RGD Reference Report - Gene expression changes of urokinase plasminogen activator and urokinase receptor in rat testes at postnatal stages. - Rat Genome Database

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Gene expression changes of urokinase plasminogen activator and urokinase receptor in rat testes at postnatal stages.

Authors: Huang, DH  Zhao, H  Tian, YH  Li, HG  Ding, XF  Xiong, CL 
Citation: Huang DH, etal., Asian J Androl. 2007 Sep;9(5):679-83.
RGD ID: 6484143
Pubmed: PMID:17712486   (View Abstract at PubMed)
DOI: DOI:10.1111/j.1745-7262.2007.00272.x   (Journal Full-text)

AIM: To investigate the gene expression changes of urokinase plasminogen activator (uPA)/urokinase receptor (uPAR) in rat testes at postnatal stages and explore the effects of uPA/uPAR system on the rat spermatogenesis. METHODS: The mRNAs of uPA and uPAR in rat testes were measured by using real-time quantitative polymerase chain reaction (PCR) at postnatal days 0, 5, 10, 15, 21, 28, 35, 42, 49 and 56, respectively. RESULTS: The tendencies of uPA and uPAR mRNA expression were similar at most postnatal stages except for D(0). The expression of uPAR mRNA in rats testes was relatively higher than that of uPA at postnatal D(0), and both were decreased until D(21), increased obviously at postnatal D(28), reached a peak at postnatal D(35), then declined sharply at postnatal D(42) and retained at a low level afterwards. CONCLUSION: The uPA/uPAR system may be strongly linked to spermiation and spermatogenesis via regulating germ cell migration and proliferation, as well as promoting the spermiation and detached residual bodies from the mature spermatids.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
PlauRatspermatogenesis  IEP  RGD 
PlaurRatspermatogenesis  IEP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Plau  (plasminogen activator, urokinase)
Plaur  (plasminogen activator, urokinase receptor)


Additional Information