-11. doi: 10.1016/j.aller.2010.09.010. Epub 2011 Feb 19.
33. Tumour-associated urokinase-type plasminogen activator (uPA) and its inhibitor PAI-1 in normal and neoplastic tissues of patients with squamous cell cancer of the oral cavity - clinical relevance and prognostic value. Hundsdorfer B, etal., J Craniomaxillofac Surg. 2005 Jun;33(3):191-6. Epub 2005 Apr 22.
34. Urokinase-type plasminogen activator system and human cationic antimicrobial protein 18 in serum and induced sputum of patients with chronic obstructive pulmonary disease. Jiang Y, etal., Respirology. 2010 Aug;15(6):939-46. Epub 2010 Jul 6.
35. Small, potent, and selective diaryl phosphonate inhibitors for urokinase-type plasminogen activator with in vivo antimetastatic properties. Joossens J, etal., J Med Chem. 2007 Dec 27;50(26):6638-46. Epub 2007 Dec 1.
36. Renal synthesis of urokinase type-plasminogen activator, its receptor, and plasminogen activator inhibitor-1 in diabetic nephropathy in rats: modulation by angiotensin-converting-enzyme inhibitor. Kenichi M, etal., J Lab Clin Med. 2004 Aug;144(2):69-77.
37. Localization of plasminogen activators in human colon cancer by immunoperoxidase staining. Kohga S, etal., Cancer Res. 1985 Apr;45(4):1787-96.
38. [Effects of acupoint-embedment of medicated-thread and acupoint-injection on expression of cortical urokinase-type plasminogen activator and plasminogen activator inhibitor-1 in rats with cerebral ischemia-reperfusion injury]. Kong LH, etal., Zhen Ci Yan Jiu. 2010 Dec;35(6):409-14.
39. Plasminogen activator inhibitor-1 (PAI-1) and urokinase plasminogen activator (uPA) in sputum of allergic asthma patients. Kowal K, etal., Folia Histochem Cytobiol. 2008;46(2):193-8.
40. Increased expression and activity of urokinase-type plasminogen activator during epileptogenesis. Lahtinen L, etal., Eur J Neurosci. 2006 Oct;24(7):1935-45. Epub 2006 Oct 16.
41. Urokinase-type plasminogen activator regulates neurodegeneration and neurogenesis but not vascular changes in the mouse hippocampus after status epilepticus. Lahtinen L, etal., Neurobiol Dis. 2010 Mar;37(3):692-703. Epub 2009 Dec 21.
42. Expression of urokinase-type plasminogen activator receptor is increased during epileptogenesis in the rat hippocampus. Lahtinen L, etal., Neuroscience. 2009 Sep 29;163(1):316-28. Epub 2009 Jun 12.
43. Angiostrongylus cantonensis: induction of urokinase-type PA and degradation of type IV collagen in rat lung granulomatous fibrosis. Lan KP and Lai SC, Exp Parasitol. 2008 Apr;118(4):472-7. Epub 2007 Oct 22.
44. [Association of uPA and uPAR expression with invasive behaviors of urinary transitional cell carcinoma]. Li YJ, etal., Ai Zheng. 2004 Jun;23(6):704-6.
45. Combination therapy of 17beta-estradiol and recombinant tissue plasminogen activator for experimental ischemic stroke. Liu R, etal., J Pharmacol Exp Ther. 2010 Mar;332(3):1006-12. doi: 10.1124/jpet.109.160937. Epub 2009 Dec 1.
46. [Changes of u-PA and PAI-1 expression in the lung tissue of neonatal rats after inhaling high concentration oxygen] Liu XY and Xue XD, Zhonghua Er Ke Za Zhi. 2008 Jun;46(6):458-63.
47. [Correlation of the content and expression of urokinase plasminogen activator with asthenospermia in rat models]. Liu Y, etal., Zhonghua Nan Ke Xue. 2008 Sep;14(9):786-91.
48. Basic mechanisms and regulation of fibrinolysis. Longstaff C and Kolev K, J Thromb Haemost. 2015 Jun;13 Suppl 1:S98-105. doi: 10.1111/jth.12935.
49. Association of Urokinase Gene 3'-UTR T/C polymorphism with bladder cancer. Manchanda PK, etal., Urol Int. 2006;77(1):81-4.
50. Multifunctionality of PAI-1 in fibrogenesis: evidence from obstructive nephropathy in PAI-1-overexpressing mice. Matsuo S, etal., Kidney Int. 2005 Jun;67(6):2221-38.
51. Elevation of urokinase-type plasminogen activator and its receptor densities as new predictors of disease progression and prognosis in men with prostate cancer. Miyake H, etal., Int J Oncol. 1999 Mar;14(3):535-41.
52. Downregulation of matrix metalloprotease-9 and urokinase plasminogen activator by TX-1877 results in decreased tumor growth and metastasis on xenograft model of rectal cancer. Miyake K, etal., Cancer Chemother Pharmacol. 2009 Oct;64(5):885-92. doi: 10.1007/s00280-009-0937-5. Epub 2009 Feb 12.
53. Identification of potential biomarkers of lymph node metastasis in oral squamous cell carcinoma by cDNA microarray analysis. Nagata M, etal., Int J Cancer. 2003 Sep 20;106(5):683-9.
54. Immunohistochemical evidence of urokinase-type plasminogen activator in primary and metastatic tumors of pulmonary adenocarcinoma. Oka T, etal., Cancer Res. 1991 Jul 1;51(13):3522-5.
55. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
56. Association of urokinase gene 3'-UTR T/C polymorphism with calcium oxalate urolithiasis in children. Ozturk M, etal., Int Urol Nephrol. 2008;40(3):563-8. doi: 10.1007/s11255-008-9335-x. Epub 2008 Feb 1.
57. Blood brain barrier (BBB) dysfunction associated with increased expression of tissue and urokinase plasminogen activators following peripheral thermal injury. Patel TH, etal., Neurosci Lett. 2008 Oct 31;444(3):222-6. Epub 2008 Aug 13.
58. Identification of a novel biomarker signature associated with risk for bone metastasis in patients with renal cell carcinoma. Paule B, etal., Int J Biol Markers. 2010 Apr-Jun;25(2):112-5.
59. Hyperfibrinolysis, uPA/suPAR system, kynurenines, and the prevalence of cardiovascular disease in patients with chronic renal failure on conservative treatment. Pawlak K, etal., Am J Med Sci. 2010 Jan;339(1):5-9.
60. Urokinase-type plasminogen activator and metalloproteinase-2 are independently related to the carotid atherosclerosis in haemodialysis patients. Pawlak K, etal., Thromb Res. 2008;121(4):543-8. Epub 2007 Aug 15.
