Nfil3 (nuclear factor, interleukin 3 regulated) - Rat Genome Database

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Gene: Nfil3 (nuclear factor, interleukin 3 regulated) Rattus norvegicus
Analyze
Symbol: Nfil3
Name: nuclear factor, interleukin 3 regulated
RGD ID: 620972
Description: Enables DNA-binding transcription factor activity. Predicted to be involved in circadian rhythm; natural killer cell differentiation; and regulation of DNA-templated transcription. Predicted to act upstream of or within cellular response to interleukin-4 and positive regulation of gene expression. Predicted to be part of RNA polymerase II transcription regulator complex. Predicted to be active in nucleus. Orthologous to human NFIL3 (nuclear factor, interleukin 3 regulated); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: E4 promoter binding-protein 4; E4 promoter-binding protein 4; E4BP4; nuclear factor interleukin-3-regulated protein; nuclear factor, interleukin 3, regulated
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81712,432,376 - 12,447,605 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1712,432,198 - 12,450,826 (+)EnsemblGRCr8
mRatBN7.21712,280,499 - 12,295,728 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1712,280,484 - 12,295,858 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1712,214,907 - 12,230,131 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01713,812,429 - 13,827,663 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01712,129,392 - 12,144,629 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01712,261,102 - 12,276,316 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1712,261,102 - 12,276,315 (+)Ensemblrn6Rnor6.0
Rnor_5.01714,359,252 - 14,374,102 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41718,092,489 - 18,107,708 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1712,046,069 - 12,061,335 (+)NCBICelera
RGSC_v3.11718,092,488 - 18,107,707 (+)NCBI
Cytogenetic Map17p14NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-alpha-phellandrene  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
(R)-noradrenaline  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-hydroxypropanoic acid  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-phellandrene  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
azoxystrobin  (EXP,ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[ghi]perylene  (ISO)
benzoates  (ISO)
beta-naphthoflavone  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bromuconazole  (EXP)
Butylbenzyl phthalate  (EXP)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cannabidiol  (ISO)
captan  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
cefaloridine  (EXP)
CGP 52608  (ISO)
chlordecone  (ISO)
chlorohydrocarbon  (EXP)
chloroprene  (EXP,ISO)
chlorpyrifos  (EXP)
choline  (ISO)
chrysene  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
CU-O LINKAGE  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
dexamethasone  (ISO)
dibenz[a,h]anthracene  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
dichloroacetic acid  (ISO)
dichloromethane  (ISO)
diclofenac  (ISO)
dimethylarsinic acid  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
epoxiconazole  (ISO)
fenpyroximate  (ISO)
fluoranthene  (ISO)
flusilazole  (ISO)
folic acid  (ISO)
folpet  (ISO)
FR900359  (ISO)
furan  (EXP)
genistein  (EXP)
gentamycin  (EXP)
geraniol  (ISO)
glyphosate  (EXP)
GSK-J4  (ISO)
hexaconazole  (ISO)
hexadecanoic acid  (ISO)
hydrogen peroxide  (ISO)
imidacloprid  (EXP)
Indeno[1,2,3-cd]pyrene  (ISO)
indole-3-methanol  (EXP)
inulin  (ISO)
iron atom  (ISO)
iron dichloride  (ISO)
iron(0)  (ISO)
isoprenaline  (ISO)
Jujuboside A  (ISO)
ketamine  (EXP)
kojic acid  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
methamphetamine  (EXP)
methotrexate  (ISO)
methylarsonic acid  (ISO)
methylmercury chloride  (EXP)
methylseleninic acid  (ISO)
midazolam  (ISO)
mitomycin C  (ISO)
monosodium L-glutamate  (ISO)
N-acetyl-L-cysteine  (EXP)
N-nitrosodiethylamine  (EXP)
nefazodone  (EXP)
nickel dichloride  (EXP,ISO)
nickel sulfate  (ISO)
nimesulide  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
parathion  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (ISO)
phenylephrine  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
rotenone  (EXP,ISO)
SCH 23390  (EXP)
sevoflurane  (EXP)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
Soman  (EXP)
styrene  (ISO)
sulindac  (ISO)
tamoxifen  (ISO)
tebufenpyrad  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
tetraphene  (ISO)
thapsigargin  (ISO)
thiabendazole  (EXP)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (EXP,ISO)
torcetrapib  (ISO)
triadimefon  (ISO)
tributylstannane  (ISO)
trichloroethene  (EXP)
trimellitic anhydride  (ISO)
triphenyl phosphate  (EXP,ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
tunicamycin  (ISO)
undecane  (EXP)
valproic acid  (ISO)
valsartan  (ISO)
vinclozolin  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Elucidating the molecular physiopathology of acute respiratory distress syndrome in severe acute respiratory syndrome patients. Kong SL, etal., Virus Res. 2009 Nov;145(2):260-9. Epub 2009 Jul 25.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. Calcium-dependent activation of nuclear factor regulated by interleukin 3/adenovirus E4 promoter-binding protein gene expression by calcineurin/nuclear factor of activated T cells and calcium/calmodulin-dependent protein kinase signaling. Nishimura Y and Tanaka T, J Biol Chem 2001 Jun 8;276(23):19921-8.
