Homer1 (homer scaffold protein 1) - Rat Genome Database

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Gene: Homer1 (homer scaffold protein 1) Rattus norvegicus
Analyze
Symbol: Homer1
Name: homer scaffold protein 1
RGD ID: 628725
Description: Enables several functions, including identical protein binding activity; scaffold protein binding activity; and type 5 metabotropic glutamate receptor binding activity. A structural constituent of postsynapse. Involved in several processes, including G protein-coupled glutamate receptor signaling pathway; protein tetramerization; and regulation of dendritic spine maintenance. Located in dendrite; excitatory synapse; and neuronal cell body. Is active in glutamatergic synapse and postsynaptic density. Orthologous to human HOMER1 (homer scaffold protein 1); PARTICIPATES IN glutamate signaling pathway; INTERACTS WITH (+)-schisandrin B; 1,2,4-trimethylbenzene; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: homer homolog 1; homer homolog 1 (Drosophila); homer protein homolog 1; homer scaffolding protein 1; homer, neuronal immediate early gene, 1; HOMER1F; PSD-Zip45; scaffold protein; VASP/Ena-related gene up-regulated during seizure and LTP 1; Vesl-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8226,279,012 - 26,388,279 (+)NCBIGRCr8
mRatBN7.2224,542,777 - 24,645,715 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl224,543,093 - 24,644,785 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx231,571,304 - 31,672,829 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0229,671,594 - 29,773,121 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0224,494,532 - 24,596,897 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0222,909,550 - 23,012,303 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl222,909,569 - 23,009,678 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0242,106,531 - 42,208,187 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera220,619,882 - 20,720,929 (+)NCBICelera
Cytogenetic Map2q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(S)-amphetamine  (ISO)
(S)-nicotine  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bexarotene  (EXP)
bisphenol A  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP)
calcium atom  (EXP)
calcium(0)  (EXP)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chaetocin  (EXP)
chromium(6+)  (ISO)
cisplatin  (ISO)
clozapine  (EXP)
cocaine  (EXP,ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclic ADP-beta-D-ribose  (EXP)
cyclosporin A  (ISO)
D-cycloserine  (EXP)
dantrolene  (ISO)
dexamethasone  (EXP)
diazinon  (EXP)
dibutyl phthalate  (EXP)
diisopropyl fluorophosphate  (EXP)
dioxygen  (EXP)
elemental selenium  (ISO)
endosulfan  (EXP)
enzyme inhibitor  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
fluoxetine  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
gentamycin  (EXP)
glycidol  (EXP)
haloperidol  (EXP)
halothane  (ISO)
hexachlorophene  (ISO)
hydrogen peroxide  (ISO)
isoprenaline  (EXP)
ivermectin  (ISO)
kainic acid  (EXP)
lead diacetate  (EXP)
lead(0)  (EXP)
linalool  (EXP)
lipopolysaccharide  (EXP)
maneb  (ISO)
methamphetamine  (EXP)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
methylisothiazolinone  (ISO)
methylphenidate  (EXP)
morphine  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
naphthalenes  (EXP)
nefazodone  (EXP)
nickel sulfate  (ISO)
niclosamide  (ISO)
nicotine  (ISO)
oxycodone  (EXP)
paracetamol  (EXP,ISO)
paraquat  (ISO)
phencyclidine  (ISO)
phenobarbital  (ISO)
phenylephrine  (EXP)
pirinixic acid  (EXP)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
ranitidine  (EXP)
risperidone  (EXP)
rotenone  (ISO)
ryanodine  (ISO)
SCH 23390  (EXP)
scopolamine  (EXP)
selenium atom  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (EXP)
Soman  (EXP)
sulfadimethoxine  (EXP)
testosterone  (EXP)
tetrachloromethane  (EXP)
tetradecane  (EXP)
toluene  (EXP)
triphenyl phosphate  (ISO)
undecane  (EXP)
valproic acid  (EXP,ISO)
vincaleukoblastine  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
apical part of cell  (IEA,ISO)
axon  (IEA,ISO)
costamere  (IEA,ISO)
cytoplasm  (IBA,IEA,ISO)
cytosol  (TAS)
dendrite  (IBA,IDA)
dendritic shaft  (IDA)
dendritic spine  (IDA)
excitatory synapse  (IDA)
glutamatergic synapse  (IDA,IEA,IMP,ISO)
membrane  (ISO)
neuron projection  (ISO)
neuron spine  (IDA)
neuronal cell body  (IDA)
plasma membrane  (IBA,IEA,ISO)
postsynapse  (ISO)
postsynaptic cytosol  (IEA,ISO)
postsynaptic density  (IBA,IDA,IEA,ISO)
Z disc  (IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Effects of proteasome inhibitors on the synaptic localization of Vesl-1S/Homer-1a proteins. Ageta H, etal., Brain Res Mol Brain Res 2001 Dec 30;97(2):186-9.