61. Effects of long-term erythropoietin therapy on fibrinolytic system in haemodialyzed patients. Pawlak K, etal., Thromb Res. 2008;121(6):787-91. Epub 2007 Sep 14.
62. Vascular endothelial growth factor and uPA/suPAR system in early and advanced chronic kidney disease patients: a new link between angiogenesis and hyperfibrinolysis? Pawlak K, etal., Transl Res. 2012 Nov;160(5):346-54. doi: 10.1016/j.trsl.2012.04.004. Epub 2012 May 8.
63. Fraxinus rhynchophylla ethanol extract attenuates carbon tetrachloride-induced liver fibrosis in rats via down-regulating the expressions of uPA, MMP-2, MMP-9 and TIMP-1. Peng WH, etal., J Ethnopharmacol. 2010 Feb 17;127(3):606-13. Epub 2009 Dec 24.
64. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
65. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
66. Proteins and carbohydrates in nipple aspirate fluid predict the presence of atypia and cancer in women requiring diagnostic breast biopsy. Qin W, etal., BMC Cancer. 2012 Feb 1;12:52. doi: 10.1186/1471-2407-12-52.
67. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
68. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
69. RGD HPO Phenotype Annotation Pipeline RGD automated import pipeline for human HPO-to-gene-to-disease annotations
70. Expression of urokinase plasminogen activator and its receptor during acute renal allograft rejection. Roelofs JJ, etal., Kidney Int. 2003 Nov;64(5):1845-53.
71. Cerebrospinal fluid u-plasminogen activator and matrix metalloproteinase-9 levels in human eosinophilic meningitis associated with angiostrongyliasis. Sanpool O, etal., Cytokine. 2010 Sep;51(3):294-7. Epub 2010 Jun 26.
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73. The expression of fibrinolytic components in chronic paranasal sinus disease. Sejima T, etal., Am J Rhinol Allergy. 2011 Jan-Feb;25(1):1-6.
74. Urokinase and its receptor in follicular and inflammatory cysts of the jaws. Serrati S, etal., Oral Dis. 2010 Nov;16(8):753-9. doi: 10.1111/j.1601-0825.2010.01679.x.
75. Neuron Regeneration and Proliferation Effects of Danshen and Tanshinone IIA. Shen JL, etal., Evid Based Complement Alternat Med. 2011;2011:378907. doi: 10.1155/2011/378907. Epub 2010 Dec 1.
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80. Components of the plasminogen activator system and their complexes in renal cell and bladder cancer: comparison between normal and matched cancerous tissues. Span PN, etal., BJU Int. 2008 Jul;102(2):177-82. doi: 10.1111/j.1464-410X.2008.07568.x. Epub 2008 Jul 1.
81. uPA, uPAR and TGFbeta(1) expression during early and late post myocardial infarction period in rat myocardium. Stavropoulou A, etal., In Vivo. 2010 Sep-Oct;24(5):647-52.
82. Evaluation of a pediatric protocol of intrapleural urokinase for pleural empyema: a prospective study. Stefanutti G, etal., Surgery. 2010 Sep;148(3):589-94. Epub 2010 Mar 20.
83. Osteopontin: a fibrosis-related marker molecule in cardiac remodeling of enterovirus myocarditis in the susceptible host. Szalay G, etal., Circ Res. 2009 Apr 10;104(7):851-9. doi: 10.1161/CIRCRESAHA.109.193805. Epub 2009 Feb 26.
84. Confronting complexity in late-onset Alzheimer disease: application of two-stage analysis approach addressing heterogeneity and epistasis. Thornton-Wells TA, etal., Genet Epidemiol. 2008 Apr;32(3):187-203.
85. Mutant prourokinase with adjunctive C1-inhibitor is an effective and safer alternative to tPA in rat stroke. Tomasi S, etal., PLoS One. 2011;6(7):e21999. Epub 2011 Jul 14.
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87. Urokinase gene 3'-UTR T/C polymorphism is associated with oral cancer. Tsai MH, etal., J Clin Lab Anal. 2004;18(5):276-9.
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90. Coexpression of Smad7 and UPA attenuates carbon tetrachloride-induced rat liver fibrosis. Wang B, etal., Med Sci Monit. 2012 Oct;18(10):BR394-401.
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94. Urokinase receptor is necessary for bacterial defense against pneumonia-derived septic melioidosis by facilitating phagocytosis. Wiersinga WJ, etal., J Immunol. 2010 Mar 15;184(6):3079-86. Epub 2010 Feb 8.
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98. Therapeutic administration of plasminogen activator inhibitor-1 prevents hypoxic-ischemic brain injury in newborns. Yang D, etal., J Neurosci. 2009 Jul 8;29(27):8669-74.
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102. Evaluation of plasma urokinase-type plasminogen activator and urokinase-type plasminogen-activator receptor in patients with acute and chronic hepatitis B. Zhou H, etal., Thromb Res. 2009;123(3):537-42. Epub 2008 Aug 8.
103. Differential patterns of local gene regulation in crush lesions of the rat optic and sciatic nerve: relevance to posttraumatic regeneration. Zickler P, etal., Cell Physiol Biochem. 2010;26(3):483-94. Epub 2010 Aug 24.
