Zc3h7a (zinc finger CCCH type containing 7 A) - Rat Genome Database

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Gene: Zc3h7a (zinc finger CCCH type containing 7 A) Rattus norvegicus
Analyze
Symbol: Zc3h7a
Name: zinc finger CCCH type containing 7 A
RGD ID: 1311225
Description: Predicted to enable miRNA binding activity. Predicted to be involved in miRNA processing. Predicted to act upstream of with a positive effect on post-transcriptional regulation of gene expression. Orthologous to human ZC3H7A (zinc finger CCCH-type containing 7A); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC103694286; LOC360466; uncharacterized LOC103694286; Zc3hdc7; zinc finger CCCH domain-containing protein 7A; zinc finger CCCH type domain containing 7; zinc finger CCCH-type containing 7A
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8104,980,147 - 5,019,637 (+)NCBIGRCr8
mRatBN7.2104,473,177 - 4,512,668 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl104,473,203 - 4,512,665 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx109,169,869 - 9,209,335 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0108,690,956 - 8,730,413 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0104,329,208 - 4,368,665 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0104,535,651 - 4,575,643 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl104,536,180 - 4,575,646 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0103,365,911 - 3,405,540 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4104,361,356 - 4,400,822 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1104,361,404 - 4,400,818 (+)NCBI
Celera103,496,703 - 3,536,174 (+)NCBICelera
Cytogenetic Map10q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleus  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:22658674   PMID:22681889   PMID:28431233  


Genomics

Comparative Map Data
Zc3h7a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8104,980,147 - 5,019,637 (+)NCBIGRCr8
mRatBN7.2104,473,177 - 4,512,668 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl104,473,203 - 4,512,665 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx109,169,869 - 9,209,335 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0108,690,956 - 8,730,413 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0104,329,208 - 4,368,665 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0104,535,651 - 4,575,643 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl104,536,180 - 4,575,646 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0103,365,911 - 3,405,540 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4104,361,356 - 4,400,822 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1104,361,404 - 4,400,818 (+)NCBI
Celera103,496,703 - 3,536,174 (+)NCBICelera
Cytogenetic Map10q11NCBI
ZC3H7A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381611,750,597 - 11,797,258 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1611,750,586 - 11,797,258 (-)EnsemblGRCh38hg38GRCh38
GRCh371611,844,453 - 11,891,114 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361611,751,943 - 11,783,909 (-)NCBINCBI36Build 36hg18NCBI36
Build 341611,751,943 - 11,783,909NCBI
Celera1612,018,794 - 12,050,728 (-)NCBICelera
Cytogenetic Map16p13.13NCBI
HuRef1611,760,486 - 11,807,710 (-)NCBIHuRef
CHM1_11611,844,381 - 11,891,048 (-)NCBICHM1_1
T2T-CHM13v2.01611,786,640 - 11,833,292 (-)NCBIT2T-CHM13v2.0
Zc3h7a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391610,954,458 - 10,994,257 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1610,954,456 - 10,994,257 (-)EnsemblGRCm39 Ensembl
GRCm381611,136,594 - 11,176,393 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1611,136,592 - 11,176,393 (-)EnsemblGRCm38mm10GRCm38
MGSCv371611,136,687 - 11,176,486 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361611,050,181 - 11,089,867 (-)NCBIMGSCv36mm8
Celera1611,766,853 - 11,808,098 (-)NCBICelera
Cytogenetic Map16A1NCBI
cM Map166.35NCBI
Zc3h7a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554426,853,936 - 6,886,079 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554426,847,224 - 6,884,537 (+)NCBIChiLan1.0ChiLan1.0
ZC3H7A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21812,299,350 - 12,346,385 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11616,070,191 - 16,117,101 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01610,691,710 - 10,738,604 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11611,917,628 - 11,948,957 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1611,917,628 - 11,948,957 (-)Ensemblpanpan1.1panPan2
ZC3H7A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1631,042,964 - 31,069,507 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl631,040,414 - 31,069,229 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha632,411,630 - 32,449,962 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0631,209,735 - 31,248,056 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl631,218,949 - 31,248,043 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1631,023,545 - 31,061,870 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0630,898,286 - 30,936,592 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0631,321,587 - 31,359,924 (+)NCBIUU_Cfam_GSD_1.0
Zc3h7a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344111,712,959 - 111,735,958 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365309,557,154 - 9,581,628 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365309,558,395 - 9,581,337 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ZC3H7A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl331,332,511 - 31,372,799 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1331,332,486 - 31,372,802 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
ZC3H7A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1511,214,635 - 11,260,839 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl511,215,368 - 11,260,791 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606818,883,498 - 18,932,054 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Zc3h7a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247826,534,513 - 6,571,103 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247826,534,313 - 6,569,946 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Zc3h7a
243 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:121
Count of miRNA genes:96
Interacting mature miRNAs:105
Transcripts:ENSRNOT00000003309
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10124158324Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135225947Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138328221Rat
7411611Foco17Food consumption QTL 1718.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)10142315980Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1041834445418344Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
1549898Neuinf3Neuroinflammation QTL 326.4nervous system integrity trait (VT:0010566)MHC Class II RT1A-positive spinal cord ventral horn area to total spinal cord ventral horn area ratio (CMO:0001980)1034063205387112Rat