2. A complex program of striatal gene expression induced by dopaminergic stimulation. Berke JD, etal., J Neurosci 1998 Jul 15;18(14):5301-10.
3. Homer: a protein that selectively binds metabotropic glutamate receptors. Brakeman PR, etal., Nature 1997 Mar 20;386(6622):284-8.
4. Homer regulates gain of ryanodine receptor type 1 channel complex. Feng W, etal., J Biol Chem 2002 Nov 22;277(47):44722-30.
5. Differential regulation by stimulants of neocortical expression of mrt1, arc, and homer1a mRNA in the rats treated with repeated methamphetamine. Fujiyama K, etal., Synapse 2003 Sep 1;49(3):143-9.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Behavioral sensitization to cocaine is associated with increased glutamate receptor trafficking to the postsynaptic density after extended withdrawal period. Ghasemzadeh MB, etal., Neuroscience. 2009 Mar 3;159(1):414-26. Epub 2008 Nov 1.
8. Cocaine activates Homer1 immediate early gene transcription in the mesocorticolimbic circuit: differential regulation by dopamine and glutamate signaling. Ghasemzadeh MB, etal., Synapse. 2009 Jan;63(1):42-53.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. The postsynaptic density proteins Homer and Shank form a polymeric network structure. Hayashi MK, etal., Cell. 2009 Apr 3;137(1):159-71. doi: 10.1016/j.cell.2009.01.050.
11. A key role for diacylglycerol lipase-alpha in metabotropic glutamate receptor-dependent endocannabinoid mobilization. Jung KM, etal., Mol Pharmacol. 2007 Sep;72(3):612-21. doi: 10.1124/mol.107.037796. Epub 2007 Jun 21.
12. Regulation of Homer and group I metabotropic glutamate receptors by nicotine. Kane JK, etal., Eur J Neurosci. 2005 Mar;21(5):1145-54.
13. vesl, a gene encoding VASP/Ena family related protein, is upregulated during seizure, long-term potentiation and synaptogenesis. Kato A, etal., FEBS Lett 1997 Jul 21;412(1):183-9.
14. Novel members of the Vesl/Homer family of PDZ proteins that bind metabotropic glutamate receptors. Kato A, etal., J Biol Chem 1998 Sep 11;273(37):23969-75.
15. Postsynaptic positioning of endocytic zones and AMPA receptor cycling by physical coupling of dynamin-3 to Homer. Lu J, etal., Neuron. 2007 Sep 20;55(6):874-89.
16. The scaffold protein Homer1b/c links metabotropic glutamate receptor 5 to extracellular signal-regulated protein kinase cascades in neurons. Mao L, etal., J Neurosci. 2005 Mar 9;25(10):2741-52.
17. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
18. Homer1a and 1bc levels in the rat somatosensory cortex vary with the time of day and sleep loss. Nelson SE, etal., Neurosci Lett. 2004 Aug 26;367(1):105-8.
19. Homer-1 mRNA in the rat suprachiasmatic nucleus is regulated differentially by the retinohypothalamic tract transmitters pituitary adenylate cyclase activating polypeptide and glutamate at time points where light phase-shifts the endogenous rhythm. Nielsen HS, etal., Brain Res Mol Brain Res 2002 Sep 30;105(1-2):79-85.
20. Gene regulation in the frontal cortex of rats exposed to the chronic mild stress paradigm, an animal model of human depression. Orsetti M, etal., Eur J Neurosci. 2008 Apr;27(8):2156-64. Epub 2008 Mar 25.