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Genomics

Comparative Map Data
PLAU
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381073,909,164 - 73,917,494 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1073,909,177 - 73,917,496 (+)EnsemblGRCh38hg38GRCh38
GRCh371075,670,890 - 75,677,252 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361075,340,896 - 75,347,261 (+)NCBINCBI36Build 36hg18NCBI36
Build 341075,340,895 - 75,347,260NCBI
Celera1068,954,178 - 68,960,575 (+)NCBICelera
Cytogenetic Map10q22.2NCBI
HuRef1069,665,797 - 69,672,195 (+)NCBIHuRef
CHM1_11075,952,624 - 75,959,021 (+)NCBICHM1_1
T2T-CHM13v2.01074,782,523 - 74,788,885 (+)NCBIT2T-CHM13v2.0
Plau
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391420,886,730 - 20,893,456 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1420,886,728 - 20,893,453 (+)EnsemblGRCm39 Ensembl
GRCm381420,836,662 - 20,843,388 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1420,836,660 - 20,843,385 (+)EnsemblGRCm38mm10GRCm38
MGSCv371421,655,884 - 21,662,610 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361419,625,259 - 19,631,940 (+)NCBIMGSCv36mm8
Celera1417,217,270 - 17,223,995 (+)NCBICelera
Cytogenetic Map14A3NCBI
cM Map1411.53NCBI
Plau
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2153,456,230 - 3,462,732 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl153,456,232 - 3,462,775 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx153,466,414 - 3,472,916 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0154,852,895 - 4,859,397 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0153,465,220 - 3,471,722 (-)NCBIRnor_WKY
Rnor_6.0153,644,296 - 3,650,765 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl153,644,769 - 3,650,819 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0153,621,057 - 3,627,467 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4153,680,072 - 3,686,232 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1153,680,073 - 3,686,275 (-)NCBI
Celera151,129,191 - 1,135,694 (+)NCBICelera
Cytogenetic Map15p16NCBI
Plau
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543717,994,537 - 18,000,209 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543717,995,726 - 18,000,542 (-)NCBIChiLan1.0ChiLan1.0
PLAU
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11073,104,808 - 73,113,136 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1073,105,895 - 73,113,136 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01070,433,340 - 70,441,569 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PLAU
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1424,329,139 - 24,333,893 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl424,328,925 - 24,334,851 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha424,466,425 - 24,471,181 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0424,609,212 - 24,613,966 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl424,578,978 - 24,727,745 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1424,506,511 - 24,511,263 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0424,706,941 - 24,711,694 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0425,061,896 - 25,066,649 (+)NCBIUU_Cfam_GSD_1.0
Plau
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721356,745,370 - 56,751,129 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365215,238,128 - 5,243,829 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLAU
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1476,629,299 - 76,635,172 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11476,629,313 - 76,635,173 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21482,755,642 - 82,761,502 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap14q24-q26NCBI
PLAU
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1957,452,904 - 57,459,345 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl957,452,761 - 57,459,286 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604818,028,912 - 18,035,356 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Plau
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247547,408,983 - 7,416,559 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247547,405,637 - 7,415,870 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Position Markers
RH92165  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371075,670,118 - 75,670,252UniSTSGRCh37
Build 361075,340,124 - 75,340,258RGDNCBI36
Celera1068,953,434 - 68,953,568RGD
Cytogenetic Map10q22.2UniSTS
HuRef1069,665,053 - 69,665,187UniSTS
GeneMap99-GB4 RH Map10380.97UniSTS
GDB:181547  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371075,672,812 - 75,673,296UniSTSGRCh37
Build 361075,342,818 - 75,343,302RGDNCBI36
Celera1068,956,129 - 68,956,613RGD
Cytogenetic Map10q22.2UniSTS
HuRef1069,667,749 - 69,668,233UniSTS
PMC229370P1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371075,671,802 - 75,672,728UniSTSGRCh37
Build 361075,341,808 - 75,342,734RGDNCBI36
Celera1068,955,118 - 68,956,045RGD
Cytogenetic Map10q22.2UniSTS
HuRef1069,666,737 - 69,667,665UniSTS
PLAU_226  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371075,676,570 - 75,677,309UniSTSGRCh37
Build 361075,346,576 - 75,347,315RGDNCBI36
Celera1068,959,887 - 68,960,625RGD
HuRef1069,671,507 - 69,672,245UniSTS
SHGC-31374  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map10q22.2UniSTS
HuRef1069,671,333 - 69,671,558UniSTS
Stanford-G3 RH Map103441.0UniSTS
GeneMap99-G3 RH Map103417.0UniSTS
PLAU  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371075,672,009 - 75,672,774UniSTSGRCh37
Celera1068,955,325 - 68,956,091UniSTS
HuRef1069,666,944 - 69,667,711UniSTS

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR193Bhsa-miR-193b-3pMirtarbaseexternal_infoWestern blot//Luciferase reporter assayFunctional MTI19701247
MIR193Bhsa-miR-193b-3pOncomiRDBexternal_infoNANA21670079
MIR193Bhsa-miR-193b-3pOncomiRDBexternal_infoNANA19701247
MIR193Bhsa-miR-193b-5pMirecordsexternal_info{unchanged}NA19701247
MIR23Bhsa-miR-23b-3pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI19490101
MIR23Bhsa-miR-23b-3pMirtarbaseexternal_infoqRT-PCR//Western blotFunctional MTI21242962
MIR23Bhsa-miR-23b-3pOncomiRDBexternal_infoNANA21242962
MIR23Bhsa-miR-23b-5pMirecordsexternal_info{unchanged}NA19490101

Predicted Target Of
Summary Value
Count of predictions:2149
Count of miRNA genes:808
Interacting mature miRNAs:925
Transcripts:ENST00000372762, ENST00000372764, ENST00000446342, ENST00000481390, ENST00000494287, ENST00000496926
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High 3 4 3 2 6 6 7 21 2
Medium 1399 1815 826 191 829 77 3034 871 538 322 775 1469 123 1144 1732 2
Low 1011 1018 856 399 847 355 1277 1310 2761 89 646 84 46 60 1056 1
