Esd (esterase D) - Rat Genome Database

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Gene: Esd (esterase D) Rattus norvegicus
Analyze
Symbol: Esd
Name: esterase D
RGD ID: 1592114
Description: Predicted to enable S-formylglutathione hydrolase activity and identical protein binding activity. Predicted to be involved in organic substance catabolic process. Predicted to be located in cytoplasmic vesicle. Predicted to be active in cytosol. Orthologous to human ESD (esterase D); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Esd_mapped; Esterase D/formylglutathione hydrolase; esterase D/formylglutathione hydrolase (mapped); FGH; S-formylglutathione hydrolase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Candidate Gene For: Bmd62
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81556,453,082 - 56,472,582 (+)NCBIGRCr8
mRatBN7.21550,043,634 - 50,063,134 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1550,043,632 - 50,063,144 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1554,194,235 - 54,213,738 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01555,305,804 - 55,325,307 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01552,145,277 - 52,164,777 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01556,756,848 - 56,776,348 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1556,756,661 - 56,776,348 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01560,479,253 - 60,498,753 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41555,556,681 - 55,576,172 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1549,676,547 - 49,696,047 (+)NCBICelera
Cytogenetic Map15q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
2-tert-butylhydroquinone  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
azoxystrobin  (EXP)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
chloroprene  (ISO)
chlorpyrifos  (EXP)
clofibrate  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
CU-O LINKAGE  (ISO)
cyclosporin A  (ISO)
DDT  (EXP)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
diethylstilbestrol  (ISO)
diuron  (EXP)
doxorubicin  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
fipronil  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fumonisin B1  (ISO)
gentamycin  (EXP)
glyphosate  (EXP,ISO)
hyaluronic acid  (EXP)
hydrogen peroxide  (EXP)
hypochlorous acid  (ISO)
imidacloprid  (EXP)
inulin  (ISO)
ivermectin  (ISO)
L-ethionine  (EXP)
lead(0)  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
microcystin RR  (ISO)
nefazodone  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
nimesulide  (EXP)
omeprazole  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phosgene  (ISO)
pirinixic acid  (EXP,ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
propiconazole  (ISO)
pyrogallol  (ISO)
rac-lactic acid  (ISO)
SB 431542  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
succimer  (ISO)
sulindac sulfide  (ISO)
sunitinib  (ISO)
temozolomide  (ISO)
tetrachloromethane  (EXP,ISO)
thalidomide  (ISO)
thapsigargin  (EXP)
thiabendazole  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
triptonide  (ISO)
trovafloxacin  (ISO)
valproic acid  (ISO)
vincristine  (ISO)
zinc sulfate  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasmic vesicle  (IEA)
cytosol  (IBA,IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. The in vitro metabolism of a pyrethroid insecticide, permethrin, and its hydrolysis products in rats. Nakamura Y, etal., Toxicology. 2007 Jun 25;235(3):176-84. Epub 2007 Mar 19.
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Comprehensive gene review and curation RGD comprehensive gene curation
5. Identification of microsomal rat liver carboxylesterases and their activity with retinyl palmitate. Sanghani SP, etal., Eur J Biochem 2002 Sep;269(18):4387-98.
Additional References at PubMed
PMID:869894   PMID:1914521   PMID:7323947   PMID:7444718   PMID:12477932   PMID:15489334   PMID:19056867   PMID:19126594   PMID:19199708   PMID:23376485   PMID:23533145   PMID:25416956  
PMID:26316108   PMID:31515488  


Genomics

Comparative Map Data
Esd
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81556,453,082 - 56,472,582 (+)NCBIGRCr8
mRatBN7.21550,043,634 - 50,063,134 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1550,043,632 - 50,063,144 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1554,194,235 - 54,213,738 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01555,305,804 - 55,325,307 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01552,145,277 - 52,164,777 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01556,756,848 - 56,776,348 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1556,756,661 - 56,776,348 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01560,479,253 - 60,498,753 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41555,556,681 - 55,576,172 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1549,676,547 - 49,696,047 (+)NCBICelera
Cytogenetic Map15q11NCBI
ESD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381346,771,256 - 46,797,700 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1346,771,256 - 46,797,420 (-)EnsemblGRCh38hg38GRCh38
GRCh371347,345,391 - 47,371,296 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361346,243,392 - 46,269,368 (-)NCBINCBI36Build 36hg18NCBI36
Build 341346,243,392 - 46,269,368NCBI
Celera1328,401,323 - 28,427,305 (-)NCBICelera
Cytogenetic Map13q14.2NCBI
HuRef1328,138,943 - 28,164,930 (-)NCBIHuRef
CHM1_11347,313,174 - 47,339,150 (-)NCBICHM1_1
T2T-CHM13v2.01345,992,477 - 46,018,921 (-)NCBIT2T-CHM13v2.0
Esd
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391474,969,591 - 74,988,205 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1474,969,737 - 74,988,205 (+)EnsemblGRCm39 Ensembl