21. A prolyl-isomerase mediates dopamine-dependent plasticity and cocaine motor sensitization. Park JM, etal., Cell. 2013 Aug 1;154(3):637-50. doi: 10.1016/j.cell.2013.07.001.
22. FRMPD4 mutations cause X-linked intellectual disability and disrupt dendritic spine morphogenesis. Piard J, etal., Hum Mol Genet. 2018 Feb 15;27(4):589-600. doi: 10.1093/hmg/ddx426.
23. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
24. Homer 1a gene expression modulation by antipsychotic drugs: involvement of the glutamate metabotropic system and effects of D-cycloserine. Polese D, etal., Neuropsychopharmacology 2002 Dec;27(6):906-13.
25. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
26. PI3 kinase enhancer-Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis. Rong R, etal., Nat Neurosci 2003 Nov;6(11):1153-61. Epub 2003 Oct 5.
27. Disassembly of shank and homer synaptic clusters is driven by soluble beta-amyloid(1-40) through divergent NMDAR-dependent signalling pathways. Roselli F, etal., PLoS One. 2009 Jun 23;4(6):e6011.
28. Inhibition of dendritic spine morphogenesis and synaptic transmission by activity-inducible protein Homer1a. Sala C, etal., J Neurosci. 2003 Jul 16;23(15):6327-37.
29. Evidence for the presence of two homer 1 transcripts in skeletal and cardiac muscles. Sandona D, etal., Biochem Biophys Res Commun 2000 Dec 20;279(2):348-53.
30. The Homer-1 protein Ania-3 interacts with the plasma membrane calcium pump. Sgambato-Faure V, etal., Biochem Biophys Res Commun. 2006 May 5;343(2):630-7. Epub 2006 Mar 15.
31. Regulation of KIF1A-Driven Dense Core Vesicle Transport: Ca2+/CaM Controls DCV Binding and Liprin-α/TANC2 Recruits DCVs to Postsynaptic Sites. Stucchi R, etal., Cell Rep. 2018 Jul 17;24(3):685-700. doi: 10.1016/j.celrep.2018.06.071.
32. Isolation of PSD-Zip45, a novel Homer/vesl family protein containing leucine zipper motifs, from rat brain. Sun J, etal., FEBS Lett 1998 Oct 23;437(3):304-8.
33. Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors. Tu JC, etal., Neuron 1998 Oct;21(4):717-26.
34. Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins. Tu JC, etal., Neuron. 1999 Jul;23(3):583-92.
35. Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins. Xiao B, etal., Neuron 1998 Oct;21(4):707-16.
Additional References at PubMed
PMID:9647694   PMID:10798399   PMID:10851183   PMID:11418862   PMID:12054806   PMID:12176012   PMID:12524440   PMID:12646135   PMID:12810060   PMID:12834253   PMID:12860966   PMID:12887973  
PMID:12911619   PMID:14505576   PMID:14559352   PMID:14698459   PMID:15033484   PMID:15294147   PMID:15574735   PMID:15579147   PMID:15632121   PMID:15673434   PMID:15691715   PMID:16002212  
PMID:16087291   PMID:17015857   PMID:17169339   PMID:17234898   PMID:17372981   PMID:17389377   PMID:17540011   PMID:17630046   PMID:17670980   PMID:18268005   PMID:18636533   PMID:18716215  
PMID:19118598   PMID:19201745   PMID:19243698   PMID:19419424   PMID:19443779   PMID:19709672   PMID:19923532   PMID:20147574   PMID:20181604   PMID:20304506   PMID:20738409   PMID:20886623  
PMID:21144999   PMID:21558424   PMID:21664258   PMID:21795692   PMID:22003220   PMID:22012123   PMID:22238580   PMID:22393587   PMID:22445886   PMID:22465321   PMID:22617701   PMID:22660975  
PMID:22732411   PMID:22814532   PMID:22871113   PMID:23523268   PMID:23587936   PMID:23733398   PMID:23791195   PMID:23800465   PMID:24036210   PMID:24377717   PMID:24530450   PMID:24554721  
PMID:24613359   PMID:24966368   PMID:25503822   PMID:25824461   PMID:26929812   PMID:27075036   PMID:27177972   PMID:27259299   PMID:28154077   PMID:28337539   PMID:28698564   PMID:29238619  
PMID:29476059   PMID:30265419   PMID:30335140   PMID:31369778   PMID:31404590   PMID:31505169   PMID:31891692   PMID:32013638   PMID:32756473   PMID:35352799  


Genomics

Comparative Map Data
Homer1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8226,279,012 - 26,388,279 (+)NCBIGRCr8
