PLAU (plasminogen activator, urokinase) - Rat Genome Database

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Gene: PLAU (plasminogen activator, urokinase) Sus scrofa
Analyze
Symbol: PLAU
Name: plasminogen activator, urokinase
RGD ID: 14177270
Description: ENCODES a protein that exhibits peptidase activity (ortholog); INVOLVED IN angiogenesis (ortholog); cellular response to fluid shear stress (ortholog); cellular response to glucose stimulus (ortholog); PARTICIPATES IN fibrinolysis pathway; fibroblast growth factor signaling pathway; ASSOCIATED WITH Acute Lung Injury (ortholog); adenocarcinoma (ortholog); adult respiratory distress syndrome (ortholog); FOUND IN extracellular space (ortholog); membrane (ortholog); INTERACTS WITH amiloride; bis(2-chloroethyl) sulfide; crocidolite asbestos
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: U-plasminogen activator; uPA; urinary plasminogen activator; urokinase-type plasminogen activator
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1476,629,299 - 76,635,172 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11476,629,313 - 76,635,173 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21482,755,642 - 82,761,502 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap14q24-q26NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Lung Injury  (ISO)
adenocarcinoma  (ISO)
adult respiratory distress syndrome  (ISO)
alcoholic liver cirrhosis  (ISO)
Alzheimer's disease  (ISO)
Alzheimer's disease 1  (ISO)
Angina Pectoris  (ISO)
anuria  (ISO)
appendicitis  (ISO)
Arterial Occlusive Diseases  (ISO)
Asthenozoospermia  (ISO)
asthma  (ISO)
atherosclerosis  (ISO)
Bone Neoplasms  (ISO)
brain edema  (ISO)
brain ischemia  (ISO)
breast cancer  (ISO)
Cardiomegaly  (ISO)
carotid artery disease  (ISO)
Cerebral Hemorrhage  (ISO)
cerebral infarction  (ISO)
cerebrovascular disease  (ISO)
cholesterol embolism  (ISO)
Chronic Allograft Nephropathy  (ISO)
Chronic Hepatitis C  (ISO)
chronic obstructive pulmonary disease  (ISO)
Colonic Neoplasms  (ISO)
Coronary Disease  (ISO)
Diabetic Nephropathies  (ISO)
Eczema  (ISO)
end stage renal disease  (ISO)
Experimental Arthritis  (ISO)
Experimental Liver Cirrhosis  (ISO)
familial hyperlipidemia  (ISO)
gliosarcoma  (ISO)
Graft Occlusion, Vascular  (ISO)
Heart Rupture, Post-Infarction  (ISO)
Hematuria  (ISO)
Hemorrhage  (ISO)
Henoch-Schoenlein purpura  (ISO)
hepatitis B  (ISO)
high grade glioma  (ISO)
Hirschsprung Disease 1  (ISO)
Hyperoxia  (ISO)
Hypotension  (ISO)
Hypoxia-Ischemia, Brain  (ISO)
idiopathic pulmonary fibrosis  (ISO)
IgA glomerulonephritis  (ISO)
Inflammation  (ISO)
intermediate coronary syndrome  (ISO)
intracranial aneurysm  (ISO)
Intracranial Embolism and Thrombosis  (ISO)
Intracranial Hemorrhages  (ISO)
ischemia  (ISO)
Jaw Cysts  (ISO)
Kidney Neoplasms  (ISO)
Left Ventricular Hypertrophy  (ISO)
liver cirrhosis  (ISO)
Lung Injury  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
Mammary Neoplasms, Experimental  (ISO)
meningitis  (ISO)
middle cerebral artery infarction  (ISO)
mitral valve prolapse  (ISO)
Mouth Neoplasms  (ISO)
myocardial infarction  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
Neoplasm Recurrence, Local  (ISO)
nephritis  (ISO)
Optic Nerve Injuries  (ISO)
oral squamous cell carcinoma  (ISO)
otitis media  (ISO)
pancreatic cancer  (ISO)
Peripheral Nerve Injuries  (ISO)
peritonitis  (ISO)
pleural empyema  (ISO)
prion disease  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
pulmonary embolism  (ISO)
pulmonary fibrosis  (ISO)
Quebec platelet disorder  (ISO)
renal cell carcinoma  (ISO)
renal fibrosis  (ISO)
Reperfusion Injury  (ISO)
rhinitis  (ISO)
sagittal sinus thrombosis  (ISO)
sciatic neuropathy  (ISO)
Sepsis  (ISO)
sinusitis  (ISO)
Spinal Cord Injuries  (ISO)
squamous cell carcinoma  (ISO)
status epilepticus  (ISO)
Stomach Neoplasms  (ISO)
Stroke  (ISO)
Strongylida Infections  (ISO)
Thromboembolism  (ISO)
thrombosis  (ISO)
thyroid gland papillary carcinoma  (ISO)
transient cerebral ischemia  (ISO)
transitional cell carcinoma  (ISO)
Transplant Rejection  (ISO)
urinary bladder cancer  (ISO)
urolithiasis  (ISO)
Venous Thrombosis  (ISO)
Ventricular Fibrillation  (ISO)
Viral Myocarditis  (ISO)
visual epilepsy  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cell surface  (IEA)
extracellular space  (IBA,ISO,ISS)
membrane  (ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:6096832   PMID:8104765   PMID:22177313  