GRCm381474,732,151 - 74,750,765 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1474,732,297 - 74,750,765 (+)EnsemblGRCm38mm10GRCm38
MGSCv371475,132,152 - 75,150,250 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361473,466,500 - 73,484,598 (+)NCBIMGSCv36mm8
Celera1472,239,696 - 72,257,798 (+)NCBICelera
Cytogenetic Map14D3NCBI
cM Map1439.38NCBI
Esd
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955431525,795 - 547,922 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955431524,491 - 551,871 (-)NCBIChiLan1.0ChiLan1.0
ESD
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21448,215,480 - 48,241,716 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11346,866,573 - 46,892,809 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01327,915,905 - 27,942,142 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11346,633,619 - 46,660,364 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1346,633,619 - 46,659,969 (-)Ensemblpanpan1.1panPan2
ESD
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1224,544,657 - 4,569,986 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl224,544,719 - 4,569,983 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha224,589,199 - 4,614,518 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0224,657,015 - 4,682,356 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl224,657,038 - 4,683,159 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1224,439,587 - 4,464,920 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0224,503,227 - 4,528,547 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0224,507,823 - 4,533,160 (+)NCBIUU_Cfam_GSD_1.0
Esd
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945156,801,739 - 156,825,369 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936565285,054 - 309,421 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936565285,789 - 309,390 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ESD
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1120,651,822 - 20,672,244 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11120,652,304 - 20,672,246 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21120,991,706 - 21,011,670 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ESD
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1324,763,433 - 24,790,164 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl324,762,987 - 24,788,868 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605719,207,062 - 19,234,254 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Esd
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247488,254,569 - 8,283,471 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247488,254,419 - 8,282,201 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Esd
74 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:22
Count of miRNA genes:20
Interacting mature miRNAs:22
Transcripts:ENSRNOT00000013324
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152211793367117933Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)152803066582262678Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)152803066582262678Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)152803066582262678Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
2293691Bmd37Bone mineral density QTL 376.60.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)153361105871477291Rat
2293686Bmd36Bone mineral density QTL 367.40.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)153361105871477291Rat
1598828Glom14Glomerulus QTL 142.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)153405413979054139Rat
1300144Rf23Renal function QTL 233.61renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)154063126898288169Rat

Markers in Region
RH143141  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21550,047,055 - 50,047,278 (+)MAPPERmRatBN7.2
Rnor_6.01556,760,270 - 56,760,492NCBIRnor6.0
Rnor_5.01560,482,675 - 60,482,897UniSTSRnor5.0
RGSC_v3.41555,560,094 - 55,560,316UniSTSRGSC3.4
Celera1549,679,969 - 49,680,191UniSTS
Cytogenetic Map15q11UniSTS
RH139133  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21550,047,056 - 50,047,208 (+)MAPPERmRatBN7.2
Rnor_6.01556,760,271 - 56,760,422NCBIRnor6.0
Rnor_5.01560,482,676 - 60,482,827UniSTSRnor5.0
RGSC_v3.41555,560,095 - 55,560,246UniSTSRGSC3.4
Celera1549,679,970 - 49,680,121UniSTS
Cytogenetic Map15q11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 39 11 8
Low 2
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001106051 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001270865 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001270866 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274165 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC158790 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473951 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM108159 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211025 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213565 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216373 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218750 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219749 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225558 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229329 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234562 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000013324   ⟹   ENSRNOP00000013324
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1550,043,780 - 50,063,144 (+)Ensembl
Rnor_6.0 Ensembl1556,756,661 - 56,776,348 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000078013   ⟹   ENSRNOP00000068608