mRatBN7.2224,542,777 - 24,645,715 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl224,543,093 - 24,644,785 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx231,571,304 - 31,672,829 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0229,671,594 - 29,773,121 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0224,494,532 - 24,596,897 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0222,909,550 - 23,012,303 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl222,909,569 - 23,009,678 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0242,106,531 - 42,208,187 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera220,619,882 - 20,720,929 (+)NCBICelera
Cytogenetic Map2q12NCBI
HOMER1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38579,372,636 - 79,514,134 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl579,372,636 - 79,514,134 (-)EnsemblGRCh38hg38GRCh38
GRCh37578,668,459 - 78,809,957 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36578,705,542 - 78,845,456 (-)NCBINCBI36Build 36hg18NCBI36
Build 34578,705,542 - 78,845,456NCBI
Celera574,569,550 - 74,709,526 (-)NCBICelera
Cytogenetic Map5q14.1NCBI
HuRef573,877,773 - 74,017,416 (-)NCBIHuRef
CHM1_1578,102,358 - 78,242,362 (-)NCBICHM1_1
T2T-CHM13v2.0579,856,812 - 79,998,313 (-)NCBIT2T-CHM13v2.0
Homer1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391393,440,265 - 93,549,471 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1393,436,143 - 93,541,637 (+)EnsemblGRCm39 Ensembl
GRCm381393,303,757 - 93,405,129 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1393,299,635 - 93,405,129 (+)EnsemblGRCm38mm10GRCm38
MGSCv371394,074,450 - 94,174,917 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361394,405,552 - 94,504,882 (+)NCBIMGSCv36mm8
Celera1396,912,321 - 97,012,695 (+)NCBICelera
Cytogenetic Map13C3NCBI
cM Map1347.83NCBI
Homer1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542521,644,571 - 21,775,735 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542521,644,577 - 21,774,843 (+)NCBIChiLan1.0ChiLan1.0
HOMER1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2435,785,689 - 35,926,708 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1533,939,170 - 34,080,335 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0535,794,627 - 35,936,111 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1536,065,045 - 36,205,928 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl536,064,665 - 36,205,928 (+)Ensemblpanpan1.1panPan2
HOMER1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1327,395,337 - 27,525,822 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl327,400,839 - 27,523,320 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha328,635,060 - 28,765,722 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0327,314,347 - 27,445,373 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl327,319,051 - 27,445,574 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1327,254,336 - 27,384,769 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0327,231,171 - 27,362,707 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0327,511,836 - 27,642,805 (+)NCBIUU_Cfam_GSD_1.0
Homer1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213183,538,579 - 183,681,403 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365497,188,850 - 7,320,312 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365497,189,588 - 7,320,117 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HOMER1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl288,122,882 - 88,255,281 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1288,116,664 - 88,253,843 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2289,846,977 - 89,904,301 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.2289,987,133 - 89,996,112 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HOMER1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1473,591,105 - 73,729,680 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl473,589,495 - 73,728,353 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604922,438,015 - 22,576,283 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Homer1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248693,880,001 - 4,012,240 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248693,878,646 - 4,012,211 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Homer1