Below cutoff 16 145 35 32 243 32 28 8 400 1 20 32 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_011904 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001145031 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001319191 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_002658 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011539866 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047425353 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide A18397 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  A21571 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  A35395 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB208961 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF377330 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH007073 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK297940 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK298560 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK312960 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL596247 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW316981 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY029537 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY820134 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC013575 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BI759308 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BI833559 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ920793 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT007391 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX360462 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB959931 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471083 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068268 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CS123918 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D00244 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D11143 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DC349055 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HI573980 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  K02286 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  K03027 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M15476 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X02419 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X02760 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y11873 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z36790 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000372764   ⟹   ENSP00000361850
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1073,911,132 - 73,917,494 (+)Ensembl
RefSeq Acc Id: ENST00000446342   ⟹   ENSP00000388474
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1073,911,104 - 73,917,496 (+)Ensembl
RefSeq Acc Id: ENST00000481390   ⟹   ENSP00000474318
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1073,909,177 - 73,913,049 (+)Ensembl
RefSeq Acc Id: ENST00000494287
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1073,911,147 - 73,913,753 (+)Ensembl
RefSeq Acc Id: ENST00000496926
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1073,910,605 - 73,911,539 (+)Ensembl
RefSeq Acc Id: NM_001145031   ⟹   NP_001138503
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381073,911,132 - 73,917,494 (+)NCBI
GRCh371075,670,862 - 75,677,259 (+)NCBI
HuRef1069,665,797 - 69,672,195 (+)ENTREZGENE
CHM1_11075,952,621 - 75,959,021 (+)NCBI
T2T-CHM13v2.01074,782,523 - 74,788,885 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001319191   ⟹   NP_001306120
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381073,911,132 - 73,917,494 (+)NCBI
CHM1_11075,952,621 - 75,959,021 (+)NCBI
T2T-CHM13v2.01074,782,523 - 74,788,885 (+)NCBI
Sequence:
RefSeq Acc Id: NM_002658   ⟹   NP_002649
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381073,911,132 - 73,917,494 (+)NCBI
GRCh371075,670,862 - 75,677,259 (+)ENTREZGENE
Build 361075,340,896 - 75,347,261 (+)NCBI Archive
HuRef1069,665,797 - 69,672,195 (+)ENTREZGENE
CHM1_11075,952,621 - 75,959,021 (+)NCBI
T2T-CHM13v2.01074,782,523 - 74,788,885 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011539866   ⟹   XP_011538168
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381073,909,164 - 73,917,494 (+)NCBI
Sequence:
RefSeq Acc Id: XM_047425353   ⟹   XP_047281309
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381073,911,132 - 73,917,494 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001138503 (Get FASTA)   NCBI Sequence Viewer  
  NP_001306120 (Get FASTA)   NCBI Sequence Viewer  
  NP_002649 (Get FASTA)   NCBI Sequence Viewer  
  XP_011538168 (Get FASTA)   NCBI Sequence Viewer  
  XP_047281309 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA61252 (Get FASTA)   NCBI Sequence Viewer  
  AAA61253 (Get FASTA)   NCBI Sequence Viewer  
  AAA61257 (Get FASTA)   NCBI Sequence Viewer  
  AAC97138 (Get FASTA)   NCBI Sequence Viewer  
  AAH13575 (Get FASTA)   NCBI Sequence Viewer  
  AAK38734 (Get FASTA)   NCBI Sequence Viewer  
  AAK53822 (Get FASTA)   NCBI Sequence Viewer  
  AAP36055 (Get FASTA)   NCBI Sequence Viewer  
  AAV70488 (Get FASTA)   NCBI Sequence Viewer  
  BAA00175 (Get FASTA)   NCBI Sequence Viewer  
  BAA01919 (Get FASTA)   NCBI Sequence Viewer  
  BAD92198 (Get FASTA)   NCBI Sequence Viewer  
  BAG35799 (Get FASTA)   NCBI Sequence Viewer  
  BAG60256 (Get FASTA)   NCBI Sequence Viewer  
  BAG60754 (Get FASTA)   NCBI Sequence Viewer  
  CAA01390 (Get FASTA)   NCBI Sequence Viewer  
  CAA01559 (Get FASTA)   NCBI Sequence Viewer  
  CAA02215 (Get FASTA)   NCBI Sequence Viewer  
  CAA26268 (Get FASTA)   NCBI Sequence Viewer  
  CAA26535 (Get FASTA)   NCBI Sequence Viewer  
  CAJ18774 (Get FASTA)   NCBI Sequence Viewer  
  CBX47479 (Get FASTA)   NCBI Sequence Viewer  
  EAW54544 (Get FASTA)   NCBI Sequence Viewer  
  EAW54545 (Get FASTA)   NCBI Sequence Viewer  
  P00749 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001138503   ⟸   NM_001145031
- Peptide Label: isoform 2
- UniProtKB: E7ET40 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_002649   ⟸   NM_002658
- Peptide Label: isoform 1 preproprotein
- UniProtKB: Q969W6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011538168   ⟸   XM_011539866
- Peptide Label: isoform X1
- UniProtKB: Q969W6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001306120   ⟸   NM_001319191
- Peptide Label: isoform 3
- Sequence:
RefSeq Acc Id: ENSP00000361850   ⟸   ENST00000372764
RefSeq Acc Id: ENSP00000474318   ⟸   ENST00000481390
RefSeq Acc Id: ENSP00000388474   ⟸   ENST00000446342
RefSeq Acc Id: XP_047281309   ⟸   XM_047425353
- Peptide Label: isoform X1
- UniProtKB: Q969W6 (UniProtKB/Swiss-Prot)
Protein Domains
EGF-like   Kringle   Peptidase S1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P00749-F1-model_v2 AlphaFold P00749 1-431 view protein structure

Promoters
RGD ID:7217887
Promoter ID:EPDNEW_H14689
Type:initiation region
Name:PLAU_2
Description:plasminogen activator, urokinase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H14690  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381073,909,184 - 73,909,244EPDNEW
RGD ID:7217889
Promoter ID:EPDNEW_H14690
Type:initiation region
Name:PLAU_1
Description:plasminogen activator, urokinase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H14689  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381073,911,132 - 73,911,192EPDNEW
RGD ID:6787994
Promoter ID:HG_KWN:10104
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:OTTHUMT00000048730
Position:
Human AssemblyChrPosition (strand)Source
Build 361075,338,001 - 75,339,317 (+)MPROMDB
RGD ID:6787995
Promoter ID:HG_KWN:10105
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000372762,   NM_001145031,   NM_002658,   OTTHUMT00000048729,   OTTHUMT00000048731,   OTTHUMT00000048733,   UC001JWB.1,   UC001JWC.1,   UC009XRQ.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361075,340,686 - 75,341,186 (+)MPROMDB
RGD ID:6849876
Promoter ID:EP14054
Type:single initiation site
Name:HS_PLAU
Description:Urokinase (urine plasminogen activator).
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Notes:homology_group=Homology group 38; Mammalian urokinase (uPA).
Experiment Methods:Nuclease protection; Primer extension; Nuclease protection with homologous sequence ladder; experiments; performed with closely related gene
Regulation:(repressed by or weakly expressed in) glucocorticoid, (induced by or strongly expressed in) EGF, (induced by or strongly expressed in) TPA
Position:No map positions available.