Markers in Region
D10Got8  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2104,494,989 - 4,495,104 (+)MAPPERmRatBN7.2
Rnor_6.0104,557,966 - 4,558,080NCBIRnor6.0
Rnor_5.0103,387,854 - 3,387,968UniSTSRnor5.0
RGSC_v3.4104,383,144 - 4,383,259RGDRGSC3.4
RGSC_v3.4104,383,145 - 4,383,259UniSTSRGSC3.4
RGSC_v3.1104,383,145 - 4,383,259RGD
Celera103,518,496 - 3,518,610UniSTS
RH 3.4 Map100.0RGD
RH 3.4 Map100.0UniSTS
Cytogenetic Map10q11UniSTS
RH130742  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2104,512,259 - 4,512,450 (+)MAPPERmRatBN7.2
Rnor_6.0104,575,234 - 4,575,424NCBIRnor6.0
Rnor_5.0103,405,131 - 3,405,321UniSTSRnor5.0
RGSC_v3.4104,400,413 - 4,400,603UniSTSRGSC3.4
Celera103,535,765 - 3,535,955UniSTS
RH 3.4 Map1041.2UniSTS
Cytogenetic Map10q11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 36 57 41 19 41 6 8 74 35 38 11 6
Low 7 2 3 3 2
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000003309   ⟹   ENSRNOP00000003309
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl104,473,203 - 4,512,665 (+)Ensembl
Rnor_6.0 Ensembl104,536,180 - 4,575,643 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000084151   ⟹   ENSRNOP00000069541
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl104,538,111 - 4,575,646 (+)Ensembl
RefSeq Acc Id: NM_001108262   ⟹   NP_001101732
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8104,980,176 - 5,019,637 (+)NCBI
mRatBN7.2104,473,204 - 4,512,668 (+)NCBI
Rnor_6.0104,536,180 - 4,575,643 (+)NCBI
Rnor_5.0103,365,911 - 3,405,540 (+)NCBI
RGSC_v3.4104,361,356 - 4,400,822 (+)RGD
Celera103,496,703 - 3,536,174 (+)RGD
Sequence:
RefSeq Acc Id: XM_008767490   ⟹   XP_008765712
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8104,980,169 - 5,019,637 (+)NCBI
mRatBN7.2104,473,187 - 4,512,668 (+)NCBI
Rnor_6.0104,535,652 - 4,575,642 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039086257   ⟹   XP_038942185
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8105,003,827 - 5,019,637 (+)NCBI
mRatBN7.2104,496,853 - 4,512,668 (+)NCBI
RefSeq Acc Id: XM_063269280   ⟹   XP_063125350
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8104,980,374 - 5,019,637 (+)NCBI
RefSeq Acc Id: XM_063269281   ⟹   XP_063125351
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8104,982,337 - 5,019,637 (+)NCBI
RefSeq Acc Id: XM_063269282   ⟹   XP_063125352
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8104,980,147 - 5,015,874 (+)NCBI
RefSeq Acc Id: XR_594546
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8104,980,147 - 5,015,874 (+)NCBI
mRatBN7.2104,473,177 - 4,512,668 (+)NCBI
Rnor_6.0104,535,651 - 4,575,642 (+)NCBI
Sequence:
RefSeq Acc Id: NP_001101732   ⟸   NM_001108262
- UniProtKB: D3ZP12 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008765712   ⟸   XM_008767490
- Peptide Label: isoform X1
- UniProtKB: D3ZP12 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000069541   ⟸   ENSRNOT00000084151
RefSeq Acc Id: ENSRNOP00000003309   ⟸   ENSRNOT00000003309
RefSeq Acc Id: XP_038942185   ⟸   XM_039086257
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063125352   ⟸   XM_063269282
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063125350   ⟸   XM_063269280
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063125351   ⟸   XM_063269281
- Peptide Label: isoform X1
Protein Domains
C3H1-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JVM3-F1-model_v2 AlphaFold A0A0G2JVM3 1-971 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311225 AgrOrtholog
BioCyc Gene G2FUF-26162 BioCyc
Ensembl Genes ENSRNOG00000002420 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000003309 ENTREZGENE
  ENSRNOT00000003309.8 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.10 UniProtKB/TrEMBL
  Classic Zinc Finger UniProtKB/TrEMBL
InterPro TPR-like_helical UniProtKB/TrEMBL
  TPR_repeat UniProtKB/TrEMBL
  ZC3H7A/B UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
  Znf_C2H2_type UniProtKB/TrEMBL
  Znf_CCCH UniProtKB/TrEMBL
  Znf_CCCH_sf UniProtKB/TrEMBL
KEGG Report rno:360466 UniProtKB/TrEMBL
NCBI Gene 360466 ENTREZGENE
PANTHER PTHR14928 UniProtKB/TrEMBL
  ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 7A UniProtKB/TrEMBL
Pfam zf-CCCH UniProtKB/TrEMBL
PhenoGen Zc3h7a PhenoGen
PROSITE ZF_C3H1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000002420 RatGTEx
SMART TPR UniProtKB/TrEMBL
  ZnF_C3H1 UniProtKB/TrEMBL
Superfamily-SCOP SSF48452 UniProtKB/TrEMBL
  SSF57667 UniProtKB/TrEMBL
  SSF90229 UniProtKB/TrEMBL
UniProt A6K4H8_RAT UniProtKB/TrEMBL
  D3ZP12 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Zc3h7a  zinc finger CCCH type containing 7 A  LOC103694286  uncharacterized LOC103694286  Data merged from RGD:9361826 737654 PROVISIONAL
2014-08-25 LOC103694286  uncharacterized LOC103694286      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-04-30 Zc3h7a  zinc finger CCCH type containing 7 A   Zc3h7a_predicted  zinc finger CCCH type containing 7 A (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Zc3h7a_predicted  zinc finger CCCH type containing 7 A (predicted)  Zc3hdc7_predicted  zinc finger CCCH type domain containing 7 (predicted)  Symbol and Name updated 1299863 APPROVED
2005-01-12 Zc3hdc7_predicted  zinc finger CCCH type domain containing 7 (predicted)      Symbol and Name status set to approved 70820 APPROVED