270 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1506
Count of miRNA genes:341
Interacting mature miRNAs:484
Transcripts:ENSRNOT00000071804, ENSRNOT00000073871
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578664Bmd9Bone mineral QTL density 95femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)21185206249003364Rat
738010Lnnr3Liver neoplastic nodule remodeling QTL 32.94liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)2141244106Rat
1357990Ael1Aortic elastin QTL 13.10.00091aorta elastin amount (VT:0003905)aortic elastin21907682564076825Rat
10755430Coatc6Coat color QTL 60.02576coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)21159110056591100Rat
1600379Mcs18Mammary carcinoma susceptibility QTL 182.6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)2788777242804738Rat
731167Glom4Glomerulus QTL 42.40.0082kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)22030467265304672Rat
738012Anxrr3Anxiety related response QTL 33.8exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)2902351954023519Rat
631682Bp115Blood pressure QTL 1154.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2137410502Rat
731184Mamtr4Mammary tumor resistance QTL 40.0003mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)21649174061491740Rat
2300168Bmd47Bone mineral density QTL 476.60.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)22066244865662448Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)25873687102844969Rat

Markers in Region
D2Rat190  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0222,988,221 - 22,988,322NCBIRnor6.0
Rnor_5.0242,184,052 - 42,184,206UniSTSRnor5.0
Celera220,697,451 - 20,697,590UniSTS
SHRSP x BN Map26.9998RGD
SHRSP x BN Map26.9998UniSTS
Cytogenetic Map2q12UniSTS
D2Rat309  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2224,590,228 - 24,590,426 (+)MAPPERmRatBN7.2
Rnor_6.0222,956,364 - 22,956,561NCBIRnor6.0
Rnor_5.0242,153,656 - 42,153,853UniSTSRnor5.0
Celera220,665,895 - 20,666,092UniSTS
SHRSP x BN Map26.9998RGD
SHRSP x BN Map26.9998UniSTS
Cytogenetic Map2q12UniSTS
D2Wox53  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2q12UniSTS
D2Wox51  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2224,601,970 - 24,602,285 (+)MAPPERmRatBN7.2
Rnor_6.0222,968,106 - 22,968,420NCBIRnor6.0
Rnor_5.0242,165,398 - 42,165,712UniSTSRnor5.0
Celera220,677,481 - 20,677,795UniSTS
Cytogenetic Map2q12UniSTS
BE119015  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2224,603,046 - 24,603,236 (+)MAPPERmRatBN7.2
Rnor_6.0222,969,182 - 22,969,371NCBIRnor6.0
Rnor_5.0242,166,474 - 42,166,663UniSTSRnor5.0
Celera220,678,557 - 20,678,746UniSTS
Cytogenetic Map2q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_031707 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006231775 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008760635 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039102105 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB003726 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB007688 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB017140 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF030088 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF093267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF093268 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ276327 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ276328 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY189942 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY189943 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473955 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U92079 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000071804   ⟹   ENSRNOP00000065989
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl224,543,604 - 24,644,785 (+)Ensembl
Rnor_6.0 Ensembl222,950,018 - 23,009,481 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000073871   ⟹   ENSRNOP00000066634
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl224,543,499 - 24,644,202 (+)Ensembl