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_002658.6(PLAU):c.422= (p.Leu141=) single nucleotide variant Alzheimer disease, late-onset, susceptibility to [RCV000013052]|not provided [RCV000948375] Chr10:73913343 [GRCh38]
Chr10:75673101 [GRCh37]
Chr10:10q22.2
risk factor|benign
NC_000010.9:g.75329022_75406959dup duplication Quebec platelet disorder [RCV000022812] Chr10:73899258..73977195 [GRCh38]
Chr10:75659016..75736953 [GRCh37]
Chr10:75329022..75406959 [NCBI36]
Chr10:10q22.2
pathogenic
GRCh38/hg38 10q21.2-22.2(chr10:62229688-74468143)x1 copy number loss See cases [RCV000052530] Chr10:62229688..74468143 [GRCh38]
Chr10:63989447..76227901 [GRCh37]
Chr10:63659453..75897907 [NCBI36]
Chr10:10q21.2-22.2
pathogenic
GRCh38/hg38 10q22.1-22.2(chr10:72720628-75612374)x1 copy number loss See cases [RCV000052531] Chr10:72720628..75612374 [GRCh38]
Chr10:74480386..77372132 [GRCh37]
Chr10:74150392..77042138 [NCBI36]
Chr10:10q22.1-22.2
pathogenic
GRCh38/hg38 10q21.1-22.2(chr10:58436466-74415216)x1 copy number loss See cases [RCV000052511] Chr10:58436466..74415216 [GRCh38]
Chr10:60196226..76174974 [GRCh37]
Chr10:59866232..75844980 [NCBI36]
Chr10:10q21.1-22.2
pathogenic
GRCh38/hg38 10q21.3-22.3(chr10:67196567-79422057)x3 copy number gain See cases [RCV000135438] Chr10:67196567..79422057 [GRCh38]
Chr10:68956325..81181813 [GRCh37]
Chr10:68626331..80851819 [NCBI36]
Chr10:10q21.3-22.3
pathogenic
GRCh38/hg38 10q21.3-22.2(chr10:63402579-75296099)x1 copy number loss See cases [RCV000136658] Chr10:63402579..75296099 [GRCh38]
Chr10:65162339..77055857 [GRCh37]
Chr10:64832345..76725863 [NCBI36]
Chr10:10q21.3-22.2
pathogenic|likely benign
GRCh38/hg38 10q11.23-23.2(chr10:50729367-87147204)x3 copy number gain See cases [RCV000138007] Chr10:50729367..87147204 [GRCh38]
Chr10:52489127..88906961 [GRCh37]
Chr10:52159133..88896941 [NCBI36]
Chr10:10q11.23-23.2
pathogenic
GRCh38/hg38 10q22.2(chr10:73881750-73942272)x1 copy number loss See cases [RCV000141182] Chr10:73881750..73942272 [GRCh38]
Chr10:75641508..75702030 [GRCh37]
Chr10:75311514..75372036 [NCBI36]
Chr10:10q22.2
likely benign
NM_002658.6(PLAU):c.172G>A (p.Gly58Arg) single nucleotide variant Hirschsprung disease, susceptibility to, 1 [RCV000201293]|Quebec platelet disorder [RCV000365591]|not provided [RCV000971917] Chr10:73912301 [GRCh38]
Chr10:75672059 [GRCh37]
Chr10:10q22.2
benign|likely benign|uncertain significance
NM_002658.6(PLAU):c.*355C>T single nucleotide variant Quebec platelet disorder [RCV000321485] Chr10:73916920 [GRCh38]
Chr10:75676678 [GRCh37]
Chr10:10q22.2
benign|likely benign
NM_002658.6(PLAU):c.1048T>C (p.Tyr350His) single nucleotide variant Quebec platelet disorder [RCV000344642]|not provided [RCV000951111] Chr10:73915328 [GRCh38]
Chr10:75675086 [GRCh37]
Chr10:10q22.2
benign|likely benign
NM_002658.6(PLAU):c.1222G>A (p.Val408Ile) single nucleotide variant Quebec platelet disorder [RCV000369055] Chr10:73916491 [GRCh38]
Chr10:75676249 [GRCh37]
Chr10:10q22.2
benign|likely benign
NM_002658.6(PLAU):c.*520G>T single nucleotide variant Quebec platelet disorder [RCV000322787] Chr10:73917085 [GRCh38]
Chr10:75676843 [GRCh37]
Chr10:10q22.2
benign
NM_002658.6(PLAU):c.*60A>C single nucleotide variant Quebec platelet disorder [RCV000370180] Chr10:73916625 [GRCh38]
Chr10:75676383 [GRCh37]
Chr10:10q22.2
benign|likely benign
NM_002658.6(PLAU):c.*444T>A single nucleotide variant Quebec platelet disorder [RCV000286448] Chr10:73917009 [GRCh38]
Chr10:75676767 [GRCh37]
Chr10:10q22.2
benign|likely benign
NM_002658.6(PLAU):c.*753C>T single nucleotide variant Quebec platelet disorder [RCV000347880] Chr10:73917318 [GRCh38]
Chr10:75677076 [GRCh37]
Chr10:10q22.2
likely benign|uncertain significance
NM_002658.6(PLAU):c.581C>T (p.Ala194Val) single nucleotide variant Quebec platelet disorder [RCV000372309] Chr10:73913659 [GRCh38]
Chr10:75673417 [GRCh37]
Chr10:10q22.2
benign|likely benign
NM_002658.6(PLAU):c.162A>G (p.Pro54=) single nucleotide variant Quebec platelet disorder [RCV000269937]|not provided [RCV000970461] Chr10:73912291 [GRCh38]
Chr10:75672049 [GRCh37]
Chr10:10q22.2
benign|likely benign
NM_002658.6(PLAU):c.236G>A (p.Arg79Gln) single nucleotide variant Quebec platelet disorder [RCV000271088] Chr10:73912966 [GRCh38]
Chr10:75672724 [GRCh37]
Chr10:10q22.2
benign|likely benign
NM_002658.6(PLAU):c.57+6T>C single nucleotide variant Quebec platelet disorder [RCV000305546] Chr10:73911618 [GRCh38]
Chr10:75671376 [GRCh37]
Chr10:10q22.2
likely benign|uncertain significance
NM_002658.6(PLAU):c.163A>G (p.Lys55Glu) single nucleotide variant Quebec platelet disorder [RCV000306361] Chr10:73912292 [GRCh38]
Chr10:75672050 [GRCh37]
Chr10:10q22.2
benign|uncertain significance
NM_002658.6(PLAU):c.*398C>T single nucleotide variant Quebec platelet disorder [RCV000376246] Chr10:73916963 [GRCh38]
Chr10:75676721 [GRCh37]
Chr10:10q22.2
benign|likely benign
NM_002658.6(PLAU):c.691A>C (p.Lys231Gln) single nucleotide variant Quebec platelet disorder [RCV000377952] Chr10:73913990 [GRCh38]
Chr10:75673748 [GRCh37]
Chr10:10q22.2
benign