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:9798653   PMID:12805554   PMID:15306565   PMID:20093779   PMID:20102225   PMID:21112399   PMID:21212137   PMID:21460847   PMID:21635892   PMID:25536374   PMID:25993115   PMID:29653076  
PMID:30555544  


Genomics

Comparative Map Data
Nfil3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81712,432,376 - 12,447,605 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1712,432,198 - 12,450,826 (+)EnsemblGRCr8
mRatBN7.21712,280,499 - 12,295,728 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1712,280,484 - 12,295,858 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1712,214,907 - 12,230,131 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01713,812,429 - 13,827,663 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01712,129,392 - 12,144,629 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01712,261,102 - 12,276,316 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1712,261,102 - 12,276,315 (+)Ensemblrn6Rnor6.0
Rnor_5.01714,359,252 - 14,374,102 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41718,092,489 - 18,107,708 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1712,046,069 - 12,061,335 (+)NCBICelera
RGSC_v3.11718,092,488 - 18,107,707 (+)NCBI
Cytogenetic Map17p14NCBI
NFIL3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38991,409,045 - 91,483,497 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl991,408,748 - 91,424,626 (-)Ensemblhg38GRCh38
GRCh37994,171,327 - 94,186,908 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36993,211,148 - 93,225,965 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34991,250,883 - 91,265,699NCBI
Celera964,605,969 - 64,620,785 (-)NCBICelera
Cytogenetic Map9q22.31NCBI
HuRef963,851,695 - 63,866,454 (-)NCBIHuRef
CHM1_1994,317,789 - 94,332,468 (-)NCBICHM1_1
T2T-CHM13v2.09103,575,185 - 103,649,759 (-)NCBIT2T-CHM13v2.0
Nfil3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391353,121,245 - 53,136,914 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1353,121,245 - 53,135,109 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381352,967,209 - 52,982,878 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1352,967,209 - 52,981,073 (-)Ensemblmm10GRCm38
MGSCv371353,062,578 - 53,076,408 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361352,979,641 - 52,993,471 (-)NCBIMGSCv36mm8
Celera1354,044,445 - 54,046,258 (-)NCBICelera
Cytogenetic Map13B1NCBI
cM Map1327.68NCBI
Nfil3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955515908,477 - 909,868 (+)Ensembl
ChiLan1.0NW_004955515908,313 - 910,159 (+)NCBIChiLan1.0ChiLan1.0
NFIL3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21148,067,420 - 48,083,270 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1948,069,982 - 48,085,660 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0962,467,360 - 62,482,926 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1990,566,818 - 90,568,862 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl990,567,116 - 90,568,504 (-)EnsemblpanPan2panpan1.1
NFIL3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1195,508,224 - 95,510,452 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl195,508,764 - 95,510,152 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha195,949,339 - 95,964,139 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0196,095,964 - 96,110,820 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UMICH_Zoey_3.1195,728,371 - 95,743,174 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0195,448,017 - 95,462,797 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0196,207,896 - 96,222,747 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Nfil3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494413,047,007 - 13,049,623 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936796367,759 - 369,150 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936796367,461 - 369,469 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NFIL3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl142,588,896 - 2,603,255 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1142,588,887 - 2,603,774 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2143,264,864 - 3,279,973 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NFIL3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.112101,845,294 - 101,860,844 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl12101,845,592 - 101,846,980 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603890,166,784 - 90,183,191 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nfil3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248681,139,595 - 1,150,370 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248681,139,575 - 1,150,370 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Nfil3
37 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:101
Count of miRNA genes:83
Interacting mature miRNAs:93
Transcripts:ENSRNOT00000015525
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
2300002Iddm36Insulin dependent diabetes mellitus QTL 361.98blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)17999128640540197Rat
631499Stl1Serum triglyceride level QTL 13.6blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)17327139827389946Rat
2293664Bmd28Bone mineral density QTL 285.10.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)17435448727028127Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17211514934551001Rat
1582224Epfw4Epididymal fat weight QTL 43.50.0058epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)17920136523653323Rat
1582225Bw67Body weight QTL 676.20.0001body mass (VT:0001259)body weight (CMO:0000012)17920136523653323Rat
1582226Bw64Body weight QTL 644.20.0017body mass (VT:0001259)body weight (CMO:0000012)17920136523653323Rat
1354651Lmblg2Limb length QTL 26tibia length (VT:0004357)tibia length (CMO:0000450)17429913069599340Rat
10401807Kidm52Kidney mass QTL 52kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17131701463Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17452803849528038Rat
1354630Cm34Cardiac mass QTL 348.7heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)17429913069599340Rat
1582208Kidm32Kidney mass QTL 323.90.0018kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17920136523653323Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)17429913069599340Rat
1354613Kidm14Kidney mass QTL 146.2kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)17429913035837242Rat
2324619Coatc4Coat color QTL 40.001coat/hair pigmentation trait (VT:0010463)pigmented dorsal coat/hair area to total dorsal coat/hair area ratio (CMO:0001811)17429913021293263Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17452803849528038Rat
70184BpQTLcluster14Blood pressure QTL cluster 143.38arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)17131990913Rat
1581553Pur14Proteinuria QTL 145.30.0001urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)17797996816317111Rat
2303561Bw91Body weight QTL 912body mass (VT:0001259)body weight (CMO:0000012)17886846253868462Rat
1582258Bw76Body weight QTL 764.60.0005body mass (VT:0001259)body weight (CMO:0000012)17920136523653323Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17137830672Rat
1582199Insul5Insulin level QTL 53.40.0119blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)17920136523653323Rat
1354596Bw32Body weight QTL 324.5body mass (VT:0001259)body weight (CMO:0000012)17429913060781592Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17169599340Rat
2293648Bmd31Bone mineral density QTL 314.50.0001femur size trait (VT:1000369)femoral neck cortical cross-sectional area (CMO:0001702)17435448727028127Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17160781592Rat
1641902Colcr7Colorectal carcinoma resistance QTL 73.350.0044intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)17211514921881669Rat
1582241Bw70Body weight QTL 704.60.0003body mass (VT:0001259)body weight (CMO:0000012)17920136523653323Rat
1582245Bw73Body weight QTL 734.60.0004body mass (VT:0001259)body weight (CMO:0000012)17920136523653323Rat