Genomics

Comparative Map Data
PLAU
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1476,629,299 - 76,635,172 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11476,629,313 - 76,635,173 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21482,755,642 - 82,761,502 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap14q24-q26NCBI
PLAU
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1073,909,177 - 73,917,496 (+)EnsemblGRCh38hg38GRCh38
GRCh381073,909,182 - 73,917,497 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371075,670,890 - 75,677,252 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361075,340,896 - 75,347,261 (+)NCBINCBI36hg18NCBI36
Build 341075,340,895 - 75,347,260NCBI
Celera1068,954,178 - 68,960,575 (+)NCBI
Cytogenetic Map10q22.2NCBI
HuRef1069,665,797 - 69,672,195 (+)NCBIHuRef
CHM1_11075,952,624 - 75,959,021 (+)NCBICHM1_1
Plau
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391420,886,730 - 20,893,456 (+)NCBIGRCm39mm39
GRCm39 Ensembl1420,886,728 - 20,893,453 (+)Ensembl
GRCm381420,836,662 - 20,843,388 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1420,836,660 - 20,843,385 (+)EnsemblGRCm38mm10GRCm38
MGSCv371421,655,884 - 21,662,610 (+)NCBIGRCm37mm9NCBIm37
MGSCv361419,625,259 - 19,631,940 (+)NCBImm8
Celera1417,217,270 - 17,223,995 (+)NCBICelera
Cytogenetic Map14A3NCBI
cM Map1411.53NCBI
Plau
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2153,456,230 - 3,462,732 (-)NCBI
Rnor_6.0 Ensembl153,644,769 - 3,650,819 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0153,644,296 - 3,650,765 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0153,621,057 - 3,627,467 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4153,680,072 - 3,686,232 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1153,680,073 - 3,686,275 (-)NCBI
Celera151,129,191 - 1,135,694 (+)NCBICelera
Cytogenetic Map15p16NCBI
Plau
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543717,994,537 - 18,000,209 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543717,995,726 - 18,000,542 (-)NCBIChiLan1.0ChiLan1.0
PLAU
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11073,104,808 - 73,113,136 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1073,105,895 - 73,113,136 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01070,433,340 - 70,441,569 (+)NCBIMhudiblu_PPA_v0panPan3
PLAU
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1424,329,139 - 24,333,893 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl424,328,925 - 24,334,851 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha424,466,425 - 24,471,181 (+)NCBI
ROS_Cfam_1.0424,609,212 - 24,613,966 (+)NCBI
UMICH_Zoey_3.1424,506,511 - 24,511,263 (+)NCBI
UNSW_CanFamBas_1.0424,706,941 - 24,711,694 (+)NCBI
UU_Cfam_GSD_1.0425,061,896 - 25,066,649 (+)NCBI
Plau
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721356,745,370 - 56,751,129 (-)NCBI
SpeTri2.0NW_0049365215,238,128 - 5,243,829 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLAU
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1957,452,904 - 57,459,345 (-)NCBI
ChlSab1.1 Ensembl957,452,761 - 57,459,286 (-)Ensembl
Vero_WHO_p1.0NW_02366604818,028,912 - 18,035,356 (-)NCBI
Plau
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247547,405,637 - 7,415,870 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 8 1 1 1 1 1
Low 2 3 3 4 1 22 2 2 2
Below cutoff 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000011287   ⟹   ENSSSCP00000010995
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1476,629,301 - 76,635,172 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000055275   ⟹   ENSSSCP00000036249
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1476,629,752 - 76,635,172 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000081718   ⟹   ENSSSCP00000061928
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1476,629,299 - 76,635,169 (+)Ensembl
RefSeq Acc Id: NM_213945   ⟹   NP_999110
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11476,629,313 - 76,635,173 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_999110 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAK58002 (Get FASTA)   NCBI Sequence Viewer  
  CAA25806 (Get FASTA)   NCBI Sequence Viewer  
  CAA26511 (Get FASTA)   NCBI Sequence Viewer  
  P04185 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_999110   ⟸   NM_213945
- Peptide Label: precursor
- UniProtKB: P04185 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSSSCP00000010995   ⟸   ENSSSCT00000011287
RefSeq Acc Id: ENSSSCP00000036249   ⟸   ENSSSCT00000055275
RefSeq Acc Id: ENSSSCP00000061928   ⟸   ENSSSCT00000081718
Protein Domains
EGF-like   Kringle   Peptidase S1


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000010312 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070003305 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000010995 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000036249 UniProtKB/TrEMBL
  ENSSSCP00000061928 UniProtKB/TrEMBL
  ENSSSCP00070005099 UniProtKB/TrEMBL
  ENSSSCP00070005101 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000011287 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000055275 UniProtKB/TrEMBL
  ENSSSCT00000081718 UniProtKB/TrEMBL
  ENSSSCT00070006264 UniProtKB/TrEMBL
  ENSSSCT00070006267 UniProtKB/TrEMBL
Gene3D-CATH 2.40.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.40.20.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro EGF-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kringle UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kringle-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kringle_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kringle_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1_PA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trypsin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Urokinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:396985 UniProtKB/Swiss-Prot
NCBI Gene PLAU ENTREZGENE
PANTHER PTHR24264:SF38 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Kringle UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS CHYMOTRYPSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE EGF_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KRINGLE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KRINGLE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SM00130 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tryp_SPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50494 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57440 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A286ZXK2_PIG UniProtKB/TrEMBL
  A0A4X1SQU8_PIG UniProtKB/TrEMBL
  A0A4X1SSL1_PIG UniProtKB/TrEMBL
  A0A5G2QBP9_PIG UniProtKB/TrEMBL
  F1SU38_PIG UniProtKB/TrEMBL
  P04185 ENTREZGENE, UniProtKB/Swiss-Prot
VGNC ID VGNC:91511 ENTREZGENE