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1550,044,101 - 50,063,134 (+)Ensembl
Rnor_6.0 Ensembl1556,757,315 - 56,776,348 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000096800   ⟹   ENSRNOP00000086420
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1550,044,101 - 50,063,134 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000106692   ⟹   ENSRNOP00000097865
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1550,043,632 - 50,059,683 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000119329   ⟹   ENSRNOP00000087309
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1550,043,814 - 50,063,133 (+)Ensembl
RefSeq Acc Id: NM_001106051   ⟹   NP_001099521
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81556,453,082 - 56,472,582 (+)NCBI
mRatBN7.21550,043,634 - 50,063,134 (+)NCBI
Rnor_6.01556,756,848 - 56,776,348 (+)NCBI
Rnor_5.01560,479,253 - 60,498,753 (+)NCBI
RGSC_v3.41555,556,681 - 55,576,172 (+)RGD
Celera1549,676,547 - 49,696,047 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001270865   ⟹   NP_001257794
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81556,453,549 - 56,472,582 (+)NCBI
mRatBN7.21550,044,101 - 50,063,134 (+)NCBI
Rnor_6.01556,757,315 - 56,776,348 (+)NCBI
Rnor_5.01560,479,253 - 60,498,753 (+)NCBI
Celera1549,677,014 - 49,696,047 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001270866   ⟹   NP_001257795
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81556,453,082 - 56,472,582 (+)NCBI
mRatBN7.21550,043,634 - 50,063,134 (+)NCBI
Rnor_6.01556,756,848 - 56,776,348 (+)NCBI
Rnor_5.01560,479,253 - 60,498,753 (+)NCBI
Celera1549,676,547 - 49,696,047 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063274165   ⟹   XP_063130235
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81556,453,358 - 56,472,582 (+)NCBI
RefSeq Acc Id: NP_001099521   ⟸   NM_001106051
- Peptide Label: isoform a
- UniProtKB: B0BNE5 (UniProtKB/Swiss-Prot),   A6HTR6 (UniProtKB/TrEMBL),   A0A8L2UIQ9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257795   ⟸   NM_001270866
- Peptide Label: isoform b
- UniProtKB: A0A8I6A7Q6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257794   ⟸   NM_001270865
- Peptide Label: isoform a
- UniProtKB: B0BNE5 (UniProtKB/Swiss-Prot),   A6HTR6 (UniProtKB/TrEMBL),   A0A8L2UIQ9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000068608   ⟸   ENSRNOT00000078013
RefSeq Acc Id: ENSRNOP00000013324   ⟸   ENSRNOT00000013324
RefSeq Acc Id: ENSRNOP00000087309   ⟸   ENSRNOT00000119329
RefSeq Acc Id: ENSRNOP00000086420   ⟸   ENSRNOT00000096800
RefSeq Acc Id: ENSRNOP00000097865   ⟸   ENSRNOT00000106692
RefSeq Acc Id: XP_063130235   ⟸   XM_063274165
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B0BNE5-F1-model_v2 AlphaFold B0BNE5 1-282 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699826
Promoter ID:EPDNEW_R10350
Type:multiple initiation site
Name:Esd_1
Description:esterase D
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01556,756,874 - 56,756,934EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1592114 AgrOrtholog
BioCyc Gene G2FUF-13144 BioCyc
Ensembl Genes ENSRNOG00000009512 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055014969 UniProtKB/Swiss-Prot
  ENSRNOG00060017008 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000013324 ENTREZGENE
  ENSRNOT00000013324.7 UniProtKB/TrEMBL
  ENSRNOT00000078013 ENTREZGENE
  ENSRNOT00000078013.2 UniProtKB/Swiss-Prot
  ENSRNOT00000096800.1 UniProtKB/TrEMBL
  ENSRNOT00000106692 ENTREZGENE
  ENSRNOT00000106692.1 UniProtKB/TrEMBL
  ENSRNOT00000119329.1 UniProtKB/TrEMBL
  ENSRNOT00055025640 UniProtKB/Swiss-Prot
  ENSRNOT00060029227 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.1820 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7308742 IMAGE-MGC_LOAD
InterPro AB_hydrolase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Esterase-like UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  S-formylglutathione_hydrol UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:290401 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:188158 IMAGE-MGC_LOAD
NCBI Gene 290401 ENTREZGENE
PANTHER PTHR10061 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S-FORMYLGLUTATHIONE HYDROLASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Esterase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Esd PhenoGen
RatGTEx ENSRNOG00000009512 RatGTEx
  ENSRNOG00055014969 RatGTEx
  ENSRNOG00060017008 RatGTEx
Superfamily-SCOP SSF53474 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6A7Q6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A8R5_RAT UniProtKB/TrEMBL
  A0A8I6AWW9_RAT UniProtKB/TrEMBL
  A0A8L2UIQ9 ENTREZGENE, UniProtKB/TrEMBL
  A6HTR6 ENTREZGENE, UniProtKB/TrEMBL
  A6HTR7_RAT UniProtKB/TrEMBL
  A6HTR8_RAT UniProtKB/TrEMBL
  A6HTR9_RAT UniProtKB/TrEMBL
  B0BNE5 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-02 Esd  esterase D  Esd  esterase D/formylglutathione hydrolase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2007-04-13   esterase D/formylglutathione hydrolase  Esd  esterase D/formylglutathione hydrolase (mapped)  Name updated 737654 APPROVED
2007-04-11 Esd  esterase D/formylglutathione hydrolase (mapped)  Esd_mapped  esterase D/formylglutathione hydrolase (mapped)  Data merged from RGD:2580 737654 APPROVED
2006-11-20 Esd  esterase D/formylglutathione hydrolase (mapped)      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-11-17 Esd_mapped  esterase D/formylglutathione hydrolase (mapped)  Esd  Esterase D/formylglutathione hydrolase  Symbol and Name updated 1556543 APPROVED
2002-06-10 Esd  Esterase D/formylglutathione hydrolase      Symbol and Name status set to approved 70586 APPROVED