Rnor_6.0 Ensembl222,909,569 - 23,009,678 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000078266   ⟹   ENSRNOP00000070611
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl224,544,099 - 24,642,932 (+)Ensembl
Rnor_6.0 Ensembl222,910,236 - 23,009,522 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000094656   ⟹   ENSRNOP00000094833
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl224,543,093 - 24,642,751 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000095158   ⟹   ENSRNOP00000097408
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl224,544,294 - 24,644,785 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000095790   ⟹   ENSRNOP00000086769
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl224,630,611 - 24,644,785 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000104131   ⟹   ENSRNOP00000080883
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl224,543,604 - 24,644,785 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000104734   ⟹   ENSRNOP00000079557
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl224,543,093 - 24,609,841 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000118061   ⟹   ENSRNOP00000080673
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl224,629,849 - 24,644,785 (+)Ensembl
RefSeq Acc Id: NM_031707   ⟹   NP_113895
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8226,279,012 - 26,380,555 (+)NCBI
mRatBN7.2224,544,000 - 24,645,547 (+)NCBI
Rnor_6.0222,910,137 - 23,012,137 (+)NCBI
Rnor_5.0242,106,531 - 42,208,187 (+)NCBI
Celera220,619,882 - 20,720,929 (+)RGD
Sequence:
RefSeq Acc Id: XM_006231775   ⟹   XP_006231837
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8226,279,170 - 26,388,279 (+)NCBI
mRatBN7.2224,542,778 - 24,645,715 (+)NCBI
Rnor_6.0222,909,550 - 23,012,303 (+)NCBI
Rnor_5.0242,106,531 - 42,208,187 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039102105   ⟹   XP_038958033
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8226,279,170 - 26,344,858 (+)NCBI
mRatBN7.2224,542,777 - 24,619,216 (+)NCBI
Protein Sequences
Protein RefSeqs NP_113895 (Get FASTA)   NCBI Sequence Viewer  
  XP_006231837 (Get FASTA)   NCBI Sequence Viewer  
  XP_038958033 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC53113 (Get FASTA)   NCBI Sequence Viewer  
  AAC71031 (Get FASTA)   NCBI Sequence Viewer  
  AAC71032 (Get FASTA)   NCBI Sequence Viewer  
  AAO39002 (Get FASTA)   NCBI Sequence Viewer  
  AAO39003 (Get FASTA)   NCBI Sequence Viewer  
  BAA21671 (Get FASTA)   NCBI Sequence Viewer  
  BAA32477 (Get FASTA)   NCBI Sequence Viewer  
  BAA34311 (Get FASTA)   NCBI Sequence Viewer  
  CAB77249 (Get FASTA)   NCBI Sequence Viewer  
  CAB77250 (Get FASTA)   NCBI Sequence Viewer  
  EDM10038 (Get FASTA)   NCBI Sequence Viewer  
  EDM10039 (Get FASTA)   NCBI Sequence Viewer  
  EDM10040 (Get FASTA)   NCBI Sequence Viewer  
  EDM10041 (Get FASTA)   NCBI Sequence Viewer  
  EDM10042 (Get FASTA)   NCBI Sequence Viewer  
  EDM10043 (Get FASTA)   NCBI Sequence Viewer  
  EDM10044 (Get FASTA)   NCBI Sequence Viewer  
  EDM10045 (Get FASTA)   NCBI Sequence Viewer  
  EDM10046 (Get FASTA)   NCBI Sequence Viewer  
  EDM10047 (Get FASTA)   NCBI Sequence Viewer  
  EDM10048 (Get FASTA)   NCBI Sequence Viewer  
  EDM10049 (Get FASTA)   NCBI Sequence Viewer  
  EDM10050 (Get FASTA)   NCBI Sequence Viewer  
  EDM10051 (Get FASTA)   NCBI Sequence Viewer  
  EDM10052 (Get FASTA)   NCBI Sequence Viewer  
  EDM10053 (Get FASTA)   NCBI Sequence Viewer  
  EDM10054 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000065989
  ENSRNOP00000065989.3
  ENSRNOP00000066634.2
  ENSRNOP00000070611.2
  ENSRNOP00000079557.1
  ENSRNOP00000080673.1
  ENSRNOP00000080883.1
  ENSRNOP00000086769.1
  ENSRNOP00000094833.1
  ENSRNOP00000097408.1
GenBank Protein Q9Z214 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_113895   ⟸   NM_031707
- UniProtKB: Q9QUJ8 (UniProtKB/Swiss-Prot),   O88800 (UniProtKB/Swiss-Prot),   O08567 (UniProtKB/Swiss-Prot),   Q9QWN5 (UniProtKB/Swiss-Prot),   Q9Z214 (UniProtKB/Swiss-Prot),   A6I4T1 (UniProtKB/TrEMBL),   A0A0H2UI35 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006231837   ⟸   XM_006231775