NM_002658.6(PLAU):c.878G>A (p.Arg293Gln) single nucleotide variant Quebec platelet disorder [RCV000308085]|not provided [RCV001355163] Chr10:73914824 [GRCh38]
Chr10:75674582 [GRCh37]
Chr10:10q22.2
benign|likely benign|uncertain significance
NM_002658.6(PLAU):c.1092C>T (p.Asp364=) single nucleotide variant Quebec platelet disorder [RCV000309659]|not provided [RCV000879758] Chr10:73915372 [GRCh38]
Chr10:75675130 [GRCh37]
Chr10:10q22.2
benign|likely benign
NM_002658.6(PLAU):c.308C>T (p.Thr103Met) single nucleotide variant Quebec platelet disorder [RCV000330967] Chr10:73913038 [GRCh38]
Chr10:75672796 [GRCh37]
Chr10:10q22.2
benign|uncertain significance
NM_002658.6(PLAU):c.581C>A (p.Ala194Glu) single nucleotide variant Quebec platelet disorder [RCV000332164] Chr10:73913659 [GRCh38]
Chr10:75673417 [GRCh37]
Chr10:10q22.2
uncertain significance
NM_002658.6(PLAU):c.*266T>C single nucleotide variant Quebec platelet disorder [RCV000356504] Chr10:73916831 [GRCh38]
Chr10:75676589 [GRCh37]
Chr10:10q22.2
benign|likely benign
NM_002658.6(PLAU):c.1053C>T (p.Tyr351=) single nucleotide variant Quebec platelet disorder [RCV000404445] Chr10:73915333 [GRCh38]
Chr10:75675091 [GRCh37]
Chr10:10q22.2
benign|likely benign
NM_002658.6(PLAU):c.43G>T (p.Val15Leu) single nucleotide variant Quebec platelet disorder [RCV000404874] Chr10:73911598 [GRCh38]
Chr10:75671356 [GRCh37]
Chr10:10q22.2
benign
NM_002658.6(PLAU):c.368+6G>C single nucleotide variant Quebec platelet disorder [RCV000277129] Chr10:73913104 [GRCh38]
Chr10:75672862 [GRCh37]
Chr10:10q22.2
uncertain significance
NM_002658.6(PLAU):c.*844del deletion Quebec platelet disorder [RCV000406801] Chr10:73917409 [GRCh38]
Chr10:75677167 [GRCh37]
Chr10:10q22.2
benign
NM_002658.6(PLAU):c.*335G>A single nucleotide variant Quebec platelet disorder [RCV000261684] Chr10:73916900 [GRCh38]
Chr10:75676658 [GRCh37]
Chr10:10q22.2
benign|likely benign
NM_002658.6(PLAU):c.*141C>T single nucleotide variant Quebec platelet disorder [RCV000261471]|not provided [RCV001672432] Chr10:73916706 [GRCh38]
Chr10:75676464 [GRCh37]
Chr10:10q22.2
benign
NM_002658.6(PLAU):c.-25C>T single nucleotide variant Quebec platelet disorder [RCV000334715] Chr10:73911531 [GRCh38]
Chr10:75671289 [GRCh37]
Chr10:10q22.2
benign|likely benign
NM_002658.6(PLAU):c.681-7C>T single nucleotide variant Quebec platelet disorder [RCV000337376]|not provided [RCV001689998] Chr10:73913973 [GRCh38]
Chr10:75673731 [GRCh37]
Chr10:10q22.2
benign
NM_002658.6(PLAU):c.111A>G (p.Gly37=) single nucleotide variant Quebec platelet disorder [RCV000360245] Chr10:73912240 [GRCh38]
Chr10:75671998 [GRCh37]
Chr10:10q22.2
benign|uncertain significance
NM_002658.6(PLAU):c.-32+9C>G single nucleotide variant Quebec platelet disorder [RCV000279693] Chr10:73911227 [GRCh38]
Chr10:75670985 [GRCh37]
Chr10:10q22.2
likely benign|uncertain significance
NM_002658.6(PLAU):c.*52T>A single nucleotide variant Quebec platelet disorder [RCV000315536] Chr10:73916617 [GRCh38]
Chr10:75676375 [GRCh37]
Chr10:10q22.2
benign|likely benign
NM_002658.6(PLAU):c.17C>A (p.Ala6Glu) single nucleotide variant Quebec platelet disorder [RCV000340376] Chr10:73911572 [GRCh38]
Chr10:75671330 [GRCh37]
Chr10:10q22.2
benign|uncertain significance
NM_002658.6(PLAU):c.-18C>A single nucleotide variant Quebec platelet disorder [RCV000299746] Chr10:73911538 [GRCh38]
Chr10:75671296 [GRCh37]
Chr10:10q22.2
benign
NM_002658.6(PLAU):c.-20A>G single nucleotide variant Quebec platelet disorder [RCV000391405] Chr10:73911536 [GRCh38]
Chr10:75671294 [GRCh37]
Chr10:10q22.2
benign|likely benign
NM_002658.6(PLAU):c.602G>T (p.Arg201Leu) single nucleotide variant Quebec platelet disorder [RCV000282402] Chr10:73913680 [GRCh38]
Chr10:75673438 [GRCh37]
Chr10:10q22.2
benign|likely benign
NM_002658.6(PLAU):c.706A>G (p.Ile236Val) single nucleotide variant Quebec platelet disorder [RCV000283375] Chr10:73914005 [GRCh38]
Chr10:75673763 [GRCh37]
Chr10:10q22.2
benign|likely benign
NM_002658.6(PLAU):c.822C>T (p.Asn274=) single nucleotide variant Quebec platelet disorder [RCV000393582]|not provided [RCV001642931] Chr10:73914121 [GRCh38]
Chr10:75673879 [GRCh37]
Chr10:10q22.2
benign
NM_002658.6(PLAU):c.*3G>A single nucleotide variant Quebec platelet disorder [RCV000274497] Chr10:73916568 [GRCh38]
Chr10:75676326 [GRCh37]
Chr10:10q22.2
uncertain significance
NM_002658.6(PLAU):c.*176G>T single nucleotide variant Quebec platelet disorder [RCV000315691] Chr10:73916741 [GRCh38]
Chr10:75676499 [GRCh37]
Chr10:10q22.2
uncertain significance
NM_002658.6(PLAU):c.*631C>T single nucleotide variant Quebec platelet disorder [RCV000382111] Chr10:73917196 [GRCh38]
Chr10:75676954 [GRCh37]
Chr10:10q22.2
uncertain significance
NM_002658.6(PLAU):c.*880T>A single nucleotide variant Quebec platelet disorder [RCV000294098] Chr10:73917445 [GRCh38]
Chr10:75677203 [GRCh37]
Chr10:10q22.2
uncertain significance
NM_002658.6(PLAU):c.*900A>G single nucleotide variant Quebec platelet disorder [RCV000348895] Chr10:73917465 [GRCh38]
Chr10:75677223 [GRCh37]
Chr10:10q22.2
uncertain significance
NM_002658.6(PLAU):c.316G>C (p.Ala106Pro) single nucleotide variant Quebec platelet disorder [RCV000385437] Chr10:73913046 [GRCh38]
