Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Plau (plasminogen activator, urokinase) Mus musculus
Analyze
Symbol: Plau
Name: plasminogen activator, urokinase
Description: Predicted to have serine-type endopeptidase activity. Involved in several processes, including fibrinolysis; response to hypoxia; and smooth muscle cell migration. Predicted to localize to the cell surface; extracellular space; and membrane. Used to study Alzheimer's disease; fatty liver disease; and hepatocellular carcinoma. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease (multiple); Quebec platelet disorder; end stage renal failure; lung disease (multiple); and mitral valve prolapse. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; integumental system; and trophectoderm. Orthologous to human PLAU (plasminogen activator, urokinase); PARTICIPATES IN fibrinolysis pathway; fibroblast growth factor signaling pathway; coagulation cascade pathway; INTERACTS WITH (S)-nicotine; 1,1-dichloroethene; 1,10-phenanthroline.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: u-PA; U-plasminogen activator; uPA; urokinase-type plasminogen activator
Orthologs:
Homo sapiens (human) : PLAU (plasminogen activator, urokinase)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Plau (plasminogen activator, urokinase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Plau (plasminogen activator, urokinase)
Pan paniscus (bonobo/pygmy chimpanzee) : PLAU (plasminogen activator, urokinase)
Canis lupus familiaris (dog) : PLAU (plasminogen activator, urokinase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Plau (plasminogen activator, urokinase)
Sus scrofa (pig) : PLAU (plasminogen activator, urokinase)
Chlorocebus sabaeus (green monkey) : PLAU (plasminogen activator, urokinase)
Heterocephalus glaber (naked mole-rat) : Plau (plasminogen activator, urokinase)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl1420,836,660 - 20,843,385 (+)Ensembl
GRCm381420,836,662 - 20,843,388 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371421,655,884 - 21,662,610 (+)NCBIGRCm37mm9NCBIm37
MGSCv361419,625,259 - 19,631,940 (+)NCBImm8
Celera1417,217,270 - 17,223,995 (+)NCBICelera
Cytogenetic Map14 A3NCBI
cM Map1411.53NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Plau
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 733174
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2019-12-18
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.