9590316Scort21Serum corticosterone level QTL 214.750.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17122871563Rat

Markers in Region
AV225605  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21712,295,604 - 12,295,722 (+)MAPPERmRatBN7.2
Rnor_6.01712,276,193 - 12,276,310NCBIRnor6.0
Rnor_5.01714,373,979 - 14,374,096UniSTSRnor5.0
RGSC_v3.41718,107,585 - 18,107,702UniSTSRGSC3.4
Celera1712,061,212 - 12,061,329UniSTS
Cytogenetic Map17p14UniSTS
RH133089  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21712,295,452 - 12,295,663 (+)MAPPERmRatBN7.2
Rnor_6.01712,276,041 - 12,276,251NCBIRnor6.0
Rnor_5.01714,373,827 - 14,374,037UniSTSRnor5.0
RGSC_v3.41718,107,433 - 18,107,643UniSTSRGSC3.4
Celera1712,061,060 - 12,061,270UniSTS
RH 3.4 Map17114.1UniSTS
Cytogenetic Map17p14UniSTS
BE107980  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21712,280,928 - 12,281,098 (+)MAPPERmRatBN7.2
Rnor_6.01712,261,532 - 12,261,701NCBIRnor6.0
Rnor_5.01714,359,682 - 14,359,851UniSTSRnor5.0
RGSC_v3.41718,092,919 - 18,093,088UniSTSRGSC3.4
Celera1712,046,499 - 12,046,668UniSTS
RH 3.4 Map17115.7UniSTS
Cytogenetic Map17p14UniSTS
UniSTS:237019  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21712,295,385 - 12,295,625 (+)MAPPERmRatBN7.2
Rnor_6.01712,275,974 - 12,276,213NCBIRnor6.0
Rnor_5.01714,373,760 - 14,373,999UniSTSRnor5.0
RGSC_v3.41718,107,366 - 18,107,605UniSTSRGSC3.4
Celera1712,060,993 - 12,061,232UniSTS
Cytogenetic Map17p14UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000015525   ⟹   ENSRNOP00000015525
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1712,441,920 - 12,448,620 (+)Ensembl
mRatBN7.2 Ensembl1712,280,484 - 12,295,858 (+)Ensembl
Rnor_6.0 Ensembl1712,261,102 - 12,276,315 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000096237   ⟹   ENSRNOP00000093138
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1712,432,198 - 12,450,826 (+)Ensembl
mRatBN7.2 Ensembl1712,284,693 - 12,295,858 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000096697   ⟹   ENSRNOP00000090522
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1712,433,150 - 12,448,620 (+)Ensembl
mRatBN7.2 Ensembl1712,284,007 - 12,295,662 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000112357   ⟹   ENSRNOP00000089110
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1712,434,209 - 12,447,735 (+)Ensembl
mRatBN7.2 Ensembl1712,282,205 - 12,295,858 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000140464   ⟹   ENSRNOP00000099686
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1712,434,170 - 12,450,826 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000144491   ⟹   ENSRNOP00000104717
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1712,434,129 - 12,448,690 (+)Ensembl
RefSeq Acc Id: NM_053727   ⟹   NP_446179
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81712,432,376 - 12,447,605 (+)NCBI
mRatBN7.21712,280,499 - 12,295,728 (+)NCBI
Rnor_6.01712,261,102 - 12,276,316 (+)NCBI
Rnor_5.01714,359,252 - 14,374,102 (+)NCBI
RGSC_v3.41718,092,489 - 18,107,708 (+)RGD
Celera1712,046,069 - 12,061,335 (+)RGD
Sequence:
RefSeq Acc Id: XM_006253667   ⟹   XP_006253729
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81712,437,340 - 12,447,605 (+)NCBI
mRatBN7.21712,285,463 - 12,295,728 (+)NCBI
Rnor_6.01712,265,389 - 12,276,316 (+)NCBI
Rnor_5.01714,359,252 - 14,374,102 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006253669   ⟹   XP_006253731
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81712,434,385 - 12,447,605 (+)NCBI
mRatBN7.21712,283,331 - 12,295,728 (+)NCBI
Rnor_6.01712,263,284 - 12,276,316 (+)NCBI
Rnor_5.01714,359,252 - 14,374,102 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006253670   ⟹   XP_006253732
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81712,436,716 - 12,447,605 (+)NCBI
mRatBN7.21712,285,206 - 12,295,728 (+)NCBI
Rnor_6.01712,265,389 - 12,276,316 (+)NCBI
Rnor_5.01714,359,252 - 14,374,102 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039095285   ⟹   XP_038951213