Chr10:75672804 [GRCh37]
Chr10:10q22.2
uncertain significance
NM_002658.6(PLAU):c.-41G>A single nucleotide variant Quebec platelet disorder [RCV000352310] Chr10:73911209 [GRCh38]
Chr10:75670967 [GRCh37]
Chr10:10q22.2
uncertain significance
NM_002658.6(PLAU):c.-32G>A single nucleotide variant Quebec platelet disorder [RCV000388238] Chr10:73911218 [GRCh38]
Chr10:75670976 [GRCh37]
Chr10:10q22.2
uncertain significance
NM_001145031.2(PLAU):c.*935A>G single nucleotide variant Quebec platelet disorder [RCV000390583] Chr10:73917500 [GRCh38]
Chr10:75677258 [GRCh37]
Chr10:10q22.2
uncertain significance
NM_002658.6(PLAU):c.*688C>T single nucleotide variant Quebec platelet disorder [RCV000288271] Chr10:73917253 [GRCh38]
Chr10:75677011 [GRCh37]
Chr10:10q22.2
uncertain significance
NM_002658.6(PLAU):c.750G>C (p.Gly250=) single nucleotide variant Quebec platelet disorder [RCV000343093] Chr10:73914049 [GRCh38]
Chr10:75673807 [GRCh37]
Chr10:10q22.2
uncertain significance
GRCh37/hg19 10q22.2-22.3(chr10:75542067-79428995)x1 copy number loss See cases [RCV000447510] Chr10:75542067..79428995 [GRCh37]
Chr10:10q22.2-22.3
pathogenic
GRCh37/hg19 10p15.3-q26.3(chr10:93297-135378918)x3 copy number gain See cases [RCV000448750] Chr10:93297..135378918 [GRCh37]
Chr10:10p15.3-q26.3
pathogenic
GRCh37/hg19 10p15.3-q26.3(chr10:100027-135427143) copy number gain See cases [RCV000511389] Chr10:100027..135427143 [GRCh37]
Chr10:10p15.3-q26.3
pathogenic|uncertain significance
GRCh37/hg19 10p15.3-q26.3(chr10:100027-135427143)x3 copy number gain See cases [RCV000510861] Chr10:100027..135427143 [GRCh37]
Chr10:10p15.3-q26.3
pathogenic
GRCh37/hg19 10q22.2(chr10:75179409-76009153)x3 copy number gain See cases [RCV000511191] Chr10:75179409..76009153 [GRCh37]
Chr10:10q22.2
uncertain significance
GRCh37/hg19 10q11.21-26.3(chr10:42347406-135534747)x1 copy number loss Poly (ADP-Ribose) polymerase inhibitor response [RCV000626438] Chr10:42347406..135534747 [GRCh37]
Chr10:10q11.21-26.3
drug response
GRCh37/hg19 10q21.3-23.32(chr10:69040366-93194993)x3 copy number gain not provided [RCV000683289] Chr10:69040366..93194993 [GRCh37]
Chr10:10q21.3-23.32
pathogenic
GRCh37/hg19 10p15.3-q26.3(chr10:98087-135477883)x3 copy number gain not provided [RCV000749465] Chr10:98087..135477883 [GRCh37]
Chr10:10p15.3-q26.3
pathogenic
GRCh37/hg19 10p15.3-q26.3(chr10:73232-135524321)x3 copy number gain not provided [RCV000749464] Chr10:73232..135524321 [GRCh37]
Chr10:10p15.3-q26.3
pathogenic
NM_002658.6(PLAU):c.744G>A (p.Thr248=) single nucleotide variant not provided [RCV000976202] Chr10:73914043 [GRCh38]
Chr10:75673801 [GRCh37]
Chr10:10q22.2
likely benign
GRCh37/hg19 10q22.2(chr10:75251395-75763287)x1 copy number loss not provided [RCV000849346] Chr10:75251395..75763287 [GRCh37]
Chr10:10q22.2
uncertain significance
NM_002658.6(PLAU):c.143T>A (p.Ile48Asn) single nucleotide variant Quebec platelet disorder [RCV001108612] Chr10:73912272 [GRCh38]
Chr10:75672030 [GRCh37]
Chr10:10q22.2
uncertain significance
NM_002658.6(PLAU):c.972C>T (p.Thr324=) single nucleotide variant Quebec platelet disorder [RCV001108684] Chr10:73915252 [GRCh38]
Chr10:75675010 [GRCh37]
Chr10:10q22.2
benign
NM_002658.6(PLAU):c.-31-121G>T single nucleotide variant not provided [RCV001639533] Chr10:73911404 [GRCh38]
Chr10:75671162 [GRCh37]
Chr10:10q22.2
benign
NM_002658.6(PLAU):c.970+66C>T single nucleotide variant not provided [RCV001611432] Chr10:73914982 [GRCh38]
Chr10:75674740 [GRCh37]
Chr10:10q22.2
benign
NM_002658.6(PLAU):c.1221C>T (p.Gly407=) single nucleotide variant not provided [RCV000930114] Chr10:73916490 [GRCh38]
Chr10:75676248 [GRCh37]
Chr10:10q22.2
likely benign
NM_002658.6(PLAU):c.445C>T (p.His149Tyr) single nucleotide variant Quebec platelet disorder [RCV001105355] Chr10:73913366 [GRCh38]
Chr10:75673124 [GRCh37]
Chr10:10q22.2
benign
NM_002658.6(PLAU):c.*538G>A single nucleotide variant Quebec platelet disorder [RCV001105458] Chr10:73917103 [GRCh38]
Chr10:75676861 [GRCh37]
Chr10:10q22.2
uncertain significance
NM_002658.6(PLAU):c.193+297_193+298insT insertion not provided [RCV001710508] Chr10:73912619..73912620 [GRCh38]
Chr10:75672377..75672378 [GRCh37]
Chr10:10q22.2
benign
NM_002658.6(PLAU):c.369-87G>A single nucleotide variant not provided [RCV001721784] Chr10:73913203 [GRCh38]
Chr10:75672961 [GRCh37]
Chr10:10q22.2
benign
NM_002658.6(PLAU):c.559A>G (p.Ile187Val) single nucleotide variant Quebec platelet disorder [RCV001105357] Chr10:73913637 [GRCh38]
Chr10:75673395 [GRCh37]
Chr10:10q22.2
benign
NM_002658.6(PLAU):c.735C>A (p.Asn245Lys) single nucleotide variant Quebec platelet disorder [RCV001106495] Chr10:73914034 [GRCh38]
Chr10:75673792 [GRCh37]
Chr10:10q22.2
uncertain significance
NM_002658.6(PLAU):c.845G>A (p.Arg282His) single nucleotide variant Quebec platelet disorder [RCV001106497] Chr10:73914791 [GRCh38]
Chr10:75674549 [GRCh37]
Chr10:10q22.2
uncertain significance
NM_002658.6(PLAU):c.*917G>A single nucleotide variant Quebec platelet disorder [RCV001106604] Chr10:73917482 [GRCh38]
Chr10:75677240 [GRCh37]
Chr10:10q22.2
uncertain significance