- Peptide Label: isoform X1
- UniProtKB: A6I4T3 (UniProtKB/TrEMBL),   A0A0H2UI35 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000070611   ⟸   ENSRNOT00000078266
Ensembl Acc Id: ENSRNOP00000066634   ⟸   ENSRNOT00000073871
Ensembl Acc Id: ENSRNOP00000065989   ⟸   ENSRNOT00000071804
RefSeq Acc Id: XP_038958033   ⟸   XM_039102105
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZMY0 (UniProtKB/TrEMBL),   A6I4U0 (UniProtKB/TrEMBL),   A6I4U1 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000080883   ⟸   ENSRNOT00000104131
Ensembl Acc Id: ENSRNOP00000097408   ⟸   ENSRNOT00000095158
Ensembl Acc Id: ENSRNOP00000080673   ⟸   ENSRNOT00000118061
Ensembl Acc Id: ENSRNOP00000094833   ⟸   ENSRNOT00000094656
Ensembl Acc Id: ENSRNOP00000086769   ⟸   ENSRNOT00000095790
Ensembl Acc Id: ENSRNOP00000079557   ⟸   ENSRNOT00000104734
Protein Domains
WH1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z214-F1-model_v2 AlphaFold Q9Z214 1-366 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691066
Promoter ID:EPDNEW_R1591
Type:single initiation site
Name:Homer1_1
Description:homer scaffolding protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0222,909,483 - 22,909,543EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628725 AgrOrtholog
BioCyc Gene G2FUF-54849 BioCyc
Ensembl Genes ENSRNOG00000047014 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000071804 UniProtKB/TrEMBL
  ENSRNOT00000071804.4 UniProtKB/Swiss-Prot
  ENSRNOT00000073871.3 UniProtKB/TrEMBL
  ENSRNOT00000078266.2 UniProtKB/TrEMBL
  ENSRNOT00000094656.1 UniProtKB/TrEMBL
  ENSRNOT00000095158.1 UniProtKB/TrEMBL
  ENSRNOT00000095790.1 UniProtKB/TrEMBL
  ENSRNOT00000104131.1 UniProtKB/TrEMBL
  ENSRNOT00000104734.1 UniProtKB/TrEMBL
  ENSRNOT00000118061.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1170.10 UniProtKB/TrEMBL
  1.20.5.1700 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Homer UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homer_EVH1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WH1/EVH1_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29546 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 29546 ENTREZGENE
PANTHER HOMER PROTEIN HOMOLOG 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10918 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam WH1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB HOMER1 RGD
PhenoGen Homer1 PhenoGen
PROSITE WH1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000047014 RatGTEx
SMART WH1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tropomyosin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0H2UI35 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZMY0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZQ49_RAT UniProtKB/TrEMBL
  A0A8I5ZQU9_RAT UniProtKB/TrEMBL
  A0A8I6A6X4_RAT UniProtKB/TrEMBL
  A0A8I6ANP3_RAT UniProtKB/TrEMBL
  A0A8I6ASW4_RAT UniProtKB/TrEMBL
  A0A8L2QXM5_RAT UniProtKB/TrEMBL
  A0A9K3Y739_RAT UniProtKB/TrEMBL
  A6I4T1 ENTREZGENE, UniProtKB/TrEMBL
  A6I4T3 ENTREZGENE, UniProtKB/TrEMBL
  A6I4U0 ENTREZGENE, UniProtKB/TrEMBL
  A6I4U1 ENTREZGENE, UniProtKB/TrEMBL
  A6I4U7_RAT UniProtKB/TrEMBL
  A6I4U9_RAT UniProtKB/TrEMBL
  A6I4V0_RAT UniProtKB/TrEMBL
  HOME1_RAT UniProtKB/Swiss-Prot
  O08567 ENTREZGENE
  O88800 ENTREZGENE
  Q811R0_RAT UniProtKB/TrEMBL
  Q811R1_RAT UniProtKB/TrEMBL
  Q9QUJ8 ENTREZGENE
  Q9QWN5 ENTREZGENE
  Q9Z214 ENTREZGENE
UniProt Secondary A0A0G2JYD5 UniProtKB/TrEMBL
  O08567 UniProtKB/Swiss-Prot
  O88800 UniProtKB/Swiss-Prot
  Q9QUJ8 UniProtKB/Swiss-Prot
  Q9QWN5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-03-16 Homer1  homer scaffold protein 1  Homer1  homer scaffolding protein 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-02-25 Homer1  homer scaffolding protein 1  Homer1  homer homolog 1 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Homer1  homer homolog 1 (Drosophila)    homer, neuronal immediate early gene, 1  Name updated 1299863 APPROVED
2003-02-27 Homer1  homer, neuronal immediate early gene, 1      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains contains a PDZ domain 633021