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Gene: Plau (plasminogen activator, urokinase) Mus musculus
Symbol: Plau
Name: plasminogen activator, urokinase
Description: Predicted to have serine-type endopeptidase activity. Involved in several processes, including fibrinolysis; response to hypoxia; and smooth muscle cell migration. Predicted to localize to the cell surface; extracellular space; and membrane. Used to study Alzheimer's disease; fatty liver disease; and hepatocellular carcinoma. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease (multiple); Quebec platelet disorder; end stage renal failure; lung disease (multiple); and mitral valve prolapse. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; integumental system; and trophectoderm. Orthologous to human PLAU (plasminogen activator, urokinase); PARTICIPATES IN fibrinolysis pathway; fibroblast growth factor signaling pathway; coagulation cascade pathway; INTERACTS WITH (S)-nicotine; 1,1-dichloroethene; 1,10-phenanthroline.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: u-PA; U-plasminogen activator; uPA; urokinase-type plasminogen activator
Homo sapiens (human) : PLAU (plasminogen activator, urokinase)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Plau (plasminogen activator, urokinase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Plau (plasminogen activator, urokinase)
Pan paniscus (bonobo/pygmy chimpanzee) : PLAU (plasminogen activator, urokinase)
Canis lupus familiaris (dog) : PLAU (plasminogen activator, urokinase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Plau (plasminogen activator, urokinase)
Sus scrofa (pig) : PLAU (plasminogen activator, urokinase)
Chlorocebus sabaeus (green monkey) : PLAU (plasminogen activator, urokinase)
Heterocephalus glaber (naked mole-rat) : Plau (plasminogen activator, urokinase)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1420,836,660 - 20,843,385 (+)Ensembl
GRCm381420,836,662 - 20,843,388 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371421,655,884 - 21,662,610 (+)NCBIGRCm37mm9NCBIm37
MGSCv361419,625,259 - 19,631,940 (+)NCBImm8
Celera1417,217,270 - 17,223,995 (+)NCBICelera
Cytogenetic Map14 A3NCBI
cM Map1411.53NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Plau
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 733174
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2019-12-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.