NM_002658.6(PLAU):c.236G>C (p.Arg79Pro) single nucleotide variant Quebec platelet disorder [RCV001103433] Chr10:73912966 [GRCh38]
Chr10:75672724 [GRCh37]
Chr10:10q22.2
likely benign
NM_002658.6(PLAU):c.1193G>T (p.Arg398Leu) single nucleotide variant Quebec platelet disorder [RCV001108685] Chr10:73916462 [GRCh38]
Chr10:75676220 [GRCh37]
Chr10:10q22.2
benign
NM_002658.6(PLAU):c.85+49G>A single nucleotide variant not provided [RCV001640909] Chr10:73912117 [GRCh38]
Chr10:75671875 [GRCh37]
Chr10:10q22.2
benign
NM_002658.6(PLAU):c.680+80C>T single nucleotide variant not provided [RCV001666396] Chr10:73913838 [GRCh38]
Chr10:75673596 [GRCh37]
Chr10:10q22.2
benign
NM_002658.6(PLAU):c.453C>T (p.Cys151=) single nucleotide variant Quebec platelet disorder [RCV001105356] Chr10:73913374 [GRCh38]
Chr10:75673132 [GRCh37]
Chr10:10q22.2
likely benign
NM_002658.6(PLAU):c.*474G>A single nucleotide variant Quebec platelet disorder [RCV001105457] Chr10:73917039 [GRCh38]
Chr10:75676797 [GRCh37]
Chr10:10q22.2
uncertain significance
NM_002658.6(PLAU):c.830-13T>C single nucleotide variant Quebec platelet disorder [RCV001106496] Chr10:73914763 [GRCh38]
Chr10:75674521 [GRCh37]
Chr10:10q22.2
benign
NM_002658.6(PLAU):c.*921T>C single nucleotide variant Quebec platelet disorder [RCV001106605] Chr10:73917486 [GRCh38]
Chr10:75677244 [GRCh37]
Chr10:10q22.2
uncertain significance
NM_002658.6(PLAU):c.194A>G (p.Asp65Gly) single nucleotide variant Quebec platelet disorder [RCV001103432] Chr10:73912924 [GRCh38]
Chr10:75672682 [GRCh37]
Chr10:10q22.2
uncertain significance
NM_002658.6(PLAU):c.*309T>C single nucleotide variant Quebec platelet disorder [RCV001103523] Chr10:73916874 [GRCh38]
Chr10:75676632 [GRCh37]
Chr10:10q22.2
uncertain significance
NM_002658.6(PLAU):c.1229C>T (p.Thr410Met) single nucleotide variant Quebec platelet disorder [RCV001330951] Chr10:73916498 [GRCh38]
Chr10:75676256 [GRCh37]
Chr10:10q22.2
uncertain significance
NM_002658.6(PLAU):c.194-207A>G single nucleotide variant not provided [RCV001541184] Chr10:73912717 [GRCh38]
Chr10:75672475 [GRCh37]
Chr10:10q22.2
benign
NM_002658.6(PLAU):c.193+298G>T single nucleotide variant not provided [RCV001614192] Chr10:73912620 [GRCh38]
Chr10:75672378 [GRCh37]
Chr10:10q22.2
benign
GRCh37/hg19 10q21.3-22.3(chr10:68735254-78885714) copy number loss not specified [RCV002052875] Chr10:68735254..78885714 [GRCh37]
Chr10:10q21.3-22.3
pathogenic
NM_002658.6(PLAU):c.467dup (p.Pro157fs) duplication Quebec platelet disorder [RCV002266808] Chr10:73913539..73913540 [GRCh38]
Chr10:75673297..75673298 [GRCh37]
Chr10:10q22.2
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:9052 AgrOrtholog
COSMIC PLAU COSMIC
Ensembl Genes ENSG00000122861 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000361850 ENTREZGENE
  ENSP00000361850.3 UniProtKB/Swiss-Prot
  ENSP00000388474 ENTREZGENE, UniProtKB/TrEMBL
  ENSP00000388474.1 UniProtKB/Swiss-Prot
  ENSP00000474318.1 UniProtKB/TrEMBL
Ensembl Transcript ENST00000372764 ENTREZGENE
  ENST00000372764.4 UniProtKB/Swiss-Prot
  ENST00000446342 ENTREZGENE, UniProtKB/TrEMBL
  ENST00000446342.5 UniProtKB/Swiss-Prot
  ENST00000481390.5 UniProtKB/TrEMBL
Gene3D-CATH 2.40.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.40.20.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000122861 GTEx
HGNC ID HGNC:9052 ENTREZGENE
Human Proteome Map PLAU Human Proteome Map
InterPro EGF-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kringle UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kringle-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kringle_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kringle_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1_PA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trypsin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Urokinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:5328 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 5328 ENTREZGENE
OMIM 104300 OMIM
  191840 OMIM
  601709 OMIM
PANTHER PTHR24264:SF38 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Kringle UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA33382 PharmGKB
PRINTS CHYMOTRYPSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE EGF_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KRINGLE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KRINGLE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SM00130 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tryp_SPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50494 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57440 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A024QZM9_HUMAN UniProtKB/TrEMBL
  B4DNJ4_HUMAN UniProtKB/TrEMBL
  E7ET40 ENTREZGENE, UniProtKB/TrEMBL
  P00749 ENTREZGENE
  Q59GZ8_HUMAN UniProtKB/TrEMBL
  Q969W6 ENTREZGENE
  Q9UEJ5_HUMAN UniProtKB/TrEMBL
  S4R3G7_HUMAN UniProtKB/TrEMBL
  UROK_HUMAN UniProtKB/Swiss-Prot
UniProt Secondary B4DPZ2 UniProtKB/Swiss-Prot
  Q15844 UniProtKB/Swiss-Prot
  Q16618 UniProtKB/Swiss-Prot
  Q53XS3 UniProtKB/Swiss-Prot
  Q5SWW9 UniProtKB/Swiss-Prot
  Q969W6 UniProtKB/Swiss-Prot