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81712,434,164 - 12,447,605 (+)NCBI
mRatBN7.21712,282,351 - 12,295,728 (+)NCBI
RefSeq Acc Id: XM_063276018   ⟹   XP_063132088
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81712,433,329 - 12,447,605 (+)NCBI
RefSeq Acc Id: NP_446179   ⟸   NM_053727
- UniProtKB: Q923M2 (UniProtKB/Swiss-Prot),   Q6IMZ0 (UniProtKB/Swiss-Prot),   A6J6R4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253731   ⟸   XM_006253669
- Peptide Label: isoform X1
- UniProtKB: Q923M2 (UniProtKB/Swiss-Prot),   Q6IMZ0 (UniProtKB/Swiss-Prot),   A6J6R4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253732   ⟸   XM_006253670
- Peptide Label: isoform X1
- UniProtKB: Q923M2 (UniProtKB/Swiss-Prot),   Q6IMZ0 (UniProtKB/Swiss-Prot),   A6J6R4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253729   ⟸   XM_006253667
- Peptide Label: isoform X1
- UniProtKB: Q923M2 (UniProtKB/Swiss-Prot),   Q6IMZ0 (UniProtKB/Swiss-Prot),   A6J6R4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000015525   ⟸   ENSRNOT00000015525
RefSeq Acc Id: XP_038951213   ⟸   XM_039095285
- Peptide Label: isoform X1
- UniProtKB: Q6IMZ0 (UniProtKB/Swiss-Prot),   Q923M2 (UniProtKB/Swiss-Prot),   A6J6R4 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000090522   ⟸   ENSRNOT00000096697
Ensembl Acc Id: ENSRNOP00000093138   ⟸   ENSRNOT00000096237
Ensembl Acc Id: ENSRNOP00000089110   ⟸   ENSRNOT00000112357
RefSeq Acc Id: XP_063132088   ⟸   XM_063276018
- Peptide Label: isoform X1
- UniProtKB: Q923M2 (UniProtKB/Swiss-Prot),   Q6IMZ0 (UniProtKB/Swiss-Prot),   A6J6R4 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000099686   ⟸   ENSRNOT00000140464
Ensembl Acc Id: ENSRNOP00000104717   ⟸   ENSRNOT00000144491
Protein Domains
bZIP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6IMZ0-F1-model_v2 AlphaFold Q6IMZ0 1-462 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700333
Promoter ID:EPDNEW_R10857
Type:multiple initiation site
Name:Nfil3_1
Description:nuclear factor, interleukin 3 regulated
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01712,261,071 - 12,261,131EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620972 AgrOrtholog
BioCyc Gene G2FUF-10114 BioCyc
Ensembl Genes ENSRNOG00000011668 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000015525.7 UniProtKB/Swiss-Prot
  ENSRNOT00000096237 ENTREZGENE
  ENSRNOT00000096237.1 UniProtKB/Swiss-Prot
  ENSRNOT00000096697 ENTREZGENE
  ENSRNOT00000096697.1 UniProtKB/Swiss-Prot
  ENSRNOT00000112357 ENTREZGENE
  ENSRNOT00000112357.1 UniProtKB/Swiss-Prot
  ENSRNOT00000140464 ENTREZGENE
  ENSRNOT00000144491 ENTREZGENE
Gene3D-CATH 1.20.5.170 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7097417 IMAGE-MGC_LOAD
InterPro bZIP UniProtKB/Swiss-Prot
  bZIP_sf UniProtKB/Swiss-Prot
  NFIL3-like UniProtKB/Swiss-Prot
  NFIL3-like_bZIP UniProtKB/Swiss-Prot
  NFIL3/E4BP4 UniProtKB/Swiss-Prot
  Vert_IL3-reg_TF UniProtKB/Swiss-Prot
KEGG Report rno:114519 UniProtKB/Swiss-Prot
MGC_CLONE MGC:91562 IMAGE-MGC_LOAD
NCBI Gene 114519 ENTREZGENE
PANTHER NUCLEAR FACTOR INTERLEUKIN-3-REGULATED PROTEIN UniProtKB/Swiss-Prot
  PTHR15284:SF1 UniProtKB/Swiss-Prot
Pfam bZIP_2 UniProtKB/Swiss-Prot
  Vert_IL3-reg_TF UniProtKB/Swiss-Prot
PhenoGen Nfil3 PhenoGen
PIRSF bZIP_E4BP4 UniProtKB/Swiss-Prot
PROSITE BZIP UniProtKB/Swiss-Prot
  BZIP_BASIC UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000011668 RatGTEx
SMART BRLZ UniProtKB/Swiss-Prot
Superfamily-SCOP SSF57959 UniProtKB/Swiss-Prot
UniProt A6J6R4 ENTREZGENE, UniProtKB/TrEMBL
  NFIL3_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q923M2 ENTREZGENE
UniProt Secondary Q923M2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-12-14 Nfil3  nuclear factor, interleukin 3 regulated    nuclear factor, interleukin 3, regulated  Name updated 1299863 APPROVED
2002-08-07 Nfil3  nuclear factor, interleukin 3, regulated      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_regulation expression regulated in a Ca2+ dependent manner by both calcineurin/NFAT and CaM kinase 633353